UniProtKB - Q9NZ72 (STMN3_HUMAN)
Protein
Stathmin-3
Gene
STMN3
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity
GO - Molecular functioni
- protein domain specific binding Source: HGNC-UCL
- tubulin binding Source: GO_Central
GO - Biological processi
- cytoplasmic microtubule organization Source: HGNC-UCL
- microtubule depolymerization Source: GO_Central
- negative regulation of Rac protein signal transduction Source: HGNC-UCL
- nervous system development Source: ProtInc
- neuron projection development Source: HGNC-UCL
- regulation of cytoskeleton organization Source: HGNC-UCL
- regulation of GTPase activity Source: HGNC-UCL
- regulation of microtubule polymerization or depolymerization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NZ72 |
Names & Taxonomyi
Protein namesi | Recommended name: Stathmin-3Alternative name(s): SCG10-like protein |
Gene namesi | Name:STMN3 Synonyms:SCLIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15926, STMN3 |
MIMi | 608362, gene |
neXtProti | NX_Q9NZ72 |
VEuPathDBi | HostDB:ENSG00000197457.9 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- growth cone 1 Publication
- axon 1 Publication
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- cytoplasm Source: HGNC-UCL
- growth cone Source: UniProtKB-SubCell
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cytoplasm, Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 50861 |
OpenTargetsi | ENSG00000197457 |
PharmGKBi | PA38049 |
Miscellaneous databases
Pharosi | Q9NZ72, Tbio |
Genetic variation databases
BioMutai | STMN3 |
DMDMi | 20141809 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182402 | 1 – 180 | Stathmin-3Add BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 22 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 24 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 50 | PhosphoserineBy similarity | 1 | |
Modified residuei | 60 | PhosphoserineBy similarity | 1 | |
Modified residuei | 65 | PhosphoserineBy similarity | 1 | |
Modified residuei | 68 | PhosphoserineBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 81 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q9NZ72 |
jPOSTi | Q9NZ72 |
MassIVEi | Q9NZ72 |
MaxQBi | Q9NZ72 |
PaxDbi | Q9NZ72 |
PeptideAtlasi | Q9NZ72 |
PRIDEi | Q9NZ72 |
ProteomicsDBi | 6691 83338 [Q9NZ72-1] |
PTM databases
iPTMneti | Q9NZ72 |
PhosphoSitePlusi | Q9NZ72 |
SwissPalmi | Q9NZ72 |
Expressioni
Tissue specificityi
Neuron specific.
Gene expression databases
Bgeei | ENSG00000197457, Expressed in anterior cingulate cortex and 192 other tissues |
ExpressionAtlasi | Q9NZ72, baseline and differential |
Genevisiblei | Q9NZ72, HS |
Organism-specific databases
HPAi | ENSG00000197457, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with STAT3.
Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).
By similarityBinary interactionsi
Hide detailsQ9NZ72
GO - Molecular functioni
- protein domain specific binding Source: HGNC-UCL
- tubulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119161, 33 interactors |
IntActi | Q9NZ72, 27 interactors |
MINTi | Q9NZ72 |
STRINGi | 9606.ENSP00000359070 |
Miscellaneous databases
RNActi | Q9NZ72, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 180 | SLDPROSITE-ProRule annotationAdd BLAST | 143 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 75 – 179 | Sequence analysisAdd BLAST | 105 |
Sequence similaritiesi
Belongs to the stathmin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1280, Eukaryota |
GeneTreei | ENSGT01020000230545 |
HOGENOMi | CLU_102026_0_0_1 |
InParanoidi | Q9NZ72 |
OMAi | EERSCFR |
OrthoDBi | 1381987at2759 |
PhylomeDBi | Q9NZ72 |
TreeFami | TF326935 |
Family and domain databases
InterProi | View protein in InterPro IPR028835, Stathmin-3 IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit PTHR10104:SF17, PTHR10104:SF17, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NZ72-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR QAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YW36 | A0A0J9YW36_HUMAN | Stathmin-3 | STMN3 | 239 | Annotation score: | ||
A0A0J9YXY4 | A0A0J9YXY4_HUMAN | Stathmin | STMN3 | 86 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | S → P in AAD12730 (PubMed:9603203).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056525 | 1 – 11 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF069709 mRNA Translation: AAD12730.1 AF217796 Genomic DNA Translation: AAF35245.1 AK094112 mRNA Translation: BAG52817.1 AK298903 mRNA Translation: BAH12900.1 AL353715 Genomic DNA No translation available. BC009381 mRNA Translation: AAH09381.1 BC025234 mRNA Translation: AAH25234.1 |
CCDSi | CCDS13529.1 [Q9NZ72-1] CCDS63330.1 [Q9NZ72-2] |
RefSeqi | NP_001263239.1, NM_001276310.1 [Q9NZ72-2] NP_056978.2, NM_015894.3 [Q9NZ72-1] |
Genome annotation databases
Ensembli | ENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1] ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2] |
GeneIDi | 50861 |
KEGGi | hsa:50861 |
UCSCi | uc002yfr.3, human [Q9NZ72-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF069709 mRNA Translation: AAD12730.1 AF217796 Genomic DNA Translation: AAF35245.1 AK094112 mRNA Translation: BAG52817.1 AK298903 mRNA Translation: BAH12900.1 AL353715 Genomic DNA No translation available. BC009381 mRNA Translation: AAH09381.1 BC025234 mRNA Translation: AAH25234.1 |
CCDSi | CCDS13529.1 [Q9NZ72-1] CCDS63330.1 [Q9NZ72-2] |
RefSeqi | NP_001263239.1, NM_001276310.1 [Q9NZ72-2] NP_056978.2, NM_015894.3 [Q9NZ72-1] |
3D structure databases
SMRi | Q9NZ72 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119161, 33 interactors |
IntActi | Q9NZ72, 27 interactors |
MINTi | Q9NZ72 |
STRINGi | 9606.ENSP00000359070 |
PTM databases
iPTMneti | Q9NZ72 |
PhosphoSitePlusi | Q9NZ72 |
SwissPalmi | Q9NZ72 |
Genetic variation databases
BioMutai | STMN3 |
DMDMi | 20141809 |
Proteomic databases
EPDi | Q9NZ72 |
jPOSTi | Q9NZ72 |
MassIVEi | Q9NZ72 |
MaxQBi | Q9NZ72 |
PaxDbi | Q9NZ72 |
PeptideAtlasi | Q9NZ72 |
PRIDEi | Q9NZ72 |
ProteomicsDBi | 6691 83338 [Q9NZ72-1] |
Protocols and materials databases
Antibodypediai | 29816, 194 antibodies |
DNASUi | 50861 |
Genome annotation databases
Ensembli | ENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1] ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2] |
GeneIDi | 50861 |
KEGGi | hsa:50861 |
UCSCi | uc002yfr.3, human [Q9NZ72-1] |
Organism-specific databases
CTDi | 50861 |
DisGeNETi | 50861 |
GeneCardsi | STMN3 |
HGNCi | HGNC:15926, STMN3 |
HPAi | ENSG00000197457, Tissue enriched (brain) |
MIMi | 608362, gene |
neXtProti | NX_Q9NZ72 |
OpenTargetsi | ENSG00000197457 |
PharmGKBi | PA38049 |
VEuPathDBi | HostDB:ENSG00000197457.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1280, Eukaryota |
GeneTreei | ENSGT01020000230545 |
HOGENOMi | CLU_102026_0_0_1 |
InParanoidi | Q9NZ72 |
OMAi | EERSCFR |
OrthoDBi | 1381987at2759 |
PhylomeDBi | Q9NZ72 |
TreeFami | TF326935 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ72 |
Miscellaneous databases
BioGRID-ORCSi | 50861, 5 hits in 994 CRISPR screens |
ChiTaRSi | STMN3, human |
GeneWikii | STMN3 |
GenomeRNAii | 50861 |
Pharosi | Q9NZ72, Tbio |
PROi | PR:Q9NZ72 |
RNActi | Q9NZ72, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197457, Expressed in anterior cingulate cortex and 192 other tissues |
ExpressionAtlasi | Q9NZ72, baseline and differential |
Genevisiblei | Q9NZ72, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028835, Stathmin-3 IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit PTHR10104:SF17, PTHR10104:SF17, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STMN3_HUMAN | |
Accessioni | Q9NZ72Primary (citable) accession number: Q9NZ72 Secondary accession number(s): B3KSQ5 Q969Y4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 23, 2002 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families