Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (23 Feb 2022)
Sequence version 3 (16 May 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Molybdenum cofactor biosynthesis protein 1

Gene

MOCS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.

1 Publication

Miscellaneous

The MOCS1 locus has initially been reported to produce MOCS1A and MOCS1B from non-overlapping reading frames within a bicistronic transcript. However, only isoform MOCS1A seems to be translated from the bicistronic transcript. Isoform MOCS1B seems to be translated from a monocistronic mRNA that is derived by alternative splicing.

Caution

The C-terminus of MOCS1A was previously believed to be thiocarboxylated, but it is now known not to be the case.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.092 min(-1) for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.1 Publication
  1. KM=0.79 µM for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73GTPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi80Iron-sulfur (4Fe-4S) 1; 4Fe-4S-S-AdoMetCurated1
Metal bindingi84Iron-sulfur (4Fe-4S) 1; 4Fe-4S-S-AdoMetCurated1
Binding sitei86S-adenosyl-L-methionineBy similarity1
Metal bindingi87Iron-sulfur (4Fe-4S) 1; 4Fe-4S-S-AdoMetCurated1
Binding sitei123GTPBy similarity1
Binding sitei127S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei154GTPBy similarity1
Binding sitei178S-adenosyl-L-methionineBy similarity1
Binding sitei215GTPBy similarity1
Binding sitei249S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi312Iron-sulfur (4Fe-4S) 2; 4Fe-4S-substrateCurated1
Metal bindingi315Iron-sulfur (4Fe-4S) 2; 4Fe-4S-substrateCurated1
Metal bindingi329Iron-sulfur (4Fe-4S) 2; 4Fe-4S-substrateCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei606For molybdenum cofactor biosynthesis protein C activitySequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processMolybdenum cofactor biosynthesis
Ligand4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.99.22, 2681
4.6.1.17, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NZB8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-947581, Molybdenum cofactor biosynthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NZB8

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00344

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdenum cofactor biosynthesis protein 1
Alternative name(s):
Cell migration-inducing gene 11 protein
Molybdenum cofactor synthesis-step 1 protein A-B
Including the following 2 domains:
GTP 3',8-cyclaseCurated (EC:4.1.99.22By similarity)
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Cyclic pyranopterin monophosphate synthaseCurated (EC:4.6.1.171 Publication)
Alternative name(s):
Molybdenum cofactor biosynthesis protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOCS1
ORF Names:MIG11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7190, MOCS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603707, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZB8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000124615

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Molybdenum cofactor deficiency, complementation group A (MOCODA)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive metabolic disorder leading to the pleiotropic loss of molybdoenzyme activities. It is clinically characterized by onset in infancy of poor feeding, intractable seizures, severe psychomotor retardation, and death in early childhood in most patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342EnsemblClinVar.1
Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702EnsemblClinVar.1
Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi80C → S: Impairs precursor Z synthesis. 1 Publication1
Mutagenesisi84C → S: Impairs precursor Z synthesis. 1 Publication1
Mutagenesisi87C → S: Impairs precursor Z synthesis. 1 Publication1
Mutagenesisi312C → S: Impairs precursor Z synthesis. 1 Publication1
Mutagenesisi315C → S: Impairs precursor Z synthesis. 1 Publication1
Mutagenesisi329C → S: Impairs precursor Z synthesis. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
4337

MalaCards human disease database

More...
MalaCardsi
MOCS1
MIMi252150, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000124615

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
308386, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30900

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NZB8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MOCS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30913216

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000978701 – 636Molybdenum cofactor biosynthesis protein 1Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1
Modified residuei198N6-acetyllysineCombined sources1
Modified residuei528N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NZB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZB8

PeptideAtlas

More...
PeptideAtlasi
Q9NZB8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83350 [Q9NZB8-1]
83351 [Q9NZB8-2]
83352 [Q9NZB8-3]
83353 [Q9NZB8-4]
83354 [Q9NZB8-5]
83355 [Q9NZB8-6]
83356 [Q9NZB8-7]
83357 [Q9NZB8-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform MOCS1A and isoform 2 are widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124615, Expressed in right lung and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZB8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZB8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124615, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110480, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NZB8, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362282

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NZB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 277Radical SAM corePROSITE-ProRule annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 383Molybdenum cofactor biosynthesis protein AAdd BLAST383
Regioni317 – 319GTP bindingBy similarity3
Regioni414 – 636Molybdenum cofactor biosynthesis protein CAdd BLAST223
Regioni456 – 480DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the MoaC family.Curated
In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2876, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009273_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMRVEGL

Database of Orthologous Groups

More...
OrthoDBi
721528at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZB8

TreeFam database of animal gene trees

More...
TreeFami
TF300424

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01420, MoaC_PE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.30.70.640, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01225_B, MoaA_B, 1 hit
MF_01224_B, MoaC_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR006638, Elp3/MiaB/NifB
IPR023045, Mo_CF_biosynth-C
IPR013483, MoaA
IPR000385, MoaA_NifB_PqqE_Fe-S-bd_CS
IPR036522, MoaC_sf
IPR010505, Mob_synth_C
IPR002820, Mopterin_CF_biosynth-C_dom
IPR007197, rSAM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01967, MoaC, 1 hit
PF06463, Mob_synth_C, 1 hit
PF04055, Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00729, Elp3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55040, SSF55040, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02666, moaA, 1 hit
TIGR00581, moaC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01305, MOAA_NIFB_PQQE, 1 hit
PS51918, RADICAL_SAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: So far, the different types of MOCS1A and MOCS1B isoforms have been investigated independently and several combinations might be possible.

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform MOCS1B (identifier: Q9NZB8-1) [UniParc]FASTAAdd to basket
Also known as: MOCS1B Type-II

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL
60 70 80 90 100
REHAAPFSAF LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN
110 120 130 140 150
LLTTEEILTL ARLFVKEGID KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT
160 170 180 190 200
IGVTTNGINL ARLLPQLQKA GLSAINISLD TLVPAKFEFI VRRKGFHKVM
210 220 230 240 250
EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP LDVRFIEYMP
260 270 280 290 300
FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ
310 320 330 340 350
ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE
360 370 380 390 400
LLRIIGAAVG RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF
410 420 430 440 450
SWDPLHVQGL RPRMSFSSQV ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT
460 470 480 490 500
SRADSDANSK CLSPGSWASA APSGPQLTSE QLTHVDSEGR AAMVDVGRKP
510 520 530 540 550
DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG VQAAKVTSQL
560 570 580 590 600
IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA
610 620 630
ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA
Note: Multidomain protein with inactive MOCS1A and active MOCS1B.
Length:636
Mass (Da):70,105
Last modified:May 16, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6774A563BAC42120
GO
Isoform MOCS1A (identifier: Q9NZB8-5) [UniParc]FASTAAdd to basket
Also known as: MOCS1A Type/Iad

The sequence of this isoform differs from the canonical sequence as follows:
     384-385: EL → GG
     386-636: Missing.

Show »
Length:385
Mass (Da):43,088
Checksum:i77AB231D6DBB267E
GO
Isoform 2 (identifier: Q9NZB8-6) [UniParc]FASTAAdd to basket
Also known as: MOCS1A Type-Ibcd

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ
     384-385: EL → GG
     386-636: Missing.

Show »
Length:385
Mass (Da):43,150
Checksum:i8E43CD0F611F8804
GO
Isoform 3 (identifier: Q9NZB8-3) [UniParc]FASTAAdd to basket
Also known as: MOCS1A Type-Ibd

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MAARPLSRMLRRLLRSSARSCSSGAPVTQPCPGESARAASE → MWKSWKLRTDVR
     384-385: EL → GG
     386-636: Missing.

Show »
Length:356
Mass (Da):40,378
Checksum:i99F4B6D6B6A7B885
GO
Isoform 4 (identifier: Q9NZB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     368-368: G → E
     369-636: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:281
Mass (Da):31,453
Checksum:i0397D4D12A8C191B
GO
Isoform 6 (identifier: Q9NZB8-2) [UniParc]FASTAAdd to basket
Also known as: MOCS1B Type-III

The sequence of this isoform differs from the canonical sequence as follows:
     368-383: Missing.

Note: Multidomain protein with inactive MOCS1A and active MOCS1B.Curated
Show »
Length:620
Mass (Da):68,257
Checksum:i23CB32E0E6F8535D
GO
Isoform 7 (identifier: Q9NZB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     368-383: Missing.

Show »
Length:533
Mass (Da):58,455
Checksum:iFBE48E29A35248D4
GO
Isoform 8 (identifier: Q9NZB8-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ

Show »
Length:636
Mass (Da):70,167
Checksum:iD78D063A89E6131D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCK1F8WCK1_HUMAN
Molybdenum cofactor biosynthesis pr...
MOCS1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB87524 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
The sequence AAS00489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC44526 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
The sequence CAI20007 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20012 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20013 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233A → V in BAG51799 (PubMed:14702039).Curated1
Sequence conflicti233A → V in BAG62053 (PubMed:14702039).Curated1
Sequence conflicti239L → H in AAB87523 (Ref. 2) Curated1
Sequence conflicti421A → G in BAG51799 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342EnsemblClinVar.1
Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702EnsemblClinVar.1
Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1
Natural variantiVAR_056131390P → H. Corresponds to variant dbSNP:rs11969769EnsemblClinVar.1
Natural variantiVAR_061346452R → L. Corresponds to variant dbSNP:rs11969206EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368211 – 87Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST87
Alternative sequenceiVSP_0368221 – 41MAARP…RAASE → MWKSWKLRTDVRVREGAGGS PCASSQPGSRGPCFLPGLSS Q in isoform 2 and isoform 8. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0368231 – 41MAARP…RAASE → MWKSWKLRTDVR in isoform 3. CuratedAdd BLAST41
Alternative sequenceiVSP_007439368 – 383Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_036824368G → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_036825369 – 636Missing in isoform 4. 1 PublicationAdd BLAST268
Alternative sequenceiVSP_036826384 – 385EL → GG in isoform MOCS1A, isoform 2 and isoform 3. 3 Publications2
Alternative sequenceiVSP_036827386 – 636Missing in isoform MOCS1A, isoform 2 and isoform 3. 3 PublicationsAdd BLAST251

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ224328 mRNA Translation: CAA11897.1
AJ224328 mRNA Translation: CAA11898.1
AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
AF034374 mRNA Translation: AAB87523.1
AF034374 mRNA Translation: AAB87524.1 Sequence problems.
AK300300 mRNA Translation: BAG62053.1
AK056740 mRNA Translation: BAG51799.1
AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20011.1
AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20014.1
AL136089 Genomic DNA Translation: CAI20015.1
BC036839 mRNA Translation: AAH36839.1
AF214022 mRNA Translation: AAF67857.1
AF214023 mRNA Translation: AAF67858.1
AY423726 mRNA Translation: AAS00489.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43460.1 [Q9NZB8-5]
CCDS87394.1 [Q9NZB8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001068566.1, NM_001075098.3 [Q9NZB8-5]
NP_005934.2, NM_005943.5 [Q9NZB8-6]
XP_011512934.1, XM_011514632.2
XP_011512935.1, XM_011514633.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340692; ENSP00000344794; ENSG00000124615
ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4337

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000340692.10; ENSP00000344794.5; NM_001358530.2; NP_001345459.1

UCSC genome browser

More...
UCSCi
uc003opa.4, human [Q9NZB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224328 mRNA Translation: CAA11897.1
AJ224328 mRNA Translation: CAA11898.1
AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
AF034374 mRNA Translation: AAB87523.1
AF034374 mRNA Translation: AAB87524.1 Sequence problems.
AK300300 mRNA Translation: BAG62053.1
AK056740 mRNA Translation: BAG51799.1
AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20011.1
AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
AL136089 Genomic DNA Translation: CAI20014.1
AL136089 Genomic DNA Translation: CAI20015.1
BC036839 mRNA Translation: AAH36839.1
AF214022 mRNA Translation: AAF67857.1
AF214023 mRNA Translation: AAF67858.1
AY423726 mRNA Translation: AAS00489.1 Different initiation.
CCDSiCCDS43460.1 [Q9NZB8-5]
CCDS87394.1 [Q9NZB8-1]
RefSeqiNP_001068566.1, NM_001075098.3 [Q9NZB8-5]
NP_005934.2, NM_005943.5 [Q9NZB8-6]
XP_011512934.1, XM_011514632.2
XP_011512935.1, XM_011514633.2

3D structure databases

SMRiQ9NZB8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110480, 28 interactors
IntActiQ9NZB8, 12 interactors
STRINGi9606.ENSP00000362282

PTM databases

iPTMnetiQ9NZB8
PhosphoSitePlusiQ9NZB8

Genetic variation databases

BioMutaiMOCS1
DMDMi30913216

Proteomic databases

MassIVEiQ9NZB8
MaxQBiQ9NZB8
PaxDbiQ9NZB8
PeptideAtlasiQ9NZB8
PRIDEiQ9NZB8
ProteomicsDBi83350 [Q9NZB8-1]
83351 [Q9NZB8-2]
83352 [Q9NZB8-3]
83353 [Q9NZB8-4]
83354 [Q9NZB8-5]
83355 [Q9NZB8-6]
83356 [Q9NZB8-7]
83357 [Q9NZB8-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51647, 194 antibodies from 21 providers

The DNASU plasmid repository

More...
DNASUi
4337

Genome annotation databases

EnsembliENST00000340692; ENSP00000344794; ENSG00000124615
ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]
GeneIDi4337
KEGGihsa:4337
MANE-SelectiENST00000340692.10; ENSP00000344794.5; NM_001358530.2; NP_001345459.1
UCSCiuc003opa.4, human [Q9NZB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4337
DisGeNETi4337

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MOCS1
HGNCiHGNC:7190, MOCS1
HPAiENSG00000124615, Low tissue specificity
MalaCardsiMOCS1
MIMi252150, phenotype
603707, gene
neXtProtiNX_Q9NZB8
OpenTargetsiENSG00000124615
Orphaneti308386, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
PharmGKBiPA30900
VEuPathDBiHostDB:ENSG00000124615

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2876, Eukaryota
GeneTreeiENSGT00390000016567
HOGENOMiCLU_009273_0_0_1
InParanoidiQ9NZB8
OMAiGMRVEGL
OrthoDBi721528at2759
PhylomeDBiQ9NZB8
TreeFamiTF300424

Enzyme and pathway databases

UniPathwayiUPA00344
BRENDAi4.1.99.22, 2681
4.6.1.17, 2681
PathwayCommonsiQ9NZB8
ReactomeiR-HSA-947581, Molybdenum cofactor biosynthesis
SignaLinkiQ9NZB8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4337, 6 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MOCS1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MOCS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4337
PharosiQ9NZB8, Tbio

Protein Ontology

More...
PROi
PR:Q9NZB8
RNActiQ9NZB8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124615, Expressed in right lung and 208 other tissues
ExpressionAtlasiQ9NZB8, baseline and differential
GenevisibleiQ9NZB8, HS

Family and domain databases

CDDicd01420, MoaC_PE, 1 hit
Gene3Di3.20.20.70, 1 hit
3.30.70.640, 1 hit
HAMAPiMF_01225_B, MoaA_B, 1 hit
MF_01224_B, MoaC_B, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR006638, Elp3/MiaB/NifB
IPR023045, Mo_CF_biosynth-C
IPR013483, MoaA
IPR000385, MoaA_NifB_PqqE_Fe-S-bd_CS
IPR036522, MoaC_sf
IPR010505, Mob_synth_C
IPR002820, Mopterin_CF_biosynth-C_dom
IPR007197, rSAM
PfamiView protein in Pfam
PF01967, MoaC, 1 hit
PF06463, Mob_synth_C, 1 hit
PF04055, Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729, Elp3, 1 hit
SUPFAMiSSF55040, SSF55040, 1 hit
TIGRFAMsiTIGR02666, moaA, 1 hit
TIGR00581, moaC, 1 hit
PROSITEiView protein in PROSITE
PS01305, MOAA_NIFB_PQQE, 1 hit
PS51918, RADICAL_SAM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOCS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZB8
Secondary accession number(s): B3KPT7
, B4DTP1, O14940, O14941, O75710, Q5J7W0, Q5TCE1, Q5TCE2, Q5TCE6, Q5TCE9, Q5TCF0, Q5TCF1, Q8N418, Q9NZB7, Q9UEM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 16, 2003
Last modified: February 23, 2022
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again