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UniProtKB - Q9NZ43 (USE1_HUMAN)

Entry version 148 (02 Dec 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Vesicle transport protein USE1

Gene

USE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZ43

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Putative MAPK-activating protein PM26
USE1-like protein
p31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USE1
Synonyms:USE1L
ORF Names:MDS032
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000053501.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:30882, USE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610675, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZ43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 231CytoplasmicSequence analysisAdd BLAST231
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei232 – 252Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini253 – 259LumenalSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55850

Open Targets

More...OpenTargetsi		ENSG00000053501

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZ43, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		USE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452858

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002155791 – 259Vesicle transport protein USE1Add BLAST259

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZ43

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZ43

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZ43

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZ43

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZ43

PeptideAtlas

More...PeptideAtlasi		Q9NZ43

PRoteomics IDEntifications database

More...PRIDEi		Q9NZ43

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83320 [Q9NZ43-1]
83321 [Q9NZ43-2]
83322 [Q9NZ43-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZ43

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NZ43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZ43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000053501, Expressed in substantia nigra and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZ43, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZ43, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000053501, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B.

Interacts directly with STX18.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120952, 73 interactors

Protein interaction database and analysis system

More...IntActi		Q9NZ43, 76 interactors

Molecular INTeraction database

More...MINTi		Q9NZ43

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263897

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZ43, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili152 – 231Sequence analysisAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the USE1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2678, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014361

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_150739_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZ43

Identification of Orthologs from Complete Genome Data

More...OMAi		YKCWLWL

Database of Orthologous Groups

More...OrthoDBi		1442410at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZ43

TreeFam database of animal gene trees

More...TreeFami		TF325006

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019150, Vesicle_transport_protein_Use1

The PANTHER Classification System

More...PANTHERi		PTHR13050, PTHR13050, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09753, Use1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA 
        60         70         80         90        100
SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR 
       110        120        130        140        150
ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS 
       160        170        180        190        200
EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT 
       210        220        230        240        250
LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL 

FIRIMPKLK
Length:259
Mass (Da):29,371
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6538ED0B231AEC05
GO
Isoform 2 (identifier: Q9NZ43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: GVAGS → PCHTH
     147-259: Missing.

Show »
Length:146
Mass (Da):16,511
Checksum:i307946785B1BAC38
GO
Isoform 3 (identifier: Q9NZ43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: EPEM → GESP
     136-259: Missing.

Show »
Length:135
Mass (Da):15,063
Checksum:i22DF3FEF395B8489
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLK1G8JLK1_HUMAN
USE1-like protein
USE1
256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYT5M0QYT5_HUMAN
USE1-like protein
USE1
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZE0M0QZE0_HUMAN
USE1-like protein
USE1
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZZ6M0QZZ6_HUMAN
Vesicle transport protein USE1
USE1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38A → V in AAH06005 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021052154L → S3 PublicationsCorresponds to variant dbSNP:rs414528Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012662132 – 135EPEM → GESP in isoform 3. 1 Publication4
Alternative sequenceiVSP_012663136 – 259Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_012664142 – 146GVAGS → PCHTH in isoform 2. 1 Publication5
Alternative sequenceiVSP_012665147 – 259Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB097050 mRNA Translation: BAC77403.1
AK074683 mRNA Translation: BAC11136.1
AF220052 mRNA Translation: AAF67645.1
AC020913 Genomic DNA No translation available.
BC006005 mRNA Translation: AAH06005.1
BC008455 mRNA Translation: AAH08455.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46011.1 [Q9NZ43-1]

NCBI Reference Sequences

More...RefSeqi		NP_060937.1, NM_018467.3 [Q9NZ43-1]
XP_016882464.1, XM_017026975.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55850

UCSC genome browser

More...UCSCi		uc002nfo.3, human [Q9NZ43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097050 mRNA Translation: BAC77403.1
AK074683 mRNA Translation: BAC11136.1
AF220052 mRNA Translation: AAF67645.1
AC020913 Genomic DNA No translation available.
BC006005 mRNA Translation: AAH06005.1
BC008455 mRNA Translation: AAH08455.1
CCDSiCCDS46011.1 [Q9NZ43-1]
RefSeqiNP_060937.1, NM_018467.3 [Q9NZ43-1]
XP_016882464.1, XM_017026975.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120952, 73 interactors
IntActiQ9NZ43, 76 interactors
MINTiQ9NZ43
STRINGi9606.ENSP00000263897

PTM databases

iPTMnetiQ9NZ43
MetOSiteiQ9NZ43
PhosphoSitePlusiQ9NZ43

Polymorphism and mutation databases

BioMutaiUSE1
DMDMi296452858

Proteomic databases

EPDiQ9NZ43
jPOSTiQ9NZ43
MassIVEiQ9NZ43
MaxQBiQ9NZ43
PaxDbiQ9NZ43
PeptideAtlasiQ9NZ43
PRIDEiQ9NZ43
ProteomicsDBi83320 [Q9NZ43-1]
83321 [Q9NZ43-2]
83322 [Q9NZ43-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7758, 215 antibodies

The DNASU plasmid repository

More...DNASUi		55850

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501 [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501 [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501 [Q9NZ43-2]
GeneIDi55850
KEGGihsa:55850
UCSCiuc002nfo.3, human [Q9NZ43-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55850
DisGeNETi55850
EuPathDBiHostDB:ENSG00000053501.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		USE1
HGNCiHGNC:30882, USE1
HPAiENSG00000053501, Low tissue specificity
MIMi610675, gene
neXtProtiNX_Q9NZ43
OpenTargetsiENSG00000053501
PharmGKBiPA162408692

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2678, Eukaryota
GeneTreeiENSGT00390000014361
HOGENOMiCLU_150739_0_0_1
InParanoidiQ9NZ43
OMAiYKCWLWL
OrthoDBi1442410at2759
PhylomeDBiQ9NZ43
TreeFamiTF325006

Enzyme and pathway databases

PathwayCommonsiQ9NZ43
ReactomeiR-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55850, 207 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USE1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		USE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55850
PharosiQ9NZ43, Tbio

Protein Ontology

More...PROi		PR:Q9NZ43
RNActiQ9NZ43, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000053501, Expressed in substantia nigra and 186 other tissues
ExpressionAtlasiQ9NZ43, baseline and differential
GenevisibleiQ9NZ43, HS

Family and domain databases

InterProiView protein in InterPro
IPR019150, Vesicle_transport_protein_Use1
PANTHERiPTHR13050, PTHR13050, 1 hit
PfamiView protein in Pfam
PF09753, Use1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZ43
Secondary accession number(s): Q8NCK1, Q9BRT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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