Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuroligin-3

Gene

NLGN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • neurexin family protein binding Source: BHF-UCL
  • scaffold protein binding Source: BHF-UCL
  • signaling receptor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-NLGN3 Neuroligin

MEROPS protease database

More...
MEROPSi
S09.987

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroligin-3
Alternative name(s):
Gliotactin homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLGN3
Synonyms:KIAA1480, NL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196338.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14289 NLGN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300336 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZ94

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini38 – 709ExtracellularSequence analysisAdd BLAST672
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 848CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autism, X-linked 1 (AUTSX1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
See also OMIM:300425
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015668451R → C in AUTSX1 and ASPGX1. 1 Publication1
Asperger syndrome, X-linked, 1 (ASPGX1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.
See also OMIM:300494
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015668451R → C in AUTSX1 and ASPGX1. 1 Publication1

Keywords - Diseasei

Asperger syndrome, Autism, Autism spectrum disorder, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54413

MalaCards human disease database

More...
MalaCardsi
NLGN3
MIMi300425 phenotype
300494 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196338

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1162 NON RARE IN EUROPE: Asperger syndrome
106 NON RARE IN EUROPE: Autism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31649

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLGN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
31076855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000864538 – 848Neuroligin-3Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 141By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi510 ↔ 544By similarity
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei745PhosphoserineBy similarity1
Modified residuei792PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NZ94

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZ94

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZ94

PeptideAtlas

More...
PeptideAtlasi
Q9NZ94

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZ94

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83341
83342 [Q9NZ94-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZ94

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZ94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196338 Expressed in 132 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_NLGN3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZ94 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZ94 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003183
HPA004066

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity). Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119944, 79 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NZ94, 54 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of protein disorder

More...
DisProti
DP00553

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NZ94

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZ94

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1516 Eukaryota
COG2272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159580

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008839

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZ94

KEGG Orthology (KO)

More...
KOi
K07378

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTHYGKL

Database of Orthologous Groups

More...
OrthoDBi
754103at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZ94

TreeFam database of animal gene trees

More...
TreeFami
TF326187

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030024 NLGN3

The PANTHER Classification System

More...
PANTHERi
PTHR43903:SF4 PTHR43903:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01090 NEUROLIGIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ94-1) [UniParc]FASTAAdd to basket
Also known as: HNL3s

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK
60 70 80 90 100
LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT
110 120 130 140 150
HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT
160 170 180 190 200
EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK
210 220 230 240 250
PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG VLGFLSTGDQ
260 270 280 290 300
AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS
310 320 330 340 350
HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD
360 370 380 390 400
CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD
410 420 430 440 450
IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL
460 470 480 490 500
RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP
510 520 530 540 550
TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND
560 570 580 590 600
VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD
610 620 630 640 650
QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP
660 670 680 690 700
DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN
710 720 730 740 750
PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP LRQPSPQRGA
760 770 780 790 800
GAPELGAAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP
810 820 830 840
DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV
Length:848
Mass (Da):93,895
Last modified:May 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3EE2FAB7E427C82
GO
Isoform 2 (identifier: Q9NZ94-2) [UniParc]FASTAAdd to basket
Also known as: HNL3

The sequence of this isoform differs from the canonical sequence as follows:
     153-172: Missing.

Show »
Length:828
Mass (Da):91,570
Checksum:iB72E4F3472678692
GO
Isoform 3 (identifier: Q9NZ94-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-192: Missing.

Note: No experimental evidence available. Gene prediction based on EST data.
Show »
Length:808
Mass (Da):89,538
Checksum:iA0686FBADE342331
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVK0E7EVK0_HUMAN
Neuroligin-3
NLGN3
513Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW27A0A087WW27_HUMAN
Neuroligin-3
NLGN3
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF71231 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA96004 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11226 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224L → P in AAF71230 (PubMed:10767552).Curated1
Sequence conflicti274F → S in BAG37248 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06888792S → Y1 PublicationCorresponds to variant dbSNP:rs17854698Ensembl.1
Natural variantiVAR_015668451R → C in AUTSX1 and ASPGX1. 1 Publication1
Natural variantiVAR_068888718L → I1 PublicationCorresponds to variant dbSNP:rs17854697Ensembl.1
Natural variantiVAR_068889751G → W1 PublicationCorresponds to variant dbSNP:rs17857400Ensembl.1
Natural variantiVAR_068890778G → S1 PublicationCorresponds to variant dbSNP:rs17857401Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053827153 – 192Missing in isoform 3. CuratedAdd BLAST40
Alternative sequenceiVSP_007534153 – 172Missing in isoform 2. 4 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF217411 mRNA Translation: AAF71230.1
AF217412 mRNA Translation: AAF71231.1 Sequence problems.
AF217413 Genomic DNA Translation: AAF71232.1
AF217413 Genomic DNA Translation: AAF71233.1
GQ489207 mRNA Translation: ADB12634.1
AK074814 mRNA Translation: BAC11226.1 Different initiation.
AK314699 mRNA Translation: BAG37248.1
AL590764 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05307.1
CH471132 Genomic DNA Translation: EAX05308.1
CH471132 Genomic DNA Translation: EAX05309.1
CH471132 Genomic DNA Translation: EAX05310.1
CH471132 Genomic DNA Translation: EAX05312.1
CH471132 Genomic DNA Translation: EAX05313.1
BC051715 mRNA Translation: AAH51715.1
AB040913 mRNA Translation: BAA96004.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14407.1 [Q9NZ94-2]
CCDS55441.1 [Q9NZ94-1]
CCDS55442.1 [Q9NZ94-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001160132.1, NM_001166660.1 [Q9NZ94-3]
NP_001308205.1, NM_001321276.1
NP_061850.2, NM_018977.3 [Q9NZ94-2]
NP_851820.1, NM_181303.1 [Q9NZ94-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.438877

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358741; ENSP00000351591; ENSG00000196338 [Q9NZ94-1]
ENST00000374051; ENSP00000363163; ENSG00000196338 [Q9NZ94-2]
ENST00000536169; ENSP00000445298; ENSG00000196338 [Q9NZ94-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54413

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217411 mRNA Translation: AAF71230.1
AF217412 mRNA Translation: AAF71231.1 Sequence problems.
AF217413 Genomic DNA Translation: AAF71232.1
AF217413 Genomic DNA Translation: AAF71233.1
GQ489207 mRNA Translation: ADB12634.1
AK074814 mRNA Translation: BAC11226.1 Different initiation.
AK314699 mRNA Translation: BAG37248.1
AL590764 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05307.1
CH471132 Genomic DNA Translation: EAX05308.1
CH471132 Genomic DNA Translation: EAX05309.1
CH471132 Genomic DNA Translation: EAX05310.1
CH471132 Genomic DNA Translation: EAX05312.1
CH471132 Genomic DNA Translation: EAX05313.1
BC051715 mRNA Translation: AAH51715.1
AB040913 mRNA Translation: BAA96004.1 Different initiation.
CCDSiCCDS14407.1 [Q9NZ94-2]
CCDS55441.1 [Q9NZ94-1]
CCDS55442.1 [Q9NZ94-3]
RefSeqiNP_001160132.1, NM_001166660.1 [Q9NZ94-3]
NP_001308205.1, NM_001321276.1
NP_061850.2, NM_018977.3 [Q9NZ94-2]
NP_851820.1, NM_181303.1 [Q9NZ94-1]
UniGeneiHs.438877

3D structure databases

DisProtiDP00553
ProteinModelPortaliQ9NZ94
SMRiQ9NZ94
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119944, 79 interactors
IntActiQ9NZ94, 54 interactors
STRINGi9606.ENSP00000351591

Protein family/group databases

ESTHERihuman-NLGN3 Neuroligin
MEROPSiS09.987

PTM databases

iPTMnetiQ9NZ94
PhosphoSitePlusiQ9NZ94

Polymorphism and mutation databases

BioMutaiNLGN3
DMDMi31076855

Proteomic databases

EPDiQ9NZ94
jPOSTiQ9NZ94
PaxDbiQ9NZ94
PeptideAtlasiQ9NZ94
PRIDEiQ9NZ94
ProteomicsDBi83341
83342 [Q9NZ94-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54413
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358741; ENSP00000351591; ENSG00000196338 [Q9NZ94-1]
ENST00000374051; ENSP00000363163; ENSG00000196338 [Q9NZ94-2]
ENST00000536169; ENSP00000445298; ENSG00000196338 [Q9NZ94-3]
GeneIDi54413
KEGGihsa:54413

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54413
DisGeNETi54413
EuPathDBiHostDB:ENSG00000196338.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NLGN3
HGNCiHGNC:14289 NLGN3
HPAiHPA003183
HPA004066
MalaCardsiNLGN3
MIMi300336 gene
300425 phenotype
300494 phenotype
neXtProtiNX_Q9NZ94
OpenTargetsiENSG00000196338
Orphaneti1162 NON RARE IN EUROPE: Asperger syndrome
106 NON RARE IN EUROPE: Autism
PharmGKBiPA31649

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00940000159580
HOVERGENiHBG008839
InParanoidiQ9NZ94
KOiK07378
OMAiNTHYGKL
OrthoDBi754103at2759
PhylomeDBiQ9NZ94
TreeFamiTF326187

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NLGN3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NLGN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54413

Protein Ontology

More...
PROi
PR:Q9NZ94

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196338 Expressed in 132 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_NLGN3
ExpressionAtlasiQ9NZ94 baseline and differential
GenevisibleiQ9NZ94 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030024 NLGN3
PANTHERiPTHR43903:SF4 PTHR43903:SF4, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLGN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZ94
Secondary accession number(s): B2RBK1
, D2X2H6, D3DVV0, D3DVV1, Q86V51, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: January 16, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again