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Protein

Glycolipid transfer protein

Gene

GLTP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140Glycolipid1 Publication1
Binding sitei207Glycolipid1 Publication1

GO - Molecular functioni

  • glycolipid binding Source: HGNC
  • glycolipid transporter activity Source: Reactome
  • identical protein binding Source: IntAct
  • intermembrane lipid transfer activity Source: BHF-UCL
  • lipid binding Source: HGNC

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolipid transfer protein
Short name:
GLTP
Gene namesi
Name:GLTP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139433.9
HGNCiHGNC:24867 GLTP
MIMi608949 gene
neXtProtiNX_Q9NZD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45I → N: 18% decrease in activity. 1 Publication1
Mutagenesisi48D → V: Significant inactivation; 15% residual activity. 1 Publication1
Mutagenesisi52N → I: Significant inactivation; 15% residual activity. 1 Publication1
Mutagenesisi55K → I: No loss of activity; 90-97% residual activity. 1 Publication1
Mutagenesisi96W → A: Almost complete inactivation; 1-3% residual activity. No effect on autophagy. 2 Publications1
Mutagenesisi96W → F: Partial inactivation; 63% residual activity. 1 Publication1
Mutagenesisi103F → S: About 25% decrease in activity. 1 Publication1
Mutagenesisi136L → R: Significant inactivation; 5% residual acti vity. 1 Publication1
Mutagenesisi140H → L: Almost complete inactivation; 1-3% residual activity. 1 Publication1
Mutagenesisi148F → S: About 50% decrease in activity. 1 Publication1
Mutagenesisi165L → R: 46% decrease in activity. 1 Publication1
Mutagenesisi183F → S: No loss of activity; 90% residual activity. 1 Publication1
Mutagenesisi207Y → L: No loss of activity; 90-97% residual activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139433
PharmGKBiPA142671729

Chemistry databases

DrugBankiDB03600 Decanoic Acid
DB04465 Lactose
DB03017 Lauric Acid
DB04224 Oleic Acid
DB03203 Sphingosine

Polymorphism and mutation databases

BioMutaiGLTP
DMDMi20138399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001489152 – 209Glycolipid transfer proteinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NZD2
MaxQBiQ9NZD2
PaxDbiQ9NZD2
PeptideAtlasiQ9NZD2
PRIDEiQ9NZD2
ProteomicsDBi83375

PTM databases

iPTMnetiQ9NZD2
PhosphoSitePlusiQ9NZD2

Expressioni

Tissue specificityi

Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000139433 Expressed in 207 organ(s), highest expression level in upper arm skin
CleanExiHS_GLTP
ExpressionAtlasiQ9NZD2 baseline and differential
GenevisibleiQ9NZD2 HS

Organism-specific databases

HPAiHPA056461

Interactioni

Subunit structurei

Monomer.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119392, 6 interactors
DIPiDIP-59418N
IntActiQ9NZD2, 2 interactors
STRINGi9606.ENSP00000315263

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZD2
SMRiQ9NZD2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZD2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 551Add BLAST11
Repeati56 – 662Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 662 X 12 AA approximate tandem repeatsAdd BLAST22
Regioni48 – 55Glycolipid binding8

Sequence similaritiesi

Belongs to the GLTP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3221 Eukaryota
ENOG410YFEA LUCA
GeneTreeiENSGT00920000149132
HOGENOMiHOG000199421
HOVERGENiHBG019001
InParanoidiQ9NZD2
OMAiACPYRKD
OrthoDBiEOG091G0IIT
PhylomeDBiQ9NZD2
TreeFamiTF317467

Family and domain databases

Gene3Di1.10.3520.10, 1 hit
InterProiView protein in InterPro
IPR036497 GLTP_sf
IPR014830 Glycolipid_transfer_prot_dom
PfamiView protein in Pfam
PF08718 GLTP, 1 hit
SUPFAMiSSF110004 SSF110004, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9NZD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS
60 70 80 90 100
GNITKIKAVY DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG
110 120 130 140 150
LRFIQVFLQS ICDGERDENH PNLIRVNATK AYEMALKKYH GWIVQKIFQA
160 170 180 190 200
ALYAAPYKSD FLKALSKGQN VTEEECLEKI RLFLVNYTAT IDVIYEMYTQ

MNAELNYKV
Length:209
Mass (Da):23,850
Last modified:January 23, 2007 - v3
Checksum:iF3DD96D702AE22CF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H0U5F5H0U5_HUMAN
Glycolipid transfer protein
GLTP
190Annotation score:
F5GZ49F5GZ49_HUMAN
Glycolipid transfer protein isoform...
GLTP
67Annotation score:
H0YFS9H0YFS9_HUMAN
Glycolipid transfer protein
GLTP
183Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209704 mRNA Translation: AAF33210.1
AY372530 mRNA Translation: AAR85984.1
AY372531 mRNA Translation: AAR85985.1
AY372532 mRNA Translation: AAR87373.1
AK313457 mRNA Translation: BAG36244.1
CH471054 Genomic DNA Translation: EAW97880.1
BC009932 mRNA Translation: AAH09932.1
CCDSiCCDS9136.1
RefSeqiNP_057517.1, NM_016433.3
UniGeneiHs.381256

Genome annotation databases

EnsembliENST00000318348; ENSP00000315263; ENSG00000139433
GeneIDi51228
KEGGihsa:51228
UCSCiuc001tpm.3 human

Similar proteinsi

Entry informationi

Entry nameiGLTP_HUMAN
AccessioniPrimary (citable) accession number: Q9NZD2
Secondary accession number(s): Q53Z13, Q96J68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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