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Protein

Vesicle transport protein USE1

Gene

USE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Putative MAPK-activating protein PM26
USE1-like protein
p31
Gene namesi
Name:USE1
Synonyms:USE1L
ORF Names:MDS032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000053501.12
HGNCiHGNC:30882 USE1
MIMi610675 gene
neXtProtiNX_Q9NZ43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 231CytoplasmicSequence analysisAdd BLAST231
Transmembranei232 – 252Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini253 – 259LumenalSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55850
OpenTargetsiENSG00000053501
PharmGKBiPA162408692

Polymorphism and mutation databases

BioMutaiUSE1
DMDMi296452858

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155791 – 259Vesicle transport protein USE1Add BLAST259

Proteomic databases

EPDiQ9NZ43
MaxQBiQ9NZ43
PaxDbiQ9NZ43
PeptideAtlasiQ9NZ43
PRIDEiQ9NZ43
ProteomicsDBi83320
83321 [Q9NZ43-2]
83322 [Q9NZ43-3]

PTM databases

iPTMnetiQ9NZ43
PhosphoSitePlusiQ9NZ43

Miscellaneous databases

PMAP-CutDBiQ9NZ43

Expressioni

Gene expression databases

BgeeiENSG00000053501 Expressed in 172 organ(s), highest expression level in substantia nigra
CleanExiHS_USE1
ExpressionAtlasiQ9NZ43 baseline and differential
GenevisibleiQ9NZ43 HS

Organism-specific databases

HPAiHPA026851
HPA047562

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120952, 52 interactors
IntActiQ9NZ43, 64 interactors
MINTiQ9NZ43
STRINGi9606.ENSP00000263897

Structurei

3D structure databases

ProteinModelPortaliQ9NZ43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 231Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the USE1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2678 Eukaryota
ENOG410ZN7C LUCA
GeneTreeiENSGT00390000014361
HOGENOMiHOG000007677
HOVERGENiHBG079328
InParanoidiQ9NZ43
KOiK08507
OMAiYKCWLWL
OrthoDBiEOG091G0HJ5
PhylomeDBiQ9NZ43
TreeFamiTF325006

Family and domain databases

InterProiView protein in InterPro
IPR019150 Vesicle_transport_protein_Use1
PANTHERiPTHR13050 PTHR13050, 1 hit
PfamiView protein in Pfam
PF09753 Use1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA
60 70 80 90 100
SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR
110 120 130 140 150
ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS
160 170 180 190 200
EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT
210 220 230 240 250
LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL

FIRIMPKLK
Length:259
Mass (Da):29,371
Last modified:May 18, 2010 - v2
Checksum:i6538ED0B231AEC05
GO
Isoform 2 (identifier: Q9NZ43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: GVAGS → PCHTH
     147-259: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,511
Checksum:i307946785B1BAC38
GO
Isoform 3 (identifier: Q9NZ43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: EPEM → GESP
     136-259: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,063
Checksum:i22DF3FEF395B8489
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLK1G8JLK1_HUMAN
Vesicle transport protein USE1
USE1
256Annotation score:
M0QYT5M0QYT5_HUMAN
Vesicle transport protein USE1
USE1
161Annotation score:
M0QZE0M0QZE0_HUMAN
Vesicle transport protein USE1
USE1
133Annotation score:
M0QZZ6M0QZZ6_HUMAN
Vesicle transport protein USE1
USE1
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38A → V in AAH06005 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021052154L → S3 PublicationsCorresponds to variant dbSNP:rs414528Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012662132 – 135EPEM → GESP in isoform 3. 1 Publication4
Alternative sequenceiVSP_012663136 – 259Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_012664142 – 146GVAGS → PCHTH in isoform 2. 1 Publication5
Alternative sequenceiVSP_012665147 – 259Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097050 mRNA Translation: BAC77403.1
AK074683 mRNA Translation: BAC11136.1
AF220052 mRNA Translation: AAF67645.1
AC020913 Genomic DNA No translation available.
BC006005 mRNA Translation: AAH06005.1
BC008455 mRNA Translation: AAH08455.1
CCDSiCCDS46011.1 [Q9NZ43-1]
RefSeqiNP_060937.1, NM_018467.3
XP_016882464.1, XM_017026975.1
UniGeneiHs.16187

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2]
GeneIDi55850
KEGGihsa:55850
UCSCiuc002nfo.3 human [Q9NZ43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097050 mRNA Translation: BAC77403.1
AK074683 mRNA Translation: BAC11136.1
AF220052 mRNA Translation: AAF67645.1
AC020913 Genomic DNA No translation available.
BC006005 mRNA Translation: AAH06005.1
BC008455 mRNA Translation: AAH08455.1
CCDSiCCDS46011.1 [Q9NZ43-1]
RefSeqiNP_060937.1, NM_018467.3
XP_016882464.1, XM_017026975.1
UniGeneiHs.16187

3D structure databases

ProteinModelPortaliQ9NZ43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120952, 52 interactors
IntActiQ9NZ43, 64 interactors
MINTiQ9NZ43
STRINGi9606.ENSP00000263897

PTM databases

iPTMnetiQ9NZ43
PhosphoSitePlusiQ9NZ43

Polymorphism and mutation databases

BioMutaiUSE1
DMDMi296452858

Proteomic databases

EPDiQ9NZ43
MaxQBiQ9NZ43
PaxDbiQ9NZ43
PeptideAtlasiQ9NZ43
PRIDEiQ9NZ43
ProteomicsDBi83320
83321 [Q9NZ43-2]
83322 [Q9NZ43-3]

Protocols and materials databases

DNASUi55850
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2]
GeneIDi55850
KEGGihsa:55850
UCSCiuc002nfo.3 human [Q9NZ43-1]

Organism-specific databases

CTDi55850
DisGeNETi55850
EuPathDBiHostDB:ENSG00000053501.12
GeneCardsiUSE1
HGNCiHGNC:30882 USE1
HPAiHPA026851
HPA047562
MIMi610675 gene
neXtProtiNX_Q9NZ43
OpenTargetsiENSG00000053501
PharmGKBiPA162408692
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2678 Eukaryota
ENOG410ZN7C LUCA
GeneTreeiENSGT00390000014361
HOGENOMiHOG000007677
HOVERGENiHBG079328
InParanoidiQ9NZ43
KOiK08507
OMAiYKCWLWL
OrthoDBiEOG091G0HJ5
PhylomeDBiQ9NZ43
TreeFamiTF325006

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

GeneWikiiUSE1
GenomeRNAii55850
PMAP-CutDBiQ9NZ43
PROiPR:Q9NZ43
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000053501 Expressed in 172 organ(s), highest expression level in substantia nigra
CleanExiHS_USE1
ExpressionAtlasiQ9NZ43 baseline and differential
GenevisibleiQ9NZ43 HS

Family and domain databases

InterProiView protein in InterPro
IPR019150 Vesicle_transport_protein_Use1
PANTHERiPTHR13050 PTHR13050, 1 hit
PfamiView protein in Pfam
PF09753 Use1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ43
Secondary accession number(s): Q8NCK1, Q9BRT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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