GLTP

Functionⁱ

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	140	Glycolipid1 Publication		1
Binding siteⁱ	207	Glycolipid1 Publication		1

GO - Molecular functionⁱ

glycolipid binding
Source: HGNC
Inferred from direct assayⁱ
- 15287756
- 15901739
glycolipid transporter activity Source: Reactome
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22078563
intermembrane lipid transfer activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15901739
lipid binding
Source: HGNC
Inferred from direct assayⁱ
- 15901739

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycosphingolipid metabolic process Source: Reactome
intermembrane lipid transfer
Source: BHF-UCL
Inferred from direct assayⁱ
- 15901739

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport

Biological process

Lipid transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism

Reactomeⁱ

R-HSA-1660662 Glycosphingolipid metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycolipid transfer protein Short name: GLTP
Gene namesⁱ	Name:GLTP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139433.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24867 GLTP
MIMⁱ	608949 gene
neXtProtⁱ	NX_Q9NZD2

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	45	I → N: 18% decrease in activity. 1 Publication	1
Mutagenesisⁱ	48	D → V: Significant inactivation; 15% residual activity. 1 Publication	1
Mutagenesisⁱ	52	N → I: Significant inactivation; 15% residual activity. 1 Publication	1
Mutagenesisⁱ	55	K → I: No loss of activity; 90-97% residual activity. 1 Publication	1
Mutagenesisⁱ	96	W → A: Almost complete inactivation; 1-3% residual activity. No effect on autophagy. 2 Publications	1
Mutagenesisⁱ	96	W → F: Partial inactivation; 63% residual activity. 1 Publication	1
Mutagenesisⁱ	103	F → S: About 25% decrease in activity. 1 Publication	1
Mutagenesisⁱ	136	L → R: Significant inactivation; 5% residual acti vity. 1 Publication	1
Mutagenesisⁱ	140	H → L: Almost complete inactivation; 1-3% residual activity. 1 Publication	1
Mutagenesisⁱ	148	F → S: About 50% decrease in activity. 1 Publication	1
Mutagenesisⁱ	165	L → R: 46% decrease in activity. 1 Publication	1
Mutagenesisⁱ	183	F → S: No loss of activity; 90% residual activity. 1 Publication	1
Mutagenesisⁱ	207	Y → L: No loss of activity; 90-97% residual activity. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000139433
PharmGKBⁱ	PA142671729

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03600 Decanoic Acid DB04465 Lactose DB03017 Lauric Acid DB04224 Oleic Acid DB03203 Sphingosine

DrugBankⁱ

DB03600 Decanoic Acid
DB04465 Lactose
DB03017 Lauric Acid
DB04224 Oleic Acid
DB03203 Sphingosine

Polymorphism and mutation databases

BioMutaⁱ	GLTP
DMDMⁱ	20138399

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000148915	2 – 209	Glycolipid transfer proteinAdd BLAST		208

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9NZD2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZD2
PaxDbⁱ	Q9NZD2
PeptideAtlas More...PeptideAtlasⁱ	Q9NZD2
PRIDEⁱ	Q9NZD2
ProteomicsDBⁱ	83375

PTM databases

iPTMnetⁱ	Q9NZD2
PhosphoSitePlusⁱ	Q9NZD2

Expressionⁱ

Tissue specificityⁱ

Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000139433 Expressed in 207 organ(s), highest expression level in upper arm skin
CleanExⁱ	HS_GLTP
ExpressionAtlasⁱ	Q9NZD2 baseline and differential
Genevisibleⁱ	Q9NZD2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056461

HPAⁱ

HPA056461

Interactionⁱ

Subunit structureⁱ

Monomer.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-2859814,EBI-2859814
CMTM5	Q96DZ9	3	EBI-2859814,EBI-2548702

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22078563

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119392, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-59418N
IntActⁱ	Q9NZD2, 2 interactors
STRINGⁱ	9606.ENSP00000315263

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 6	Combined sources	3
Helixⁱ	20 – 27	Combined sources	8
Turnⁱ	28 – 30	Combined sources	3
Helixⁱ	31 – 36	Combined sources	6
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	43 – 62	Combined sources	20
Turnⁱ	64 – 67	Combined sources	4
Helixⁱ	70 – 81	Combined sources	12
Helixⁱ	82 – 84	Combined sources	3
Helixⁱ	89 – 112	Combined sources	24
Beta strandⁱ	118 – 120	Combined sources	3
Helixⁱ	125 – 135	Combined sources	11
Helixⁱ	137 – 139	Combined sources	3
Helixⁱ	142 – 151	Combined sources	10
Helixⁱ	152 – 154	Combined sources	3
Helixⁱ	158 – 165	Combined sources	8
Turnⁱ	166 – 168	Combined sources	3
Helixⁱ	173 – 200	Combined sources	28

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZD2
SMRⁱ	Q9NZD2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NZD2

EvolutionaryTraceⁱ

Q9NZD2

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	45 – 55	1Add BLAST		11
Repeatⁱ	56 – 66	2Add BLAST		11

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	45 – 66	2 X 12 AA approximate tandem repeatsAdd BLAST		22
Regionⁱ	48 – 55	Glycolipid binding		8

Sequence similaritiesⁱ

Belongs to the GLTP family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3221 Eukaryota ENOG410YFEA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149132
HOGENOMⁱ	HOG000199421
HOVERGENⁱ	HBG019001
InParanoidⁱ	Q9NZD2
OMAⁱ	ACPYRKD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IIT
PhylomeDBⁱ	Q9NZD2
TreeFamⁱ	TF317467

Family and domain databases

Gene3Dⁱ	1.10.3520.10, 1 hit
InterProⁱ	View protein in InterPro IPR036497 GLTP_sf IPR014830 Glycolipid_transfer_prot_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08718 GLTP, 1 hit
SUPFAMⁱ	SSF110004 SSF110004, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.ⁱShow all

Q9NZD2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS 
        60         70         80         90        100
GNITKIKAVY DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG 
       110        120        130        140        150
LRFIQVFLQS ICDGERDENH PNLIRVNATK AYEMALKKYH GWIVQKIFQA 
       160        170        180        190        200
ALYAAPYKSD FLKALSKGQN VTEEECLEKI RLFLVNYTAT IDVIYEMYTQ 

MNAELNYKV

Length:209

Mass (Da):23,850

Last modified:January 23, 2007 - v3

Checksum:ⁱF3DD96D702AE22CF

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
F5H0U5	F5H0U5_HUMAN	Glycolipid transfer protein Glycolipid transfer protein	GLTP	190	Annotation score:
F5GZ49	F5GZ49_HUMAN	Glycolipid transfer protein isoform... Glycolipid transfer protein isoform 1	GLTP	67	Annotation score:
H0YFS9	H0YFS9_HUMAN	Glycolipid transfer protein Glycolipid transfer protein	GLTP	183	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF209704 mRNA Translation: AAF33210.1 AY372530 mRNA Translation: AAR85984.1 AY372531 mRNA Translation: AAR85985.1 AY372532 mRNA Translation: AAR87373.1 AK313457 mRNA Translation: BAG36244.1 CH471054 Genomic DNA Translation: EAW97880.1 BC009932 mRNA Translation: AAH09932.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9136.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057517.1, NM_016433.3
UniGeneⁱ	Hs.381256

Genome annotation databases

Ensemblⁱ	ENST00000318348; ENSP00000315263; ENSG00000139433
GeneIDⁱ	51228
KEGGⁱ	hsa:51228
UCSC genome browser More...UCSCⁱ	uc001tpm.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD2	Glycolipid transfer protein		PANTR		209	UniRef100_Q9NZD2
Glycolipid transfer protein, isoform CRA_a		HUMAN		209
Glycolipid transfer protein		MACMU		209
Glycolipid transfer protein		CALJA		209
Glycolipid transfer protein		SAIBB		209
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD2	Glycolipid transfer protein		PANTR		209	UniRef90_Q9NZD2
Glycolipid transfer protein	)	BOVIN		209
Glycolipid transfer protein		PIG		209
Glycolipid transfer protein, isoform CRA_a		HUMAN		209
Glycolipid transfer protein		MACMU		209
+57

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD2	Glycolipid transfer protein		PANTR		209	UniRef50_Q9NZD2
Glycolipid transfer protein	)	BOVIN		209
Glycolipid transfer protein		PIG		209
Glycolipid transfer protein		DANRE		209
Glycolipid transfer protein		RAT		209
+262

Entry informationⁱ

Entry nameⁱ	GLTP_HUMAN
Accessionⁱ	Q9NZD2Primary (citable) accession number: Q9NZD2 Secondary accession number(s): Q53Z13, Q96J68
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NZD2 (GLTP_HUMAN)

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Glycolipid transfer protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ