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Entry version 174 (16 Jan 2019)
Sequence version 1 (01 Oct 2000)
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Protein

WW domain-containing oxidoreductase

Gene

WWOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.By similarity7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei260SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei293Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi131 – 137NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • coenzyme binding Source: UniProtKB
  • cofactor binding Source: UniProtKB
  • enzyme binding Source: BHF-UCL
  • oxidoreductase activity Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • transcription coactivator activity Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Wnt signaling pathway
LigandNADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9NZC7

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NZC7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Alternative name(s):
Fragile site FRA16D oxidoreductase
Short chain dehydrogenase/reductase family 41C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WWOX
Synonyms:FOR, SDR41C1, WOX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186153.16

Human Gene Nomenclature Database

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HGNCi
HGNC:12799 WWOX

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605131 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NZC7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers (PubMed:10861292). Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect (PubMed:10861292, PubMed:11572989, PubMed:15266310, PubMed:15073125, PubMed:15131042).5 Publications
Esophageal cancer (ESCR)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
See also OMIM:133239
Spinocerebellar ataxia, autosomal recessive, 12 (SCAR12)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with mental retardation. Some patients may also show spasticity.
See also OMIM:614322
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07099247P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar.1
Natural variantiVAR_070993372G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar.1
Epileptic encephalopathy, early infantile, 28 (EIEE28)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
See also OMIM:616211
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07235147P → R in EIEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28K → T: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with V-29. 1 Publication1
Mutagenesisi29D → V: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with T-28. 1 Publication1
Mutagenesisi33Y → F: Loss of phosphorylation. 2 Publications1
Mutagenesisi33Y → R: Abolishes interaction with TP53, TP73, MAPK8 and ERBB4. Partial loss of interaction with TFAP2C. Loss of phosphorylation. Loss of the proapoptotic activity. 2 Publications1
Mutagenesisi44 – 47WEHP → FEHA: Abolishes interaction with LITAF. 1 Publication4
Mutagenesisi61Y → R: No effect on interaction with TP73. 1 Publication1
Mutagenesisi85 – 88YLDP → ALDA: No effect on interaction with LITAF. 1 Publication4
Mutagenesisi287Y → A: Loss of phosphorylation by TNK2. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Neurodegeneration, Tumor suppressor

Organism-specific databases

DisGeNET

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DisGeNETi
51741

MalaCards human disease database

More...
MalaCardsi
WWOX
MIMi133239 phenotype
614322 phenotype
616211 phenotype

Open Targets

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OpenTargetsi
ENSG00000186153

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
251510 46,XY partial gonadal dysgenesis
284282 Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency
99977 Squamous cell carcinoma of the esophagus
442835 Undetermined early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37398

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WWOX

Domain mapping of disease mutations (DMDM)

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DMDMi
74725363

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000548151 – 414WW domain-containing oxidoreductaseAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphothreonineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei33Phosphotyrosine2 Publications1
Modified residuei287Phosphotyrosine; by TNK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation.3 Publications
Ubiquitinated when phosphorylated by TNK2, leading to its degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NZC7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NZC7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NZC7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NZC7

PeptideAtlas

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PeptideAtlasi
Q9NZC7

PRoteomics IDEntifications database

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PRIDEi
Q9NZC7

ProteomicsDB human proteome resource

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ProteomicsDBi
83364
83365 [Q9NZC7-2]
83366 [Q9NZC7-3]
83367 [Q9NZC7-4]
83368 [Q9NZC7-5]
83369 [Q9NZC7-6]
83370 [Q9NZC7-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NZC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NZC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186153 Expressed in 222 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NZC7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NZC7 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA050992

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119707, 258 interactors

Protein interaction database and analysis system

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IntActi
Q9NZC7, 118 interactors

Molecular INTeraction database

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MINTi
Q9NZC7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000457230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMVNMR-A51-101[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NZC7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NZC7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9NZC7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 49WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini57 – 90WW 2PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 414Interaction with MAPTBy similarityAdd BLAST290
Regioni209 – 273Mediates targeting to the mitochondriaBy similarityAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi50 – 55Nuclear localization signalBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INSS Eukaryota
COG5021 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157389

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG078800

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NZC7

KEGG Orthology (KO)

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KOi
K19329

Identification of Orthologs from Complete Genome Data

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OMAi
DDGTVCY

Database of Orthologous Groups

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OrthoDBi
1413827at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NZC7

TreeFam database of animal gene trees

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TreeFami
TF105428

Family and domain databases

Conserved Domains Database

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CDDi
cd00201 WW, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00081 GDHRDH

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZC7-1) [UniParc]FASTAAdd to basket
Also known as: FOR II, FOR2, WWOXv1, WWOX v8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG
60 70 80 90 100
KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK
110 120 130 140 150
PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH
160 170 180 190 200
VILACRNMAR ASEAVSRILE EWHKAKVEAM TLDLALLRSV QHFAEAFKAK
210 220 230 240 250
NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS
260 270 280 290 300
APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN
310 320 330 340 350
ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK
360 370 380 390 400
SMQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL
410
SERLIQERLG SQSG
Length:414
Mass (Da):46,677
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4D9A649E6CB05DF
GO
Isoform 2 (identifier: Q9NZC7-2) [UniParc]FASTAAdd to basket
Also known as: FOR I, FOR1, WOX2, WWOXv2

The sequence of this isoform differs from the canonical sequence as follows:
     353-363: QQGAATTVYCA → VSDCLVEGGHF
     364-414: Missing.

Show »
Length:363
Mass (Da):41,128
Checksum:iC1BB208B887281C3
GO
Isoform 3 (identifier: Q9NZC7-3) [UniParc]FASTAAdd to basket
Also known as: FOR III, FOR3, WOX3

The sequence of this isoform differs from the canonical sequence as follows:
     173-189: HKAKVEAMTLDLALLRS → KTKYHPPPEKCRIKIFH
     190-414: Missing.

Show »
Length:189
Mass (Da):21,559
Checksum:i82155A9AD7C824C7
GO
Isoform 4 (identifier: Q9NZC7-4) [UniParc]FASTAAdd to basket
Also known as: FOR IV

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: N → K
     37-414: Missing.

Show »
Length:36
Mass (Da):4,150
Checksum:iA6D0FEE1CAE266B2
GO
Isoform 5 (identifier: Q9NZC7-5) [UniParc]FASTAAdd to basket
Also known as: WWOXdelta6-8, WWOXv4

The sequence of this isoform differs from the canonical sequence as follows:
     173-352: Missing.

Show »
Length:234
Mass (Da):26,148
Checksum:iC69FB6B3E87635F4
GO
Isoform 6 (identifier: Q9NZC7-6) [UniParc]FASTAAdd to basket
Also known as: WWOXdelta5-8, WWOXv3

The sequence of this isoform differs from the canonical sequence as follows:
     137-414: GFETAKSFAL...IQERLGSQSG → ATGSCHHRVL...FSFFYCYRIA

Show »
Length:311
Mass (Da):35,042
Checksum:i8EF6B9823F90C9F7
GO
Isoform 7 (identifier: Q9NZC7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-213: FETAKSFALH...LHVLVCNAAT → KASCHVGRTL...PGPCGRSARG
     214-414: Missing.

Show »
Length:213
Mass (Da):23,868
Checksum:iA21054FF8214CC7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3R5F5H3R5_HUMAN
WW domain-containing oxidoreductase
WWOX
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMD1H3BMD1_HUMAN
WW domain-containing oxidoreductase
WWOX
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZG5A0A087WZG5_HUMAN
WW domain-containing oxidoreductase
WWOX
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP94227 differs from that shown. Reason: Frameshift at position 362.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07235147P → R in EIEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar.1
Natural variantiVAR_07099247P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar.1
Natural variantiVAR_02391698P → L1 PublicationCorresponds to variant dbSNP:rs144601717EnsemblClinVar.1
Natural variantiVAR_023917111T → S in a Burkitt lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs114755364EnsemblClinVar.1
Natural variantiVAR_023918120R → W in a primary colorectal tumor and a histiocytic lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs141361080EnsemblClinVar.1
Natural variantiVAR_023919179A → T2 PublicationsCorresponds to variant dbSNP:rs11545029EnsemblClinVar.1
Natural variantiVAR_052323216L → V. Corresponds to variant dbSNP:rs7201683EnsemblClinVar.1
Natural variantiVAR_023920272L → F1 PublicationCorresponds to variant dbSNP:rs186745328EnsemblClinVar.1
Natural variantiVAR_023921282P → A1 PublicationCorresponds to variant dbSNP:rs3764340EnsemblClinVar.1
Natural variantiVAR_023922291L → P Found in a esophageal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs119487098EnsemblClinVar.1
Natural variantiVAR_023923314R → H in a cervical carcinoma cell line. 1 PublicationCorresponds to variant dbSNP:rs73572838EnsemblClinVar.1
Natural variantiVAR_070993372G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar.1
Isoform 3 (identifier: Q9NZC7-3)
Natural varianti182K → E Found in a primary colorectal tumor and tumor cells. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01635836N → K in isoform 4. 1 Publication1
Alternative sequenceiVSP_01635937 – 414Missing in isoform 4. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_016360137 – 414GFETA…GSQSG → ATGSCHHRVLCCCPRTGGSG RDVLQQLLPLHALTRSSERR DGPDPVGAQREADPRTAWQP VRLSGAQSGWAHTPALCVSP HASARAGPLPNVPPTQIRKS KGNKSSHNRVKNLKYQWEAG NSWGKVSLFWGWARHRSLCF LVVACLKVKTCLVCRFRISL EKHQQFSFFYCYRIA in isoform 6. 1 PublicationAdd BLAST278
Alternative sequenceiVSP_016362138 – 213FETAK…CNAAT → KASCHVGRTLKHTRVEELSL LPTAINRELPPPCTVLLSQN WRVWEGCTSTTAAAACPHQK LRAKRRPGPCGRSARG in isoform 7. CuratedAdd BLAST76
Alternative sequenceiVSP_016363173 – 352Missing in isoform 5. 3 PublicationsAdd BLAST180
Alternative sequenceiVSP_016364173 – 189HKAKV…ALLRS → KTKYHPPPEKCRIKIFH in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016365190 – 414Missing in isoform 3. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_016366214 – 414Missing in isoform 7. CuratedAdd BLAST201
Alternative sequenceiVSP_016367353 – 363QQGAATTVYCA → VSDCLVEGGHF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_016369364 – 414Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF211943 mRNA Translation: AAF27049.1
AF212843 Genomic DNA Translation: AAF27050.1
AH009490 Genomic DNA Translation: AAF78197.1
AF227526 mRNA Translation: AAF82053.1
AF227527 mRNA Translation: AAF82054.1
AF227528 mRNA Translation: AAF82055.1
AF227529 mRNA Translation: AAF82056.1
AF395123 mRNA Translation: AAK81727.1
AF395124 mRNA Translation: AAK81728.1
AF325432
, AF325423, AF325424, AF325425, AF325426, AF325427, AF325428, AF325430, AF325431 Genomic DNA Translation: AAL05449.1
AF325429
, AF325423, AF325424, AF325425, AF325426, AF325427 Genomic DNA Translation: AAL05450.1
AF325432
, AF325423, AF325424, AF325425, AF325426, AF325433 Genomic DNA Translation: AAL05451.1
AY256821 mRNA Translation: AAP94227.1 Frameshift.
AK290438 mRNA Translation: BAF83127.1
BT007445 mRNA Translation: AAP36113.1
BC003184 mRNA Translation: AAH03184.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42196.1 [Q9NZC7-1]
CCDS42197.1 [Q9NZC7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001278926.1, NM_001291997.1
NP_057457.1, NM_016373.3 [Q9NZC7-1]
NP_570607.1, NM_130791.3 [Q9NZC7-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.461453

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355860; ENSP00000348119; ENSG00000186153 [Q9NZC7-3]
ENST00000402655; ENSP00000384238; ENSG00000186153 [Q9NZC7-6]
ENST00000406884; ENSP00000384495; ENSG00000186153 [Q9NZC7-5]
ENST00000408984; ENSP00000386161; ENSG00000186153 [Q9NZC7-2]
ENST00000566780; ENSP00000457230; ENSG00000186153 [Q9NZC7-1]
ENST00000569818; ENSP00000454485; ENSG00000186153 [Q9NZC7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51741

UCSC genome browser

More...
UCSCi
uc002ffi.3 human [Q9NZC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211943 mRNA Translation: AAF27049.1
AF212843 Genomic DNA Translation: AAF27050.1
AH009490 Genomic DNA Translation: AAF78197.1
AF227526 mRNA Translation: AAF82053.1
AF227527 mRNA Translation: AAF82054.1
AF227528 mRNA Translation: AAF82055.1
AF227529 mRNA Translation: AAF82056.1
AF395123 mRNA Translation: AAK81727.1
AF395124 mRNA Translation: AAK81728.1
AF325432
, AF325423, AF325424, AF325425, AF325426, AF325427, AF325428, AF325430, AF325431 Genomic DNA Translation: AAL05449.1
AF325429
, AF325423, AF325424, AF325425, AF325426, AF325427 Genomic DNA Translation: AAL05450.1
AF325432
, AF325423, AF325424, AF325425, AF325426, AF325433 Genomic DNA Translation: AAL05451.1
AY256821 mRNA Translation: AAP94227.1 Frameshift.
AK290438 mRNA Translation: BAF83127.1
BT007445 mRNA Translation: AAP36113.1
BC003184 mRNA Translation: AAH03184.1
CCDSiCCDS42196.1 [Q9NZC7-1]
CCDS42197.1 [Q9NZC7-3]
RefSeqiNP_001278926.1, NM_001291997.1
NP_057457.1, NM_016373.3 [Q9NZC7-1]
NP_570607.1, NM_130791.3 [Q9NZC7-3]
UniGeneiHs.461453

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMVNMR-A51-101[»]
ProteinModelPortaliQ9NZC7
SMRiQ9NZC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119707, 258 interactors
IntActiQ9NZC7, 118 interactors
MINTiQ9NZC7
STRINGi9606.ENSP00000457230

PTM databases

iPTMnetiQ9NZC7
PhosphoSitePlusiQ9NZC7

Polymorphism and mutation databases

BioMutaiWWOX
DMDMi74725363

Proteomic databases

EPDiQ9NZC7
jPOSTiQ9NZC7
MaxQBiQ9NZC7
PaxDbiQ9NZC7
PeptideAtlasiQ9NZC7
PRIDEiQ9NZC7
ProteomicsDBi83364
83365 [Q9NZC7-2]
83366 [Q9NZC7-3]
83367 [Q9NZC7-4]
83368 [Q9NZC7-5]
83369 [Q9NZC7-6]
83370 [Q9NZC7-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355860; ENSP00000348119; ENSG00000186153 [Q9NZC7-3]
ENST00000402655; ENSP00000384238; ENSG00000186153 [Q9NZC7-6]
ENST00000406884; ENSP00000384495; ENSG00000186153 [Q9NZC7-5]
ENST00000408984; ENSP00000386161; ENSG00000186153 [Q9NZC7-2]
ENST00000566780; ENSP00000457230; ENSG00000186153 [Q9NZC7-1]
ENST00000569818; ENSP00000454485; ENSG00000186153 [Q9NZC7-4]
GeneIDi51741
KEGGihsa:51741
UCSCiuc002ffi.3 human [Q9NZC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51741
DisGeNETi51741
EuPathDBiHostDB:ENSG00000186153.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WWOX
HGNCiHGNC:12799 WWOX
HPAiHPA050992
MalaCardsiWWOX
MIMi133239 phenotype
605131 gene
614322 phenotype
616211 phenotype
neXtProtiNX_Q9NZC7
OpenTargetsiENSG00000186153
Orphaneti251510 46,XY partial gonadal dysgenesis
284282 Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency
99977 Squamous cell carcinoma of the esophagus
442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA37398

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INSS Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000157389
HOVERGENiHBG078800
InParanoidiQ9NZC7
KOiK19329
OMAiDDGTVCY
OrthoDBi1413827at2759
PhylomeDBiQ9NZC7
TreeFamiTF105428

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
SignaLinkiQ9NZC7
SIGNORiQ9NZC7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WWOX human
EvolutionaryTraceiQ9NZC7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WWOX

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51741

Protein Ontology

More...
PROi
PR:Q9NZC7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186153 Expressed in 222 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ9NZC7 baseline and differential
GenevisibleiQ9NZC7 HS

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits
PRINTSiPR00081 GDHRDH
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWWOX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZC7
Secondary accession number(s): A8K323
, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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