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UniProtKB - Q9NZC7 (WWOX_HUMAN)

Entry version 184 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

WW domain-containing oxidoreductase

Gene

WWOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.By similarity7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei260SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei293Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi131 – 137NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Wnt signaling pathway
LigandNADP

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZC7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NZC7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NZC7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Alternative name(s):
Fragile site FRA16D oxidoreductase
Short chain dehydrogenase/reductase family 41C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WWOX
Synonyms:FOR, SDR41C1, WOX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000186153.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:12799, WWOX

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605131, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZC7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers (PubMed:10861292). Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect (PubMed:10861292, PubMed:11572989, PubMed:15266310, PubMed:15073125, PubMed:15131042).5 Publications
Esophageal cancer (ESCR)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
Related information in OMIM
Spinocerebellar ataxia, autosomal recessive, 12 (SCAR12)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with mental retardation. Some patients may also show spasticity.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07099247P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar.1
Natural variantiVAR_070993372G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar.1
Epileptic encephalopathy, early infantile, 28 (EIEE28)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07235147P → R in EIEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28K → T: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with V-29. 1 Publication1
Mutagenesisi29D → V: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with T-28. 1 Publication1
Mutagenesisi33Y → F: Loss of phosphorylation. 2 Publications1
Mutagenesisi33Y → R: Abolishes interaction with TP53, TP73, MAPK8 and ERBB4. Partial loss of interaction with TFAP2C. Loss of phosphorylation. Loss of the proapoptotic activity. 2 Publications1
Mutagenesisi44 – 47WEHP → FEHA: Abolishes interaction with LITAF. 1 Publication4
Mutagenesisi61Y → R: No effect on interaction with TP73. 1 Publication1
Mutagenesisi85 – 88YLDP → ALDA: No effect on interaction with LITAF. 1 Publication4
Mutagenesisi287Y → A: Loss of phosphorylation by TNK2. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Neurodegeneration, Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		51741

MalaCards human disease database

More...MalaCardsi		WWOX
MIMi133239, phenotype
614322, phenotype
616211, phenotype

NIAGADS Genomics Database

More...NIAGADSi		ENSG00000186153

Open Targets

More...OpenTargetsi		ENSG00000186153

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		251510, 46,XY partial gonadal dysgenesis
284282, Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency
99977, Squamous cell carcinoma of the esophagus
442835, Undetermined early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37398

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZC7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WWOX

Domain mapping of disease mutations (DMDM)

More...DMDMi		74725363

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000548151 – 414WW domain-containing oxidoreductaseAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphothreonineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei33Phosphotyrosine2 Publications1
Modified residuei287Phosphotyrosine; by TNK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation.3 Publications
Ubiquitinated when phosphorylated by TNK2, leading to its degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZC7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZC7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZC7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZC7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZC7

PeptideAtlas

More...PeptideAtlasi		Q9NZC7

PRoteomics IDEntifications database

More...PRIDEi		Q9NZC7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83364 [Q9NZC7-1]
83365 [Q9NZC7-2]
83366 [Q9NZC7-3]
83367 [Q9NZC7-4]
83368 [Q9NZC7-5]
83369 [Q9NZC7-6]
83370 [Q9NZC7-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186153, Expressed in parotid gland and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZC7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZC7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186153, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP53, p73/TP73 and MAPK8.

Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity).

Forms a ternary complex with TP53 and MDM2.

Interacts with ERBB4, LITAF and WBP1.

Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Interacts with TNK2.

Interacts with TMEM207.

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NZC7
With#Exp.IntAct
FAM189B [P81408]2EBI-4320739,EBI-6366314
LITAF [Q99732]5EBI-4320739,EBI-725647
SHISA5 [Q8N114]2EBI-4320739,EBI-2115556
TP53 [P04637]2EBI-4320739,EBI-366083
WBP1 [Q96G27]3EBI-4320739,EBI-3867685
Bcl9l [Q67FY2] from Mus musculus.3EBI-4320739,EBI-5234367
Dvl2 [Q60838] from Mus musculus.2EBI-4320739,EBI-641940
Erbb4 [Q61527] from Mus musculus.3EBI-4320739,EBI-4398741
WWOX - isoform 5 [Q9NZC7-5]
With#Exp.IntAct
ABHD11 - isoform 4 [Q8NFV4-4]3EBI-12040603,EBI-12318443
ABI2 - isoform 2 [Q9NYB9-2]5EBI-12040603,EBI-11096309
ACAT2 [Q9BWD1]3EBI-12040603,EBI-1047273
ACY1 [Q03154]3EBI-12040603,EBI-742064
ADRA2C [P18825]3EBI-12040603,EBI-12015266
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-12040603,EBI-12224467
ANXA11 [P50995]3EBI-12040603,EBI-715243
ARRDC3 [Q96B67]8EBI-12040603,EBI-2875665
C10orf55 [Q5SWW7]3EBI-12040603,EBI-12809220
C11orf87 [Q6NUJ2]3EBI-12040603,EBI-6660291
C12orf10 [Q9HB07]3EBI-12040603,EBI-709754
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-12040603,EBI-11976299
CCDC24 [Q8N4L8]3EBI-12040603,EBI-1104933
CEACAM6 [P40199]3EBI-12040603,EBI-4314501
CNNM3 [Q8NE01]3EBI-12040603,EBI-741032
CPSF6 - isoform 2 [Q16630-2]3EBI-12040603,EBI-11088043
CREB5 - isoform 3 [Q02930-3]3EBI-12040603,EBI-10192698
CSNK2B [P67870]3EBI-12040603,EBI-348169
CTAG1B [P78358]3EBI-12040603,EBI-1188472
CTDSP1 [Q9GZU7]3EBI-12040603,EBI-751587
DAZAP2 [Q15038]6EBI-12040603,EBI-724310
DMRT3 [Q9NQL9]3EBI-12040603,EBI-9679045
ENKD1 [Q9H0I2]3EBI-12040603,EBI-744099
FAM214B [Q7L5A3]3EBI-12040603,EBI-745689
FAM222B [Q8WU58]5EBI-12040603,EBI-2807642
FEM1A [Q9BSK4]3EBI-12040603,EBI-2515349
FOXD4L1 [Q9NU39]3EBI-12040603,EBI-11320806
FOXI1 - isoform 2 [Q12951-2]3EBI-12040603,EBI-12018822
FRS3 [O43559]3EBI-12040603,EBI-725515
GCM2 [O75603]3EBI-12040603,EBI-10188645
GEM [P55040]3EBI-12040603,EBI-744104
GLIS2 [Q9BZE0]3EBI-12040603,EBI-7251368
GNE - isoform 2 [Q9Y223-2]3EBI-12040603,EBI-11975289
HOXA1 [P49639]3EBI-12040603,EBI-740785
HOXC8 [P31273]3EBI-12040603,EBI-1752118
HSPB2 [Q16082]3EBI-12040603,EBI-739395
IFIT2 [Q8IZ03]3EBI-12040603,EBI-746217
INCA1 [Q0VD86]3EBI-12040603,EBI-6509505
KLHDC7B [Q96G42]3EBI-12040603,EBI-9478422
KLHL38 [Q2WGJ6]3EBI-12040603,EBI-6426443
KRT3 [P12035]3EBI-12040603,EBI-2430095
KRT34 [O76011]3EBI-12040603,EBI-1047093
KRT75 [O95678]3EBI-12040603,EBI-2949715
KRTAP11-1 [Q8IUC1]3EBI-12040603,EBI-1052037
LASP1 - isoform 2 [Q14847-2]3EBI-12040603,EBI-9088686
LITAF [Q99732]3EBI-12040603,EBI-725647
LMO3 - isoform 4 [Q8TAP4-4]3EBI-12040603,EBI-11742507
MED25 [Q71SY5]3EBI-12040603,EBI-394558
MKRN3 [Q13064]3EBI-12040603,EBI-2340269
MYOZ1 [Q9NP98]3EBI-12040603,EBI-744402
MYOZ2 [Q9NPC6]3EBI-12040603,EBI-746712
NEDD9 - isoform 2 [Q14511-2]3EBI-12040603,EBI-11746523
OLIG3 [Q7RTU3]3EBI-12040603,EBI-10225049
OTX1 [P32242]3EBI-12040603,EBI-740446
PATL1 [Q86TB9]5EBI-12040603,EBI-2562092
PATZ1 - isoform 4 [Q9HBE1-4]5EBI-12040603,EBI-11022007
PAX9 [P55771]3EBI-12040603,EBI-12111000
PBX4 [Q9BYU1]3EBI-12040603,EBI-10302990
PEF1 [Q9UBV8]3EBI-12040603,EBI-724639
PITX2 - isoform PTX2C [Q99697-2]3EBI-12040603,EBI-12138495
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-12040603,EBI-12014286
PLSCR3 [Q9NRY6]3EBI-12040603,EBI-750734
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-12040603,EBI-12000762
PSMB8 - isoform 2 [P28062-2]3EBI-12040603,EBI-372312
RAMAC [Q9BTL3]3EBI-12040603,EBI-744023
RUSC1 [Q9BVN2]3EBI-12040603,EBI-6257312
SAXO1 [Q8IYX7]3EBI-12040603,EBI-3957636
SH2D4A [Q9H788]5EBI-12040603,EBI-747035
SHC3 [Q92529]5EBI-12040603,EBI-79084
SLC15A2 [Q16348]3EBI-12040603,EBI-12806032
SMR3A [Q99954]3EBI-12040603,EBI-12067698
SNRPC [P09234]3EBI-12040603,EBI-766589
TCHP [Q9BT92]3EBI-12040603,EBI-740781
TEKT3 [Q9BXF9]3EBI-12040603,EBI-8644516
TEX37 [Q96LM6]3EBI-12040603,EBI-743976
TFG [Q92734]3EBI-12040603,EBI-357061
TRIM69 - isoform 2 [Q86WT6-2]3EBI-12040603,EBI-11525489
TSGA10IP [Q3SY00]5EBI-12040603,EBI-10241197
UFSP1 [Q6NVU6]3EBI-12040603,EBI-12068150
VENTX [O95231]5EBI-12040603,EBI-10191303
VEZF1 [Q14119]3EBI-12040603,EBI-11980193
VPS37C [A5D8V6]3EBI-12040603,EBI-2559305
itself3EBI-12040603,EBI-12040603
ZBTB32 [A0A0C4DGF1]6EBI-12040603,EBI-10188476
ZIC1 [Q15915]3EBI-12040603,EBI-11963196
ZNF135 [P52742]3EBI-12040603,EBI-7101455
ZNF414 [Q96IQ9]3EBI-12040603,EBI-744257
ZNF581 [Q9P0T4]3EBI-12040603,EBI-745520
Q96EJ43EBI-12040603,EBI-750454

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119707, 469 interactors

Protein interaction database and analysis system

More...IntActi		Q9NZC7, 119 interactors

Molecular INTeraction database

More...MINTi		Q9NZC7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000457230

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZC7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZC7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NZC7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 49WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini57 – 90WW 2PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 414Interaction with MAPTBy similarityAdd BLAST290
Regioni209 – 273Mediates targeting to the mitochondriaBy similarityAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi50 – 55Nuclear localization signalBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1208, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157389

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010194_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZC7

KEGG Orthology (KO)

More...KOi		K19329

Identification of Orthologs from Complete Genome Data

More...OMAi		DDGTVCY

Database of Orthologous Groups

More...OrthoDBi		1413827at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZC7

TreeFam database of animal gene trees

More...TreeFami		TF105428

Family and domain databases

Conserved Domains Database

More...CDDi		cd09809, human_WWOX_like_SDR_c-like, 1 hit
cd00201, WW, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR042732, WWOX_SDR_c-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106, adh_short, 1 hit
PF00397, WW, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081, GDHRDH

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 2 hits
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZC7-1) [UniParc]FASTAAdd to basket
Also known as: FOR II, FOR2, WWOXv1, WWOX v8

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG 
        60         70         80         90        100
KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK 
       110        120        130        140        150
PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH 
       160        170        180        190        200
VILACRNMAR ASEAVSRILE EWHKAKVEAM TLDLALLRSV QHFAEAFKAK 
       210        220        230        240        250
NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS 
       260        270        280        290        300
APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN 
       310        320        330        340        350
ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK 
       360        370        380        390        400
SMQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL 
       410 
SERLIQERLG SQSG
Length:414
Mass (Da):46,677
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4D9A649E6CB05DF
GO
Isoform 2 (identifier: Q9NZC7-2) [UniParc]FASTAAdd to basket
Also known as: FOR I, FOR1, WOX2, WWOXv2

The sequence of this isoform differs from the canonical sequence as follows:
     353-363: QQGAATTVYCA → VSDCLVEGGHF
     364-414: Missing.

Show »
Length:363
Mass (Da):41,128
Checksum:iC1BB208B887281C3
GO
Isoform 3 (identifier: Q9NZC7-3) [UniParc]FASTAAdd to basket
Also known as: FOR III, FOR3, WOX3

The sequence of this isoform differs from the canonical sequence as follows:
     173-189: HKAKVEAMTLDLALLRS → KTKYHPPPEKCRIKIFH
     190-414: Missing.

Show »
Length:189
Mass (Da):21,559
Checksum:i82155A9AD7C824C7
GO
Isoform 4 (identifier: Q9NZC7-4) [UniParc]FASTAAdd to basket
Also known as: FOR IV

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: N → K
     37-414: Missing.

Show »
Length:36
Mass (Da):4,150
Checksum:iA6D0FEE1CAE266B2
GO
Isoform 5 (identifier: Q9NZC7-5) [UniParc]FASTAAdd to basket
Also known as: WWOXdelta6-8, WWOXv4

The sequence of this isoform differs from the canonical sequence as follows:
     173-352: Missing.

Show »
Length:234
Mass (Da):26,148
Checksum:iC69FB6B3E87635F4
GO
Isoform 6 (identifier: Q9NZC7-6) [UniParc]FASTAAdd to basket
Also known as: WWOXdelta5-8, WWOXv3

The sequence of this isoform differs from the canonical sequence as follows:
     137-414: GFETAKSFAL...IQERLGSQSG → ATGSCHHRVL...FSFFYCYRIA

Show »
Length:311
Mass (Da):35,042
Checksum:i8EF6B9823F90C9F7
GO
Isoform 7 (identifier: Q9NZC7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-213: FETAKSFALH...LHVLVCNAAT → KASCHVGRTL...PGPCGRSARG
     214-414: Missing.

Show »
Length:213
Mass (Da):23,868
Checksum:iA21054FF8214CC7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3R5F5H3R5_HUMAN
WW domain-containing oxidoreductase
WWOX
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMD1H3BMD1_HUMAN
WW domain-containing oxidoreductase
WWOX
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZG5A0A087WZG5_HUMAN
WW domain-containing oxidoreductase
WWOX
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP94227 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07235147P → R in EIEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar.1
Natural variantiVAR_07099247P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar.1
Natural variantiVAR_02391698P → L1 PublicationCorresponds to variant dbSNP:rs144601717EnsemblClinVar.1
Natural variantiVAR_023917111T → S in a Burkitt lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs114755364EnsemblClinVar.1
Natural variantiVAR_023918120R → W in a primary colorectal tumor and a histiocytic lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs141361080EnsemblClinVar.1
Natural variantiVAR_023919179A → T2 PublicationsCorresponds to variant dbSNP:rs11545029EnsemblClinVar.1
Natural variantiVAR_052323216L → V. Corresponds to variant dbSNP:rs7201683EnsemblClinVar.1
Natural variantiVAR_023920272L → F1 PublicationCorresponds to variant dbSNP:rs186745328EnsemblClinVar.1
Natural variantiVAR_023921282P → A1 PublicationCorresponds to variant dbSNP:rs3764340EnsemblClinVar.1
Natural variantiVAR_023922291L → P Found in a esophageal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs119487098EnsemblClinVar.1
Natural variantiVAR_023923314R → H in a cervical carcinoma cell line. 1 PublicationCorresponds to variant dbSNP:rs73572838EnsemblClinVar.1
Natural variantiVAR_070993372G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar.1
Isoform 3 (identifier: Q9NZC7-3)
Natural variantiVAR_082915182K → E Found in a primary colorectal tumor and tumor cells. Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01635836N → K in isoform 4. 1 Publication1
Alternative sequenceiVSP_01635937 – 414Missing in isoform 4. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_016360137 – 414GFETA…GSQSG → ATGSCHHRVLCCCPRTGGSG RDVLQQLLPLHALTRSSERR DGPDPVGAQREADPRTAWQP VRLSGAQSGWAHTPALCVSP HASARAGPLPNVPPTQIRKS KGNKSSHNRVKNLKYQWEAG NSWGKVSLFWGWARHRSLCF LVVACLKVKTCLVCRFRISL EKHQQFSFFYCYRIA in isoform 6. 1 PublicationAdd BLAST278
Alternative sequenceiVSP_016362138 – 213FETAK…CNAAT → KASCHVGRTLKHTRVEELSL LPTAINRELPPPCTVLLSQN WRVWEGCTSTTAAAACPHQK LRAKRRPGPCGRSARG in isoform 7. CuratedAdd BLAST76
Alternative sequenceiVSP_016363173 – 352Missing in isoform 5. 3 PublicationsAdd BLAST180
Alternative sequenceiVSP_016364173 – 189HKAKV…ALLRS → KTKYHPPPEKCRIKIFH in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016365190 – 414Missing in isoform 3. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_016366214 – 414Missing in isoform 7. CuratedAdd BLAST201
Alternative sequenceiVSP_016367353 – 363QQGAATTVYCA → VSDCLVEGGHF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_016369364 – 414Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF211943 mRNA Translation: AAF27049.1
AF212843 Genomic DNA Translation: AAF27050.1
AH009490 Genomic DNA Translation: AAF78197.1
AF227526 mRNA Translation: AAF82053.1
AF227527 mRNA Translation: AAF82054.1
AF227528 mRNA Translation: AAF82055.1
AF227529 mRNA Translation: AAF82056.1
AF395123 mRNA Translation: AAK81727.1
AF395124 mRNA Translation: AAK81728.1
AF325432 AF325431 Genomic DNA Translation: AAL05449.1
AF325429 AF325427 Genomic DNA Translation: AAL05450.1
AF325432 AF325433 Genomic DNA Translation: AAL05451.1
AY256821 mRNA Translation: AAP94227.1 Frameshift.
AK290438 mRNA Translation: BAF83127.1
BT007445 mRNA Translation: AAP36113.1
BC003184 mRNA Translation: AAH03184.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42196.1 [Q9NZC7-1]
CCDS42197.1 [Q9NZC7-3]

NCBI Reference Sequences

More...RefSeqi		NP_001278926.1, NM_001291997.1
NP_057457.1, NM_016373.3 [Q9NZC7-1]
NP_570607.1, NM_130791.3 [Q9NZC7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355860; ENSP00000348119; ENSG00000186153 [Q9NZC7-3]
ENST00000402655; ENSP00000384238; ENSG00000186153 [Q9NZC7-6]
ENST00000406884; ENSP00000384495; ENSG00000186153 [Q9NZC7-5]
ENST00000408984; ENSP00000386161; ENSG00000186153 [Q9NZC7-2]
ENST00000566780; ENSP00000457230; ENSG00000186153 [Q9NZC7-1]
ENST00000569818; ENSP00000454485; ENSG00000186153 [Q9NZC7-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51741

UCSC genome browser

More...UCSCi		uc002ffi.3, human [Q9NZC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211943 mRNA Translation: AAF27049.1
AF212843 Genomic DNA Translation: AAF27050.1
AH009490 Genomic DNA Translation: AAF78197.1
AF227526 mRNA Translation: AAF82053.1
AF227527 mRNA Translation: AAF82054.1
AF227528 mRNA Translation: AAF82055.1
AF227529 mRNA Translation: AAF82056.1
AF395123 mRNA Translation: AAK81727.1
AF395124 mRNA Translation: AAK81728.1
AF325432 AF325431 Genomic DNA Translation: AAL05449.1
AF325429 AF325427 Genomic DNA Translation: AAL05450.1
AF325432 AF325433 Genomic DNA Translation: AAL05451.1
AY256821 mRNA Translation: AAP94227.1 Frameshift.
AK290438 mRNA Translation: BAF83127.1
BT007445 mRNA Translation: AAP36113.1
BC003184 mRNA Translation: AAH03184.1
CCDSiCCDS42196.1 [Q9NZC7-1]
CCDS42197.1 [Q9NZC7-3]
RefSeqiNP_001278926.1, NM_001291997.1
NP_057457.1, NM_016373.3 [Q9NZC7-1]
NP_570607.1, NM_130791.3 [Q9NZC7-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMVNMR-A51-101[»]
SMRiQ9NZC7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119707, 469 interactors
IntActiQ9NZC7, 119 interactors
MINTiQ9NZC7
STRINGi9606.ENSP00000457230

PTM databases

iPTMnetiQ9NZC7
PhosphoSitePlusiQ9NZC7

Polymorphism and mutation databases

BioMutaiWWOX
DMDMi74725363

Proteomic databases

EPDiQ9NZC7
jPOSTiQ9NZC7
MassIVEiQ9NZC7
MaxQBiQ9NZC7
PaxDbiQ9NZC7
PeptideAtlasiQ9NZC7
PRIDEiQ9NZC7
ProteomicsDBi83364 [Q9NZC7-1]
83365 [Q9NZC7-2]
83366 [Q9NZC7-3]
83367 [Q9NZC7-4]
83368 [Q9NZC7-5]
83369 [Q9NZC7-6]
83370 [Q9NZC7-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8291, 342 antibodies

The DNASU plasmid repository

More...DNASUi		51741

Genome annotation databases

EnsembliENST00000355860; ENSP00000348119; ENSG00000186153 [Q9NZC7-3]
ENST00000402655; ENSP00000384238; ENSG00000186153 [Q9NZC7-6]
ENST00000406884; ENSP00000384495; ENSG00000186153 [Q9NZC7-5]
ENST00000408984; ENSP00000386161; ENSG00000186153 [Q9NZC7-2]
ENST00000566780; ENSP00000457230; ENSG00000186153 [Q9NZC7-1]
ENST00000569818; ENSP00000454485; ENSG00000186153 [Q9NZC7-4]
GeneIDi51741
KEGGihsa:51741
UCSCiuc002ffi.3, human [Q9NZC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51741
DisGeNETi51741
EuPathDBiHostDB:ENSG00000186153.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		WWOX
HGNCiHGNC:12799, WWOX
HPAiENSG00000186153, Low tissue specificity
MalaCardsiWWOX
MIMi133239, phenotype
605131, gene
614322, phenotype
616211, phenotype
neXtProtiNX_Q9NZC7
NIAGADSiENSG00000186153
OpenTargetsiENSG00000186153
Orphaneti251510, 46,XY partial gonadal dysgenesis
284282, Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency
99977, Squamous cell carcinoma of the esophagus
442835, Undetermined early-onset epileptic encephalopathy
PharmGKBiPA37398

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1208, Eukaryota
GeneTreeiENSGT00940000157389
HOGENOMiCLU_010194_44_0_1
InParanoidiQ9NZC7
KOiK19329
OMAiDDGTVCY
OrthoDBi1413827at2759
PhylomeDBiQ9NZC7
TreeFamiTF105428

Enzyme and pathway databases

PathwayCommonsiQ9NZC7
ReactomeiR-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors
SignaLinkiQ9NZC7
SIGNORiQ9NZC7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51741, 3 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WWOX, human
EvolutionaryTraceiQ9NZC7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WWOX

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51741
PharosiQ9NZC7, Tbio

Protein Ontology

More...PROi		PR:Q9NZC7
RNActiQ9NZC7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186153, Expressed in parotid gland and 237 other tissues
ExpressionAtlasiQ9NZC7, baseline and differential
GenevisibleiQ9NZC7, HS

Family and domain databases

CDDicd09809, human_WWOX_like_SDR_c-like, 1 hit
cd00201, WW, 2 hits
InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR042732, WWOX_SDR_c-like
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PF00397, WW, 2 hits
PRINTSiPR00081, GDHRDH
SMARTiView protein in SMART
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
SSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWWOX_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZC7
Secondary accession number(s): A8K323
, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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