Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 147 (10 Apr 2019)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Triggering receptor expressed on myeloid cells 2

Gene

TREM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849). May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines (PubMed:10799849). Associates with TYROBP on dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Association with TYROBP mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In microglia, required with TYROBP/DAP12 for phagocytosis of apoptotic neurons (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triggering receptor expressed on myeloid cells 2
Short name:
TREM-2
Alternative name(s):
Triggering receptor expressed on monocytes 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TREM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000095970.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17761 TREM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605086 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZC2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 174ExtracellularSequence analysisAdd BLAST156
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 230CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRecessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
See also OMIM:221770
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019334134D → G in PLOSL. 1 PublicationCorresponds to variant dbSNP:rs28939079EnsemblClinVar.1
Natural variantiVAR_019335186K → N in PLOSL. 1 PublicationCorresponds to variant dbSNP:rs28937876EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38Y → C: Increases protein aggregation; decreases cell membrane localization; protein is secreted. 1 Publication1
Mutagenesisi47R → H: Decreases binding to NA2 and THP-1 cells; induces small conformational change; no change in thermal stability; no effect on cell membrane localization. 1 Publication1
Mutagenesisi62R → H: Does not change protein structure; no change in thermal stability; no effect on cell membrane localization. 1 Publication1
Mutagenesisi66T → M: Increases protein aggregation; decreases cell membrane localization; protein is secreted. 1 Publication1
Mutagenesisi68N → K: No effect on cell membrane localization. 1 Publication1
Mutagenesisi76R → D: Decreases binding to THP-1 cells. 1 Publication1
Mutagenesisi77R → D: Decreases binding to THP-1 cells. 1 Publication1
Mutagenesisi87D → N: No effect on cell membrane localization. 1 Publication1
Mutagenesisi126V → G: Increases protein aggregation; decreases cell membrane localization; protein is secreted. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54209

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TREM2

MalaCards human disease database

More...
MalaCardsi
TREM2
MIMi221770 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000095970

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis
275864 Behavioral variant of frontotemporal dementia
1020 Early-onset autosomal dominant Alzheimer disease
2770 Nasu-Hakola disease
238616 NON RARE IN EUROPE: Alzheimer disease
100070 Progressive non-fluent aphasia
100069 Semantic dementia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38468

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TREM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401689

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001498719 – 230Triggering receptor expressed on myeloid cells 2Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 110Combined sources1 Publication
Disulfide bondi51 ↔ 60Combined sources1 Publication
Glycosylationi79N-linked (GlcNAc...) asparagineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes ectodomain shedding through proteolytic cleavage to produce a transmembrane segment, the TREM2 C-terminal fragment (TREM2-CTF), which is subsequently cleaved by gamma-secretase.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZC2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZC2

PeptideAtlas

More...
PeptideAtlasi
Q9NZC2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZC2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83358
83359 [Q9NZC2-2]
83360 [Q9NZC2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZC2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095970 Expressed in 135 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZC2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZC2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010917
HPA012571

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:27995897). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabililization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9NZC2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362205

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELIX-ray3.10A/B19-133[»]
5UD7X-ray2.20A/B/C/D/E/F19-174[»]
5UD8X-ray1.80A/B19-130[»]
6B8OX-ray2.20A/B/C/D/E/F19-174[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NZC2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZC2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 112Ig-like V-typeAdd BLAST84

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXBY Eukaryota
ENOG410YZ1S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00470000042297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000118075

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058623

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZC2

KEGG Orthology (KO)

More...
KOi
K14378

Identification of Orthologs from Complete Genome Data

More...
OMAi
WAAAWHG

Database of Orthologous Groups

More...
OrthoDBi
1385259at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZC2

TreeFam database of animal gene trees

More...
TreeFami
TF334441

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NZC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW
60 70 80 90 100
CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL
110 120 130 140 150
QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF
160 170 180 190 200
EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG
210 220 230
QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT
Length:230
Mass (Da):25,447
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC894AA210F708AF7
GO
Isoform 2 (identifier: Q9NZC2-2) [UniParc]FASTAAdd to basket
Also known as: TREM-2V

The sequence of this isoform differs from the canonical sequence as follows:
     162-230: SLLEGEIPFP...LQTLPGLRDT → AERHVKEDDG...FSWTLEAGTG

Note: No experimental confirmation available.1 Publication
Show »
Length:219
Mass (Da):24,328
Checksum:i9C9B1E89807967EA
GO
Isoform 3 (identifier: Q9NZC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-230: SLLEGEIPFP...LQTLPGLRDT → PSQGSHLPSC...WTEARDTSTQ

Note: No experimental confirmation available.
Show »
Length:222
Mass (Da):24,669
Checksum:i9E842B1CC1C35718
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB78736 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06132996T → K Does not change protein structure; changes protein stability; increases binding to THP-1 cells. 1 PublicationCorresponds to variant dbSNP:rs2234253EnsemblClinVar.1
Natural variantiVAR_06133096T → R. Corresponds to variant dbSNP:rs2234253EnsemblClinVar.1
Natural variantiVAR_019334134D → G in PLOSL. 1 PublicationCorresponds to variant dbSNP:rs28939079EnsemblClinVar.1
Natural variantiVAR_033625157H → Y Polymorphism; may be associated with an increased risk for late-onset Alzheimer disease. 1 PublicationCorresponds to variant dbSNP:rs2234255EnsemblClinVar.1
Natural variantiVAR_019335186K → N in PLOSL. 1 PublicationCorresponds to variant dbSNP:rs28937876EnsemblClinVar.1
Natural variantiVAR_077696192A → T1 PublicationCorresponds to variant dbSNP:rs150277350Ensembl.1
Natural variantiVAR_033626211L → P. Corresponds to variant dbSNP:rs2234256EnsemblClinVar.1
Isoform 2 (identifier: Q9NZC2-2)
Natural varianti183S → C1 PublicationCorresponds to variant dbSNP:rs200820365Ensembl.1
Natural varianti200W → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010792162 – 230SLLEG…GLRDT → AERHVKEDDGRKSPGEVPPG TSPACILATWPPGLLVLLWQ ETTLPEHCFSWTLEAGTG in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_010793162 – 230SLLEG…GLRDT → PSQGSHLPSCLSKEPLGRRN PLPTHFHPSPPGLHLSHQDS SSQRPLGCSLAWTEARDTST Q in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF213457 mRNA Translation: AAF69824.1
AB062787 mRNA Translation: BAB78736.1 Different initiation.
BC032362 mRNA Translation: AAH32362.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4852.1 [Q9NZC2-1]
CCDS64422.1 [Q9NZC2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001258750.1, NM_001271821.1 [Q9NZC2-2]
NP_061838.1, NM_018965.3 [Q9NZC2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.435295

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338469; ENSP00000342651; ENSG00000095970 [Q9NZC2-2]
ENST00000373113; ENSP00000362205; ENSG00000095970 [Q9NZC2-1]
ENST00000373122; ENSP00000362214; ENSG00000095970 [Q9NZC2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54209

UCSC genome browser

More...
UCSCi
uc003opy.4 human [Q9NZC2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213457 mRNA Translation: AAF69824.1
AB062787 mRNA Translation: BAB78736.1 Different initiation.
BC032362 mRNA Translation: AAH32362.1
CCDSiCCDS4852.1 [Q9NZC2-1]
CCDS64422.1 [Q9NZC2-2]
RefSeqiNP_001258750.1, NM_001271821.1 [Q9NZC2-2]
NP_061838.1, NM_018965.3 [Q9NZC2-1]
UniGeneiHs.435295

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELIX-ray3.10A/B19-133[»]
5UD7X-ray2.20A/B/C/D/E/F19-174[»]
5UD8X-ray1.80A/B19-130[»]
6B8OX-ray2.20A/B/C/D/E/F19-174[»]
ProteinModelPortaliQ9NZC2
SMRiQ9NZC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NZC2, 1 interactor
STRINGi9606.ENSP00000362205

PTM databases

iPTMnetiQ9NZC2
PhosphoSitePlusiQ9NZC2

Polymorphism and mutation databases

BioMutaiTREM2
DMDMi50401689

Proteomic databases

jPOSTiQ9NZC2
PaxDbiQ9NZC2
PeptideAtlasiQ9NZC2
PRIDEiQ9NZC2
ProteomicsDBi83358
83359 [Q9NZC2-2]
83360 [Q9NZC2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54209
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338469; ENSP00000342651; ENSG00000095970 [Q9NZC2-2]
ENST00000373113; ENSP00000362205; ENSG00000095970 [Q9NZC2-1]
ENST00000373122; ENSP00000362214; ENSG00000095970 [Q9NZC2-3]
GeneIDi54209
KEGGihsa:54209
UCSCiuc003opy.4 human [Q9NZC2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54209
DisGeNETi54209
EuPathDBiHostDB:ENSG00000095970.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TREM2
GeneReviewsiTREM2
HGNCiHGNC:17761 TREM2
HPAiHPA010917
HPA012571
MalaCardsiTREM2
MIMi221770 phenotype
605086 gene
neXtProtiNX_Q9NZC2
OpenTargetsiENSG00000095970
Orphaneti803 Amyotrophic lateral sclerosis
275864 Behavioral variant of frontotemporal dementia
1020 Early-onset autosomal dominant Alzheimer disease
2770 Nasu-Hakola disease
238616 NON RARE IN EUROPE: Alzheimer disease
100070 Progressive non-fluent aphasia
100069 Semantic dementia
PharmGKBiPA38468

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXBY Eukaryota
ENOG410YZ1S LUCA
GeneTreeiENSGT00470000042297
HOGENOMiHOG000118075
HOVERGENiHBG058623
InParanoidiQ9NZC2
KOiK14378
OMAiWAAAWHG
OrthoDBi1385259at2759
PhylomeDBiQ9NZC2
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-416700 Other semaphorin interactions

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TREM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54209

Protein Ontology

More...
PROi
PR:Q9NZC2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095970 Expressed in 135 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9NZC2 baseline and differential
GenevisibleiQ9NZC2 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTREM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZC2
Secondary accession number(s): Q8N5H8, Q8WYN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: April 10, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again