UniProtKB - Q9NZC7 (WWOX_HUMAN)
WW domain-containing oxidoreductase
WWOX
Functioni
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity).
May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
By similarity7 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 260 | SubstrateBy similarity | 1 | |
Active sitei | 293 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 131 – 137 | NADPBy similarity | 7 |
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- identical protein binding Source: IntAct
- oxidoreductase activity Source: UniProtKB
- transcription coactivator activity Source: Ensembl
GO - Biological processi
- cellular response to transforming growth factor beta stimulus Source: BHF-UCL
- extrinsic apoptotic signaling pathway Source: Ensembl
- intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
- negative regulation of Wnt signaling pathway Source: UniProtKB
- osteoblast differentiation Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- skeletal system morphogenesis Source: BHF-UCL
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Apoptosis, Wnt signaling pathway |
Ligand | NADP |
Enzyme and pathway databases
PathwayCommonsi | Q9NZC7 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
SignaLinki | Q9NZC7 |
SIGNORi | Q9NZC7 |
Names & Taxonomyi
Protein namesi | Recommended name: WW domain-containing oxidoreductase (EC:1.1.1.-)Alternative name(s): Fragile site FRA16D oxidoreductase Short chain dehydrogenase/reductase family 41C member 1 |
Gene namesi | Name:WWOX Synonyms:FOR, SDR41C1, WOX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12799, WWOX |
MIMi | 605131, gene |
neXtProti | NX_Q9NZC7 |
VEuPathDBi | HostDB:ENSG00000186153 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 5 Publications
Golgi apparatus
- Golgi apparatus Curated
Mitochondrion
- Mitochondrion 1 Publication
Nucleus
- Nucleus 4 Publications
Note: Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus.By similarity2 Publications
Cytosol
- cytosol Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Mitochondrion
- mitochondrion Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Esophageal cancer (ESCR)1 Publication
Spinocerebellar ataxia, autosomal recessive, 12 (SCAR12)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070992 | 47 | P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar. | 1 | |
Natural variantiVAR_070993 | 372 | G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar. | 1 |
Developmental and epileptic encephalopathy 28 (DEE28)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072351 | 47 | P → R in DEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | K → T: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with V-29. 1 Publication | 1 | |
Mutagenesisi | 29 | D → V: No effect on interaction with TP53. Abolishes interaction with MAPK8; when associated with T-28. 1 Publication | 1 | |
Mutagenesisi | 33 | Y → F: Loss of phosphorylation. 2 Publications | 1 | |
Mutagenesisi | 33 | Y → R: Abolishes interaction with TP53, TP73, MAPK8 and ERBB4. Partial loss of interaction with TFAP2C. Loss of phosphorylation. Loss of the proapoptotic activity. 2 Publications | 1 | |
Mutagenesisi | 44 – 47 | WEHP → FEHA: Abolishes interaction with LITAF. 1 Publication | 4 | |
Mutagenesisi | 61 | Y → R: No effect on interaction with TP73. 1 Publication | 1 | |
Mutagenesisi | 85 – 88 | YLDP → ALDA: No effect on interaction with LITAF. 1 Publication | 4 | |
Mutagenesisi | 287 | Y → A: Loss of phosphorylation by TNK2. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Epilepsy, Neurodegeneration, Tumor suppressorOrganism-specific databases
DisGeNETi | 51741 |
MalaCardsi | WWOX |
MIMi | 133239, phenotype 614322, phenotype 616211, phenotype |
NIAGADSi | ENSG00000186153 |
OpenTargetsi | ENSG00000186153 |
Orphaneti | 251510, 46,XY partial gonadal dysgenesis 284282, Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency 442835, Non-specific early-onset epileptic encephalopathy 99977, Squamous cell carcinoma of the esophagus |
PharmGKBi | PA37398 |
Miscellaneous databases
Pharosi | Q9NZC7, Tbio |
Genetic variation databases
BioMutai | WWOX |
DMDMi | 74725363 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054815 | 1 – 414 | WW domain-containing oxidoreductaseAdd BLAST | 414 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 33 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 287 | Phosphotyrosine; by TNK21 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NZC7 |
jPOSTi | Q9NZC7 |
MassIVEi | Q9NZC7 |
MaxQBi | Q9NZC7 |
PaxDbi | Q9NZC7 |
PeptideAtlasi | Q9NZC7 |
PRIDEi | Q9NZC7 |
ProteomicsDBi | 83364 [Q9NZC7-1] 83365 [Q9NZC7-2] 83366 [Q9NZC7-3] 83367 [Q9NZC7-4] 83368 [Q9NZC7-5] 83369 [Q9NZC7-6] 83370 [Q9NZC7-7] |
PTM databases
iPTMneti | Q9NZC7 |
PhosphoSitePlusi | Q9NZC7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000186153, Expressed in parotid gland and 238 other tissues |
ExpressionAtlasi | Q9NZC7, baseline and differential |
Genevisiblei | Q9NZC7, HS |
Organism-specific databases
HPAi | ENSG00000186153, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TP53, p73/TP73 and MAPK8.
Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity).
Forms a ternary complex with TP53 and MDM2.
Interacts with ERBB4, LITAF and WBP1.
Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.
Interacts with TNK2.
Interacts with TMEM207.
By similarity10 PublicationsBinary interactionsi
Q9NZC7
WWOX - isoform 5 [Q9NZC7-5]
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 119707, 614 interactors |
IntActi | Q9NZC7, 148 interactors |
MINTi | Q9NZC7 |
STRINGi | 9606.ENSP00000457230 |
Miscellaneous databases
RNActi | Q9NZC7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9NZC7 |
SMRi | Q9NZC7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZC7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 49 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 57 – 90 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 125 – 414 | Interaction with MAPTBy similarityAdd BLAST | 290 | |
Regioni | 209 – 273 | Mediates targeting to the mitochondriaBy similarityAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 50 – 55 | Nuclear localization signalBy similarity | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000157389 |
HOGENOMi | CLU_010194_44_0_1 |
InParanoidi | Q9NZC7 |
OMAi | VHPGNMV |
OrthoDBi | 1413827at2759 |
PhylomeDBi | Q9NZC7 |
TreeFami | TF105428 |
Family and domain databases
CDDi | cd09809, human_WWOX_like_SDR_c-like, 1 hit cd00201, WW, 2 hits |
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam IPR001202, WW_dom IPR036020, WW_dom_sf IPR042732, WWOX_SDR_c-like |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit PF00397, WW, 2 hits |
PRINTSi | PR00081, GDHRDH |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG
60 70 80 90 100
KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK
110 120 130 140 150
PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH
160 170 180 190 200
VILACRNMAR ASEAVSRILE EWHKAKVEAM TLDLALLRSV QHFAEAFKAK
210 220 230 240 250
NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS
260 270 280 290 300
APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN
310 320 330 340 350
ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK
360 370 380 390 400
SMQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL
410
SERLIQERLG SQSG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H3R5 | F5H3R5_HUMAN | WW domain-containing oxidoreductase | WWOX | 213 | Annotation score: | ||
A0A804HJX9 | A0A804HJX9_HUMAN | WW domain-containing oxidoreductase | WWOX | 367 | Annotation score: | ||
A0A0D9SER1 | A0A0D9SER1_HUMAN | WW domain-containing oxidoreductase | WWOX | 446 | Annotation score: | ||
H3BMD1 | H3BMD1_HUMAN | WW domain-containing oxidoreductase | WWOX | 45 | Annotation score: | ||
A0A087WZG5 | A0A087WZG5_HUMAN | WW domain-containing oxidoreductase | WWOX | 150 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_072351 | 47 | P → R in DEE28. 1 PublicationCorresponds to variant dbSNP:rs730880292EnsemblClinVar. | 1 | ||
Natural variantiVAR_070992 | 47 | P → T in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777128EnsemblClinVar. | 1 | ||
Natural variantiVAR_023916 | 98 | P → L1 PublicationCorresponds to variant dbSNP:rs144601717EnsemblClinVar. | 1 | ||
Natural variantiVAR_023917 | 111 | T → S in a Burkitt lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs114755364EnsemblClinVar. | 1 | ||
Natural variantiVAR_023918 | 120 | R → W in a primary colorectal tumor and a histiocytic lymphoma cell line. 1 PublicationCorresponds to variant dbSNP:rs141361080EnsemblClinVar. | 1 | ||
Natural variantiVAR_023919 | 179 | A → T2 PublicationsCorresponds to variant dbSNP:rs11545029EnsemblClinVar. | 1 | ||
Natural variantiVAR_052323 | 216 | L → V. Corresponds to variant dbSNP:rs7201683EnsemblClinVar. | 1 | ||
Natural variantiVAR_023920 | 272 | L → F1 PublicationCorresponds to variant dbSNP:rs186745328EnsemblClinVar. | 1 | ||
Natural variantiVAR_023921 | 282 | P → A1 PublicationCorresponds to variant dbSNP:rs3764340EnsemblClinVar. | 1 | ||
Natural variantiVAR_023922 | 291 | L → P Found in a esophageal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs119487098EnsemblClinVar. | 1 | ||
Natural variantiVAR_023923 | 314 | R → H1 PublicationCorresponds to variant dbSNP:rs73572838EnsemblClinVar. | 1 | ||
Natural variantiVAR_070993 | 372 | G → R in SCAR12. 1 PublicationCorresponds to variant dbSNP:rs587777127EnsemblClinVar. | 1 | ||
Isoform 3 (identifier: Q9NZC7-3) | |||||
Natural variantiVAR_082915 | 182 | K → E Found in a primary colorectal tumor and tumor cells. CuratedCorresponds to variant dbSNP:rs77067228Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016358 | 36 | N → K in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_016359 | 37 – 414 | Missing in isoform 4. 1 PublicationAdd BLAST | 378 | |
Alternative sequenceiVSP_016360 | 137 – 414 | GFETA…GSQSG → ATGSCHHRVLCCCPRTGGSG RDVLQQLLPLHALTRSSERR DGPDPVGAQREADPRTAWQP VRLSGAQSGWAHTPALCVSP HASARAGPLPNVPPTQIRKS KGNKSSHNRVKNLKYQWEAG NSWGKVSLFWGWARHRSLCF LVVACLKVKTCLVCRFRISL EKHQQFSFFYCYRIA in isoform 6. 1 PublicationAdd BLAST | 278 | |
Alternative sequenceiVSP_016362 | 138 – 213 | FETAK…CNAAT → KASCHVGRTLKHTRVEELSL LPTAINRELPPPCTVLLSQN WRVWEGCTSTTAAAACPHQK LRAKRRPGPCGRSARG in isoform 7. CuratedAdd BLAST | 76 | |
Alternative sequenceiVSP_016363 | 173 – 352 | Missing in isoform 5. 3 PublicationsAdd BLAST | 180 | |
Alternative sequenceiVSP_016364 | 173 – 189 | HKAKV…ALLRS → KTKYHPPPEKCRIKIFH in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_016365 | 190 – 414 | Missing in isoform 3. 1 PublicationAdd BLAST | 225 | |
Alternative sequenceiVSP_016366 | 214 – 414 | Missing in isoform 7. CuratedAdd BLAST | 201 | |
Alternative sequenceiVSP_016367 | 353 – 363 | QQGAATTVYCA → VSDCLVEGGHF in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_016369 | 364 – 414 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000355860.7; ENSP00000348119.3; ENSG00000186153.18 [Q9NZC7-3] ENST00000402655.6; ENSP00000384238.2; ENSG00000186153.18 [Q9NZC7-6] ENST00000406884.6; ENSP00000384495.2; ENSG00000186153.18 [Q9NZC7-5] ENST00000408984.7; ENSP00000386161.3; ENSG00000186153.18 [Q9NZC7-2] ENST00000566780.6; ENSP00000457230.1; ENSG00000186153.18 ENST00000569818.1; ENSP00000454485.1; ENSG00000186153.18 [Q9NZC7-4] |
GeneIDi | 51741 |
KEGGi | hsa:51741 |
MANE-Selecti | ENST00000566780.6; ENSP00000457230.1; NM_016373.4; NP_057457.1 |
UCSCi | uc002ffi.3, human [Q9NZC7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WMV | NMR | - | A | 51-101 | [»] | |
AlphaFoldDBi | Q9NZC7 | |||||
SMRi | Q9NZC7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119707, 614 interactors |
IntActi | Q9NZC7, 148 interactors |
MINTi | Q9NZC7 |
STRINGi | 9606.ENSP00000457230 |
PTM databases
iPTMneti | Q9NZC7 |
PhosphoSitePlusi | Q9NZC7 |
Genetic variation databases
BioMutai | WWOX |
DMDMi | 74725363 |
Proteomic databases
EPDi | Q9NZC7 |
jPOSTi | Q9NZC7 |
MassIVEi | Q9NZC7 |
MaxQBi | Q9NZC7 |
PaxDbi | Q9NZC7 |
PeptideAtlasi | Q9NZC7 |
PRIDEi | Q9NZC7 |
ProteomicsDBi | 83364 [Q9NZC7-1] 83365 [Q9NZC7-2] 83366 [Q9NZC7-3] 83367 [Q9NZC7-4] 83368 [Q9NZC7-5] 83369 [Q9NZC7-6] 83370 [Q9NZC7-7] |
Protocols and materials databases
Antibodypediai | 8291, 367 antibodies from 40 providers |
DNASUi | 51741 |
Genome annotation databases
Organism-specific databases
CTDi | 51741 |
DisGeNETi | 51741 |
GeneCardsi | WWOX |
HGNCi | HGNC:12799, WWOX |
HPAi | ENSG00000186153, Low tissue specificity |
MalaCardsi | WWOX |
MIMi | 133239, phenotype 605131, gene 614322, phenotype 616211, phenotype |
neXtProti | NX_Q9NZC7 |
NIAGADSi | ENSG00000186153 |
OpenTargetsi | ENSG00000186153 |
Orphaneti | 251510, 46,XY partial gonadal dysgenesis 284282, Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency 442835, Non-specific early-onset epileptic encephalopathy 99977, Squamous cell carcinoma of the esophagus |
PharmGKBi | PA37398 |
VEuPathDBi | HostDB:ENSG00000186153 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000157389 |
HOGENOMi | CLU_010194_44_0_1 |
InParanoidi | Q9NZC7 |
OMAi | VHPGNMV |
OrthoDBi | 1413827at2759 |
PhylomeDBi | Q9NZC7 |
TreeFami | TF105428 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZC7 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
SignaLinki | Q9NZC7 |
SIGNORi | Q9NZC7 |
Miscellaneous databases
BioGRID-ORCSi | 51741, 8 hits in 1080 CRISPR screens |
ChiTaRSi | WWOX, human |
EvolutionaryTracei | Q9NZC7 |
GeneWikii | WWOX |
GenomeRNAii | 51741 |
Pharosi | Q9NZC7, Tbio |
PROi | PR:Q9NZC7 |
RNActi | Q9NZC7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186153, Expressed in parotid gland and 238 other tissues |
ExpressionAtlasi | Q9NZC7, baseline and differential |
Genevisiblei | Q9NZC7, HS |
Family and domain databases
CDDi | cd09809, human_WWOX_like_SDR_c-like, 1 hit cd00201, WW, 2 hits |
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam IPR001202, WW_dom IPR036020, WW_dom_sf IPR042732, WWOX_SDR_c-like |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit PF00397, WW, 2 hits |
PRINTSi | PR00081, GDHRDH |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | WWOX_HUMAN | |
Accessioni | Q9NZC7Primary (citable) accession number: Q9NZC7 Secondary accession number(s): A8K323 Q9NZC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families