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Protein

Ubiquitin-associated protein 1

Gene

UBAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-associated protein 1
Short name:
UBAP-1
Alternative name(s):
Nasopharyngeal carcinoma-associated gene 20 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBAP1
ORF Names:NAG20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165006.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12461 UBAP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609787 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZ09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17 – 19LDD → AAA: Abolishes association with the ESCRT-I complex. 1 Publication3
Mutagenesisi20 – 22VPF → AAA: Abolishes association with the ESCRT-I complex. 1 Publication3
Mutagenesisi37P → A: Abolishes association with the ESCRT-I complex. 1 Publication1
Mutagenesisi59E → G: Abolishes association with the ESCRT-I complex. 1 Publication1
Mutagenesisi404Y → A: Strongly reduced interaction with ubiquitinated proteins. 1 Publication1
Mutagenesisi472F → A: Strongly reduced interaction with ubiquitinated proteins. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51271

Open Targets

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OpenTargetsi
ENSG00000165006

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37111

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBAP1

Domain mapping of disease mutations (DMDM)

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DMDMi
67475018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110171 – 502Ubiquitin-associated protein 1Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NZ09

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NZ09

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NZ09

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NZ09

PeptideAtlas

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PeptideAtlasi
Q9NZ09

PRoteomics IDEntifications database

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PRIDEi
Q9NZ09

ProteomicsDB human proteome resource

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ProteomicsDBi
83314
83315 [Q9NZ09-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NZ09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NZ09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165006 Expressed in 225 organ(s), highest expression level in vagina

CleanEx database of gene expression profiles

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CleanExi
HS_UBAP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NZ09 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NZ09 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019804
HPA041590

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Can be a component of ESCRT-I complexes containing VPS37B, VPS37C and VPS37D (in vitro) (PubMed:22405001), but may have a preference for the ESCRT-I complex containing VPS37A (PubMed:21757351). Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PPICP458773EBI-9641159,EBI-953909

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119424, 23 interactors

Database of interacting proteins

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DIPi
DIP-47291N

Protein interaction database and analysis system

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IntActi
Q9NZ09, 6 interactors

Molecular INTeraction database

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MINTi
Q9NZ09

STRING: functional protein association networks

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STRINGi
9606.ENSP00000441024

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGNNMR-A381-430[»]
4AE4X-ray1.65A/B389-502[»]
5LM1X-ray2.55B261-280[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NZ09

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NZ09

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9NZ09

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 63UMAPROSITE-ProRule annotationAdd BLAST47
Domaini389 – 430UBA 1PROSITE-ProRule annotationAdd BLAST42
Domaini451 – 498UBA 2PROSITE-ProRule annotationAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UMA domain mediates association with the ESCRT-I complex.2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG52 Eukaryota
ENOG410ZK9H LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231678

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG060426

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NZ09

Identification of Orthologs from Complete Genome Data

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OMAi
PCNIRSL

Database of Orthologous Groups

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OrthoDBi
683409at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NZ09

TreeFam database of animal gene trees

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TreeFami
TF329247

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR038870 UBAP1
IPR023340 UMA

The PANTHER Classification System

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PANTHERi
PTHR15960 PTHR15960, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46934 SSF46934, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50030 UBA, 2 hits
PS51497 UMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZ09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR
60 70 80 90 100
EVQYDFSLEK KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS
110 120 130 140 150
KMSFSKTHST ATMPPPINPI LASLQHNSIL TPTRVSSSAT KQKVLSPPHI
160 170 180 190 200
KADFNLADFE CEEDPFDNLE LKTIDEKEEL RNILVGTTGP IMAQLLDNNL
210 220 230 240 250
PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL GNCEKMSLSS
260 270 280 290 300
KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN
310 320 330 340 350
SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT
360 370 380 390 400
EESSPPNTGP TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV
410 420 430 440 450
NMGYSYECVL RAMKKKGENI EQILDYLFAH GQLCEKGFDP LLVEEALEMH
460 470 480 490 500
QCSEEKMMEF LQLMSKFKEM GFELKDIKEV LLLHNNDQDN ALEDLMARAG

AS
Length:502
Mass (Da):55,084
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i548457B0B2ABC0F4
GO
Isoform 2 (identifier: Q9NZ09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-422: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:441
Mass (Da):48,247
Checksum:i001566AEC2898859
GO
Isoform 3 (identifier: Q9NZ09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MASKKLGADF...DCLQVVREVQ → MSGAVRGRRR...LLRSWVQIFM

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):58,982
Checksum:iC88D72AB978B9358
GO
Isoform 4 (identifier: Q9NZ09-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MASKKLGADFH → MSGAVRGRRR...LLRRRQQRHS

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):61,845
Checksum:i66126A6497B8BC94
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SG79A0A0D9SG79_HUMAN
Ubiquitin-associated protein 1
UBAP1
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11162 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAH12084 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81C → R in CAG38582 (Ref. 4) Curated1
Sequence conflicti187T → N in BAH14025 (PubMed:14702039).Curated1
Sequence conflicti331E → D in BAC11176 (PubMed:14702039).Curated1
Sequence conflicti398T → M in BAH12084 (PubMed:14702039).Curated1
Sequence conflicti403G → C in BAC11323 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034577357N → K1 PublicationCorresponds to variant dbSNP:rs16935457Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468661 – 53MASKK…VREVQ → MSGAVRGRRREVGLQHGGCG TGGGYGDGLARSGQSWRWWR SLSLGAVGSSAGTEPGRPAG ASTFRLLRRRQQRHSGSKWL LRSWVQIFM in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0468671 – 11MASKKLGADFH → MSGAVRGRRREVGLQHGGCG TGGGYGDGLARSGQSWRWWR SLSLGAVGSSAGTEPGRPAG ASTFRLLRRRQQRHS in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013650362 – 422Missing in isoform 2. CuratedAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF222043 mRNA Translation: AAF37827.2
AL136733 mRNA Translation: CAB66667.1
AK074724 mRNA Translation: BAC11162.1 Different initiation.
AK074745 mRNA Translation: BAC11176.1
AK074812 mRNA Translation: BAC11224.1
AK074969 mRNA Translation: BAC11323.1
AK074995 mRNA Translation: BAC11342.1
AK295482 mRNA Translation: BAH12084.1 Different initiation.
AK303711 mRNA Translation: BAH14025.1
CR533551 mRNA Translation: CAG38582.1
AK223235 mRNA Translation: BAD96955.1
AL353662 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58467.1
CH471071 Genomic DNA Translation: EAW58468.1
CH471071 Genomic DNA Translation: EAW58469.1
CH471071 Genomic DNA Translation: EAW58470.1
BC020950 mRNA Translation: AAH20950.1
BC098141 mRNA Translation: AAH98141.1
BC098316 mRNA Translation: AAH98316.1
BC099726 mRNA Translation: AAH99726.1
BC100668 mRNA Translation: AAI00669.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55303.1 [Q9NZ09-4]
CCDS6550.1 [Q9NZ09-1]

NCBI Reference Sequences

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RefSeqi
NP_001164672.1, NM_001171201.1 [Q9NZ09-4]
NP_001164673.1, NM_001171202.1 [Q9NZ09-3]
NP_001164674.1, NM_001171203.2 [Q9NZ09-1]
NP_001164675.1, NM_001171204.2 [Q9NZ09-1]
NP_057609.2, NM_016525.4 [Q9NZ09-1]
XP_006716842.1, XM_006716779.3 [Q9NZ09-1]
XP_011516201.1, XM_011517899.1 [Q9NZ09-1]
XP_016870290.1, XM_017014801.1 [Q9NZ09-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.268963

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297661; ENSP00000297661; ENSG00000165006 [Q9NZ09-1]
ENST00000359544; ENSP00000352541; ENSG00000165006 [Q9NZ09-1]
ENST00000379186; ENSP00000368484; ENSG00000165006 [Q9NZ09-2]
ENST00000625521; ENSP00000486574; ENSG00000165006 [Q9NZ09-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51271

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51271

UCSC genome browser

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UCSCi
uc003ztx.4 human [Q9NZ09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222043 mRNA Translation: AAF37827.2
AL136733 mRNA Translation: CAB66667.1
AK074724 mRNA Translation: BAC11162.1 Different initiation.
AK074745 mRNA Translation: BAC11176.1
AK074812 mRNA Translation: BAC11224.1
AK074969 mRNA Translation: BAC11323.1
AK074995 mRNA Translation: BAC11342.1
AK295482 mRNA Translation: BAH12084.1 Different initiation.
AK303711 mRNA Translation: BAH14025.1
CR533551 mRNA Translation: CAG38582.1
AK223235 mRNA Translation: BAD96955.1
AL353662 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58467.1
CH471071 Genomic DNA Translation: EAW58468.1
CH471071 Genomic DNA Translation: EAW58469.1
CH471071 Genomic DNA Translation: EAW58470.1
BC020950 mRNA Translation: AAH20950.1
BC098141 mRNA Translation: AAH98141.1
BC098316 mRNA Translation: AAH98316.1
BC099726 mRNA Translation: AAH99726.1
BC100668 mRNA Translation: AAI00669.1
CCDSiCCDS55303.1 [Q9NZ09-4]
CCDS6550.1 [Q9NZ09-1]
RefSeqiNP_001164672.1, NM_001171201.1 [Q9NZ09-4]
NP_001164673.1, NM_001171202.1 [Q9NZ09-3]
NP_001164674.1, NM_001171203.2 [Q9NZ09-1]
NP_001164675.1, NM_001171204.2 [Q9NZ09-1]
NP_057609.2, NM_016525.4 [Q9NZ09-1]
XP_006716842.1, XM_006716779.3 [Q9NZ09-1]
XP_011516201.1, XM_011517899.1 [Q9NZ09-1]
XP_016870290.1, XM_017014801.1 [Q9NZ09-1]
UniGeneiHs.268963

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGNNMR-A381-430[»]
4AE4X-ray1.65A/B389-502[»]
5LM1X-ray2.55B261-280[»]
ProteinModelPortaliQ9NZ09
SMRiQ9NZ09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119424, 23 interactors
DIPiDIP-47291N
IntActiQ9NZ09, 6 interactors
MINTiQ9NZ09
STRINGi9606.ENSP00000441024

PTM databases

iPTMnetiQ9NZ09
PhosphoSitePlusiQ9NZ09

Polymorphism and mutation databases

BioMutaiUBAP1
DMDMi67475018

Proteomic databases

EPDiQ9NZ09
jPOSTiQ9NZ09
MaxQBiQ9NZ09
PaxDbiQ9NZ09
PeptideAtlasiQ9NZ09
PRIDEiQ9NZ09
ProteomicsDBi83314
83315 [Q9NZ09-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51271
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297661; ENSP00000297661; ENSG00000165006 [Q9NZ09-1]
ENST00000359544; ENSP00000352541; ENSG00000165006 [Q9NZ09-1]
ENST00000379186; ENSP00000368484; ENSG00000165006 [Q9NZ09-2]
ENST00000625521; ENSP00000486574; ENSG00000165006 [Q9NZ09-4]
GeneIDi51271
KEGGihsa:51271
UCSCiuc003ztx.4 human [Q9NZ09-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51271
DisGeNETi51271
EuPathDBiHostDB:ENSG00000165006.13

GeneCards: human genes, protein and diseases

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GeneCardsi
UBAP1
HGNCiHGNC:12461 UBAP1
HPAiHPA019804
HPA041590
MIMi609787 gene
neXtProtiNX_Q9NZ09
OpenTargetsiENSG00000165006
PharmGKBiPA37111

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG52 Eukaryota
ENOG410ZK9H LUCA
GeneTreeiENSGT00390000008092
HOGENOMiHOG000231678
HOVERGENiHBG060426
InParanoidiQ9NZ09
OMAiPCNIRSL
OrthoDBi683409at2759
PhylomeDBiQ9NZ09
TreeFamiTF329247

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBAP1 human
EvolutionaryTraceiQ9NZ09

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UBAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51271

Protein Ontology

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PROi
PR:Q9NZ09

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165006 Expressed in 225 organ(s), highest expression level in vagina
CleanExiHS_UBAP1
ExpressionAtlasiQ9NZ09 baseline and differential
GenevisibleiQ9NZ09 HS

Family and domain databases

InterProiView protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR038870 UBAP1
IPR023340 UMA
PANTHERiPTHR15960 PTHR15960, 1 hit
SUPFAMiSSF46934 SSF46934, 2 hits
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
PS51497 UMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZ09
Secondary accession number(s): B7Z348
, B7Z8N9, D3DRL7, F5GXE2, F5H0J8, Q4V759, Q53FP7, Q5T7B3, Q6FI75, Q8NC52, Q8NCG6, Q8NCH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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