UniProtKB - Q9NZ43 (USE1_HUMAN)
Protein
Vesicle transport protein USE1
Gene
USE1
Organism
Homo sapiens (Human)
Status
Functioni
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
GO - Biological processi
- lysosomal transport Source: HGNC-UCL
- protein catabolic process Source: HGNC-UCL
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
- secretion by cell Source: HGNC-UCL
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ43 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle transport protein USE1Alternative name(s): Putative MAPK-activating protein PM26 USE1-like protein p31 |
Gene namesi | Name:USE1 Synonyms:USE1L ORF Names:MDS032 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000053501.12 |
HGNCi | HGNC:30882, USE1 |
MIMi | 610675, gene |
neXtProti | NX_Q9NZ43 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: HGNC-UCL
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- COPI-coated vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 231 | CytoplasmicSequence analysisAdd BLAST | 231 | |
Transmembranei | 232 – 252 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 253 – 259 | LumenalSequence analysis | 7 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55850 |
OpenTargetsi | ENSG00000053501 |
PharmGKBi | PA162408692 |
Miscellaneous databases
Pharosi | Q9NZ43, Tbio |
Polymorphism and mutation databases
BioMutai | USE1 |
DMDMi | 296452858 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215579 | 1 – 259 | Vesicle transport protein USE1Add BLAST | 259 |
Proteomic databases
EPDi | Q9NZ43 |
jPOSTi | Q9NZ43 |
MassIVEi | Q9NZ43 |
MaxQBi | Q9NZ43 |
PaxDbi | Q9NZ43 |
PeptideAtlasi | Q9NZ43 |
PRIDEi | Q9NZ43 |
ProteomicsDBi | 83320 [Q9NZ43-1] 83321 [Q9NZ43-2] 83322 [Q9NZ43-3] |
PTM databases
iPTMneti | Q9NZ43 |
MetOSitei | Q9NZ43 |
PhosphoSitePlusi | Q9NZ43 |
Expressioni
Gene expression databases
Bgeei | ENSG00000053501, Expressed in substantia nigra and 186 other tissues |
ExpressionAtlasi | Q9NZ43, baseline and differential |
Genevisiblei | Q9NZ43, HS |
Organism-specific databases
HPAi | ENSG00000053501, Low tissue specificity |
Interactioni
Subunit structurei
Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B.
Interacts directly with STX18.
2 PublicationsBinary interactionsi
Hide detailsQ9NZ43
Protein-protein interaction databases
BioGRIDi | 120952, 73 interactors |
IntActi | Q9NZ43, 76 interactors |
MINTi | Q9NZ43 |
STRINGi | 9606.ENSP00000263897 |
Miscellaneous databases
RNActi | Q9NZ43, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 152 – 231 | Sequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the USE1 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2678, Eukaryota |
GeneTreei | ENSGT00390000014361 |
HOGENOMi | CLU_150739_0_0_1 |
InParanoidi | Q9NZ43 |
OMAi | YKCWLWL |
OrthoDBi | 1442410at2759 |
PhylomeDBi | Q9NZ43 |
TreeFami | TF325006 |
Family and domain databases
InterProi | View protein in InterPro IPR019150, Vesicle_transport_protein_Use1 |
PANTHERi | PTHR13050, PTHR13050, 1 hit |
Pfami | View protein in Pfam PF09753, Use1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA
60 70 80 90 100
SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR
110 120 130 140 150
ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS
160 170 180 190 200
EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT
210 220 230 240 250
LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL
FIRIMPKLK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG8JLK1 | G8JLK1_HUMAN | USE1-like protein | USE1 | 256 | Annotation score: | ||
M0QYT5 | M0QYT5_HUMAN | USE1-like protein | USE1 | 161 | Annotation score: | ||
M0QZE0 | M0QZE0_HUMAN | USE1-like protein | USE1 | 133 | Annotation score: | ||
M0QZZ6 | M0QZZ6_HUMAN | Vesicle transport protein USE1 | USE1 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | A → V in AAH06005 (PubMed:15057824).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021052 | 154 | L → S3 PublicationsCorresponds to variant dbSNP:rs414528Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012662 | 132 – 135 | EPEM → GESP in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_012663 | 136 – 259 | Missing in isoform 3. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_012664 | 142 – 146 | GVAGS → PCHTH in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_012665 | 147 – 259 | Missing in isoform 2. 1 PublicationAdd BLAST | 113 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097050 mRNA Translation: BAC77403.1 AK074683 mRNA Translation: BAC11136.1 AF220052 mRNA Translation: AAF67645.1 AC020913 Genomic DNA No translation available. BC006005 mRNA Translation: AAH06005.1 BC008455 mRNA Translation: AAH08455.1 |
CCDSi | CCDS46011.1 [Q9NZ43-1] |
RefSeqi | NP_060937.1, NM_018467.3 [Q9NZ43-1] XP_016882464.1, XM_017026975.1 |
Genome annotation databases
Ensembli | ENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1] ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3] ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2] |
GeneIDi | 55850 |
KEGGi | hsa:55850 |
UCSCi | uc002nfo.3, human [Q9NZ43-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097050 mRNA Translation: BAC77403.1 AK074683 mRNA Translation: BAC11136.1 AF220052 mRNA Translation: AAF67645.1 AC020913 Genomic DNA No translation available. BC006005 mRNA Translation: AAH06005.1 BC008455 mRNA Translation: AAH08455.1 |
CCDSi | CCDS46011.1 [Q9NZ43-1] |
RefSeqi | NP_060937.1, NM_018467.3 [Q9NZ43-1] XP_016882464.1, XM_017026975.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120952, 73 interactors |
IntActi | Q9NZ43, 76 interactors |
MINTi | Q9NZ43 |
STRINGi | 9606.ENSP00000263897 |
PTM databases
iPTMneti | Q9NZ43 |
MetOSitei | Q9NZ43 |
PhosphoSitePlusi | Q9NZ43 |
Polymorphism and mutation databases
BioMutai | USE1 |
DMDMi | 296452858 |
Proteomic databases
EPDi | Q9NZ43 |
jPOSTi | Q9NZ43 |
MassIVEi | Q9NZ43 |
MaxQBi | Q9NZ43 |
PaxDbi | Q9NZ43 |
PeptideAtlasi | Q9NZ43 |
PRIDEi | Q9NZ43 |
ProteomicsDBi | 83320 [Q9NZ43-1] 83321 [Q9NZ43-2] 83322 [Q9NZ43-3] |
Protocols and materials databases
Antibodypediai | 7758, 215 antibodies |
DNASUi | 55850 |
Genome annotation databases
Ensembli | ENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1] ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3] ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2] |
GeneIDi | 55850 |
KEGGi | hsa:55850 |
UCSCi | uc002nfo.3, human [Q9NZ43-1] |
Organism-specific databases
CTDi | 55850 |
DisGeNETi | 55850 |
EuPathDBi | HostDB:ENSG00000053501.12 |
GeneCardsi | USE1 |
HGNCi | HGNC:30882, USE1 |
HPAi | ENSG00000053501, Low tissue specificity |
MIMi | 610675, gene |
neXtProti | NX_Q9NZ43 |
OpenTargetsi | ENSG00000053501 |
PharmGKBi | PA162408692 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2678, Eukaryota |
GeneTreei | ENSGT00390000014361 |
HOGENOMi | CLU_150739_0_0_1 |
InParanoidi | Q9NZ43 |
OMAi | YKCWLWL |
OrthoDBi | 1442410at2759 |
PhylomeDBi | Q9NZ43 |
TreeFami | TF325006 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZ43 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 55850, 207 hits in 847 CRISPR screens |
ChiTaRSi | USE1, human |
GeneWikii | USE1 |
GenomeRNAii | 55850 |
Pharosi | Q9NZ43, Tbio |
PROi | PR:Q9NZ43 |
RNActi | Q9NZ43, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000053501, Expressed in substantia nigra and 186 other tissues |
ExpressionAtlasi | Q9NZ43, baseline and differential |
Genevisiblei | Q9NZ43, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019150, Vesicle_transport_protein_Use1 |
PANTHERi | PTHR13050, PTHR13050, 1 hit |
Pfami | View protein in Pfam PF09753, Use1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | USE1_HUMAN | |
Accessioni | Q9NZ43Primary (citable) accession number: Q9NZ43 Secondary accession number(s): Q8NCK1, Q9BRT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations