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Protein

Golgi apparatus membrane protein TVP23 homolog B

Gene

TVP23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP23 homolog B
Gene namesi
Name:TVP23B
Synonyms:FAM18B, FAM18B1
ORF Names:CGI-148, NPD008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171928.13
HGNCiHGNC:20399 TVP23B
neXtProtiNX_Q9NYZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 53HelicalSequence analysisAdd BLAST20
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171928
PharmGKBiPA134871046

Polymorphism and mutation databases

BioMutaiTVP23B
DMDMi296434501

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128281 – 205Golgi apparatus membrane protein TVP23 homolog BAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NYZ1
PaxDbiQ9NYZ1
PeptideAtlasiQ9NYZ1
PRIDEiQ9NYZ1
ProteomicsDBi83302

PTM databases

iPTMnetiQ9NYZ1
PhosphoSitePlusiQ9NYZ1

Expressioni

Gene expression databases

BgeeiENSG00000171928
CleanExiHS_FAM18B
ExpressionAtlasiQ9NYZ1 baseline and differential
GenevisibleiQ9NYZ1 HS

Organism-specific databases

HPAiHPA019585
HPA065603

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YIPF6Q96EC84EBI-11343401,EBI-751210

Protein-protein interaction databases

BioGridi119236, 2 interactors
IntActiQ9NYZ1, 19 interactors
STRINGi9606.ENSP00000305654

Structurei

3D structure databases

ProteinModelPortaliQ9NYZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3195 Eukaryota
ENOG4111GAN LUCA
GeneTreeiENSGT00390000004428
HOVERGENiHBG051531
InParanoidiQ9NYZ1
OMAiCNYGASK
OrthoDBiEOG091G0MH1
PhylomeDBiQ9NYZ1
TreeFamiTF312906

Family and domain databases

InterProiView protein in InterPro
IPR008564 TVP23-like
PANTHERiPTHR13019 PTHR13019, 1 hit
PfamiView protein in Pfam
PF05832 DUF846, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV
60 70 80 90 100
YLLCGLLSSS FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG
110 120 130 140 150
KSHWVFESRK ESSQENKTVS EAESRIFWLG LIACPVLWVI FAFSALFSFR
160 170 180 190 200
VKWLAVVIMG VVLQGANLYG YIRCKVRSRK HLTSMATSYF GKQFLRQNTG

DDQTS
Length:205
Mass (Da):23,576
Last modified:May 18, 2010 - v2
Checksum:iE221C320822187FC
GO

Sequence cautioni

The sequence AAD34143 differs from that shown. Reason: Frameshift at position 178.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48I → T in BAF83502 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06047655G → E4 PublicationsCorresponds to variant dbSNP:rs61075345Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151906 mRNA Translation: AAD34143.1 Frameshift.
AF223467 mRNA Translation: AAF64142.1
BX537929 mRNA Translation: CAD97906.1
AK290813 mRNA Translation: BAF83502.1
AC107982 Genomic DNA No translation available.
BC008430 mRNA Translation: AAH08430.1
CCDSiCCDS42274.1
RefSeqiNP_001303848.1, NM_001316919.1
NP_001303849.1, NM_001316920.1
NP_001303850.1, NM_001316921.1
NP_001303851.1, NM_001316922.1
NP_001303852.1, NM_001316923.1
NP_001303853.1, NM_001316924.1
NP_057162.4, NM_016078.5
UniGeneiHs.87295

Genome annotation databases

EnsembliENST00000307767; ENSP00000305654; ENSG00000171928
GeneIDi51030
KEGGihsa:51030
UCSCiuc002gum.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTV23B_HUMAN
AccessioniPrimary (citable) accession number: Q9NYZ1
Secondary accession number(s): A8K448, Q96HK5, Q9Y3E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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