STMN3

Functionⁱ

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functionⁱ

protein domain specific binding Source: HGNC
tubulin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst hatching Source: Ensembl
cytoplasmic microtubule organization Source: HGNC
microtubule depolymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of Rac protein signal transduction Source: HGNC
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9603203
neuron projection development Source: HGNC
regulation of cytoskeleton organization Source: HGNC
regulation of GTPase activity Source: HGNC
regulation of microtubule polymerization or depolymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Stathmin-3 Alternative name(s): SCG10-like protein
Gene namesⁱ	Name:STMN3 Synonyms:SCLIP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197457.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15926 STMN3
MIMⁱ	608362 gene
neXtProtⁱ	NX_Q9NZ72

Keywords - Cellular componentⁱ

Cell projection, Golgi apparatus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50861
Open Targets More...OpenTargetsⁱ	ENSG00000197457
PharmGKBⁱ	PA38049

Polymorphism and mutation databases

DMDMⁱ	20141809

DMDMⁱ

20141809

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000182402	1 – 180	Stathmin-3Add BLAST		180

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	22	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	24	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	50	PhosphoserineBy similarity	1
Modified residueⁱ	60	PhosphoserineBy similarity	1
Modified residueⁱ	65	PhosphoserineBy similarity	1
Modified residueⁱ	68	PhosphoserineBy similarity	1
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	73	PhosphoserineBy similarity	1
Modified residueⁱ	81	PhosphoserineBy similarity	1

Post-translational modificationⁱ

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NZ72
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZ72
PaxDbⁱ	Q9NZ72
PeptideAtlas More...PeptideAtlasⁱ	Q9NZ72
PRIDEⁱ	Q9NZ72
ProteomicsDBⁱ	83338

PTM databases

iPTMnetⁱ	Q9NZ72
PhosphoSitePlusⁱ	Q9NZ72
SwissPalmⁱ	Q9NZ72

Expressionⁱ

Tissue specificityⁱ

Neuron specific.

Gene expression databases

Bgeeⁱ	ENSG00000197457 Expressed in 176 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_STMN3
ExpressionAtlasⁱ	Q9NZ72 baseline and differential
Genevisibleⁱ	Q9NZ72 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012947

HPAⁱ

HPA012947

Interactionⁱ

Subunit structureⁱ

Interacts with STAT3.By similarity

GO - Molecular functionⁱ

protein domain specific binding Source: HGNC
tubulin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119161, 10 interactors
IntActⁱ	Q9NZ72, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q9NZ72
STRINGⁱ	9606.ENSP00000359070

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NZ72
SMRⁱ	Q9NZ72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 180	SLDPROSITE-ProRule annotationAdd BLAST		143

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	75 – 179	Sequence analysisAdd BLAST		105

Sequence similaritiesⁱ

Belongs to the stathmin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEAZ Eukaryota ENOG4111H1E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003691
HOGENOMⁱ	HOG000013197
HOVERGENⁱ	HBG054037
InParanoidⁱ	Q9NZ72
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y2U
PhylomeDBⁱ	Q9NZ72
TreeFamⁱ	TF326935

Family and domain databases

InterProⁱ	View protein in InterPro IPR028835 Stathmin-3 IPR030514 Stathmin_CS IPR000956 Stathmin_fam IPR036002 Stathmin_sf
PANTHERⁱ	PTHR10104 PTHR10104, 1 hit PTHR10104:SF17 PTHR10104:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00836 Stathmin, 1 hit
PIRSFⁱ	PIRSF002285 Stathmin, 1 hit
PRINTSⁱ	PR00345 STATHMIN
SUPFAMⁱ	SSF101494 SSF101494, 1 hit
PROSITEⁱ	View protein in PROSITE PS00563 STATHMIN_1, 1 hit PS01041 STATHMIN_2, 1 hit PS51663 STATHMIN_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NZ72-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS 
        60         70         80         90        100
GQSFEVILKS PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE 
       110        120        130        140        150
AQVLKQLAER REHEREVLHK ALEENNNFSR QAEEKLNYKM ELSKEIREAH 
       160        170        180
LAALRERLRE KELHAAEVRR NKEQREEMSG

Length:180

Mass (Da):21,017

Last modified:January 23, 2002 - v3

Checksum:ⁱ52F5E8A605FE10D0

GO

Isoform 2 (identifier: Q9NZ72-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-11: Missing.

« Hide

        10         20         30         40         50
MKELSVLSLI CSCFYTQPHP NTVYQYGDME VKQLDKRASG QSFEVILKSP 
        60         70         80         90        100
SDLSPESPML SSPPKKKDTS LEELQKRLEA AEERRKTQEA QVLKQLAERR 
       110        120        130        140        150
EHEREVLHKA LEENNNFSRQ AEEKLNYKME LSKEIREAHL AALRERLREK 
       160 
ELHAAEVRRN KEQREEMSG

Note: No experimental confirmation available.

Show »

Length:169

Mass (Da):19,806

Checksum:ⁱEAA6AE260D7BD4CB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0J9YXY4	A0A0J9YXY4_HUMAN	Stathmin Stathmin	STMN3	86	Annotation score:
A0A0J9YW36	A0A0J9YW36_HUMAN	Stathmin-3 Stathmin-3	STMN3	239	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	72	S → P in AAD12730 (PubMed:9603203).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056525	1 – 11	Missing in isoform 2. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF069709 mRNA Translation: AAD12730.1 AF217796 Genomic DNA Translation: AAF35245.1 AK094112 mRNA Translation: BAG52817.1 AK298903 mRNA Translation: BAH12900.1 AL353715 Genomic DNA No translation available. BC009381 mRNA Translation: AAH09381.1 BC025234 mRNA Translation: AAH25234.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13529.1 [Q9NZ72-1] CCDS63330.1 [Q9NZ72-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001263239.1, NM_001276310.1 [Q9NZ72-2] NP_056978.2, NM_015894.3 [Q9NZ72-1]
UniGeneⁱ	Hs.639609

Genome annotation databases

Ensemblⁱ	ENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1] ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2]
GeneIDⁱ	50861
KEGGⁱ	hsa:50861
UCSC genome browser More...UCSCⁱ	uc002yfr.3 human [Q9NZ72-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ72	Stathmin-3		PONAB		180	UniRef100_Q9NZ72
Stathmin		PANTR		180
Stathmin		PONAB		180
Q9NZ72-2	Stathmin		PONAB		169	UniRef100_A0A2J8RAW8
Stathmin		PANPA		94
Stathmin-3 (Fragment)		HUMAN		239
Stathmin (Fragment)		PANTR		86
Stathmin (Fragment)		HUMAN		86
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ72	Stathmin-3		MOUSE		180	UniRef90_O70166
Stathmin-3		RAT		180
Stathmin-3		MACFA		180
Stathmin-3		PONAB		180
Stathmin-3		BOVIN		180
+107
Q9NZ72-2	Stathmin		PANTR		192	UniRef90_A0A2I3TUY2
STMN3 isoform 3 (Fragment)		PONAB		238
Stathmin		PANPA		94
Stathmin-3 (Fragment)		HUMAN		239
UPI0002ADB35A		NOMLE		208
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ72	Stathmin-3		MOUSE		180	UniRef50_O70166
Stathmin-3		RAT		180
Stathmin-3		PONAB		180
Stathmin-3		BOVIN		180
Stathmin-3		MACFA		180
+110
Q9NZ72-2	Stathmin-4	)	HUMAN		189	UniRef50_Q9H169
Stathmin-4		PONAB		189
Stathmin-4		MOUSE		189
Stathmin-4	)	RAT		189
Stathmin		BOVIN		189
+133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF069709 mRNA Translation: AAD12730.1 AF217796 Genomic DNA Translation: AAF35245.1 AK094112 mRNA Translation: BAG52817.1 AK298903 mRNA Translation: BAH12900.1 AL353715 Genomic DNA No translation available. BC009381 mRNA Translation: AAH09381.1 BC025234 mRNA Translation: AAH25234.1
CCDSⁱ	CCDS13529.1 [Q9NZ72-1] CCDS63330.1 [Q9NZ72-2]
RefSeqⁱ	NP_001263239.1, NM_001276310.1 [Q9NZ72-2] NP_056978.2, NM_015894.3 [Q9NZ72-1]
UniGeneⁱ	Hs.639609

3D structure databases

ProteinModelPortalⁱ	Q9NZ72
SMRⁱ	Q9NZ72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119161, 10 interactors
IntActⁱ	Q9NZ72, 22 interactors
MINTⁱ	Q9NZ72
STRINGⁱ	9606.ENSP00000359070

PTM databases

iPTMnetⁱ	Q9NZ72
PhosphoSitePlusⁱ	Q9NZ72
SwissPalmⁱ	Q9NZ72

Polymorphism and mutation databases

DMDMⁱ	20141809

DMDMⁱ

20141809

Proteomic databases

EPDⁱ	Q9NZ72
MaxQBⁱ	Q9NZ72
PaxDbⁱ	Q9NZ72
PeptideAtlasⁱ	Q9NZ72
PRIDEⁱ	Q9NZ72
ProteomicsDBⁱ	83338

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50861
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370053; ENSP00000359070; ENSG00000197457 [Q9NZ72-1] ENST00000540534; ENSP00000439840; ENSG00000197457 [Q9NZ72-2]
GeneIDⁱ	50861
KEGGⁱ	hsa:50861
UCSCⁱ	uc002yfr.3 human [Q9NZ72-1]

Organism-specific databases

CTDⁱ	50861
DisGeNETⁱ	50861
EuPathDBⁱ	HostDB:ENSG00000197457.9
GeneCardsⁱ	STMN3
HGNCⁱ	HGNC:15926 STMN3
HPAⁱ	HPA012947
MIMⁱ	608362 gene
neXtProtⁱ	NX_Q9NZ72
OpenTargetsⁱ	ENSG00000197457
PharmGKBⁱ	PA38049
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEAZ Eukaryota ENOG4111H1E LUCA
GeneTreeⁱ	ENSGT00390000003691
HOGENOMⁱ	HOG000013197
HOVERGENⁱ	HBG054037
InParanoidⁱ	Q9NZ72
OrthoDBⁱ	EOG091G0Y2U
PhylomeDBⁱ	Q9NZ72
TreeFamⁱ	TF326935

Miscellaneous databases

ChiTaRSⁱ	STMN3 human
GeneWikiⁱ	STMN3
GenomeRNAiⁱ	50861
Protein Ontology More...PROⁱ	PR:Q9NZ72
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197457 Expressed in 176 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_STMN3
ExpressionAtlasⁱ	Q9NZ72 baseline and differential
Genevisibleⁱ	Q9NZ72 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028835 Stathmin-3 IPR030514 Stathmin_CS IPR000956 Stathmin_fam IPR036002 Stathmin_sf
PANTHERⁱ	PTHR10104 PTHR10104, 1 hit PTHR10104:SF17 PTHR10104:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF00836 Stathmin, 1 hit
PIRSFⁱ	PIRSF002285 Stathmin, 1 hit
PRINTSⁱ	PR00345 STATHMIN
SUPFAMⁱ	SSF101494 SSF101494, 1 hit
PROSITEⁱ	View protein in PROSITE PS00563 STATHMIN_1, 1 hit PS01041 STATHMIN_2, 1 hit PS51663 STATHMIN_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STMN3_HUMAN
Accessionⁱ	Q9NZ72Primary (citable) accession number: Q9NZ72 Secondary accession number(s): B3KSQ5 , B7WP52, B7Z5G4, O75527, Q969Y4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q9NZ72 (STMN3_HUMAN)

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Stathmin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Golgi apparatus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ