UniProtKB - Q9NZ81 (PRR13_HUMAN)
Protein
Proline-rich protein 13
Gene
PRR13
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.1 Publication
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ81 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-rich protein 13Alternative name(s): Taxane-resistance protein |
Gene namesi | Name:PRR13 Synonyms:TXR1 ORF Names:BM-041 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000205352.10 |
HGNCi | HGNC:24528, PRR13 |
MIMi | 610459, gene |
neXtProti | NX_Q9NZ81 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54458 |
OpenTargetsi | ENSG00000205352 |
PharmGKBi | PA143485583 |
Miscellaneous databases
Pharosi | Q9NZ81, Tdark |
Polymorphism and mutation databases
BioMutai | PRR13 |
DMDMi | 74734721 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000243946 | 1 – 148 | Proline-rich protein 13Add BLAST | 148 |
Proteomic databases
MassIVEi | Q9NZ81 |
PaxDbi | Q9NZ81 |
PeptideAtlasi | Q9NZ81 |
PRIDEi | Q9NZ81 |
ProteomicsDBi | 83339 [Q9NZ81-1] 83340 [Q9NZ81-2] |
PTM databases
iPTMneti | Q9NZ81 |
PhosphoSitePlusi | Q9NZ81 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205352, Expressed in blood and 118 other tissues |
ExpressionAtlasi | Q9NZ81, baseline and differential |
Genevisiblei | Q9NZ81, HS |
Organism-specific databases
HPAi | ENSG00000205352, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsQ9NZ81
Protein-protein interaction databases
BioGRIDi | 119965, 52 interactors |
IntActi | Q9NZ81, 50 interactors |
MINTi | Q9NZ81 |
STRINGi | 9606.ENSP00000412064 |
Miscellaneous databases
RNActi | Q9NZ81, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 101 | Pro-richAdd BLAST | 98 | |
Compositional biasi | 117 – 135 | His-richAdd BLAST | 19 | |
Compositional biasi | 136 – 147 | Ser-richAdd BLAST | 12 |
Phylogenomic databases
eggNOGi | ENOG502R4RR, Eukaryota |
GeneTreei | ENSGT00730000111608 |
HOGENOMi | CLU_2432475_0_0_1 |
InParanoidi | Q9NZ81 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NZ81-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG
60 70 80 90 100
NPAFPPGGPP HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG
110 120 130 140
PAVIVDKKMQ KKMKKAHKKM HKHQKHHKYH KHGKHSSSSS SSSSSDSD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VRX0 | F8VRX0_HUMAN | Proline-rich protein 13 | PRR13 | 116 | Annotation score: | ||
F8VU40 | F8VU40_HUMAN | Proline-rich protein 13 | PRR13 | 151 | Annotation score: | ||
F8VZP4 | F8VZP4_HUMAN | Proline-rich protein 13 | PRR13 | 162 | Annotation score: | ||
F8VP70 | F8VP70_HUMAN | Proline-rich protein 13 | PRR13 | 52 | Annotation score: | ||
F8W1R5 | F8W1R5_HUMAN | Proline-rich protein 13 | PRR13 | 55 | Annotation score: | ||
F8VWB5 | F8VWB5_HUMAN | Proline-rich protein 13 | PRR13 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | P → S in CAG38490 (Ref. 2) Curated | 1 | |
Sequence conflicti | 73 | P → L in AAH66943 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 137 | S → P in CAE45980 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024394 | 7 – 56 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF217517 mRNA Translation: AAF67628.1 CR533459 mRNA Translation: CAG38490.1 BX640962 mRNA Translation: CAE45980.1 CH471054 Genomic DNA Translation: EAW96703.1 BC014257 mRNA Translation: AAH14257.1 BC016064 mRNA Translation: AAH16064.1 BC066943 mRNA Translation: AAH66943.1 BK005847 mRNA Translation: DAA05782.1 |
CCDSi | CCDS31811.1 [Q9NZ81-2] CCDS44899.1 [Q9NZ81-1] |
RefSeqi | NP_001005354.1, NM_001005354.2 [Q9NZ81-2] NP_060927.1, NM_018457.3 [Q9NZ81-1] |
Genome annotation databases
Ensembli | ENST00000379786; ENSP00000369112; ENSG00000205352 [Q9NZ81-2] ENST00000429243; ENSP00000412064; ENSG00000205352 [Q9NZ81-1] ENST00000549135; ENSP00000447777; ENSG00000205352 [Q9NZ81-1] ENST00000549581; ENSP00000448153; ENSG00000205352 [Q9NZ81-2] ENST00000549924; ENSP00000448761; ENSG00000205352 [Q9NZ81-1] |
GeneIDi | 54458 |
KEGGi | hsa:54458 |
UCSCi | uc001scy.5, human [Q9NZ81-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF217517 mRNA Translation: AAF67628.1 CR533459 mRNA Translation: CAG38490.1 BX640962 mRNA Translation: CAE45980.1 CH471054 Genomic DNA Translation: EAW96703.1 BC014257 mRNA Translation: AAH14257.1 BC016064 mRNA Translation: AAH16064.1 BC066943 mRNA Translation: AAH66943.1 BK005847 mRNA Translation: DAA05782.1 |
CCDSi | CCDS31811.1 [Q9NZ81-2] CCDS44899.1 [Q9NZ81-1] |
RefSeqi | NP_001005354.1, NM_001005354.2 [Q9NZ81-2] NP_060927.1, NM_018457.3 [Q9NZ81-1] |
3D structure databases
SMRi | Q9NZ81 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119965, 52 interactors |
IntActi | Q9NZ81, 50 interactors |
MINTi | Q9NZ81 |
STRINGi | 9606.ENSP00000412064 |
PTM databases
iPTMneti | Q9NZ81 |
PhosphoSitePlusi | Q9NZ81 |
Polymorphism and mutation databases
BioMutai | PRR13 |
DMDMi | 74734721 |
Proteomic databases
MassIVEi | Q9NZ81 |
PaxDbi | Q9NZ81 |
PeptideAtlasi | Q9NZ81 |
PRIDEi | Q9NZ81 |
ProteomicsDBi | 83339 [Q9NZ81-1] 83340 [Q9NZ81-2] |
Protocols and materials databases
Antibodypediai | 43374, 53 antibodies |
DNASUi | 54458 |
Genome annotation databases
Ensembli | ENST00000379786; ENSP00000369112; ENSG00000205352 [Q9NZ81-2] ENST00000429243; ENSP00000412064; ENSG00000205352 [Q9NZ81-1] ENST00000549135; ENSP00000447777; ENSG00000205352 [Q9NZ81-1] ENST00000549581; ENSP00000448153; ENSG00000205352 [Q9NZ81-2] ENST00000549924; ENSP00000448761; ENSG00000205352 [Q9NZ81-1] |
GeneIDi | 54458 |
KEGGi | hsa:54458 |
UCSCi | uc001scy.5, human [Q9NZ81-1] |
Organism-specific databases
CTDi | 54458 |
DisGeNETi | 54458 |
EuPathDBi | HostDB:ENSG00000205352.10 |
GeneCardsi | PRR13 |
HGNCi | HGNC:24528, PRR13 |
HPAi | ENSG00000205352, Tissue enhanced (blood) |
MIMi | 610459, gene |
neXtProti | NX_Q9NZ81 |
OpenTargetsi | ENSG00000205352 |
PharmGKBi | PA143485583 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R4RR, Eukaryota |
GeneTreei | ENSGT00730000111608 |
HOGENOMi | CLU_2432475_0_0_1 |
InParanoidi | Q9NZ81 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ81 |
Miscellaneous databases
BioGRID-ORCSi | 54458, 209 hits in 842 CRISPR screens |
ChiTaRSi | PRR13, human |
GenomeRNAii | 54458 |
Pharosi | Q9NZ81, Tdark |
PROi | PR:Q9NZ81 |
RNActi | Q9NZ81, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205352, Expressed in blood and 118 other tissues |
ExpressionAtlasi | Q9NZ81, baseline and differential |
Genevisiblei | Q9NZ81, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRR13_HUMAN | |
Accessioni | Q9NZ81Primary (citable) accession number: Q9NZ81 Secondary accession number(s): Q0V8U0 Q6PKF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM