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Protein

Interleukin-20

Gene

IL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-20 receptor binding Source: UniProtKB
  • interleukin-22 receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9NYY1
SIGNORiQ9NYY1

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
Gene namesi
Name:IL20
Synonyms:ZCYTO10
ORF Names:UNQ852/PRO1801
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162891.10
HGNCiHGNC:6002 IL20
MIMi605619 gene
neXtProtiNX_Q9NYY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi50604
OpenTargetsiENSG00000162891
PharmGKBiPA29817

Chemistry databases

ChEMBLiCHEMBL3713449

Polymorphism and mutation databases

BioMutaiIL20
DMDMi38258955

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001538125 – 176Interleukin-20Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Disulfide bondi81 ↔ 1341 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NYY1
PeptideAtlasiQ9NYY1
PRIDEiQ9NYY1
ProteomicsDBi83298

PTM databases

iPTMnetiQ9NYY1
PhosphoSitePlusiQ9NYY1

Expressioni

Tissue specificityi

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.1 Publication

Inductioni

Up-regulated by UV-B irradiation in epithelial keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000162891 Expressed in 43 organ(s), highest expression level in omental fat pad
CleanExiHS_IL20
GenevisibleiQ9NYY1 HS

Organism-specific databases

HPAiCAB025802

Interactioni

Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119086, 9 interactors
IntActiQ9NYY1, 3 interactors
STRINGi9606.ENSP00000356063

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NYY1
SMRiQ9NYY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW76 Eukaryota
ENOG410YMTB LUCA
GeneTreeiENSGT00410000025637
HOGENOMiHOG000113033
HOVERGENiHBG108002
InParanoidiQ9NYY1
KOiK22667
OMAiHHTLRKI
OrthoDBiEOG091G0Q0Q
PhylomeDBiQ9NYY1
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
IPR020442 IL-20
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01935 INTRLEUKIN20
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYY1-1) [UniParc]FASTAAdd to basket
Also known as: IL-20W, Wild type

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR
60 70 80 90 100
GSVQAKDGNI DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT
110 120 130 140 150
PDHYTLRKIS SLANSFLTIK KDLRLCHAHM TCHCGEEAMK KYSQILSHFE
160 170
KLEPQAAVVK ALGELDILLQ WMEETE
Length:176
Mass (Da):20,072
Last modified:October 31, 2003 - v2
Checksum:i8385992500B6C447
GO
Isoform 2 (identifier: Q9NYY1-2) [UniParc]FASTAAdd to basket
Also known as: IL-20S, ex4-del, Short

The sequence of this isoform differs from the canonical sequence as follows:
     127-151: Missing.

Note: Lung-specific.
Show »
Length:151
Mass (Da):17,144
Checksum:i417BF88DDD9E5DCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48E → D in AAF36679 (PubMed:11163236).Curated1
Sequence conflicti126C → S in AAQ88686 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049577107R → Q. Corresponds to variant dbSNP:rs35856950Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054904127 – 151Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224266 mRNA Translation: AAF36679.1
AY876922 mRNA Translation: AAW78348.1
AY358320 mRNA Translation: AAQ88686.1
AF402002 Genomic DNA Translation: AAK84423.1
AC098935 Genomic DNA No translation available.
BC069311 mRNA Translation: AAH69311.1
BC069364 mRNA Translation: AAH69364.1
BC069398 mRNA Translation: AAH69398.1
BC069425 mRNA Translation: AAH69425.1
BC069449 mRNA Translation: AAH69449.1
BC069487 mRNA Translation: AAH69487.1
BC069523 mRNA Translation: AAH69523.1
BC069559 mRNA Translation: AAH69559.1
BC074948 mRNA Translation: AAH74948.1
BC074949 mRNA Translation: AAH74949.1
BC117386 mRNA Translation: AAI17387.1
BC117390 mRNA Translation: AAI17391.1
CCDSiCCDS1470.1 [Q9NYY1-1]
RefSeqiNP_061194.2, NM_018724.3 [Q9NYY1-1]
UniGeneiHs.272373

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891 [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891 [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891 [Q9NYY1-2]
GeneIDi50604
KEGGihsa:50604
UCSCiuc001her.4 human [Q9NYY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224266 mRNA Translation: AAF36679.1
AY876922 mRNA Translation: AAW78348.1
AY358320 mRNA Translation: AAQ88686.1
AF402002 Genomic DNA Translation: AAK84423.1
AC098935 Genomic DNA No translation available.
BC069311 mRNA Translation: AAH69311.1
BC069364 mRNA Translation: AAH69364.1
BC069398 mRNA Translation: AAH69398.1
BC069425 mRNA Translation: AAH69425.1
BC069449 mRNA Translation: AAH69449.1
BC069487 mRNA Translation: AAH69487.1
BC069523 mRNA Translation: AAH69523.1
BC069559 mRNA Translation: AAH69559.1
BC074948 mRNA Translation: AAH74948.1
BC074949 mRNA Translation: AAH74949.1
BC117386 mRNA Translation: AAI17387.1
BC117390 mRNA Translation: AAI17391.1
CCDSiCCDS1470.1 [Q9NYY1-1]
RefSeqiNP_061194.2, NM_018724.3 [Q9NYY1-1]
UniGeneiHs.272373

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortaliQ9NYY1
SMRiQ9NYY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119086, 9 interactors
IntActiQ9NYY1, 3 interactors
STRINGi9606.ENSP00000356063

Chemistry databases

ChEMBLiCHEMBL3713449

PTM databases

iPTMnetiQ9NYY1
PhosphoSitePlusiQ9NYY1

Polymorphism and mutation databases

BioMutaiIL20
DMDMi38258955

Proteomic databases

PaxDbiQ9NYY1
PeptideAtlasiQ9NYY1
PRIDEiQ9NYY1
ProteomicsDBi83298

Protocols and materials databases

DNASUi50604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891 [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891 [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891 [Q9NYY1-2]
GeneIDi50604
KEGGihsa:50604
UCSCiuc001her.4 human [Q9NYY1-1]

Organism-specific databases

CTDi50604
DisGeNETi50604
EuPathDBiHostDB:ENSG00000162891.10
GeneCardsiIL20
HGNCiHGNC:6002 IL20
HPAiCAB025802
MIMi605619 gene
neXtProtiNX_Q9NYY1
OpenTargetsiENSG00000162891
PharmGKBiPA29817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW76 Eukaryota
ENOG410YMTB LUCA
GeneTreeiENSGT00410000025637
HOGENOMiHOG000113033
HOVERGENiHBG108002
InParanoidiQ9NYY1
KOiK22667
OMAiHHTLRKI
OrthoDBiEOG091G0Q0Q
PhylomeDBiQ9NYY1
TreeFamiTF333253

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9NYY1
SIGNORiQ9NYY1

Miscellaneous databases

ChiTaRSiIL20 human
GenomeRNAii50604
PROiPR:Q9NYY1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162891 Expressed in 43 organ(s), highest expression level in omental fat pad
CleanExiHS_IL20
GenevisibleiQ9NYY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
IPR020442 IL-20
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01935 INTRLEUKIN20
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL20_HUMAN
AccessioniPrimary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q2THG6, Q96QZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 31, 2003
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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