UniProtKB - Q9NZC2 (TREM2_HUMAN)
Triggering receptor expressed on myeloid cells 2
TREM2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 67 | Phospholipid1 Publication | 1 | |
Binding sitei | 68 | Phospholipid; via amide nitrogen1 Publication | 1 | |
Binding sitei | 77 | Phospholipid1 Publication | 1 | |
Binding sitei | 88 | Phospholipid1 Publication | 1 |
GO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- apolipoprotein A-I binding Source: ARUK-UCL
- apolipoprotein binding Source: ARUK-UCL
- high-density lipoprotein particle binding Source: ARUK-UCL
- lipid binding Source: ARUK-UCL
- lipoprotein particle binding Source: ARUK-UCL
- low-density lipoprotein particle binding Source: ARUK-UCL
- phospholipid binding Source: UniProtKB
- protein-containing complex binding Source: ARUK-UCL
- protein tyrosine kinase binding Source: ARUK-UCL
- scaffold protein binding Source: BHF-UCL
- signaling receptor activity Source: ARUK-UCL
- very-low-density lipoprotein particle binding Source: ARUK-UCL
GO - Biological processi
- apoptotic cell clearance Source: UniProtKB
- astrocyte activation Source: ARUK-UCL
- cellular response to amyloid-beta Source: ARUK-UCL
- dendritic cell differentiation Source: BHF-UCL
- humoral immune response Source: ProtInc
- import into cell Source: ARUK-UCL
- innate immune response Source: Reactome
- microglial cell activation Source: ARUK-UCL
- negative regulation of autophagic cell death Source: ARUK-UCL
- negative regulation of autophagy Source: ARUK-UCL
- osteoclast differentiation Source: UniProtKB
- positive regulation of amyloid-beta clearance Source: ARUK-UCL
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II Source: BHF-UCL
- positive regulation of ATP biosynthetic process Source: ARUK-UCL
- positive regulation of calcium-mediated signaling Source: BHF-UCL
- positive regulation of CAMKK-AMPK signaling cascade Source: ARUK-UCL
- positive regulation of C-C chemokine receptor CCR7 signaling pathway Source: BHF-UCL
- positive regulation of CD40 signaling pathway Source: BHF-UCL
- positive regulation of chemotaxis Source: ARUK-UCL
- positive regulation of engulfment of apoptotic cell Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of inward rectifier potassium channel activity Source: ARUK-UCL
- positive regulation of macrophage fusion Source: UniProtKB
- positive regulation of microglial cell activation Source: UniProtKB
- positive regulation of microglial cell migration Source: ARUK-UCL
- positive regulation of mitochondrion organization Source: ARUK-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phagocytosis, engulfment Source: UniProtKB
- positive regulation of proteasomal protein catabolic process Source: ARUK-UCL
- positive regulation of protein localization to plasma membrane Source: BHF-UCL
- positive regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of protein secretion Source: UniProtKB
- positive regulation of TOR signaling Source: ARUK-UCL
- regulation of gene expression Source: ARUK-UCL
- regulation of immune response Source: Reactome
- regulation of interleukin-6 production Source: ARUK-UCL
- regulation of intracellular signal transduction Source: ARUK-UCL
- regulation of macrophage inflammatory protein 1 alpha production Source: ARUK-UCL
- regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- regulation of plasma membrane bounded cell projection organization Source: ARUK-UCL
- regulation of resting membrane potential Source: ARUK-UCL
- regulation of TOR signaling Source: ARUK-UCL
Keywordsi
Molecular function | Receptor |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NZC2 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2172127, DAP12 interactions R-HSA-2424491, DAP12 signaling R-HSA-416700, Other semaphorin interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Triggering receptor expressed on myeloid cells 2Short name: TREM-2 Alternative name(s): Triggering receptor expressed on monocytes 2 |
Gene namesi | Name:TREM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000095970.16 |
HGNCi | HGNC:17761, TREM2 |
MIMi | 605086, gene |
neXtProti | NX_Q9NZC2 |
Subcellular locationi
Plasma membrane
- Cell membrane 8 Publications; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 174 | ExtracellularSequence analysisAdd BLAST | 156 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 196 – 230 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 (PLOSL2)9 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081676 | 14 – 230 | Missing in PLOSL2; results in decreased osteoclast differentiation; no TREM2 transcripts can be detected in patient cells homozygous for the variant. 1 PublicationAdd BLAST | 217 | |
Natural variantiVAR_081677 | 33 – 230 | Missing in PLOSL2; no protein detected by Wester blot. 5 PublicationsAdd BLAST | 198 | |
Natural variantiVAR_081678 | 44 – 230 | Missing in PLOSL2. 1 PublicationAdd BLAST | 187 | |
Natural variantiVAR_081679 | 78 – 230 | Missing in PLOSL2. 1 PublicationAdd BLAST | 153 | |
Natural variantiVAR_081680 | 126 | V → G in PLOSL2; results in defective protein maturation; increases protein aggregation; decreases cell membrane localization. 3 PublicationsCorresponds to variant dbSNP:rs121908402EnsemblClinVar. | 1 | |
Natural variantiVAR_019334 | 134 | D → G in PLOSL2; unknown pathological significance; decreased protein level. 2 PublicationsCorresponds to variant dbSNP:rs28939079EnsemblClinVar. | 1 | |
Natural variantiVAR_019335 | 186 | K → N in PLOSL2; unknown pathological significance; increased localization at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs28937876EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 20 | N → D: Loss of glycosylation. 1 Publication | 1 | |
Mutagenesisi | 36 | C → A: Loss of proteolytic cleavage by ADAM10 and ectodomain shedding. Decreases protein maturation and cell membrane localization. 1 Publication | 1 | |
Mutagenesisi | 48 | K → M: Loss of LDL, CLU and APOE binding. 1 Publication | 1 | |
Mutagenesisi | 60 | C → A: Loss of proteolytic cleavage by ADAM10 and ectodomain shedding. Decreases protein maturation and cell membrane localization. 1 Publication | 1 | |
Mutagenesisi | 68 | N → K: No effect on cell membrane localization. 1 Publication | 1 | |
Mutagenesisi | 76 | R → D: Decreases binding to THP-1 cells. 1 Publication | 1 | |
Mutagenesisi | 77 | R → D: Decreases binding to THP-1 cells. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, NeurodegenerationOrganism-specific databases
DisGeNETi | 54209 |
GeneReviewsi | TREM2 |
MalaCardsi | TREM2 |
MIMi | 618193, phenotype |
NIAGADSi | ENSG00000095970 |
OpenTargetsi | ENSG00000095970 |
Orphaneti | 803, Amyotrophic lateral sclerosis 275864, Behavioral variant of frontotemporal dementia 1020, Early-onset autosomal dominant Alzheimer disease 2770, Nasu-Hakola disease 238616, NON RARE IN EUROPE: Alzheimer disease 100070, Progressive non-fluent aphasia 100069, Semantic dementia |
PharmGKBi | PA38468 |
Miscellaneous databases
Pharosi | Q9NZC2, Tbio |
Polymorphism and mutation databases
BioMutai | TREM2 |
DMDMi | 50401689 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014987 | 19 – 230 | Triggering receptor expressed on myeloid cells 2Add BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 20 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 36 ↔ 110 | Combined sources2 Publications | ||
Disulfide bondi | 51 ↔ 60 | Combined sources2 Publications | ||
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 157 – 158 | Cleavage of ectodomain2 Publications | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9NZC2 |
MassIVEi | Q9NZC2 |
PaxDbi | Q9NZC2 |
PeptideAtlasi | Q9NZC2 |
PRIDEi | Q9NZC2 |
ProteomicsDBi | 83358 [Q9NZC2-1] 83359 [Q9NZC2-2] 83360 [Q9NZC2-3] |
PTM databases
GlyGeni | Q9NZC2, 2 sites |
iPTMneti | Q9NZC2 |
PhosphoSitePlusi | Q9NZC2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000095970, Expressed in substantia nigra and 155 other tissues |
ExpressionAtlasi | Q9NZC2, baseline and differential |
Genevisiblei | Q9NZC2, HS |
Organism-specific databases
HPAi | ENSG00000095970, Tissue enhanced (adipose tissue, brain, lung) |
Interactioni
Subunit structurei
Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134).
Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).
4 PublicationsBinary interactionsi
Hide detailsQ9NZC2
With | #Exp. | IntAct |
---|---|---|
APOE [P02649] | 4 | EBI-14036387,EBI-1222467 |
Amyloid-beta protein 42 (PRO_0000000092) | 4 | EBI-14036387,EBI-821758 |
PSEN1 [P49768] | 5 | EBI-14036387,EBI-297277 |
TYROBP [O43914] | 4 | EBI-14036387,EBI-2214794 |
GO - Molecular functioni
- apolipoprotein A-I binding Source: ARUK-UCL
- apolipoprotein binding Source: ARUK-UCL
- protein tyrosine kinase binding Source: ARUK-UCL
- scaffold protein binding Source: BHF-UCL
- very-low-density lipoprotein particle binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 119925, 9 interactors |
IntActi | Q9NZC2, 6 interactors |
STRINGi | 9606.ENSP00000362205 |
Miscellaneous databases
RNActi | Q9NZC2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZC2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 112 | Ig-like V-typeAdd BLAST | 84 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4HV, Eukaryota |
GeneTreei | ENSGT00470000042297 |
HOGENOMi | CLU_076120_0_0_1 |
InParanoidi | Q9NZC2 |
OMAi | AWHGQKQ |
PhylomeDBi | Q9NZC2 |
TreeFami | TF334441 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW
60 70 80 90 100
CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL
110 120 130 140 150
QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF
160 170 180 190 200
EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG
210 220 230
QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_081676 | 14 – 230 | Missing in PLOSL2; results in decreased osteoclast differentiation; no TREM2 transcripts can be detected in patient cells homozygous for the variant. 1 PublicationAdd BLAST | 217 | ||
Natural variantiVAR_081812 | 27 | V → M Found in patients with late onset Alzheimer disease; unknown pathological significance; no effect on cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs768745050Ensembl. | 1 | ||
Natural variantiVAR_081813 | 28 | A → V Found in patients with late onset Alzheimer disease; unknown pathological significance; increases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs2234252Ensembl. | 1 | ||
Natural variantiVAR_081814 | 31 | S → F Found in patients with late onset Alzheimer disease; unknown pathological significance; decreases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs746216516Ensembl. | 1 | ||
Natural variantiVAR_081677 | 33 – 230 | Missing in PLOSL2; no protein detected by Wester blot. 5 PublicationsAdd BLAST | 198 | ||
Natural variantiVAR_081815 | 38 | Y → C Results in defective protein maturation and trafficking; loss of proteolytic cleavage by ADAM10 and ectodomain shedding; increases protein aggregation; decreases cell membrane localization; decreased phagocytosis; loss of LDL, CLU and APOE binding; greatly decreases LDL and CLU uptake into cells. 6 PublicationsCorresponds to variant dbSNP:rs797044603EnsemblClinVar. | 1 | ||
Natural variantiVAR_081678 | 44 – 230 | Missing in PLOSL2. 1 PublicationAdd BLAST | 187 | ||
Natural variantiVAR_081816 | 47 | R → C Found in patients with late onset Alzheimer disease; unknown pathological significance; decreases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs753325601Ensembl. | 1 | ||
Natural variantiVAR_081817 | 47 | R → H Found in patients with late onset Alzheimer disease; unknown pathological significance; no effect on cell membrane localization; no effect on autophagy in microglia; no effect on phagocystosis, including amyloid plaque clearance by microglia; reduces ectodomain shedding caused by proteolytic cleavage by ADAM10, while also reducing the oligomerization of the extracellular domain after shedding; decreases binding to and uptake of LDL and CLU into cells; decreases binding to APOE, phospholipids and oligomeric APP cleavage product beta-amyloid peptide 42. 9 PublicationsCorresponds to variant dbSNP:rs75932628EnsemblClinVar. | 1 | ||
Natural variantiVAR_081818 | 62 | R → H Does not affect protein structure; no effect on cell membrane localization; increases autophagy in microglia; decreases LDL, CLU and APOE binding; decreases LDL uptake into cells; no effect on CLU uptake into cells; decreases the uptake of APP-LDL complex in macrophages; decreases binding to oligomeric APP cleavage product beta-amyloid peptide 42. 4 PublicationsCorresponds to variant dbSNP:rs143332484EnsemblClinVar. | 1 | ||
Natural variantiVAR_081819 | 66 | T → M Results in defective protein maturation and trafficking; loss of proteolytic cleavage by ADAM10 and ectodomain shedding; increases protein aggregation; decreases cell membrane localization; decreases phagocytosis; loss of LDL, CLU and APOE binding; greatly decreases LDL and CLU uptake into cells. 5 PublicationsCorresponds to variant dbSNP:rs201258663EnsemblClinVar. | 1 | ||
Natural variantiVAR_081679 | 78 – 230 | Missing in PLOSL2. 1 PublicationAdd BLAST | 153 | ||
Natural variantiVAR_081820 | 87 | D → N Polymorphism; decreases LDL, CLU and APOE binding; decreases LDL and CLU uptake into cells; no effect on cell membrane localization. 3 PublicationsCorresponds to variant dbSNP:rs142232675EnsemblClinVar. | 1 | ||
Natural variantiVAR_061329 | 96 | T → K Does not change protein structure; changes protein stability; increases binding to THP-1 cells. 1 PublicationCorresponds to variant dbSNP:rs2234253EnsemblClinVar. | 1 | ||
Natural variantiVAR_061330 | 96 | T → R. Corresponds to variant dbSNP:rs2234253EnsemblClinVar. | 1 | ||
Natural variantiVAR_081680 | 126 | V → G in PLOSL2; results in defective protein maturation; increases protein aggregation; decreases cell membrane localization. 3 PublicationsCorresponds to variant dbSNP:rs121908402EnsemblClinVar. | 1 | ||
Natural variantiVAR_081821 | 130 | A → S Polymorphism; no effect on protein expression and maturation. 1 Publication | 1 | ||
Natural variantiVAR_019334 | 134 | D → G in PLOSL2; unknown pathological significance; decreased protein level. 2 PublicationsCorresponds to variant dbSNP:rs28939079EnsemblClinVar. | 1 | ||
Natural variantiVAR_081822 | 136 | R → Q Found in patients with Alzheimer disease; unknown pathological significance; slightly decreases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs149622783EnsemblClinVar. | 1 | ||
Natural variantiVAR_081823 | 136 | R → W Found in patients with Alzheimer disease; unknown pathological significance; decreases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs772641807Ensembl. | 1 | ||
Natural variantiVAR_081824 | 151 | E → K Found in patients with late onset Alzheimer disease; unknown pathological significance; decreases cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs79011726Ensembl. | 1 | ||
Natural variantiVAR_033625 | 157 | H → Y Polymorphism; may be associated with an increased risk for late-onset Alzheimer disease; accelerates ectodomain shedding but does not alter the cleavage site; decreases cell membrane localization; decreases phagocytosis. 3 PublicationsCorresponds to variant dbSNP:rs2234255EnsemblClinVar. | 1 | ||
Natural variantiVAR_081825 | 162 | S → R Polymorphism; no effect on protein expression and maturation. 1 PublicationCorresponds to variant dbSNP:rs371702633Ensembl. | 1 | ||
Natural variantiVAR_019335 | 186 | K → N in PLOSL2; unknown pathological significance; increased localization at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs28937876EnsemblClinVar. | 1 | ||
Natural variantiVAR_077696 | 192 | A → T1 PublicationCorresponds to variant dbSNP:rs150277350Ensembl. | 1 | ||
Natural variantiVAR_033626 | 211 | L → P. Corresponds to variant dbSNP:rs2234256EnsemblClinVar. | 1 | ||
Natural variantiVAR_081826 | 223 | T → I Polymorphism; affects protein maturation. 1 PublicationCorresponds to variant dbSNP:rs138355759EnsemblClinVar. | 1 | ||
Isoform 2 (identifier: Q9NZC2-2) | |||||
Natural variantiVAR_082839 | 183 | S → C1 PublicationCorresponds to variant dbSNP:rs200820365Ensembl. | 1 | ||
Natural variantiVAR_082840 | 200 | W → C1 PublicationCorresponds to variant dbSNP:rs1391283629Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010792 | 162 – 230 | SLLEG…GLRDT → AERHVKEDDGRKSPGEVPPG TSPACILATWPPGLLVLLWQ ETTLPEHCFSWTLEAGTG in isoform 2. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_010793 | 162 – 230 | SLLEG…GLRDT → PSQGSHLPSCLSKEPLGRRN PLPTHFHPSPPGLHLSHQDS SSQRPLGCSLAWTEARDTST Q in isoform 3. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213457 mRNA Translation: AAF69824.1 AB062787 mRNA Translation: BAB78736.1 Different initiation. BC032362 mRNA Translation: AAH32362.1 |
CCDSi | CCDS4852.1 [Q9NZC2-1] CCDS64422.1 [Q9NZC2-2] |
RefSeqi | NP_001258750.1, NM_001271821.1 [Q9NZC2-2] NP_061838.1, NM_018965.3 [Q9NZC2-1] |
Genome annotation databases
Ensembli | ENST00000338469; ENSP00000342651; ENSG00000095970 [Q9NZC2-2] ENST00000373113; ENSP00000362205; ENSG00000095970 [Q9NZC2-1] ENST00000373122; ENSP00000362214; ENSG00000095970 [Q9NZC2-3] |
GeneIDi | 54209 |
KEGGi | hsa:54209 |
UCSCi | uc003opy.4, human [Q9NZC2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213457 mRNA Translation: AAF69824.1 AB062787 mRNA Translation: BAB78736.1 Different initiation. BC032362 mRNA Translation: AAH32362.1 |
CCDSi | CCDS4852.1 [Q9NZC2-1] CCDS64422.1 [Q9NZC2-2] |
RefSeqi | NP_001258750.1, NM_001271821.1 [Q9NZC2-2] NP_061838.1, NM_018965.3 [Q9NZC2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5ELI | X-ray | 3.10 | A/B | 19-133 | [»] | |
5UD7 | X-ray | 2.20 | A/B/C/D/E/F | 19-174 | [»] | |
5UD8 | X-ray | 1.80 | A/B | 19-130 | [»] | |
6B8O | X-ray | 2.20 | A/B/C/D/E/F | 19-174 | [»] | |
SMRi | Q9NZC2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119925, 9 interactors |
IntActi | Q9NZC2, 6 interactors |
STRINGi | 9606.ENSP00000362205 |
PTM databases
GlyGeni | Q9NZC2, 2 sites |
iPTMneti | Q9NZC2 |
PhosphoSitePlusi | Q9NZC2 |
Polymorphism and mutation databases
BioMutai | TREM2 |
DMDMi | 50401689 |
Proteomic databases
jPOSTi | Q9NZC2 |
MassIVEi | Q9NZC2 |
PaxDbi | Q9NZC2 |
PeptideAtlasi | Q9NZC2 |
PRIDEi | Q9NZC2 |
ProteomicsDBi | 83358 [Q9NZC2-1] 83359 [Q9NZC2-2] 83360 [Q9NZC2-3] |
Protocols and materials databases
Antibodypediai | 2280, 555 antibodies |
DNASUi | 54209 |
Genome annotation databases
Ensembli | ENST00000338469; ENSP00000342651; ENSG00000095970 [Q9NZC2-2] ENST00000373113; ENSP00000362205; ENSG00000095970 [Q9NZC2-1] ENST00000373122; ENSP00000362214; ENSG00000095970 [Q9NZC2-3] |
GeneIDi | 54209 |
KEGGi | hsa:54209 |
UCSCi | uc003opy.4, human [Q9NZC2-1] |
Organism-specific databases
CTDi | 54209 |
DisGeNETi | 54209 |
EuPathDBi | HostDB:ENSG00000095970.16 |
GeneCardsi | TREM2 |
GeneReviewsi | TREM2 |
HGNCi | HGNC:17761, TREM2 |
HPAi | ENSG00000095970, Tissue enhanced (adipose tissue, brain, lung) |
MalaCardsi | TREM2 |
MIMi | 605086, gene 618193, phenotype |
neXtProti | NX_Q9NZC2 |
NIAGADSi | ENSG00000095970 |
OpenTargetsi | ENSG00000095970 |
Orphaneti | 803, Amyotrophic lateral sclerosis 275864, Behavioral variant of frontotemporal dementia 1020, Early-onset autosomal dominant Alzheimer disease 2770, Nasu-Hakola disease 238616, NON RARE IN EUROPE: Alzheimer disease 100070, Progressive non-fluent aphasia 100069, Semantic dementia |
PharmGKBi | PA38468 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4HV, Eukaryota |
GeneTreei | ENSGT00470000042297 |
HOGENOMi | CLU_076120_0_0_1 |
InParanoidi | Q9NZC2 |
OMAi | AWHGQKQ |
PhylomeDBi | Q9NZC2 |
TreeFami | TF334441 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZC2 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2172127, DAP12 interactions R-HSA-2424491, DAP12 signaling R-HSA-416700, Other semaphorin interactions |
Miscellaneous databases
BioGRID-ORCSi | 54209, 4 hits in 838 CRISPR screens |
ChiTaRSi | TREM2, human |
GeneWikii | TREM2 |
GenomeRNAii | 54209 |
Pharosi | Q9NZC2, Tbio |
PROi | PR:Q9NZC2 |
RNActi | Q9NZC2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095970, Expressed in substantia nigra and 155 other tissues |
ExpressionAtlasi | Q9NZC2, baseline and differential |
Genevisiblei | Q9NZC2, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TREM2_HUMAN | |
Accessioni | Q9NZC2Primary (citable) accession number: Q9NZC2 Secondary accession number(s): Q8N5H8, Q8WYN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations