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Entry version 164 (08 May 2019)
Sequence version 3 (16 May 2003)
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Protein

Molybdenum cofactor biosynthesis protein 1

Gene

MOCS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.1 Publication

Miscellaneous

The MOCS1 locus has initially been reported to produce MOCS1A and MOCS1B from non-overlapping reading frames within a bicistronic transcript. However, only isoform MOCS1A seems to be translated from the bicistronic transcript. Isoform MOCS1B seems to be translated from a monocistronic mRNA that is derived by alternative splicing.

Caution

The C-terminus of MOCS1A was previously believed to be thiocarboxylated, but it is now known not to be the case.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.092 min(-1) for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.1 Publication
  1. KM=0.79 µM for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: molybdopterin biosynthesis

    This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73GTPBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi80Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Metal bindingi84Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Binding sitei86S-adenosyl-L-methionineBy similarity1
    Metal bindingi87Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Binding sitei123GTPBy similarity1
    Binding sitei127S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
    Binding sitei154GTPBy similarity1
    Binding sitei178S-adenosyl-L-methionineBy similarity1
    Binding sitei215GTPBy similarity1
    Binding sitei249S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
    Metal bindingi312Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    Metal bindingi315Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    Metal bindingi329Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei606For molybdenum cofactor biosynthesis protein C activitySequence analysis1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processMolybdenum cofactor biosynthesis
    Ligand4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-947581 Molybdenum cofactor biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00344

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Molybdenum cofactor biosynthesis protein 1
    Alternative name(s):
    Cell migration-inducing gene 11 protein
    Molybdenum cofactor synthesis-step 1 protein A-B
    Including the following 2 domains:
    GTP 3',8-cyclaseCurated (EC:4.1.99.22By similarity)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein A
    Cyclic pyranopterin monophosphate synthaseCurated (EC:4.6.1.171 Publication)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein C
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MOCS1
    ORF Names:MIG11
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7190 MOCS1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603707 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NZB8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Molybdenum cofactor deficiency, complementation group A (MOCODA)4 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive metabolic disorder leading to the pleiotropic loss of molybdoenzyme activities. It is clinically characterized by onset in infancy of poor feeding, intractable seizures, severe psychomotor retardation, and death in early childhood in most patients.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
    Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
    Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
    Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
    Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342Ensembl.1
    Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702Ensembl.1
    Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
    Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
    Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
    Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi80C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi84C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi87C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi312C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi315C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi329C → S: Impairs precursor Z synthesis. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4337

    MalaCards human disease database

    More...
    MalaCardsi
    MOCS1
    MIMi252150 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000124615

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    308386 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30900

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MOCS1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    30913216

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000978701 – 636Molybdenum cofactor biosynthesis protein 1Add BLAST636

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1
    Modified residuei198N6-acetyllysineCombined sources1
    Modified residuei528N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NZB8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NZB8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NZB8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NZB8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NZB8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NZB8

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    83350
    83351 [Q9NZB8-2]
    83352 [Q9NZB8-3]
    83353 [Q9NZB8-4]
    83354 [Q9NZB8-5]
    83355 [Q9NZB8-6]
    83356 [Q9NZB8-7]
    83357 [Q9NZB8-8]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NZB8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NZB8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform MOCS1A and isoform 2 are widely expressed.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000124615 Expressed in 194 organ(s), highest expression level in right lung

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NZB8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NZB8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA045783
    HPA058177
    HPA075505

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.Curated

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    110480, 16 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NZB8, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000362282

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NZB8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 383Molybdenum cofactor biosynthesis protein AAdd BLAST383
    Regioni317 – 319GTP bindingBy similarity3
    Regioni414 – 636Molybdenum cofactor biosynthesis protein CAdd BLAST223

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the C-terminal section; belongs to the MoaC family.Curated
    In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2876 Eukaryota
    COG2896 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000016567

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NZB8

    KEGG Orthology (KO)

    More...
    KOi
    K20967

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IEFMPIG

    Database of Orthologous Groups

    More...
    OrthoDBi
    721528at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NZB8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300424

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01420 MoaC_PE, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit
    3.30.70.640, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01225_B MoaA_B, 1 hit
    MF_01224_B MoaC_B, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR023045 Mo_CF_biosynth-C
    IPR013483 MoaA
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR036522 MoaC_sf
    IPR010505 Mob_synth_C
    IPR002820 Mopterin_CF_biosynth-C_dom
    IPR007197 rSAM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01967 MoaC, 1 hit
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00729 Elp3, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55040 SSF55040, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02666 moaA, 1 hit
    TIGR00581 moaC, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: So far, the different types of MOCS1A and MOCS1B isoforms have been investigated independently and several combinations might be possible.

    This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform MOCS1B (identifier: Q9NZB8-1) [UniParc]FASTAAdd to basket
    Also known as: MOCS1B Type-II

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL
    60 70 80 90 100
    REHAAPFSAF LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN
    110 120 130 140 150
    LLTTEEILTL ARLFVKEGID KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT
    160 170 180 190 200
    IGVTTNGINL ARLLPQLQKA GLSAINISLD TLVPAKFEFI VRRKGFHKVM
    210 220 230 240 250
    EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP LDVRFIEYMP
    260 270 280 290 300
    FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ
    310 320 330 340 350
    ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE
    360 370 380 390 400
    LLRIIGAAVG RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF
    410 420 430 440 450
    SWDPLHVQGL RPRMSFSSQV ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT
    460 470 480 490 500
    SRADSDANSK CLSPGSWASA APSGPQLTSE QLTHVDSEGR AAMVDVGRKP
    510 520 530 540 550
    DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG VQAAKVTSQL
    560 570 580 590 600
    IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA
    610 620 630
    ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA
    Note: Multidomain protein with inactive MOCS1A and active MOCS1B.
    Length:636
    Mass (Da):70,105
    Last modified:May 16, 2003 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6774A563BAC42120
    GO
    Isoform MOCS1A (identifier: Q9NZB8-5) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type/Iad

    The sequence of this isoform differs from the canonical sequence as follows:
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:385
    Mass (Da):43,088
    Checksum:i77AB231D6DBB267E
    GO
    Isoform 2 (identifier: Q9NZB8-6) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type-Ibcd

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:385
    Mass (Da):43,150
    Checksum:i8E43CD0F611F8804
    GO
    Isoform 3 (identifier: Q9NZB8-3) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type-Ibd

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRMLRRLLRSSARSCSSGAPVTQPCPGESARAASE → MWKSWKLRTDVR
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:356
    Mass (Da):40,378
    Checksum:i99F4B6D6B6A7B885
    GO
    Isoform 4 (identifier: Q9NZB8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         368-368: G → E
         369-636: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:281
    Mass (Da):31,453
    Checksum:i0397D4D12A8C191B
    GO
    Isoform 6 (identifier: Q9NZB8-2) [UniParc]FASTAAdd to basket
    Also known as: MOCS1B Type-III

    The sequence of this isoform differs from the canonical sequence as follows:
         368-383: Missing.

    Note: Multidomain protein with inactive MOCS1A and active MOCS1B.
    Show »
    Length:620
    Mass (Da):68,257
    Checksum:i23CB32E0E6F8535D
    GO
    Isoform 7 (identifier: Q9NZB8-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         368-383: Missing.

    Show »
    Length:533
    Mass (Da):58,455
    Checksum:iFBE48E29A35248D4
    GO
    Isoform 8 (identifier: Q9NZB8-8) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ

    Show »
    Length:636
    Mass (Da):70,167
    Checksum:iD78D063A89E6131D
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8WCK1F8WCK1_HUMAN
    Molybdenum cofactor biosynthesis pr...
    MOCS1
    98Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB87524 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
    The sequence AAS00489 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAC44526 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
    The sequence CAI20007 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence CAI20012 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence CAI20013 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233A → V in BAG51799 (PubMed:14702039).Curated1
    Sequence conflicti233A → V in BAG62053 (PubMed:14702039).Curated1
    Sequence conflicti239L → H in AAB87523 (Ref. 2) Curated1
    Sequence conflicti421A → G in BAG51799 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
    Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
    Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
    Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
    Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342Ensembl.1
    Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702Ensembl.1
    Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
    Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
    Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
    Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1
    Natural variantiVAR_056131390P → H. Corresponds to variant dbSNP:rs11969769Ensembl.1
    Natural variantiVAR_061346452R → L. Corresponds to variant dbSNP:rs11969206Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368211 – 87Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST87
    Alternative sequenceiVSP_0368221 – 41MAARP…RAASE → MWKSWKLRTDVRVREGAGGS PCASSQPGSRGPCFLPGLSS Q in isoform 2 and isoform 8. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_0368231 – 41MAARP…RAASE → MWKSWKLRTDVR in isoform 3. CuratedAdd BLAST41
    Alternative sequenceiVSP_007439368 – 383Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST16
    Alternative sequenceiVSP_036824368G → E in isoform 4. 1 Publication1
    Alternative sequenceiVSP_036825369 – 636Missing in isoform 4. 1 PublicationAdd BLAST268
    Alternative sequenceiVSP_036826384 – 385EL → GG in isoform MOCS1A, isoform 2 and isoform 3. 3 Publications2
    Alternative sequenceiVSP_036827386 – 636Missing in isoform MOCS1A, isoform 2 and isoform 3. 3 PublicationsAdd BLAST251

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ224328 mRNA Translation: CAA11897.1
    AJ224328 mRNA Translation: CAA11898.1
    AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
    AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
    AF034374 mRNA Translation: AAB87523.1
    AF034374 mRNA Translation: AAB87524.1 Sequence problems.
    AK300300 mRNA Translation: BAG62053.1
    AK056740 mRNA Translation: BAG51799.1
    AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20011.1
    AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20014.1
    AL136089 Genomic DNA Translation: CAI20015.1
    BC036839 mRNA Translation: AAH36839.1
    AF214022 mRNA Translation: AAF67857.1
    AF214023 mRNA Translation: AAF67858.1
    AY423726 mRNA Translation: AAS00489.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS43460.1 [Q9NZB8-5]
    CCDS87394.1 [Q9NZB8-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001068566.1, NM_001075098.3 [Q9NZB8-5]
    NP_005934.2, NM_005943.5 [Q9NZB8-6]
    XP_011512934.1, XM_011514632.2
    XP_011512935.1, XM_011514633.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000340692; ENSP00000344794; ENSG00000124615 [Q9NZB8-1]
    ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
    ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
    ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4337

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4337

    UCSC genome browser

    More...
    UCSCi
    uc003opa.4 human [Q9NZB8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ224328 mRNA Translation: CAA11897.1
    AJ224328 mRNA Translation: CAA11898.1
    AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
    AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
    AF034374 mRNA Translation: AAB87523.1
    AF034374 mRNA Translation: AAB87524.1 Sequence problems.
    AK300300 mRNA Translation: BAG62053.1
    AK056740 mRNA Translation: BAG51799.1
    AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20011.1
    AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20014.1
    AL136089 Genomic DNA Translation: CAI20015.1
    BC036839 mRNA Translation: AAH36839.1
    AF214022 mRNA Translation: AAF67857.1
    AF214023 mRNA Translation: AAF67858.1
    AY423726 mRNA Translation: AAS00489.1 Different initiation.
    CCDSiCCDS43460.1 [Q9NZB8-5]
    CCDS87394.1 [Q9NZB8-1]
    RefSeqiNP_001068566.1, NM_001075098.3 [Q9NZB8-5]
    NP_005934.2, NM_005943.5 [Q9NZB8-6]
    XP_011512934.1, XM_011514632.2
    XP_011512935.1, XM_011514633.2

    3D structure databases

    SMRiQ9NZB8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi110480, 16 interactors
    IntActiQ9NZB8, 2 interactors
    STRINGi9606.ENSP00000362282

    PTM databases

    iPTMnetiQ9NZB8
    PhosphoSitePlusiQ9NZB8

    Polymorphism and mutation databases

    BioMutaiMOCS1
    DMDMi30913216

    Proteomic databases

    EPDiQ9NZB8
    jPOSTiQ9NZB8
    MaxQBiQ9NZB8
    PaxDbiQ9NZB8
    PeptideAtlasiQ9NZB8
    PRIDEiQ9NZB8
    ProteomicsDBi83350
    83351 [Q9NZB8-2]
    83352 [Q9NZB8-3]
    83353 [Q9NZB8-4]
    83354 [Q9NZB8-5]
    83355 [Q9NZB8-6]
    83356 [Q9NZB8-7]
    83357 [Q9NZB8-8]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    4337
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000340692; ENSP00000344794; ENSG00000124615 [Q9NZB8-1]
    ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
    ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
    ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]
    GeneIDi4337
    KEGGihsa:4337
    UCSCiuc003opa.4 human [Q9NZB8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4337
    DisGeNETi4337

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MOCS1
    HGNCiHGNC:7190 MOCS1
    HPAiHPA045783
    HPA058177
    HPA075505
    MalaCardsiMOCS1
    MIMi252150 phenotype
    603707 gene
    neXtProtiNX_Q9NZB8
    OpenTargetsiENSG00000124615
    Orphaneti308386 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
    PharmGKBiPA30900

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2876 Eukaryota
    COG2896 LUCA
    GeneTreeiENSGT00390000016567
    InParanoidiQ9NZB8
    KOiK20967
    OMAiIEFMPIG
    OrthoDBi721528at2759
    PhylomeDBiQ9NZB8
    TreeFamiTF300424

    Enzyme and pathway databases

    UniPathwayiUPA00344
    ReactomeiR-HSA-947581 Molybdenum cofactor biosynthesis

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MOCS1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4337

    Protein Ontology

    More...
    PROi
    PR:Q9NZB8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000124615 Expressed in 194 organ(s), highest expression level in right lung
    ExpressionAtlasiQ9NZB8 baseline and differential
    GenevisibleiQ9NZB8 HS

    Family and domain databases

    CDDicd01420 MoaC_PE, 1 hit
    Gene3Di3.20.20.70, 1 hit
    3.30.70.640, 1 hit
    HAMAPiMF_01225_B MoaA_B, 1 hit
    MF_01224_B MoaC_B, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR023045 Mo_CF_biosynth-C
    IPR013483 MoaA
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR036522 MoaC_sf
    IPR010505 Mob_synth_C
    IPR002820 Mopterin_CF_biosynth-C_dom
    IPR007197 rSAM
    PfamiView protein in Pfam
    PF01967 MoaC, 1 hit
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit
    SMARTiView protein in SMART
    SM00729 Elp3, 1 hit
    SUPFAMiSSF55040 SSF55040, 1 hit
    TIGRFAMsiTIGR02666 moaA, 1 hit
    TIGR00581 moaC, 1 hit
    PROSITEiView protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOCS1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZB8
    Secondary accession number(s): B3KPT7
    , B4DTP1, O14940, O14941, O75710, Q5J7W0, Q5TCE1, Q5TCE2, Q5TCE6, Q5TCE9, Q5TCF0, Q5TCF1, Q8N418, Q9NZB7, Q9UEM1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: May 16, 2003
    Last modified: May 8, 2019
    This is version 164 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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