UniProtKB - Q9NZD2 (GLTP_HUMAN)
Protein
Glycolipid transfer protein
Gene
GLTP
Organism
Homo sapiens (Human)
Status
Functioni
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.4 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 140 | Glycolipid1 Publication | 1 | |
Binding sitei | 207 | Glycolipid1 Publication | 1 |
GO - Molecular functioni
- ceramide 1-phosphate binding Source: GO_Central
- ceramide 1-phosphate transfer activity Source: GO_Central
- glycolipid binding Source: HGNC-UCL
- glycolipid transfer activity Source: Reactome
- identical protein binding Source: IntAct
- lipid binding Source: HGNC-UCL
- lipid transfer activity Source: BHF-UCL
GO - Biological processi
- ceramide transport Source: GO_Central
- glycosphingolipid metabolic process Source: Reactome
- intermembrane lipid transfer Source: BHF-UCL
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NZD2 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Glycolipid transfer proteinShort name: GLTP |
Gene namesi | Name:GLTP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139433.9 |
HGNCi | HGNC:24867, GLTP |
MIMi | 608949, gene |
neXtProti | NX_Q9NZD2 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 45 | I → N: 18% decrease in activity. 1 Publication | 1 | |
Mutagenesisi | 48 | D → V: Significant inactivation; 15% residual activity. 1 Publication | 1 | |
Mutagenesisi | 52 | N → I: Significant inactivation; 15% residual activity. 1 Publication | 1 | |
Mutagenesisi | 55 | K → I: No loss of activity; 90-97% residual activity. 1 Publication | 1 | |
Mutagenesisi | 96 | W → A: Almost complete inactivation; 1-3% residual activity. No effect on autophagy. 2 Publications | 1 | |
Mutagenesisi | 96 | W → F: Partial inactivation; 63% residual activity. 1 Publication | 1 | |
Mutagenesisi | 103 | F → S: About 25% decrease in activity. 1 Publication | 1 | |
Mutagenesisi | 136 | L → R: Significant inactivation; 5% residual acti vity. 1 Publication | 1 | |
Mutagenesisi | 140 | H → L: Almost complete inactivation; 1-3% residual activity. 1 Publication | 1 | |
Mutagenesisi | 148 | F → S: About 50% decrease in activity. 1 Publication | 1 | |
Mutagenesisi | 165 | L → R: 46% decrease in activity. 1 Publication | 1 | |
Mutagenesisi | 183 | F → S: No loss of activity; 90% residual activity. 1 Publication | 1 | |
Mutagenesisi | 207 | Y → L: No loss of activity; 90-97% residual activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51228 |
OpenTargetsi | ENSG00000139433 |
PharmGKBi | PA142671729 |
Miscellaneous databases
Pharosi | Q9NZD2, Tbio |
Chemistry databases
DrugBanki | DB03600, Capric acid DB04465, Lactose DB03017, Lauric acid DB03203, Sphingosine |
Polymorphism and mutation databases
BioMutai | GLTP |
DMDMi | 20138399 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000148915 | 2 – 209 | Glycolipid transfer proteinAdd BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9NZD2 |
jPOSTi | Q9NZD2 |
MassIVEi | Q9NZD2 |
MaxQBi | Q9NZD2 |
PaxDbi | Q9NZD2 |
PeptideAtlasi | Q9NZD2 |
PRIDEi | Q9NZD2 |
ProteomicsDBi | 83375 |
PTM databases
iPTMneti | Q9NZD2 |
PhosphoSitePlusi | Q9NZD2 |
Expressioni
Tissue specificityi
Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.2 Publications
Gene expression databases
Bgeei | ENSG00000139433, Expressed in upper arm skin and 221 other tissues |
ExpressionAtlasi | Q9NZD2, baseline and differential |
Genevisiblei | Q9NZD2, HS |
Organism-specific databases
HPAi | ENSG00000139433, Tissue enhanced (esophagus, lymphoid tissue, skin) |
Interactioni
Subunit structurei
Monomer.
2 PublicationsBinary interactionsi
Hide detailsQ9NZD2
With | #Exp. | IntAct |
---|---|---|
CMTM5 [Q96DZ9] | 4 | EBI-2859814,EBI-2548702 |
itself | 2 | EBI-2859814,EBI-2859814 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 119392, 6 interactors |
DIPi | DIP-59418N |
IntActi | Q9NZD2, 6 interactors |
STRINGi | 9606.ENSP00000315263 |
Miscellaneous databases
RNActi | Q9NZD2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NZD2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZD2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 45 – 55 | 1Add BLAST | 11 | |
Repeati | 56 – 66 | 2Add BLAST | 11 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 66 | 2 X 12 AA approximate tandem repeatsAdd BLAST | 22 | |
Regioni | 48 – 55 | Glycolipid binding | 8 |
Sequence similaritiesi
Belongs to the GLTP family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3221, Eukaryota |
GeneTreei | ENSGT00940000155182 |
HOGENOMi | CLU_079400_2_1_1 |
InParanoidi | Q9NZD2 |
OMAi | AMSACPY |
OrthoDBi | 1160303at2759 |
PhylomeDBi | Q9NZD2 |
TreeFami | TF317467 |
Family and domain databases
Gene3Di | 1.10.3520.10, 1 hit |
InterProi | View protein in InterPro IPR036497, GLTP_sf IPR014830, Glycolipid_transfer_prot_dom |
Pfami | View protein in Pfam PF08718, GLTP, 1 hit |
SUPFAMi | SSF110004, SSF110004, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9NZD2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS
60 70 80 90 100
GNITKIKAVY DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG
110 120 130 140 150
LRFIQVFLQS ICDGERDENH PNLIRVNATK AYEMALKKYH GWIVQKIFQA
160 170 180 190 200
ALYAAPYKSD FLKALSKGQN VTEEECLEKI RLFLVNYTAT IDVIYEMYTQ
MNAELNYKV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H0U5 | F5H0U5_HUMAN | Glycolipid transfer protein | GLTP | 190 | Annotation score: | ||
F5GZ49 | F5GZ49_HUMAN | Glycolipid transfer protein | GLTP | 67 | Annotation score: | ||
H0YFS9 | H0YFS9_HUMAN | Glycolipid transfer protein | GLTP | 183 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF209704 mRNA Translation: AAF33210.1 AY372530 mRNA Translation: AAR85984.1 AY372531 mRNA Translation: AAR85985.1 AY372532 mRNA Translation: AAR87373.1 AK313457 mRNA Translation: BAG36244.1 CH471054 Genomic DNA Translation: EAW97880.1 BC009932 mRNA Translation: AAH09932.1 |
CCDSi | CCDS9136.1 |
RefSeqi | NP_057517.1, NM_016433.3 |
Genome annotation databases
Ensembli | ENST00000318348; ENSP00000315263; ENSG00000139433 |
GeneIDi | 51228 |
KEGGi | hsa:51228 |
UCSCi | uc001tpm.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF209704 mRNA Translation: AAF33210.1 AY372530 mRNA Translation: AAR85984.1 AY372531 mRNA Translation: AAR85985.1 AY372532 mRNA Translation: AAR87373.1 AK313457 mRNA Translation: BAG36244.1 CH471054 Genomic DNA Translation: EAW97880.1 BC009932 mRNA Translation: AAH09932.1 |
CCDSi | CCDS9136.1 |
RefSeqi | NP_057517.1, NM_016433.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SWX | X-ray | 1.65 | A | 1-209 | [»] | |
1SX6 | X-ray | 1.95 | A | 1-209 | [»] | |
2EUK | X-ray | 1.85 | A | 1-209 | [»] | |
2EUM | X-ray | 2.30 | A | 1-209 | [»] | |
2EVD | X-ray | 2.00 | A | 1-209 | [»] | |
2EVL | X-ray | 2.20 | A | 1-209 | [»] | |
2EVS | X-ray | 2.20 | A/E | 1-209 | [»] | |
2EVT | X-ray | 1.99 | A | 1-209 | [»] | |
3RIC | X-ray | 2.10 | A | 1-209 | [»] | |
3RWV | X-ray | 1.50 | A/B | 1-209 | [»] | |
3RZN | X-ray | 1.10 | A | 1-209 | [»] | |
3S0I | X-ray | 1.50 | A | 1-209 | [»] | |
3S0K | X-ray | 1.40 | A | 1-209 | [»] | |
4GH0 | X-ray | 1.35 | A | 1-209 | [»] | |
4GHP | X-ray | 1.90 | A | 1-209 | [»] | |
4GHS | X-ray | 3.20 | A/B | 1-209 | [»] | |
4GIX | X-ray | 1.80 | A | 1-209 | [»] | |
4GJQ | X-ray | 2.00 | A/B | 1-209 | [»] | |
4GVT | X-ray | 2.90 | A | 1-209 | [»] | |
4GXD | X-ray | 2.10 | A | 1-209 | [»] | |
4GXG | X-ray | 2.40 | A/B/D/E | 1-209 | [»] | |
4H2Z | X-ray | 1.45 | A | 1-209 | [»] | |
SMRi | Q9NZD2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119392, 6 interactors |
DIPi | DIP-59418N |
IntActi | Q9NZD2, 6 interactors |
STRINGi | 9606.ENSP00000315263 |
Chemistry databases
DrugBanki | DB03600, Capric acid DB04465, Lactose DB03017, Lauric acid DB03203, Sphingosine |
PTM databases
iPTMneti | Q9NZD2 |
PhosphoSitePlusi | Q9NZD2 |
Polymorphism and mutation databases
BioMutai | GLTP |
DMDMi | 20138399 |
Proteomic databases
EPDi | Q9NZD2 |
jPOSTi | Q9NZD2 |
MassIVEi | Q9NZD2 |
MaxQBi | Q9NZD2 |
PaxDbi | Q9NZD2 |
PeptideAtlasi | Q9NZD2 |
PRIDEi | Q9NZD2 |
ProteomicsDBi | 83375 |
Protocols and materials databases
Antibodypediai | 30918, 101 antibodies |
DNASUi | 51228 |
Genome annotation databases
Ensembli | ENST00000318348; ENSP00000315263; ENSG00000139433 |
GeneIDi | 51228 |
KEGGi | hsa:51228 |
UCSCi | uc001tpm.3, human |
Organism-specific databases
CTDi | 51228 |
DisGeNETi | 51228 |
EuPathDBi | HostDB:ENSG00000139433.9 |
GeneCardsi | GLTP |
HGNCi | HGNC:24867, GLTP |
HPAi | ENSG00000139433, Tissue enhanced (esophagus, lymphoid tissue, skin) |
MIMi | 608949, gene |
neXtProti | NX_Q9NZD2 |
OpenTargetsi | ENSG00000139433 |
PharmGKBi | PA142671729 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3221, Eukaryota |
GeneTreei | ENSGT00940000155182 |
HOGENOMi | CLU_079400_2_1_1 |
InParanoidi | Q9NZD2 |
OMAi | AMSACPY |
OrthoDBi | 1160303at2759 |
PhylomeDBi | Q9NZD2 |
TreeFami | TF317467 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZD2 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism |
Miscellaneous databases
BioGRID-ORCSi | 51228, 21 hits in 843 CRISPR screens |
ChiTaRSi | GLTP, human |
EvolutionaryTracei | Q9NZD2 |
GeneWikii | GLTP |
GenomeRNAii | 51228 |
Pharosi | Q9NZD2, Tbio |
PROi | PR:Q9NZD2 |
RNActi | Q9NZD2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139433, Expressed in upper arm skin and 221 other tissues |
ExpressionAtlasi | Q9NZD2, baseline and differential |
Genevisiblei | Q9NZD2, HS |
Family and domain databases
Gene3Di | 1.10.3520.10, 1 hit |
InterProi | View protein in InterPro IPR036497, GLTP_sf IPR014830, Glycolipid_transfer_prot_dom |
Pfami | View protein in Pfam PF08718, GLTP, 1 hit |
SUPFAMi | SSF110004, SSF110004, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLTP_HUMAN | |
Accessioni | Q9NZD2Primary (citable) accession number: Q9NZD2 Secondary accession number(s): Q53Z13, Q96J68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM