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UniProtKB - Q9NZ09 (UBAP1_HUMAN)

Entry version 177 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Ubiquitin-associated protein 1

Gene

UBAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368).

Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001).

Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368).

4 Publications

Caution

According to a report, can also be a component of ESCRT-I complexes containing VPS37B, VPS37C or VPS37D (PubMed:22405001). However, another publication showed that UBAP1 has specificity for complexes containing VPS37A and not VPS37 paralogs (PubMed:24284069).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZ09

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162588, Budding and maturation of HIV virion
R-HSA-174490, Membrane binding and targetting of GAG proteins
R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379, HCMV Late Events
R-HSA-9615710, Late endosomal microautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NZ09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-associated protein 11 Publication
Short name:
UBAP-11 Publication
Alternative name(s):
Nasopharyngeal carcinoma-associated gene 20 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBAP11 PublicationImported
ORF Names:NAG20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12461, UBAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609787, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZ09

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165006

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 80, autosomal dominant (SPG80)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082199125 – 502Missing in SPG80. 1 PublicationAdd BLAST378
Natural variantiVAR_082200176 – 502Missing in SPG80; unknown pathological significance. 1 PublicationAdd BLAST327

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17 – 19LDD → AAA: Abolishes association with the ESCRT-I complex. 1 Publication3
Mutagenesisi20 – 22VPF → AAA: Abolishes association with the ESCRT-I complex. 1 Publication3
Mutagenesisi37P → A: Abolishes association with the ESCRT-I complex. 1 Publication1
Mutagenesisi59E → G: Abolishes association with the ESCRT-I complex. 1 Publication1
Mutagenesisi268F → S: Abolished interaction with PTPN23. 1 Publication1
Mutagenesisi269P → A: Does not affect interaction with PTPN23. 1 Publication1
Mutagenesisi271L → A: Does not affect interaction with PTPN23. 1 Publication1
Mutagenesisi404Y → A: Strongly reduced interaction with ubiquitinated proteins. 1 Publication1
Mutagenesisi472F → A: Strongly reduced interaction with ubiquitinated proteins. 1 Publication1

Keywords - Diseasei

Disease variant, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		51271

MalaCards human disease database

More...MalaCardsi		UBAP1
MIMi618418, phenotype

Open Targets

More...OpenTargetsi		ENSG00000165006

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		100993, Autosomal dominant spastic paraplegia type 12

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37111

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZ09, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		67475018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110171 – 502Ubiquitin-associated protein 1Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZ09

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZ09

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZ09

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZ09

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZ09

PeptideAtlas

More...PeptideAtlasi		Q9NZ09

PRoteomics IDEntifications database

More...PRIDEi		Q9NZ09

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24396
25363
83314 [Q9NZ09-1]
83315 [Q9NZ09-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZ09, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZ09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZ09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165006, Expressed in vagina and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZ09, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZ09, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165006, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry (PubMed:21757351, PubMed:24284069, PubMed:22405001, PubMed:31203368) (Probable).

Interacts with PTPN23 (PubMed:21757351, PubMed:27839950).

Interacts (via UBA domains) with ubiquitinated proteins (PubMed:22405001, PubMed:30929741).

1 Publication6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119424, 30 interactors

Database of interacting proteins

More...DIPi		DIP-47291N

Protein interaction database and analysis system

More...IntActi		Q9NZ09, 11 interactors

Molecular INTeraction database

More...MINTi		Q9NZ09

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297661

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZ09, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NZ09

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9NZ09

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZ09

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NZ09

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 63UMAPROSITE-ProRule annotationAdd BLAST47
Domaini389 – 430UBA 1PROSITE-ProRule annotationAdd BLAST42
Domaini451 – 498UBA 2PROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 95Interaction with ESCRT-I1 PublicationAdd BLAST95
Regioni86 – 117DisorderedSequence analysisAdd BLAST32
Regioni260 – 290Interaction with PTPN231 PublicationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 117Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UMA domain mediates association with the ESCRT-I complex.2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTJC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041679_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZ09

Identification of Orthologs from Complete Genome Data

More...OMAi		ETQYDFS

Database of Orthologous Groups

More...OrthoDBi		683409at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZ09

TreeFam database of animal gene trees

More...TreeFami		TF329247

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.1920, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015940, UBA
IPR009060, UBA-like_sf
IPR038870, UBAP1
IPR042575, UBAP1_C
IPR023340, UMA

The PANTHER Classification System

More...PANTHERi		PTHR15960, PTHR15960, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46934, SSF46934, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50030, UBA, 2 hits
PS51497, UMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR 
        60         70         80         90        100
EVQYDFSLEK KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS 
       110        120        130        140        150
KMSFSKTHST ATMPPPINPI LASLQHNSIL TPTRVSSSAT KQKVLSPPHI 
       160        170        180        190        200
KADFNLADFE CEEDPFDNLE LKTIDEKEEL RNILVGTTGP IMAQLLDNNL 
       210        220        230        240        250
PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL GNCEKMSLSS 
       260        270        280        290        300
KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN 
       310        320        330        340        350
SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT 
       360        370        380        390        400
EESSPPNTGP TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV 
       410        420        430        440        450
NMGYSYECVL RAMKKKGENI EQILDYLFAH GQLCEKGFDP LLVEEALEMH 
       460        470        480        490        500
QCSEEKMMEF LQLMSKFKEM GFELKDIKEV LLLHNNDQDN ALEDLMARAG 

AS
Length:502
Mass (Da):55,084
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i548457B0B2ABC0F4
GO
Isoform 2 (identifier: Q9NZ09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-422: Missing.

Show »
Length:441
Mass (Da):48,247
Checksum:i001566AEC2898859
GO
Isoform 3 (identifier: Q9NZ09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MASKKLGADF...DCLQVVREVQ → MSGAVRGRRR...LLRSWVQIFM

Show »
Length:538
Mass (Da):58,982
Checksum:iC88D72AB978B9358
GO
Isoform 4 (identifier: Q9NZ09-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MASKKLGADFH → MSGAVRGRRR...LLRRRQQRHS

Show »
Length:566
Mass (Da):61,845
Checksum:i66126A6497B8BC94
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SG79A0A0D9SG79_HUMAN
Ubiquitin-associated protein 1
UBAP1
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11162 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAH12084 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81C → R in CAG38582 (Ref. 4) Curated1
Sequence conflicti187T → N in BAH14025 (PubMed:14702039).Curated1
Sequence conflicti331E → D in BAC11176 (PubMed:14702039).Curated1
Sequence conflicti398T → M in BAH12084 (PubMed:14702039).Curated1
Sequence conflicti403G → C in BAC11323 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082199125 – 502Missing in SPG80. 1 PublicationAdd BLAST378
Natural variantiVAR_082200176 – 502Missing in SPG80; unknown pathological significance. 1 PublicationAdd BLAST327
Natural variantiVAR_034577357N → K1 PublicationCorresponds to variant dbSNP:rs16935457Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468661 – 53MASKK…VREVQ → MSGAVRGRRREVGLQHGGCG TGGGYGDGLARSGQSWRWWR SLSLGAVGSSAGTEPGRPAG ASTFRLLRRRQQRHSGSKWL LRSWVQIFM in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0468671 – 11MASKKLGADFH → MSGAVRGRRREVGLQHGGCG TGGGYGDGLARSGQSWRWWR SLSLGAVGSSAGTEPGRPAG ASTFRLLRRRQQRHS in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013650362 – 422Missing in isoform 2. CuratedAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF222043 mRNA Translation: AAF37827.2
AL136733 mRNA Translation: CAB66667.1
AK074724 mRNA Translation: BAC11162.1 Different initiation.
AK074745 mRNA Translation: BAC11176.1
AK074812 mRNA Translation: BAC11224.1
AK074969 mRNA Translation: BAC11323.1
AK074995 mRNA Translation: BAC11342.1
AK295482 mRNA Translation: BAH12084.1 Different initiation.
AK303711 mRNA Translation: BAH14025.1
CR533551 mRNA Translation: CAG38582.1
AK223235 mRNA Translation: BAD96955.1
AL353662 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58467.1
CH471071 Genomic DNA Translation: EAW58468.1
CH471071 Genomic DNA Translation: EAW58469.1
CH471071 Genomic DNA Translation: EAW58470.1
BC020950 mRNA Translation: AAH20950.1
BC098141 mRNA Translation: AAH98141.1
BC098316 mRNA Translation: AAH98316.1
BC099726 mRNA Translation: AAH99726.1
BC100668 mRNA Translation: AAI00669.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55303.1 [Q9NZ09-4]
CCDS6550.1 [Q9NZ09-1]

NCBI Reference Sequences

More...RefSeqi		NP_001164672.1, NM_001171201.1 [Q9NZ09-4]
NP_001164673.1, NM_001171202.1 [Q9NZ09-3]
NP_001164674.1, NM_001171203.2 [Q9NZ09-1]
NP_001164675.1, NM_001171204.2 [Q9NZ09-1]
NP_057609.2, NM_016525.4 [Q9NZ09-1]
XP_006716842.1, XM_006716779.3 [Q9NZ09-1]
XP_011516201.1, XM_011517899.1 [Q9NZ09-1]
XP_016870290.1, XM_017014801.1 [Q9NZ09-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297661.9; ENSP00000297661.4; ENSG00000165006.14
ENST00000359544.2; ENSP00000352541.2; ENSG00000165006.14
ENST00000379186.8; ENSP00000368484.3; ENSG00000165006.14 [Q9NZ09-2]
ENST00000625521.2; ENSP00000486574.1; ENSG00000165006.14 [Q9NZ09-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51271

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51271

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000297661.9; ENSP00000297661.4; NM_016525.5; NP_057609.2

UCSC genome browser

More...UCSCi		uc003ztx.4, human [Q9NZ09-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222043 mRNA Translation: AAF37827.2
AL136733 mRNA Translation: CAB66667.1
AK074724 mRNA Translation: BAC11162.1 Different initiation.
AK074745 mRNA Translation: BAC11176.1
AK074812 mRNA Translation: BAC11224.1
AK074969 mRNA Translation: BAC11323.1
AK074995 mRNA Translation: BAC11342.1
AK295482 mRNA Translation: BAH12084.1 Different initiation.
AK303711 mRNA Translation: BAH14025.1
CR533551 mRNA Translation: CAG38582.1
AK223235 mRNA Translation: BAD96955.1
AL353662 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58467.1
CH471071 Genomic DNA Translation: EAW58468.1
CH471071 Genomic DNA Translation: EAW58469.1
CH471071 Genomic DNA Translation: EAW58470.1
BC020950 mRNA Translation: AAH20950.1
BC098141 mRNA Translation: AAH98141.1
BC098316 mRNA Translation: AAH98316.1
BC099726 mRNA Translation: AAH99726.1
BC100668 mRNA Translation: AAI00669.1
CCDSiCCDS55303.1 [Q9NZ09-4]
CCDS6550.1 [Q9NZ09-1]
RefSeqiNP_001164672.1, NM_001171201.1 [Q9NZ09-4]
NP_001164673.1, NM_001171202.1 [Q9NZ09-3]
NP_001164674.1, NM_001171203.2 [Q9NZ09-1]
NP_001164675.1, NM_001171204.2 [Q9NZ09-1]
NP_057609.2, NM_016525.4 [Q9NZ09-1]
XP_006716842.1, XM_006716779.3 [Q9NZ09-1]
XP_011516201.1, XM_011517899.1 [Q9NZ09-1]
XP_016870290.1, XM_017014801.1 [Q9NZ09-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGNNMR-A381-430[»]
4AE4X-ray1.65A/B389-502[»]
5LM1X-ray2.55B261-280[»]
AlphaFoldDBiQ9NZ09
BMRBiQ9NZ09
SMRiQ9NZ09
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119424, 30 interactors
DIPiDIP-47291N
IntActiQ9NZ09, 11 interactors
MINTiQ9NZ09
STRINGi9606.ENSP00000297661

PTM databases

GlyGeniQ9NZ09, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NZ09
PhosphoSitePlusiQ9NZ09

Genetic variation databases

BioMutaiUBAP1
DMDMi67475018

Proteomic databases

EPDiQ9NZ09
jPOSTiQ9NZ09
MassIVEiQ9NZ09
MaxQBiQ9NZ09
PaxDbiQ9NZ09
PeptideAtlasiQ9NZ09
PRIDEiQ9NZ09
ProteomicsDBi24396
25363
83314 [Q9NZ09-1]
83315 [Q9NZ09-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11158, 210 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		51271

Genome annotation databases

EnsembliENST00000297661.9; ENSP00000297661.4; ENSG00000165006.14
ENST00000359544.2; ENSP00000352541.2; ENSG00000165006.14
ENST00000379186.8; ENSP00000368484.3; ENSG00000165006.14 [Q9NZ09-2]
ENST00000625521.2; ENSP00000486574.1; ENSG00000165006.14 [Q9NZ09-4]
GeneIDi51271
KEGGihsa:51271
MANE-SelectiENST00000297661.9; ENSP00000297661.4; NM_016525.5; NP_057609.2
UCSCiuc003ztx.4, human [Q9NZ09-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51271
DisGeNETi51271

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBAP1
HGNCiHGNC:12461, UBAP1
HPAiENSG00000165006, Low tissue specificity
MalaCardsiUBAP1
MIMi609787, gene
618418, phenotype
neXtProtiNX_Q9NZ09
OpenTargetsiENSG00000165006
Orphaneti100993, Autosomal dominant spastic paraplegia type 12
PharmGKBiPA37111
VEuPathDBiHostDB:ENSG00000165006

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTJC, Eukaryota
GeneTreeiENSGT00390000008092
HOGENOMiCLU_041679_0_0_1
InParanoidiQ9NZ09
OMAiETQYDFS
OrthoDBi683409at2759
PhylomeDBiQ9NZ09
TreeFamiTF329247

Enzyme and pathway databases

PathwayCommonsiQ9NZ09
ReactomeiR-HSA-162588, Budding and maturation of HIV virion
R-HSA-174490, Membrane binding and targetting of GAG proteins
R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379, HCMV Late Events
R-HSA-9615710, Late endosomal microautophagy
SignaLinkiQ9NZ09

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51271, 604 hits in 1085 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBAP1, human
EvolutionaryTraceiQ9NZ09

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51271
PharosiQ9NZ09, Tbio

Protein Ontology

More...PROi		PR:Q9NZ09
RNActiQ9NZ09, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165006, Expressed in vagina and 238 other tissues
ExpressionAtlasiQ9NZ09, baseline and differential
GenevisibleiQ9NZ09, HS

Family and domain databases

Gene3Di1.20.120.1920, 1 hit
InterProiView protein in InterPro
IPR015940, UBA
IPR009060, UBA-like_sf
IPR038870, UBAP1
IPR042575, UBAP1_C
IPR023340, UMA
PANTHERiPTHR15960, PTHR15960, 1 hit
SUPFAMiSSF46934, SSF46934, 2 hits
PROSITEiView protein in PROSITE
PS50030, UBA, 2 hits
PS51497, UMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZ09
Secondary accession number(s): B7Z348
, B7Z8N9, D3DRL7, F5GXE2, F5H0J8, Q4V759, Q53FP7, Q5T7B3, Q6FI75, Q8NC52, Q8NCG6, Q8NCH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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