GGA3

Functionⁱ

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.1 Publication

GO - Molecular functionⁱ

ADP-ribosylation factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10749927

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
intracellular protein transport
Source: UniProtKB
Non-traceable author statementⁱ
- 10749927
positive regulation of protein catabolic process Source: Ensembl
protein localization to lysosome Source: Ensembl
vesicle-mediated transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs R-HSA-8875656 MET receptor recycling R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs
R-HSA-8875656 MET receptor recycling
R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP-ribosylation factor-binding protein GGA3 Alternative name(s): Golgi-localized, gamma ear-containing, ARF-binding protein 3
Gene namesⁱ	Name:GGA3 Synonyms:KIAA0154
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125447.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17079 GGA3
MIMⁱ	606006 gene
neXtProtⁱ	NX_Q9NZ52

Keywords - Cellular componentⁱ

Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	194	N → A: Loss of interaction with ARF1 and Golgi localization. 1 Publication	1
Mutagenesisⁱ	199	S → P: Loss of interaction with ARF1 and Golgi localization. 1 Publication	1
Mutagenesisⁱ	217	T → P: Loss of interaction with ARF1 and Golgi localization. 1 Publication	1
Mutagenesisⁱ	247	L → P: Loss of UBC-binding and ubiquitination. 1 Publication	1
Mutagenesisⁱ	258	K → M: No effect. Confers an affinity to RABEP1 identical to GGA1; when associated with N-283. 1 Publication	1
Mutagenesisⁱ	262	L → S: Loss of UBC-binding and ubiquitination. 1 Publication	1
Mutagenesisⁱ	276	L → A: Loss of UBC-binding and ubiquitination. 2 Publications	1
Mutagenesisⁱ	276	L → S: Loss of UBC-binding and ubiquitination. 2 Publications	1
Mutagenesisⁱ	280	L → R: Loss of UBC-binding and ubiquitination. 1 Publication	1
Mutagenesisⁱ	283	S → N: Can bind RABEP1. Confers an affinity to RABEP1 identical to GGA1; when associated with M-258. 1 Publication	1
Mutagenesisⁱ	284	D → G: Loss of UBC-binding and ubiquitination. 1 Publication	1
Mutagenesisⁱ	293	Y → H: Loss of UBC-binding and ubiquitination. 1 Publication	1
Mutagenesisⁱ	391 – 395	DEELL → AAAAA: Increased binding to IGF2R. 1 Publication	5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23163
Open Targets More...OpenTargetsⁱ	ENSG00000125447
PharmGKBⁱ	PA28659

Polymorphism and mutation databases

BioMutaⁱ	GGA3
DMDMⁱ	14548064

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212684	1 – 723	ADP-ribosylation factor-binding protein GGA3Add BLAST		723

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	159	PhosphoserineCombined sources		1
Modified residueⁱ	275	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.By similarity

Ubiquitinated.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NZ52
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZ52
PaxDbⁱ	Q9NZ52
PeptideAtlas More...PeptideAtlasⁱ	Q9NZ52
PRIDEⁱ	Q9NZ52
ProteomicsDBⁱ	83324 83325 [Q9NZ52-2]

PTM databases

iPTMnetⁱ	Q9NZ52
PhosphoSitePlusⁱ	Q9NZ52

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000125447 Expressed in 211 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_GGA3
ExpressionAtlasⁱ	Q9NZ52 baseline and differential
Genevisibleⁱ	Q9NZ52 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022945 HPA024645

HPAⁱ

HPA022945
HPA024645

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200 (By similarity). Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC.By similarity13 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PACS1	Q6VY07	5	EBI-447404,EBI-2555014
RABEP1	Q15276	4	EBI-447404,EBI-447043
UBB	P0CG47	2	EBI-447404,EBI-413034

GO - Molecular functionⁱ

ADP-ribosylation factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10749927

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116775, 38 interactors
Database of interacting proteins More...DIPⁱ	DIP-31600N
ELMⁱ	Q9NZ52
IntActⁱ	Q9NZ52, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q9NZ52
STRINGⁱ	9606.ENSP00000245541

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 16	Combined sources	8
Helixⁱ	26 – 38	Combined sources	13
Helixⁱ	42 – 54	Combined sources	13
Helixⁱ	59 – 75	Combined sources	17
Helixⁱ	77 – 84	Combined sources	8
Helixⁱ	87 – 97	Combined sources	11
Helixⁱ	99 – 103	Combined sources	5
Helixⁱ	108 – 124	Combined sources	17
Helixⁱ	129 – 140	Combined sources	12
Helixⁱ	218 – 231	Combined sources	14
Turnⁱ	232 – 234	Combined sources	3
Turnⁱ	237 – 239	Combined sources	3
Helixⁱ	242 – 267	Combined sources	26
Helixⁱ	276 – 290	Combined sources	15
Helixⁱ	292 – 295	Combined sources	4
Turnⁱ	296 – 298	Combined sources	3
Helixⁱ	588 – 590	Combined sources	3
Beta strandⁱ	599 – 604	Combined sources	6
Beta strandⁱ	607 – 616	Combined sources	10
Beta strandⁱ	624 – 633	Combined sources	10
Beta strandⁱ	635 – 637	Combined sources	3
Beta strandⁱ	639 – 647	Combined sources	9
Beta strandⁱ	652 – 656	Combined sources	5
Beta strandⁱ	675 – 683	Combined sources	9
Beta strandⁱ	692 – 700	Combined sources	9
Beta strandⁱ	703 – 711	Combined sources	9
Helixⁱ	717 – 719	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZ52
SMRⁱ	Q9NZ52
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NZ52

EvolutionaryTraceⁱ

Q9NZ52

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	16 – 146	VHSPROSITE-ProRule annotationAdd BLAST	131
Domainⁱ	171 – 298	GATPROSITE-ProRule annotationAdd BLAST	128
Domainⁱ	594 – 715	GAEPROSITE-ProRule annotationAdd BLAST	122

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 313	Binds to ARF1 (in long isoform)Add BLAST		313
Regionⁱ	299 – 593	Unstructured hingeAdd BLAST		295

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	391 – 395	Autoinhibitory		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	357 – 360	Poly-Pro	4
Compositional biasⁱ	453 – 457	Poly-Ser	5
Compositional biasⁱ	624 – 629	Poly-Val	6

Domainⁱ

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).

The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.

The unstructured hinge region contains clathrin-binding and an autoinhibitory (AC-LL) motifs.

The GAE domain binds accessory proteins regulating GGAs function.

Sequence similaritiesⁱ

Belongs to the GGA protein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150934
HOGENOMⁱ	HOG000231169
HOVERGENⁱ	HBG015945
InParanoidⁱ	Q9NZ52
KEGG Orthology (KO) More...KOⁱ	K12404
OMAⁱ	DFQFEAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQK
PhylomeDBⁱ	Q9NZ52
TreeFamⁱ	TF318574

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR008942 ENTH_VHS IPR008153 GAE_dom IPR004152 GAT_dom IPR038425 GAT_sf IPR027422 GGA3 IPR002014 VHS_dom
PANTHERⁱ	PTHR13856:SF34 PTHR13856:SF34, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02883 Alpha_adaptinC2, 1 hit PF03127 GAT, 1 hit PF00790 VHS, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit SSF49348 SSF49348, 1 hit
PROSITEⁱ	View protein in PROSITE PS50180 GAE, 1 hit PS50909 GAT, 1 hit PS50179 VHS, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: Q9NZ52-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL 
        60         70         80         90        100
AHKIQSPQEW EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK 
       110        120        130        140        150
YLGDRVSEKV KTKVIELLYS WTMALPEEAK IKDAYHMLKR QGIVQSDPPI 
       160        170        180        190        200
PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK LLKSKNPDDL QEANKLIKSM 
       210        220        230        240        250
VKEDEARIQK VTKRLHTLEE VNNNVRLLSE MLLHYSQEDS SDGDRELMKE 
       260        270        280        290        300
LFDQCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ 
       310        320        330        340        350
VINGEVATLT LPDSEGNSQC SNQGTLIDLA ELDTTNSLSS VLAPAPTPPS 
       360        370        380        390        400
SGIPILPPPP QASGPPRSRS SSQAEATLGP SSTSNALSWL DEELLCLGLA 
       410        420        430        440        450
DPAPNVPPKE SAGNSQWHLL QREQSDLDFF SPRPGTAACG ASDAPLLQPS 
       460        470        480        490        500
APSSSSSQAP LPPPFPAPVV PASVPAPSAG SSLFSTGVAP ALAPKVEPAV 
       510        520        530        540        550
PGHHGLALGN SALHHLDALD QLLEEAKVTS GLVKPTTSPL IPTTTPARPL 
       560        570        580        590        600
LPFSTGPGSP LFQPLSFQSQ GSPPKGPELS LASIHVPLES IKPSSALPVT 
       610        620        630        640        650
AYDKNGFRIL FHFAKECPPG RPDVLVVVVS MLNTAPLPVK SIVLQAAVPK 
       660        670        680        690        700
SMKVKLQPPS GTELSPFSPI QPPAAITQVM LLANPLKEKV RLRYKLTFAL 
       710        720 
GEQLSTEVGE VDQFPPVEQW GNL

Length:723

Mass (Da):78,315

Last modified:October 1, 2000 - v1

Checksum:ⁱ4F80D6032239168C

GO

Isoform Short (identifier: Q9NZ52-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
68-100: Missing.

« Hide

        10         20         30         40         50
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL 
        60         70         80         90        100
AHKIQSPQEW EALQALTYLG DRVSEKVKTK VIELLYSWTM ALPEEAKIKD 
       110        120        130        140        150
AYHMLKRQGI VQSDPPIPVD RTLIPSPPPR PKNPVFDDEE KSKLLAKLLK 
       160        170        180        190        200
SKNPDDLQEA NKLIKSMVKE DEARIQKVTK RLHTLEEVNN NVRLLSEMLL 
       210        220        230        240        250
HYSQEDSSDG DRELMKELFD QCENKRRTLF KLASETEDND NSLGDILQAS 
       260        270        280        290        300
DNLSRVINSY KTIIEGQVIN GEVATLTLPD SEGNSQCSNQ GTLIDLAELD 
       310        320        330        340        350
TTNSLSSVLA PAPTPPSSGI PILPPPPQAS GPPRSRSSSQ AEATLGPSST 
       360        370        380        390        400
SNALSWLDEE LLCLGLADPA PNVPPKESAG NSQWHLLQRE QSDLDFFSPR 
       410        420        430        440        450
PGTAACGASD APLLQPSAPS SSSSQAPLPP PFPAPVVPAS VPAPSAGSSL 
       460        470        480        490        500
FSTGVAPALA PKVEPAVPGH HGLALGNSAL HHLDALDQLL EEAKVTSGLV 
       510        520        530        540        550
KPTTSPLIPT TTPARPLLPF STGPGSPLFQ PLSFQSQGSP PKGPELSLAS 
       560        570        580        590        600
IHVPLESIKP SSALPVTAYD KNGFRILFHF AKECPPGRPD VLVVVVSMLN 
       610        620        630        640        650
TAPLPVKSIV LQAAVPKSMK VKLQPPSGTE LSPFSPIQPP AAITQVMLLA 
       660        670        680        690
NPLKEKVRLR YKLTFALGEQ LSTEVGEVDQ FPPVEQWGNL

Show »

Length:690

Mass (Da):74,470

Checksum:ⁱE3A1C841AB3966C8

GO

Isoform 3 (identifier: Q9NZ52-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-122: Missing.
688-723: EKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL → KQVLSFLGKACLQPWGQAILLTTSCLA

« Hide

        10         20         30         40         50
MALPEEAKIK DAYHMLKRQG IVQSDPPIPV DRTLIPSPPP RPKNPVFDDE 
        60         70         80         90        100
EKSKLLAKLL KSKNPDDLQE ANKLIKSMVK EDEARIQKVT KRLHTLEEVN 
       110        120        130        140        150
NNVRLLSEML LHYSQEDSSD GDRELMKELF DQCENKRRTL FKLASETEDN 
       160        170        180        190        200
DNSLGDILQA SDNLSRVINS YKTIIEGQVI NGEVATLTLP DSEGNSQCSN 
       210        220        230        240        250
QGTLIDLAEL DTTNSLSSVL APAPTPPSSG IPILPPPPQA SGPPRSRSSS 
       260        270        280        290        300
QAEATLGPSS TSNALSWLDE ELLCLGLADP APNVPPKESA GNSQWHLLQR 
       310        320        330        340        350
EQSDLDFFSP RPGTAACGAS DAPLLQPSAP SSSSSQAPLP PPFPAPVVPA 
       360        370        380        390        400
SVPAPSAGSS LFSTGVAPAL APKVEPAVPG HHGLALGNSA LHHLDALDQL 
       410        420        430        440        450
LEEAKVTSGL VKPTTSPLIP TTTPARPLLP FSTGPGSPLF QPLSFQSQGS 
       460        470        480        490        500
PPKGPELSLA SIHVPLESIK PSSALPVTAY DKNGFRILFH FAKECPPGRP 
       510        520        530        540        550
DVLVVVVSML NTAPLPVKSI VLQAAVPKSM KVKLQPPSGT ELSPFSPIQP 
       560        570        580        590 
PAAITQVMLL ANPLKKQVLS FLGKACLQPW GQAILLTTSC LA

Show »

Length:592

Mass (Da):62,921

Checksum:ⁱCACD3268CEE80BBE

GO

Isoform 4 (identifier: Q9NZ52-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-72: Missing.

« Hide

        10         20         30         40         50
MKNCGRRFHN EVGKFRFLNE LIKVVSPKYL GDRVSEKVKT KVIELLYSWT 
        60         70         80         90        100
MALPEEAKIK DAYHMLKRQG IVQSDPPIPV DRTLIPSPPP RPKNPVFDDE 
       110        120        130        140        150
EKSKLLAKLL KSKNPDDLQE ANKLIKSMVK EDEARIQKVT KRLHTLEEVN 
       160        170        180        190        200
NNVRLLSEML LHYSQEDSSD GDRELMKELF DQCENKRRTL FKLASETEDN 
       210        220        230        240        250
DNSLGDILQA SDNLSRVINS YKTIIEGQVI NGEVATLTLP DSEGNSQCSN 
       260        270        280        290        300
QGTLIDLAEL DTTNSLSSVL APAPTPPSSG IPILPPPPQA SGPPRSRSSS 
       310        320        330        340        350
QAEATLGPSS TSNALSWLDE ELLCLGLADP APNVPPKESA GNSQWHLLQR 
       360        370        380        390        400
EQSDLDFFSP RPGTAACGAS DAPLLQPSAP SSSSSQAPLP PPFPAPVVPA 
       410        420        430        440        450
SVPAPSAGSS LFSTGVAPAL APKVEPAVPG HHGLALGNSA LHHLDALDQL 
       460        470        480        490        500
LEEAKVTSGL VKPTTSPLIP TTTPARPLLP FSTGPGSPLF QPLSFQSQGS 
       510        520        530        540        550
PPKGPELSLA SIHVPLESIK PSSALPVTAY DKNGFRILFH FAKECPPGRP 
       560        570        580        590        600
DVLVVVVSML NTAPLPVKSI VLQAAVPKSM KVKLQPPSGT ELSPFSPIQP 
       610        620        630        640        650
PAAITQVMLL ANPLKEKVRL RYKLTFALGE QLSTEVGEVD QFPPVEQWGN 

L

Note: No experimental confirmation available.

Show »

Length:651

Mass (Da):70,148

Checksum:ⁱ416484203E34542A

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	J3KSS7	J3KSS7_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	632	Annotation score:
	J3KTR5	J3KTR5_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	110	Annotation score:
	J3QS87	J3QS87_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	158	Annotation score:
	J3KSG3	J3KSG3_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	136	Annotation score:
	B7Z1E9	B7Z1E9_HUMAN	cDNA FLJ59841, highly similar to AD... cDNA FLJ59841, highly similar to ADP-ribosylation factor-binding protein GGA3	GGA3	153	Annotation score:
	J3QRS8	J3QRS8_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	106	Annotation score:
	J3QRP3	J3QRP3_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	152	Annotation score:
	A0A087WYN2	A0A087WYN2_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	46	Annotation score:
	J3KS27	J3KS27_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	64	Annotation score:
	J3QRK7	J3QRK7_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA3	GGA3	76	Annotation score:
There is more potential isoformShow all

Sequence cautionⁱ

The sequence BAA09926 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	448	Q → K in AAH70044 (PubMed:15489334).Curated		1
Sequence conflictⁱ	562	F → S in BAH13665 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_075715	132	K → R1 PublicationCorresponds to variant dbSNP:rs117805695Ensembl.	1
Natural variantⁱVAR_075716	321	S → G1 PublicationCorresponds to variant dbSNP:rs146877619Ensembl.	1
Natural variantⁱVAR_036524	574	P → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776324450Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045133	1 – 122	Missing in isoform 3. 1 PublicationAdd BLAST	122
Alternative sequenceⁱVSP_046868	1 – 72	Missing in isoform 4. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_001745	68 – 100	Missing in isoform Short. 4 PublicationsAdd BLAST	33
Alternative sequenceⁱVSP_045134	688 – 723	EKVRL…QWGNL → KQVLSFLGKACLQPWGQAIL LTTSCLA in isoform 3. 1 PublicationAdd BLAST	36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF219138 mRNA Translation: AAF42848.1 AF190864 mRNA Translation: AAF05709.1 AF219139 mRNA Translation: AAF42849.1 D63876 mRNA Translation: BAA09926.1 Different initiation. AK301895 mRNA Translation: BAH13578.1 AK302278 mRNA Translation: BAH13665.1 AC022211 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89258.1 BC070044 mRNA Translation: AAH70044.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11716.1 [Q9NZ52-2] CCDS11717.1 [Q9NZ52-1] CCDS54164.1 [Q9NZ52-4] CCDS58597.1 [Q9NZ52-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001166174.1, NM_001172703.2 [Q9NZ52-4] NP_001166175.1, NM_001172704.2 [Q9NZ52-3] NP_001278570.1, NM_001291641.1 [Q9NZ52-4] NP_001278571.1, NM_001291642.1 NP_054720.1, NM_014001.4 [Q9NZ52-2] NP_619525.1, NM_138619.3 [Q9NZ52-1]
UniGeneⁱ	Hs.87726

Genome annotation databases

Ensemblⁱ	ENST00000537686; ENSP00000438085; ENSG00000125447 [Q9NZ52-1] ENST00000538886; ENSP00000446421; ENSG00000125447 [Q9NZ52-2] ENST00000578348; ENSP00000463288; ENSG00000125447 [Q9NZ52-3] ENST00000582717; ENSP00000462081; ENSG00000125447 [Q9NZ52-4]
GeneIDⁱ	23163
KEGGⁱ	hsa:23163
UCSC genome browser More...UCSCⁱ	uc010wrw.3 human [Q9NZ52-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ52	Isoform 4 of ADP-ribosylation factor-binding protein GGA3		HUMAN		651	UniRef100_Q9NZ52
cDNA FLJ59569, highly similar to ADP-ribosylation factor-binding protein GGA3		HUMAN		601

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ52	Isoform 4 of ADP-ribosylation factor-binding protein GGA3		HUMAN		651	UniRef90_Q9NZ52
GGA3 isoform 10		PONAB		745
GGA3 isoform 12 (Fragment)		PANTR		136
Uncharacterized protein		CERAT		744
Uncharacterized protein		MACNE		735
+95
Q9NZ52-2	Uncharacterized protein		MACNE		702	UniRef90_Q9NZ52-2
cDNA FLJ75879, highly similar to Homo sapiens GGA3 short isoform		HUMAN		690
GGA3 isoform 9		PANTR		690
Uncharacterized protein		COLAP		690
Uncharacterized protein		CERAT		690
+17
Q9NZ52-3	Golgi associated, gamma adaptin ear containing, ARF binding protein 3		SAIBB		722	UniRef90_Q9NZ52-3
GGA3 isoform 3		PANTR		592
GGA3 isoform 7		PONAB		592
Uncharacterized protein		MANLE		592
Uncharacterized protein		PAPAN		591
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9NZ52	Isoform 4 of ADP-ribosylation factor-binding protein GGA3		HUMAN		651	UniRef50_Q9NZ52
GGA3 isoform 10		PONAB		745
GGA3 isoform 12 (Fragment)		PANTR		136
Uncharacterized protein		CERAT		744
Uncharacterized protein		MACNE		735
+310

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF219138 mRNA Translation: AAF42848.1 AF190864 mRNA Translation: AAF05709.1 AF219139 mRNA Translation: AAF42849.1 D63876 mRNA Translation: BAA09926.1 Different initiation. AK301895 mRNA Translation: BAH13578.1 AK302278 mRNA Translation: BAH13665.1 AC022211 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89258.1 BC070044 mRNA Translation: AAH70044.1
CCDSⁱ	CCDS11716.1 [Q9NZ52-2] CCDS11717.1 [Q9NZ52-1] CCDS54164.1 [Q9NZ52-4] CCDS58597.1 [Q9NZ52-3]
RefSeqⁱ	NP_001166174.1, NM_001172703.2 [Q9NZ52-4] NP_001166175.1, NM_001172704.2 [Q9NZ52-3] NP_001278570.1, NM_001291641.1 [Q9NZ52-4] NP_001278571.1, NM_001291642.1 NP_054720.1, NM_014001.4 [Q9NZ52-2] NP_619525.1, NM_138619.3 [Q9NZ52-1]
UniGeneⁱ	Hs.87726

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JPL	X-ray	2.40	A/B/C/D	1-166	[»]
	1JUQ	X-ray	2.20	A/B/C/D	1-166	[»]
	1LF8	X-ray	2.30	A/B/C/D	1-166	[»]
	1P4U	X-ray	2.20	A	571-723	[»]
	1WR6	X-ray	2.60	A/B/C/D	209-319	[»]
	1YD8	X-ray	2.80	G/H	208-301	[»]
ProteinModelPortalⁱ	Q9NZ52
SMRⁱ	Q9NZ52
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116775, 38 interactors
DIPⁱ	DIP-31600N
ELMⁱ	Q9NZ52
IntActⁱ	Q9NZ52, 25 interactors
MINTⁱ	Q9NZ52
STRINGⁱ	9606.ENSP00000245541

PTM databases

iPTMnetⁱ	Q9NZ52
PhosphoSitePlusⁱ	Q9NZ52

Polymorphism and mutation databases

BioMutaⁱ	GGA3
DMDMⁱ	14548064

Proteomic databases

EPDⁱ	Q9NZ52
MaxQBⁱ	Q9NZ52
PaxDbⁱ	Q9NZ52
PeptideAtlasⁱ	Q9NZ52
PRIDEⁱ	Q9NZ52
ProteomicsDBⁱ	83324 83325 [Q9NZ52-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000537686; ENSP00000438085; ENSG00000125447 [Q9NZ52-1] ENST00000538886; ENSP00000446421; ENSG00000125447 [Q9NZ52-2] ENST00000578348; ENSP00000463288; ENSG00000125447 [Q9NZ52-3] ENST00000582717; ENSP00000462081; ENSG00000125447 [Q9NZ52-4]
GeneIDⁱ	23163
KEGGⁱ	hsa:23163
UCSCⁱ	uc010wrw.3 human [Q9NZ52-1]

Organism-specific databases

CTDⁱ	23163
DisGeNETⁱ	23163
EuPathDBⁱ	HostDB:ENSG00000125447.16
GeneCardsⁱ	GGA3
HGNCⁱ	HGNC:17079 GGA3
HPAⁱ	HPA022945 HPA024645
MIMⁱ	606006 gene
neXtProtⁱ	NX_Q9NZ52
OpenTargetsⁱ	ENSG00000125447
PharmGKBⁱ	PA28659
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
GeneTreeⁱ	ENSGT00930000150934
HOGENOMⁱ	HOG000231169
HOVERGENⁱ	HBG015945
InParanoidⁱ	Q9NZ52
KOⁱ	K12404
OMAⁱ	DFQFEAS
OrthoDBⁱ	EOG091G0BQK
PhylomeDBⁱ	Q9NZ52
TreeFamⁱ	TF318574

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs R-HSA-8875656 MET receptor recycling R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs
R-HSA-8875656 MET receptor recycling
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

ChiTaRSⁱ	GGA3 human
EvolutionaryTraceⁱ	Q9NZ52
GeneWikiⁱ	GGA3
GenomeRNAiⁱ	23163
Protein Ontology More...PROⁱ	PR:Q9NZ52
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125447 Expressed in 211 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_GGA3
ExpressionAtlasⁱ	Q9NZ52 baseline and differential
Genevisibleⁱ	Q9NZ52 HS

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR008942 ENTH_VHS IPR008153 GAE_dom IPR004152 GAT_dom IPR038425 GAT_sf IPR027422 GGA3 IPR002014 VHS_dom
PANTHERⁱ	PTHR13856:SF34 PTHR13856:SF34, 1 hit
Pfamⁱ	View protein in Pfam PF02883 Alpha_adaptinC2, 1 hit PF03127 GAT, 1 hit PF00790 VHS, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit SSF49348 SSF49348, 1 hit
PROSITEⁱ	View protein in PROSITE PS50180 GAE, 1 hit PS50909 GAT, 1 hit PS50179 VHS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GGA3_HUMAN
Accessionⁱ	Q9NZ52Primary (citable) accession number: Q9NZ52 Secondary accession number(s): B7Z7E2 , B7Z7M9, J3KRN0, Q15017, Q6IS16, Q9UJY3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9NZ52 (GGA3_HUMAN)

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ADP-ribosylation factor-binding protein GGA3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

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Sequence databases

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ