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Protein

Molybdenum cofactor biosynthesis protein 1

Gene

MOCS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.1 Publication

Miscellaneous

The MOCS1 locus has initially been reported to produce MOCS1A and MOCS1B from non-overlapping reading frames within a bicistronic transcript. However, only isoform MOCS1A seems to be translated from the bicistronic transcript. Isoform MOCS1B seems to be translated from a monocistronic mRNA that is derived by alternative splicing.

Caution

The C-terminus of MOCS1A was previously believed to be thiocarboxylated, but it is now known not to be the case.1 Publication

Catalytic activityi

GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor.By similarity
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.1 Publication

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.1 Publication

Kineticsi

kcat is 0.092 min(-1) for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.1 Publication
  1. KM=0.79 µM for (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate1 Publication

    Pathwayi: molybdopterin biosynthesis

    This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei73GTPBy similarity1
    Metal bindingi80Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Metal bindingi84Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Binding sitei86S-adenosyl-L-methionineBy similarity1
    Metal bindingi87Iron-sulfur 1 (4Fe-4S-S-AdoMet)Curated1
    Binding sitei123GTPBy similarity1
    Binding sitei127S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
    Binding sitei154GTPBy similarity1
    Binding sitei178S-adenosyl-L-methionineBy similarity1
    Binding sitei215GTPBy similarity1
    Binding sitei249S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
    Metal bindingi312Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    Metal bindingi315Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    Metal bindingi329Iron-sulfur 2 (4Fe-4S-substrate)Curated1
    Active sitei606For molybdenum cofactor biosynthesis protein C activitySequence analysis1

    GO - Molecular functioni

    • 4 iron, 4 sulfur cluster binding Source: UniProtKB
    • cyclic pyranopterin monophosphate synthase activity Source: MGI
    • GTP 3',8'-cyclase activity Source: MGI
    • GTP binding Source: UniProtKB-KW
    • metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    Keywordsi

    Molecular functionLyase
    Biological processMolybdenum cofactor biosynthesis
    Ligand4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    ReactomeiR-HSA-947581 Molybdenum cofactor biosynthesis
    UniPathwayi
    UPA00344

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Molybdenum cofactor biosynthesis protein 1
    Alternative name(s):
    Cell migration-inducing gene 11 protein
    Molybdenum cofactor synthesis-step 1 protein A-B
    Including the following 2 domains:
    GTP 3',8-cyclaseCurated (EC:4.1.99.22By similarity)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein A
    Cyclic pyranopterin monophosphate synthaseCurated (EC:4.6.1.171 Publication)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein C
    Gene namesi
    Name:MOCS1
    ORF Names:MIG11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000124615.17
    HGNCiHGNC:7190 MOCS1
    MIMi603707 gene
    neXtProtiNX_Q9NZB8

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Pathology & Biotechi

    Involvement in diseasei

    Molybdenum cofactor deficiency, complementation group A (MOCODA)4 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive metabolic disorder leading to the pleiotropic loss of molybdoenzyme activities. It is clinically characterized by onset in infancy of poor feeding, intractable seizures, severe psychomotor retardation, and death in early childhood in most patients.
    See also OMIM:252150
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
    Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
    Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
    Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
    Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342Ensembl.1
    Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702Ensembl.1
    Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
    Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
    Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
    Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi80C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi84C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi87C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi312C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi315C → S: Impairs precursor Z synthesis. 1 Publication1
    Mutagenesisi329C → S: Impairs precursor Z synthesis. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi4337
    MalaCardsiMOCS1
    MIMi252150 phenotype
    OpenTargetsiENSG00000124615
    Orphaneti308386 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
    PharmGKBiPA30900

    Polymorphism and mutation databases

    BioMutaiMOCS1
    DMDMi30913216

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000978701 – 636Molybdenum cofactor biosynthesis protein 1Add BLAST636

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei64PhosphoserineCombined sources1
    Modified residuei198N6-acetyllysineCombined sources1
    Modified residuei528N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiQ9NZB8
    MaxQBiQ9NZB8
    PaxDbiQ9NZB8
    PeptideAtlasiQ9NZB8
    PRIDEiQ9NZB8
    ProteomicsDBi83350
    83351 [Q9NZB8-2]
    83352 [Q9NZB8-3]
    83353 [Q9NZB8-4]
    83354 [Q9NZB8-5]
    83355 [Q9NZB8-6]
    83356 [Q9NZB8-7]
    83357 [Q9NZB8-8]

    PTM databases

    iPTMnetiQ9NZB8
    PhosphoSitePlusiQ9NZB8

    Expressioni

    Tissue specificityi

    Isoform MOCS1A and isoform 2 are widely expressed.2 Publications

    Gene expression databases

    BgeeiENSG00000124615 Expressed in 194 organ(s), highest expression level in right lung
    CleanExiHS_MOCS1
    ExpressionAtlasiQ9NZB8 baseline and differential
    GenevisibleiQ9NZB8 HS

    Organism-specific databases

    HPAiHPA045783
    HPA058177
    HPA075505

    Interactioni

    Subunit structurei

    Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.Curated

    Protein-protein interaction databases

    BioGridi110480, 16 interactors
    IntActiQ9NZB8, 1 interactor
    STRINGi9606.ENSP00000362282

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZB8
    SMRiQ9NZB8
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1 – 383Molybdenum cofactor biosynthesis protein AAdd BLAST383
    Regioni317 – 319GTP bindingBy similarity3
    Regioni414 – 636Molybdenum cofactor biosynthesis protein CAdd BLAST223

    Sequence similaritiesi

    In the C-terminal section; belongs to the MoaC family.Curated
    In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.Curated

    Phylogenomic databases

    eggNOGiKOG2876 Eukaryota
    COG2896 LUCA
    GeneTreeiENSGT00390000016567
    InParanoidiQ9NZB8
    KOiK20967
    OMAiIEFMPIG
    OrthoDBiEOG091G0HQS
    PhylomeDBiQ9NZB8
    TreeFamiTF300424

    Family and domain databases

    CDDicd01420 MoaC_PE, 1 hit
    Gene3Di3.20.20.70, 1 hit
    3.30.70.640, 1 hit
    HAMAPiMF_01225_B MoaA_B, 1 hit
    MF_01224_B MoaC_B, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR034481 Main_SPASM_domain-containing
    IPR023045 Mo_CF_biosynth-C
    IPR013483 MoaA
    IPR040064 MoaA-like
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR036522 MoaC_sf
    IPR010505 Mob_synth_C
    IPR002820 Mopterin_CF_biosynth-C_dom
    IPR007197 rSAM
    IPR034395 SPASM/twitch_domain-containing
    PfamiView protein in Pfam
    PF01967 MoaC, 1 hit
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit
    SFLDiSFLDG01067 SPASM/twitch_domain_containing, 1 hit
    SFLDG01383 cyclic_pyranopterin_phosphate_, 1 hit
    SFLDG01386 main_SPASM_domain-containing, 1 hit
    SFLDS00029 Radical_SAM, 1 hit
    SMARTiView protein in SMART
    SM00729 Elp3, 1 hit
    SUPFAMiSSF55040 SSF55040, 1 hit
    TIGRFAMsiTIGR02666 moaA, 1 hit
    TIGR00581 moaC, 1 hit
    PROSITEiView protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit

    Sequences (8+)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
    Note: So far, the different types of MOCS1A and MOCS1B isoforms have been investigated independently and several combinations might be possible.

    This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform MOCS1B (identifier: Q9NZB8-1) [UniParc]FASTAAdd to basket
    Also known as: MOCS1B Type-II

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL
    60 70 80 90 100
    REHAAPFSAF LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN
    110 120 130 140 150
    LLTTEEILTL ARLFVKEGID KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT
    160 170 180 190 200
    IGVTTNGINL ARLLPQLQKA GLSAINISLD TLVPAKFEFI VRRKGFHKVM
    210 220 230 240 250
    EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP LDVRFIEYMP
    260 270 280 290 300
    FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ
    310 320 330 340 350
    ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE
    360 370 380 390 400
    LLRIIGAAVG RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF
    410 420 430 440 450
    SWDPLHVQGL RPRMSFSSQV ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT
    460 470 480 490 500
    SRADSDANSK CLSPGSWASA APSGPQLTSE QLTHVDSEGR AAMVDVGRKP
    510 520 530 540 550
    DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG VQAAKVTSQL
    560 570 580 590 600
    IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA
    610 620 630
    ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA
    Note: Multidomain protein with inactive MOCS1A and active MOCS1B.
    Length:636
    Mass (Da):70,105
    Last modified:May 16, 2003 - v3
    Checksum:i6774A563BAC42120
    GO
    Isoform MOCS1A (identifier: Q9NZB8-5) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type/Iad

    The sequence of this isoform differs from the canonical sequence as follows:
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:385
    Mass (Da):43,088
    Checksum:i77AB231D6DBB267E
    GO
    Isoform 2 (identifier: Q9NZB8-6) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type-Ibcd

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:385
    Mass (Da):43,150
    Checksum:i8E43CD0F611F8804
    GO
    Isoform 3 (identifier: Q9NZB8-3) [UniParc]FASTAAdd to basket
    Also known as: MOCS1A Type-Ibd

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRMLRRLLRSSARSCSSGAPVTQPCPGESARAASE → MWKSWKLRTDVR
         384-385: EL → GG
         386-636: Missing.

    Show »
    Length:356
    Mass (Da):40,378
    Checksum:i99F4B6D6B6A7B885
    GO
    Isoform 4 (identifier: Q9NZB8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         368-368: G → E
         369-636: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:281
    Mass (Da):31,453
    Checksum:i0397D4D12A8C191B
    GO
    Isoform 6 (identifier: Q9NZB8-2) [UniParc]FASTAAdd to basket
    Also known as: MOCS1B Type-III

    The sequence of this isoform differs from the canonical sequence as follows:
         368-383: Missing.

    Note: Multidomain protein with inactive MOCS1A and active MOCS1B.
    Show »
    Length:620
    Mass (Da):68,257
    Checksum:i23CB32E0E6F8535D
    GO
    Isoform 7 (identifier: Q9NZB8-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         368-383: Missing.

    Show »
    Length:533
    Mass (Da):58,455
    Checksum:iFBE48E29A35248D4
    GO
    Isoform 8 (identifier: Q9NZB8-8) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MAARPLSRML...PGESARAASE → MWKSWKLRTD...PCFLPGLSSQ

    Show »
    Length:636
    Mass (Da):70,167
    Checksum:iD78D063A89E6131D
    GO

    Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8WCK1F8WCK1_HUMAN
    Molybdenum cofactor biosynthesis pr...
    MOCS1
    98Annotation score:

    Sequence cautioni

    The sequence AAB87524 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
    The sequence AAS00489 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAC44526 differs from that shown. Alternative splicing in the MOCS1A-MOCS1B joining region.Curated
    The sequence CAI20007 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence CAI20012 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence CAI20013 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti233A → V in BAG51799 (PubMed:14702039).Curated1
    Sequence conflicti233A → V in BAG62053 (PubMed:14702039).Curated1
    Sequence conflicti239L → H in AAB87523 (Ref. 2) Curated1
    Sequence conflicti421A → G in BAG51799 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05482367R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs754441164Ensembl.1
    Natural variantiVAR_01565873R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893970EnsemblClinVar.1
    Natural variantiVAR_05482480C → G in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs151141411Ensembl.1
    Natural variantiVAR_05482584C → F in MOCODA. 1 Publication1
    Natural variantiVAR_054826123R → W in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs779592342Ensembl.1
    Natural variantiVAR_015659126G → D in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs372246702Ensembl.1
    Natural variantiVAR_015660127G → D in MOCODA. 1 Publication1
    Natural variantiVAR_015661319R → Q in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs104893969EnsemblClinVar.1
    Natural variantiVAR_015662324G → E in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs1187685038Ensembl.1
    Natural variantiVAR_054827324G → R in MOCODA. 1 PublicationCorresponds to variant dbSNP:rs762253951Ensembl.1
    Natural variantiVAR_056131390P → H. Corresponds to variant dbSNP:rs11969769Ensembl.1
    Natural variantiVAR_061346452R → L. Corresponds to variant dbSNP:rs11969206Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0368211 – 87Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST87
    Alternative sequenceiVSP_0368221 – 41MAARP…RAASE → MWKSWKLRTDVRVREGAGGS PCASSQPGSRGPCFLPGLSS Q in isoform 2 and isoform 8. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_0368231 – 41MAARP…RAASE → MWKSWKLRTDVR in isoform 3. CuratedAdd BLAST41
    Alternative sequenceiVSP_007439368 – 383Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST16
    Alternative sequenceiVSP_036824368G → E in isoform 4. 1 Publication1
    Alternative sequenceiVSP_036825369 – 636Missing in isoform 4. 1 PublicationAdd BLAST268
    Alternative sequenceiVSP_036826384 – 385EL → GG in isoform MOCS1A, isoform 2 and isoform 3. 3 Publications2
    Alternative sequenceiVSP_036827386 – 636Missing in isoform MOCS1A, isoform 2 and isoform 3. 3 PublicationsAdd BLAST251

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ224328 mRNA Translation: CAA11897.1
    AJ224328 mRNA Translation: CAA11898.1
    AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
    AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
    AF034374 mRNA Translation: AAB87523.1
    AF034374 mRNA Translation: AAB87524.1 Sequence problems.
    AK300300 mRNA Translation: BAG62053.1
    AK056740 mRNA Translation: BAG51799.1
    AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20011.1
    AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20014.1
    AL136089 Genomic DNA Translation: CAI20015.1
    BC036839 mRNA Translation: AAH36839.1
    AF214022 mRNA Translation: AAF67857.1
    AF214023 mRNA Translation: AAF67858.1
    AY423726 mRNA Translation: AAS00489.1 Different initiation.
    CCDSiCCDS43460.1 [Q9NZB8-5]
    CCDS87394.1 [Q9NZB8-1]
    RefSeqiNP_001068566.1, NM_001075098.3 [Q9NZB8-5]
    NP_005934.2, NM_005943.5 [Q9NZB8-6]
    XP_011512934.1, XM_011514632.2
    XP_011512935.1, XM_011514633.2
    UniGeneiHs.357128
    Hs.718492

    Genome annotation databases

    EnsembliENST00000340692; ENSP00000344794; ENSG00000124615 [Q9NZB8-1]
    ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
    ENST00000373186; ENSP00000362282; ENSG00000124615 [Q9NZB8-6]
    ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
    ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]
    GeneIDi4337
    KEGGihsa:4337
    UCSCiuc003opa.4 human [Q9NZB8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ224328 mRNA Translation: CAA11897.1
    AJ224328 mRNA Translation: CAA11898.1
    AJ404969 Genomic DNA Translation: CAC44526.1 Sequence problems.
    AJ293577, AJ293578, AJ293579 Genomic DNA Translation: CAC44527.1
    AF034374 mRNA Translation: AAB87523.1
    AF034374 mRNA Translation: AAB87524.1 Sequence problems.
    AK300300 mRNA Translation: BAG62053.1
    AK056740 mRNA Translation: BAG51799.1
    AL136089 Genomic DNA Translation: CAI20007.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20011.1
    AL136089 Genomic DNA Translation: CAI20012.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20013.1 Sequence problems.
    AL136089 Genomic DNA Translation: CAI20014.1
    AL136089 Genomic DNA Translation: CAI20015.1
    BC036839 mRNA Translation: AAH36839.1
    AF214022 mRNA Translation: AAF67857.1
    AF214023 mRNA Translation: AAF67858.1
    AY423726 mRNA Translation: AAS00489.1 Different initiation.
    CCDSiCCDS43460.1 [Q9NZB8-5]
    CCDS87394.1 [Q9NZB8-1]
    RefSeqiNP_001068566.1, NM_001075098.3 [Q9NZB8-5]
    NP_005934.2, NM_005943.5 [Q9NZB8-6]
    XP_011512934.1, XM_011514632.2
    XP_011512935.1, XM_011514633.2
    UniGeneiHs.357128
    Hs.718492

    3D structure databases

    ProteinModelPortaliQ9NZB8
    SMRiQ9NZB8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi110480, 16 interactors
    IntActiQ9NZB8, 1 interactor
    STRINGi9606.ENSP00000362282

    PTM databases

    iPTMnetiQ9NZB8
    PhosphoSitePlusiQ9NZB8

    Polymorphism and mutation databases

    BioMutaiMOCS1
    DMDMi30913216

    Proteomic databases

    EPDiQ9NZB8
    MaxQBiQ9NZB8
    PaxDbiQ9NZB8
    PeptideAtlasiQ9NZB8
    PRIDEiQ9NZB8
    ProteomicsDBi83350
    83351 [Q9NZB8-2]
    83352 [Q9NZB8-3]
    83353 [Q9NZB8-4]
    83354 [Q9NZB8-5]
    83355 [Q9NZB8-6]
    83356 [Q9NZB8-7]
    83357 [Q9NZB8-8]

    Protocols and materials databases

    DNASUi4337
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000340692; ENSP00000344794; ENSG00000124615 [Q9NZB8-1]
    ENST00000373181; ENSP00000362277; ENSG00000124615 [Q9NZB8-4]
    ENST00000373186; ENSP00000362282; ENSG00000124615 [Q9NZB8-6]
    ENST00000373188; ENSP00000362284; ENSG00000124615 [Q9NZB8-5]
    ENST00000373195; ENSP00000362291; ENSG00000124615 [Q9NZB8-7]
    GeneIDi4337
    KEGGihsa:4337
    UCSCiuc003opa.4 human [Q9NZB8-1]

    Organism-specific databases

    CTDi4337
    DisGeNETi4337
    EuPathDBiHostDB:ENSG00000124615.17
    GeneCardsiMOCS1
    HGNCiHGNC:7190 MOCS1
    HPAiHPA045783
    HPA058177
    HPA075505
    MalaCardsiMOCS1
    MIMi252150 phenotype
    603707 gene
    neXtProtiNX_Q9NZB8
    OpenTargetsiENSG00000124615
    Orphaneti308386 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
    PharmGKBiPA30900
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2876 Eukaryota
    COG2896 LUCA
    GeneTreeiENSGT00390000016567
    InParanoidiQ9NZB8
    KOiK20967
    OMAiIEFMPIG
    OrthoDBiEOG091G0HQS
    PhylomeDBiQ9NZB8
    TreeFamiTF300424

    Enzyme and pathway databases

    UniPathwayi
    UPA00344

    ReactomeiR-HSA-947581 Molybdenum cofactor biosynthesis

    Miscellaneous databases

    GeneWikiiMOCS1
    GenomeRNAii4337
    PROiPR:Q9NZB8
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000124615 Expressed in 194 organ(s), highest expression level in right lung
    CleanExiHS_MOCS1
    ExpressionAtlasiQ9NZB8 baseline and differential
    GenevisibleiQ9NZB8 HS

    Family and domain databases

    CDDicd01420 MoaC_PE, 1 hit
    Gene3Di3.20.20.70, 1 hit
    3.30.70.640, 1 hit
    HAMAPiMF_01225_B MoaA_B, 1 hit
    MF_01224_B MoaC_B, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR034481 Main_SPASM_domain-containing
    IPR023045 Mo_CF_biosynth-C
    IPR013483 MoaA
    IPR040064 MoaA-like
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR036522 MoaC_sf
    IPR010505 Mob_synth_C
    IPR002820 Mopterin_CF_biosynth-C_dom
    IPR007197 rSAM
    IPR034395 SPASM/twitch_domain-containing
    PfamiView protein in Pfam
    PF01967 MoaC, 1 hit
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit
    SFLDiSFLDG01067 SPASM/twitch_domain_containing, 1 hit
    SFLDG01383 cyclic_pyranopterin_phosphate_, 1 hit
    SFLDG01386 main_SPASM_domain-containing, 1 hit
    SFLDS00029 Radical_SAM, 1 hit
    SMARTiView protein in SMART
    SM00729 Elp3, 1 hit
    SUPFAMiSSF55040 SSF55040, 1 hit
    TIGRFAMsiTIGR02666 moaA, 1 hit
    TIGR00581 moaC, 1 hit
    PROSITEiView protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiMOCS1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZB8
    Secondary accession number(s): B3KPT7
    , B4DTP1, O14940, O14941, O75710, Q5J7W0, Q5TCE1, Q5TCE2, Q5TCE6, Q5TCE9, Q5TCF0, Q5TCF1, Q8N418, Q9NZB7, Q9UEM1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: May 16, 2003
    Last modified: November 7, 2018
    This is version 160 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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