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Protein

Stathmin-3

Gene

STMN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: HGNC
  • tubulin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
SCG10-like protein
Gene namesi
Name:STMN3
Synonyms:SCLIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000197457.9
HGNCiHGNC:15926 STMN3
MIMi608362 gene
neXtProtiNX_Q9NZ72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi50861
OpenTargetsiENSG00000197457
PharmGKBiPA38049

Polymorphism and mutation databases

DMDMi20141809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824021 – 180Stathmin-3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22S-palmitoyl cysteineBy similarity1
Lipidationi24S-palmitoyl cysteineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NZ72
MaxQBiQ9NZ72
PaxDbiQ9NZ72
PeptideAtlasiQ9NZ72
PRIDEiQ9NZ72
ProteomicsDBi83338

PTM databases

iPTMnetiQ9NZ72
PhosphoSitePlusiQ9NZ72
SwissPalmiQ9NZ72

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSG00000197457 Expressed in 176 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STMN3
ExpressionAtlasiQ9NZ72 baseline and differential
GenevisibleiQ9NZ72 HS

Organism-specific databases

HPAiHPA012947

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119161, 10 interactors
IntActiQ9NZ72, 22 interactors
MINTiQ9NZ72
STRINGi9606.ENSP00000359070

Structurei

3D structure databases

ProteinModelPortaliQ9NZ72
SMRiQ9NZ72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 180SLDPROSITE-ProRule annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAZ Eukaryota
ENOG4111H1E LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ9NZ72
OrthoDBiEOG091G0Y2U
PhylomeDBiQ9NZ72
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR028835 Stathmin-3
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF17 PTHR10104:SF17, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR QAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):21,017
Last modified:January 23, 2002 - v3
Checksum:i52F5E8A605FE10D0
GO
Isoform 2 (identifier: Q9NZ72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,806
Checksum:iEAA6AE260D7BD4CB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YXY4A0A0J9YXY4_HUMAN
Stathmin
STMN3
86Annotation score:
A0A0J9YW36A0A0J9YW36_HUMAN
Stathmin-3
STMN3
239Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72S → P in AAD12730 (PubMed:9603203).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565251 – 11Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069709 mRNA Translation: AAD12730.1
AF217796 Genomic DNA Translation: AAF35245.1
AK094112 mRNA Translation: BAG52817.1
AK298903 mRNA Translation: BAH12900.1
AL353715 Genomic DNA No translation available.
BC009381 mRNA Translation: AAH09381.1
BC025234 mRNA Translation: AAH25234.1
CCDSiCCDS13529.1 [Q9NZ72-1]
CCDS63330.1 [Q9NZ72-2]
RefSeqiNP_001263239.1, NM_001276310.1 [Q9NZ72-2]
NP_056978.2, NM_015894.3 [Q9NZ72-1]
UniGeneiHs.639609

Genome annotation databases

EnsembliENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1]
ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2]
GeneIDi50861
KEGGihsa:50861
UCSCiuc002yfr.3 human [Q9NZ72-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069709 mRNA Translation: AAD12730.1
AF217796 Genomic DNA Translation: AAF35245.1
AK094112 mRNA Translation: BAG52817.1
AK298903 mRNA Translation: BAH12900.1
AL353715 Genomic DNA No translation available.
BC009381 mRNA Translation: AAH09381.1
BC025234 mRNA Translation: AAH25234.1
CCDSiCCDS13529.1 [Q9NZ72-1]
CCDS63330.1 [Q9NZ72-2]
RefSeqiNP_001263239.1, NM_001276310.1 [Q9NZ72-2]
NP_056978.2, NM_015894.3 [Q9NZ72-1]
UniGeneiHs.639609

3D structure databases

ProteinModelPortaliQ9NZ72
SMRiQ9NZ72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119161, 10 interactors
IntActiQ9NZ72, 22 interactors
MINTiQ9NZ72
STRINGi9606.ENSP00000359070

PTM databases

iPTMnetiQ9NZ72
PhosphoSitePlusiQ9NZ72
SwissPalmiQ9NZ72

Polymorphism and mutation databases

DMDMi20141809

Proteomic databases

EPDiQ9NZ72
MaxQBiQ9NZ72
PaxDbiQ9NZ72
PeptideAtlasiQ9NZ72
PRIDEiQ9NZ72
ProteomicsDBi83338

Protocols and materials databases

DNASUi50861
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1]
ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2]
GeneIDi50861
KEGGihsa:50861
UCSCiuc002yfr.3 human [Q9NZ72-1]

Organism-specific databases

CTDi50861
DisGeNETi50861
EuPathDBiHostDB:ENSG00000197457.9
GeneCardsiSTMN3
HGNCiHGNC:15926 STMN3
HPAiHPA012947
MIMi608362 gene
neXtProtiNX_Q9NZ72
OpenTargetsiENSG00000197457
PharmGKBiPA38049
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAZ Eukaryota
ENOG4111H1E LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ9NZ72
OrthoDBiEOG091G0Y2U
PhylomeDBiQ9NZ72
TreeFamiTF326935

Miscellaneous databases

ChiTaRSiSTMN3 human
GeneWikiiSTMN3
GenomeRNAii50861
PROiPR:Q9NZ72
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197457 Expressed in 176 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STMN3
ExpressionAtlasiQ9NZ72 baseline and differential
GenevisibleiQ9NZ72 HS

Family and domain databases

InterProiView protein in InterPro
IPR028835 Stathmin-3
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF17 PTHR10104:SF17, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ72
Secondary accession number(s): B3KSQ5
, B7WP52, B7Z5G4, O75527, Q969Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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