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Entry version 159 (18 Sep 2019)
Sequence version 2 (11 Sep 2007)
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Protein

Constitutive coactivator of PPAR-gamma-like protein 1

Gene

FAM120A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 1
Alternative name(s):
Oxidative stress-associated Src activator
Protein FAM120A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM120A
Synonyms:C9orf10, KIAA0183, OSSA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13247 FAM120A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612265 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZB2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
23196

Open Targets

More...
OpenTargetsi
ENSG00000048828

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954136

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM120A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158523294

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002216271 – 1118Constitutive coactivator of PPAR-gamma-like protein 1Add BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei655PhosphothreonineCombined sources1
Modified residuei873Omega-N-methylarginineCombined sources1
Modified residuei884Omega-N-methylarginineCombined sources1
Modified residuei886Omega-N-methylarginineCombined sources1
Modified residuei932N6-acetyllysineBy similarity1
Modified residuei960PhosphoserineCombined sources1
Modified residuei982Omega-N-methylarginineCombined sources1
Modified residuei986Omega-N-methylarginineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1045PhosphoserineCombined sources1
Modified residuei1048PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NZB2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZB2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NZB2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZB2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZB2

PeptideAtlas

More...
PeptideAtlasi
Q9NZB2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZB2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83345 [Q9NZB2-1]
83346 [Q9NZB2-2]
83347 [Q9NZB2-4]
83348 [Q9NZB2-5]
83349 [Q9NZB2-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZB2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZB2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NZB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000048828 Expressed in 241 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZB2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZB2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019734
HPA055800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PURA (By similarity).

Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116805, 73 interactors

Protein interaction database and analysis system

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IntActi
Q9NZB2, 58 interactors

Molecular INTeraction database

More...
MINTi
Q9NZB2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000277165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZB2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni339 – 405Interaction with YES1, SRC and FYN1 PublicationAdd BLAST67
Regioni829 – 1118RNA bindingAdd BLAST290

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IE6R Eukaryota
ENOG410XPY7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063168

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZB2

Identification of Orthologs from Complete Genome Data

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OMAi
SNDSKMC

Database of Orthologous Groups

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OrthoDBi
203269at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZB2

TreeFam database of animal gene trees

More...
TreeFami
TF328642

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026784 Coact_PPARg
IPR029060 PIN-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15976 PTHR15976, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88723 SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NZB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA
60 70 80 90 100
DNCLHRLYGG FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL
110 120 130 140 150
EKARLHEWVK RQGNERQTAQ QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL
160 170 180 190 200
ALIRFHVKVA QSIEDHHQEV IGFCRENGFH GLVAYDSDYA LCNIPYYFSA
210 220 230 240 250
HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL GNHILPDEDL
260 270 280 290 300
ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD
310 320 330 340 350
AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF
360 370 380 390 400
GMPGMVPPHV PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP
410 420 430 440 450
APLTLDTSGK NLTEQNSYSN IPHEGKHTPL YERSSPINPA QSGSPNHVDS
460 470 480 490 500
AYFPGSSTSS SSDNDEGSGG ATNHISGNKI GWEKTGSHSE PQARGDPGDQ
510 520 530 540 550
TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH MDITTPPLPP
560 570 580 590 600
VAPEVLRVAE HRHKKGLMYP YIFHVLTKGE IKIAVSIEDE ANKDLPPAAL
610 620 630 640 650
LYRPVRQYVY GVLFSLAESR KKTERLAFRK NRLPPEFSPV IIKEWAAYKG
660 670 680 690 700
KSPQTPELVE ALAFREWTCP NLKRLWLGKA VEDKNRRMRA FLACMRSDTP
710 720 730 740 750
AMLNPANVPT HLMVLCCVLR YMVQWPGARI LRRQELDAFL AQALSPKLYE
760 770 780 790 800
PDQLQELKIE NLDPRGIQLS ALFMSGVDMA LFANDACGQP IPWEHCCPWM
810 820 830 840 850
YFDGKLFQSK LLKASREKTP LIDLCDGQAD QAAKVEKMRQ SVLEGLSFSR
860 870 880 890 900
QSHTLPFPPP PALPFYPASA YPRHFGPVPP SQGRGRGFAG VCGFGGPYGE
910 920 930 940 950
TVATGPYRAF RVAAASGHCG AFSGSDSSRT SKSQGGVQPI PSQGGKLEIA
960 970 980 990 1000
GTVVGHWAGS RRGRGGRGPF PLQVVSVGGP ARGRPRGVIS TPVIRTFGRG
1010 1020 1030 1040 1050
GRYYGRGYKN QAAIQGRPPY AASAEEVAKE LKSKSGESKS SAMSSDGSLA
1060 1070 1080 1090 1100
ENGVMAEEKP APQMNGSTGD ARAPSHSESA LNNDSKTCNT NPHLNALSTD
1110
SACRREAALE AAVLNKEE
Length:1,118
Mass (Da):121,888
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9171EA01C8D17A0
GO
Isoform B (identifier: Q9NZB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-628: GEIKIAVSIE...SRKKTERLAF → VLSKGPWSGF...KFTFPFLNIE
     629-1118: Missing.

Show »
Length:628
Mass (Da):68,993
Checksum:i4C39CFE952A4A18D
GO
Isoform D (identifier: Q9NZB2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-935: Missing.

Show »
Length:1,072
Mass (Da):117,406
Checksum:i591F2B96B0E4DB49
GO
Isoform E (identifier: Q9NZB2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-651: FSPVIIKEWAAYKGK → CMYCNNPLFVFLGTS
     652-1118: Missing.

Show »
Length:651
Mass (Da):71,561
Checksum:i013F2DADA8C3008E
GO
Isoform F (identifier: Q9NZB2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-473: N → KPFQLYLQKNFVFHKENSIVLCSRILRHG

Show »
Length:1,146
Mass (Da):125,272
Checksum:i3E79D081CBABBD9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH52A0A0C4DH52_HUMAN
Constitutive coactivator of PPAR-ga...
FAM120A
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG79A0A0C4DG79_HUMAN
Constitutive coactivator of PPAR-ga...
FAM120A
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0Y9A0A494C0Y9_HUMAN
Constitutive coactivator of PPAR-ga...
FAM120A
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF72866 differs from that shown. Reason: Frameshift at position 1055.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti517 – 520EGKG → DSRR in AAF72867 (Ref. 1) Curated4
Sequence conflicti556L → V in AAF72867 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054400327Y → H. Corresponds to variant dbSNP:rs11541747Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036324473N → KPFQLYLQKNFVFHKENSIV LCSRILRHG in isoform F. 1 Publication1
Alternative sequenceiVSP_004147579 – 628GEIKI…ERLAF → VLSKGPWSGFCYLMSGHSYG CFVLLSFFEPFFCLTNLLET KFTFPFLNIE in isoform B. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_004148629 – 1118Missing in isoform B. 1 PublicationAdd BLAST490
Alternative sequenceiVSP_017278637 – 651FSPVI…AYKGK → CMYCNNPLFVFLGTS in isoform E. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_017279652 – 1118Missing in isoform E. 1 PublicationAdd BLAST467
Alternative sequenceiVSP_017280890 – 935Missing in isoform D. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF214737 mRNA Translation: AAF72866.1 Frameshift.
AF214738 mRNA Translation: AAF72867.1
AL353629 Genomic DNA No translation available.
BC007879 mRNA Translation: AAH07879.2
BC098584 mRNA Translation: AAH98584.1
BC111736 mRNA Translation: AAI11737.1
D80005 mRNA Translation: BAA11500.2
AY266457 mRNA Translation: AAP31031.1
AF055017 mRNA Translation: AAC09364.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6706.1 [Q9NZB2-1]
CCDS75859.1 [Q9NZB2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273651.1, NM_001286722.1
NP_001273652.1, NM_001286723.1 [Q9NZB2-5]
NP_001273653.1, NM_001286724.1 [Q9NZB2-2]
NP_055427.2, NM_014612.4 [Q9NZB2-1]
XP_011516714.1, XM_011518412.2 [Q9NZB2-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000277165; ENSP00000277165; ENSG00000048828 [Q9NZB2-1]
ENST00000375389; ENSP00000364538; ENSG00000048828 [Q9NZB2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23196

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23196

UCSC genome browser

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UCSCi
uc004atv.5 human [Q9NZB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214737 mRNA Translation: AAF72866.1 Frameshift.
AF214738 mRNA Translation: AAF72867.1
AL353629 Genomic DNA No translation available.
BC007879 mRNA Translation: AAH07879.2
BC098584 mRNA Translation: AAH98584.1
BC111736 mRNA Translation: AAI11737.1
D80005 mRNA Translation: BAA11500.2
AY266457 mRNA Translation: AAP31031.1
AF055017 mRNA Translation: AAC09364.1
CCDSiCCDS6706.1 [Q9NZB2-1]
CCDS75859.1 [Q9NZB2-2]
RefSeqiNP_001273651.1, NM_001286722.1
NP_001273652.1, NM_001286723.1 [Q9NZB2-5]
NP_001273653.1, NM_001286724.1 [Q9NZB2-2]
NP_055427.2, NM_014612.4 [Q9NZB2-1]
XP_011516714.1, XM_011518412.2 [Q9NZB2-6]

3D structure databases

SMRiQ9NZB2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116805, 73 interactors
IntActiQ9NZB2, 58 interactors
MINTiQ9NZB2
STRINGi9606.ENSP00000277165

PTM databases

iPTMnetiQ9NZB2
PhosphoSitePlusiQ9NZB2
SwissPalmiQ9NZB2

Polymorphism and mutation databases

BioMutaiFAM120A
DMDMi158523294

Proteomic databases

EPDiQ9NZB2
jPOSTiQ9NZB2
MassIVEiQ9NZB2
MaxQBiQ9NZB2
PaxDbiQ9NZB2
PeptideAtlasiQ9NZB2
PRIDEiQ9NZB2
ProteomicsDBi83345 [Q9NZB2-1]
83346 [Q9NZB2-2]
83347 [Q9NZB2-4]
83348 [Q9NZB2-5]
83349 [Q9NZB2-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277165; ENSP00000277165; ENSG00000048828 [Q9NZB2-1]
ENST00000375389; ENSP00000364538; ENSG00000048828 [Q9NZB2-2]
GeneIDi23196
KEGGihsa:23196
UCSCiuc004atv.5 human [Q9NZB2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23196
DisGeNETi23196

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM120A
HGNCiHGNC:13247 FAM120A
HPAiHPA019734
HPA055800
MIMi612265 gene
neXtProtiNX_Q9NZB2
OpenTargetsiENSG00000048828
PharmGKBiPA134954136

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE6R Eukaryota
ENOG410XPY7 LUCA
GeneTreeiENSGT00530000063168
InParanoidiQ9NZB2
OMAiSNDSKMC
OrthoDBi203269at2759
PhylomeDBiQ9NZB2
TreeFamiTF328642

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM120A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FAM120A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23196

Pharos

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Pharosi
Q9NZB2

Protein Ontology

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PROi
PR:Q9NZB2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000048828 Expressed in 241 organ(s), highest expression level in colon
ExpressionAtlasiQ9NZB2 baseline and differential
GenevisibleiQ9NZB2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026784 Coact_PPARg
IPR029060 PIN-like_dom_sf
PANTHERiPTHR15976 PTHR15976, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF120A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZB2
Secondary accession number(s): A6NGU0
, C4AMC6, O60649, Q14688, Q4VXF4, Q4VXF5, Q4VXG2, Q86V69, Q96I21, Q9NZB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 11, 2007
Last modified: September 18, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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