UniProtKB - Q9NZ52 (GGA3_HUMAN)
ADP-ribosylation factor-binding protein GGA3
GGA3
Functioni
GO - Molecular functioni
- protein-containing complex binding Source: ARUK-UCL
- small GTPase binding Source: UniProtKB
- ubiquitin binding Source: UniProtKB
GO - Biological processi
- amyloid fibril formation Source: Reactome
- endocytic recycling Source: Ensembl
- Golgi to plasma membrane protein transport Source: UniProtKB
- intracellular protein transport Source: UniProtKB
- negative regulation of amyloid-beta formation Source: UniProtKB
- positive regulation of protein catabolic process Source: Ensembl
- protein destabilization Source: UniProtKB
- protein localization to cell surface Source: UniProtKB
- protein targeting to lysosome Source: ARUK-UCL
- regulation of protein stability Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ52 |
Reactomei | R-HSA-8854214, TBC/RABGAPs R-HSA-8875656, MET receptor recycling R-HSA-977225, Amyloid fiber formation |
Protein family/group databases
TCDBi | 9.B.278.1.3, the organellar-targeting adaptor protein complex (o-apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: ADP-ribosylation factor-binding protein GGA3CuratedAlternative name(s): Golgi-localized, gamma ear-containing, ARF-binding protein 3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17079, GGA3 |
MIMi | 606006, gene |
neXtProti | NX_Q9NZ52 |
VEuPathDBi | HostDB:ENSG00000125447.16 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane 2 Publications; Peripheral membrane protein 2 Publications
Endosome
- Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication
- Early endosome membrane 1 Publication; Peripheral membrane protein Curated
- Recycling endosome membrane By similarity; Peripheral membrane protein Curated
Endosome
- early endosome membrane Source: Reactome
- endosome membrane Source: Reactome
- recycling endosome membrane Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
- trans-Golgi network Source: UniProtKB
Lysosome
- lysosome Source: ARUK-UCL
Other locations
- protein-containing complex Source: ARUK-UCL
Keywords - Cellular componenti
Endosome, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 91 | N → A: No effect on regulation of BACE1 degradation. 1 Publication | 1 | |
Mutagenesisi | 194 | N → A: Loss of interaction with ARF1 and Golgi localization. 1 Publication | 1 | |
Mutagenesisi | 199 | S → P: Loss of interaction with ARF1 and Golgi localization. 1 Publication | 1 | |
Mutagenesisi | 217 | T → P: Loss of interaction with ARF1 and Golgi localization. 1 Publication | 1 | |
Mutagenesisi | 247 | L → P: Loss of UBC-binding and ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 258 | K → M: No effect. Confers an affinity to RABEP1 identical to GGA1; when associated with N-283. 1 Publication | 1 | |
Mutagenesisi | 262 | L → S: Loss of UBC-binding and ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 276 | L → A: Loss of UBC-binding and ubiquitination. Abolishes binding to ubiquitin. Abolishes regulation of BACE1 degradation. No effect on interaction with NTRK1. 4 Publications | 1 | |
Mutagenesisi | 276 | L → S: Loss of UBC-binding and ubiquitination. 2 Publications | 1 | |
Mutagenesisi | 280 | L → R: Loss of UBC-binding and ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 283 | S → N: Can bind RABEP1. Confers an affinity to RABEP1 identical to GGA1; when associated with M-258. 1 Publication | 1 | |
Mutagenesisi | 284 | D → G: Loss of UBC-binding and ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 293 | Y → H: Loss of UBC-binding and ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 313 | D → A: Acts as dominant negatif. Prevents proteolytic cleavage by CASP3; when associated with A-328, A-333 and A-428. 1 Publication | 1 | |
Mutagenesisi | 328 | D → A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-333 and A-428. 1 Publication | 1 | |
Mutagenesisi | 333 | D → A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-328 and A-428. 1 Publication | 1 | |
Mutagenesisi | 391 – 395 | DEELL → AAAAA: Increased binding to IGF2R. 1 Publication | 5 | |
Mutagenesisi | 428 | D → A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-328 and A-333. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23163 |
OpenTargetsi | ENSG00000125447 |
PharmGKBi | PA28659 |
Miscellaneous databases
Pharosi | Q9NZ52, Tbio |
Genetic variation databases
BioMutai | GGA3 |
DMDMi | 14548064 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212684 | 1 – 723 | ADP-ribosylation factor-binding protein GGA3Add BLAST | 723 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 159 | PhosphoserineCombined sources | 1 | |
Modified residuei | 275 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NZ52 |
jPOSTi | Q9NZ52 |
MassIVEi | Q9NZ52 |
MaxQBi | Q9NZ52 |
PaxDbi | Q9NZ52 |
PeptideAtlasi | Q9NZ52 |
PRIDEi | Q9NZ52 |
ProteomicsDBi | 83324 [Q9NZ52-1] 83325 [Q9NZ52-2] |
PTM databases
iPTMneti | Q9NZ52 |
PhosphoSitePlusi | Q9NZ52 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000125447, Expressed in sural nerve and 222 other tissues |
ExpressionAtlasi | Q9NZ52, baseline and differential |
Genevisiblei | Q9NZ52, HS |
Organism-specific databases
HPAi | ENSG00000125447, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (Probable).
Interacts with GGA1 and GGA2 (PubMed:14638859). Binds to clathrin and activated ARFs, such as ARF1, ARF5 and ARF6 (PubMed:11301005, PubMed:11950392). Binds RABEP1 and RABGEF1 (PubMed:12505986, PubMed:15143060).
Interacts with the membrane proteins M6PR/CD-MPR and IGF2R/CI-MPR and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin (PubMed:10814529, PubMed:11387475, PubMed:12060753, PubMed:12213833, PubMed:14665628).
Interacts with TSG101 and UBC (PubMed:14660606, PubMed:15039775).
Interacts with ADRA2B (PubMed:26811329).
Interacts with NTRK1; the interaction is independent of NTRK1 activation and ubiquitination (PubMed:26446845).
Interacts (via VHS domain) with BACE1 (via DXXLL motif) (PubMed:14567678).
Curated15 PublicationsBinary interactionsi
Hide detailsQ9NZ52
Isoform Short [Q9NZ52-2]
GO - Molecular functioni
- small GTPase binding Source: UniProtKB
- ubiquitin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116775, 66 interactors |
DIPi | DIP-31600N |
ELMi | Q9NZ52 |
IntActi | Q9NZ52, 29 interactors |
MINTi | Q9NZ52 |
STRINGi | 9606.ENSP00000438085 |
Miscellaneous databases
RNActi | Q9NZ52, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZ52 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZ52 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 146 | VHSPROSITE-ProRule annotationAdd BLAST | 131 | |
Domaini | 171 – 298 | GATPROSITE-ProRule annotationAdd BLAST | 128 | |
Domaini | 594 – 715 | GAEPROSITE-ProRule annotationAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 313 | Binds to ARF1 (in long isoform)Add BLAST | 313 | |
Regioni | 299 – 593 | Unstructured hingeAdd BLAST | 295 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 391 – 395 | DXXLL1 Publication | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 357 – 360 | Poly-Pro | 4 | |
Compositional biasi | 453 – 457 | Poly-Ser | 5 | |
Compositional biasi | 624 – 629 | Poly-Val | 6 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000157333 |
HOGENOMi | CLU_015010_0_0_1 |
InParanoidi | Q9NZ52 |
OMAi | DFQFEAS |
OrthoDBi | 594067at2759 |
PhylomeDBi | Q9NZ52 |
TreeFami | TF318574 |
Family and domain databases
CDDi | cd14240, GAT_GGA3, 1 hit |
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008152, Clathrin_a/b/g-adaptin_app_Ig IPR013041, Clathrin_app_Ig-like_sf IPR008942, ENTH_VHS IPR008153, GAE_dom IPR004152, GAT_dom IPR044111, GAT_GGA3 IPR038425, GAT_sf IPR027422, GGA3 IPR041198, GGA_N-GAT IPR002014, VHS_dom |
PANTHERi | PTHR45905:SF3, PTHR45905:SF3, 1 hit |
Pfami | View protein in Pfam PF02883, Alpha_adaptinC2, 1 hit PF03127, GAT, 1 hit PF18308, GGA_N-GAT, 1 hit PF00790, VHS, 1 hit |
SMARTi | View protein in SMART SM00809, Alpha_adaptinC2, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF49348, SSF49348, 1 hit |
PROSITEi | View protein in PROSITE PS50180, GAE, 1 hit PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL
60 70 80 90 100
AHKIQSPQEW EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK
110 120 130 140 150
YLGDRVSEKV KTKVIELLYS WTMALPEEAK IKDAYHMLKR QGIVQSDPPI
160 170 180 190 200
PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK LLKSKNPDDL QEANKLIKSM
210 220 230 240 250
VKEDEARIQK VTKRLHTLEE VNNNVRLLSE MLLHYSQEDS SDGDRELMKE
260 270 280 290 300
LFDQCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ
310 320 330 340 350
VINGEVATLT LPDSEGNSQC SNQGTLIDLA ELDTTNSLSS VLAPAPTPPS
360 370 380 390 400
SGIPILPPPP QASGPPRSRS SSQAEATLGP SSTSNALSWL DEELLCLGLA
410 420 430 440 450
DPAPNVPPKE SAGNSQWHLL QREQSDLDFF SPRPGTAACG ASDAPLLQPS
460 470 480 490 500
APSSSSSQAP LPPPFPAPVV PASVPAPSAG SSLFSTGVAP ALAPKVEPAV
510 520 530 540 550
PGHHGLALGN SALHHLDALD QLLEEAKVTS GLVKPTTSPL IPTTTPARPL
560 570 580 590 600
LPFSTGPGSP LFQPLSFQSQ GSPPKGPELS LASIHVPLES IKPSSALPVT
610 620 630 640 650
AYDKNGFRIL FHFAKECPPG RPDVLVVVVS MLNTAPLPVK SIVLQAAVPK
660 670 680 690 700
SMKVKLQPPS GTELSPFSPI QPPAAITQVM LLANPLKEKV RLRYKLTFAL
710 720
GEQLSTEVGE VDQFPPVEQW GNL
The sequence of this isoform differs from the canonical sequence as follows:
68-100: Missing.
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSS7 | J3KSS7_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 632 | Annotation score: | ||
J3KSG3 | J3KSG3_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 136 | Annotation score: | ||
J3QRK7 | J3QRK7_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 76 | Annotation score: | ||
J3KS27 | J3KS27_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 64 | Annotation score: | ||
J3QS87 | J3QS87_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 158 | Annotation score: | ||
J3KTR5 | J3KTR5_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 110 | Annotation score: | ||
J3QRS8 | J3QRS8_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 106 | Annotation score: | ||
B7Z1E9 | B7Z1E9_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 153 | Annotation score: | ||
J3QRP3 | J3QRP3_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 152 | Annotation score: | ||
A0A087WYN2 | A0A087WYN2_HUMAN | ADP-ribosylation factor-binding pro... | GGA3 | 46 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 448 | Q → K in AAH70044 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 562 | F → S in BAH13665 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075715 | 132 | K → R1 PublicationCorresponds to variant dbSNP:rs117805695Ensembl. | 1 | |
Natural variantiVAR_075716 | 321 | S → G1 PublicationCorresponds to variant dbSNP:rs146877619Ensembl. | 1 | |
Natural variantiVAR_036524 | 574 | P → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776324450Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045133 | 1 – 122 | Missing in isoform 3. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_046868 | 1 – 72 | Missing in isoform 4. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_001745 | 68 – 100 | Missing in isoform Short. 4 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_045134 | 688 – 723 | EKVRL…QWGNL → KQVLSFLGKACLQPWGQAIL LTTSCLA in isoform 3. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF219138 mRNA Translation: AAF42848.1 AF190864 mRNA Translation: AAF05709.1 AF219139 mRNA Translation: AAF42849.1 D63876 mRNA Translation: BAA09926.1 Different initiation. AK301895 mRNA Translation: BAH13578.1 AK302278 mRNA Translation: BAH13665.1 AC022211 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89258.1 BC070044 mRNA Translation: AAH70044.1 |
CCDSi | CCDS11716.1 [Q9NZ52-2] CCDS11717.1 [Q9NZ52-1] CCDS54164.1 [Q9NZ52-4] CCDS58597.1 [Q9NZ52-3] |
RefSeqi | NP_001166174.1, NM_001172703.2 [Q9NZ52-4] NP_001166175.1, NM_001172704.2 [Q9NZ52-3] NP_001278570.1, NM_001291641.1 [Q9NZ52-4] NP_001278571.1, NM_001291642.1 NP_054720.1, NM_014001.4 [Q9NZ52-2] NP_619525.1, NM_138619.3 [Q9NZ52-1] |
Genome annotation databases
Ensembli | ENST00000537686; ENSP00000438085; ENSG00000125447 [Q9NZ52-1] ENST00000538886; ENSP00000446421; ENSG00000125447 [Q9NZ52-2] ENST00000578348; ENSP00000463288; ENSG00000125447 [Q9NZ52-3] ENST00000582717; ENSP00000462081; ENSG00000125447 [Q9NZ52-4] ENST00000649398; ENSP00000496890; ENSG00000125447 [Q9NZ52-1] |
GeneIDi | 23163 |
KEGGi | hsa:23163 |
UCSCi | uc010wrw.3, human [Q9NZ52-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF219138 mRNA Translation: AAF42848.1 AF190864 mRNA Translation: AAF05709.1 AF219139 mRNA Translation: AAF42849.1 D63876 mRNA Translation: BAA09926.1 Different initiation. AK301895 mRNA Translation: BAH13578.1 AK302278 mRNA Translation: BAH13665.1 AC022211 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89258.1 BC070044 mRNA Translation: AAH70044.1 |
CCDSi | CCDS11716.1 [Q9NZ52-2] CCDS11717.1 [Q9NZ52-1] CCDS54164.1 [Q9NZ52-4] CCDS58597.1 [Q9NZ52-3] |
RefSeqi | NP_001166174.1, NM_001172703.2 [Q9NZ52-4] NP_001166175.1, NM_001172704.2 [Q9NZ52-3] NP_001278570.1, NM_001291641.1 [Q9NZ52-4] NP_001278571.1, NM_001291642.1 NP_054720.1, NM_014001.4 [Q9NZ52-2] NP_619525.1, NM_138619.3 [Q9NZ52-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JPL | X-ray | 2.40 | A/B/C/D | 1-166 | [»] | |
1JUQ | X-ray | 2.20 | A/B/C/D | 1-166 | [»] | |
1LF8 | X-ray | 2.30 | A/B/C/D | 1-166 | [»] | |
1P4U | X-ray | 2.20 | A | 571-723 | [»] | |
1WR6 | X-ray | 2.60 | A/B/C/D | 209-319 | [»] | |
1YD8 | X-ray | 2.80 | G/H | 208-301 | [»] | |
SMRi | Q9NZ52 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116775, 66 interactors |
DIPi | DIP-31600N |
ELMi | Q9NZ52 |
IntActi | Q9NZ52, 29 interactors |
MINTi | Q9NZ52 |
STRINGi | 9606.ENSP00000438085 |
Protein family/group databases
TCDBi | 9.B.278.1.3, the organellar-targeting adaptor protein complex (o-apc) family |
PTM databases
iPTMneti | Q9NZ52 |
PhosphoSitePlusi | Q9NZ52 |
Genetic variation databases
BioMutai | GGA3 |
DMDMi | 14548064 |
Proteomic databases
EPDi | Q9NZ52 |
jPOSTi | Q9NZ52 |
MassIVEi | Q9NZ52 |
MaxQBi | Q9NZ52 |
PaxDbi | Q9NZ52 |
PeptideAtlasi | Q9NZ52 |
PRIDEi | Q9NZ52 |
ProteomicsDBi | 83324 [Q9NZ52-1] 83325 [Q9NZ52-2] |
Protocols and materials databases
Antibodypediai | 19520, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000537686; ENSP00000438085; ENSG00000125447 [Q9NZ52-1] ENST00000538886; ENSP00000446421; ENSG00000125447 [Q9NZ52-2] ENST00000578348; ENSP00000463288; ENSG00000125447 [Q9NZ52-3] ENST00000582717; ENSP00000462081; ENSG00000125447 [Q9NZ52-4] ENST00000649398; ENSP00000496890; ENSG00000125447 [Q9NZ52-1] |
GeneIDi | 23163 |
KEGGi | hsa:23163 |
UCSCi | uc010wrw.3, human [Q9NZ52-1] |
Organism-specific databases
CTDi | 23163 |
DisGeNETi | 23163 |
GeneCardsi | GGA3 |
HGNCi | HGNC:17079, GGA3 |
HPAi | ENSG00000125447, Low tissue specificity |
MIMi | 606006, gene |
neXtProti | NX_Q9NZ52 |
OpenTargetsi | ENSG00000125447 |
PharmGKBi | PA28659 |
VEuPathDBi | HostDB:ENSG00000125447.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000157333 |
HOGENOMi | CLU_015010_0_0_1 |
InParanoidi | Q9NZ52 |
OMAi | DFQFEAS |
OrthoDBi | 594067at2759 |
PhylomeDBi | Q9NZ52 |
TreeFami | TF318574 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ52 |
Reactomei | R-HSA-8854214, TBC/RABGAPs R-HSA-8875656, MET receptor recycling R-HSA-977225, Amyloid fiber formation |
Miscellaneous databases
BioGRID-ORCSi | 23163, 29 hits in 990 CRISPR screens |
ChiTaRSi | GGA3, human |
EvolutionaryTracei | Q9NZ52 |
GeneWikii | GGA3 |
GenomeRNAii | 23163 |
Pharosi | Q9NZ52, Tbio |
PROi | PR:Q9NZ52 |
RNActi | Q9NZ52, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125447, Expressed in sural nerve and 222 other tissues |
ExpressionAtlasi | Q9NZ52, baseline and differential |
Genevisiblei | Q9NZ52, HS |
Family and domain databases
CDDi | cd14240, GAT_GGA3, 1 hit |
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008152, Clathrin_a/b/g-adaptin_app_Ig IPR013041, Clathrin_app_Ig-like_sf IPR008942, ENTH_VHS IPR008153, GAE_dom IPR004152, GAT_dom IPR044111, GAT_GGA3 IPR038425, GAT_sf IPR027422, GGA3 IPR041198, GGA_N-GAT IPR002014, VHS_dom |
PANTHERi | PTHR45905:SF3, PTHR45905:SF3, 1 hit |
Pfami | View protein in Pfam PF02883, Alpha_adaptinC2, 1 hit PF03127, GAT, 1 hit PF18308, GGA_N-GAT, 1 hit PF00790, VHS, 1 hit |
SMARTi | View protein in SMART SM00809, Alpha_adaptinC2, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF49348, SSF49348, 1 hit |
PROSITEi | View protein in PROSITE PS50180, GAE, 1 hit PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GGA3_HUMAN | |
Accessioni | Q9NZ52Primary (citable) accession number: Q9NZ52 Secondary accession number(s): B7Z7E2 Q9UJY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families