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Protein

Interleukin-20

Gene

IL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-20 receptor binding Source: UniProtKB
  • interleukin-22 receptor binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854691 Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NYY1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NYY1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL20
Synonyms:ZCYTO10
ORF Names:UNQ852/PRO1801
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162891.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6002 IL20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605619 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50604

Open Targets

More...
OpenTargetsi
ENSG00000162891

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29817

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3713449

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001538125 – 176Interleukin-20Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Disulfide bondi81 ↔ 1341 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYY1

PeptideAtlas

More...
PeptideAtlasi
Q9NYY1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYY1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83298

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by UV-B irradiation in epithelial keratinocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162891 Expressed in 43 organ(s), highest expression level in omental fat pad

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL20

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYY1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119086, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NYY1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356063

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NYY1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYY1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IW76 Eukaryota
ENOG410YMTB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113033

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108002

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYY1

KEGG Orthology (KO)

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KOi
K22667

Identification of Orthologs from Complete Genome Data

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OMAi
RDSVQAK

Database of Orthologous Groups

More...
OrthoDBi
1189017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYY1

TreeFam database of animal gene trees

More...
TreeFami
TF333253

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
IPR020442 IL-20

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00726 IL10, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01935 INTRLEUKIN20

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00188 IL10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYY1-1) [UniParc]FASTAAdd to basket
Also known as: IL-20W, Wild type

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR
60 70 80 90 100
GSVQAKDGNI DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT
110 120 130 140 150
PDHYTLRKIS SLANSFLTIK KDLRLCHAHM TCHCGEEAMK KYSQILSHFE
160 170
KLEPQAAVVK ALGELDILLQ WMEETE
Length:176
Mass (Da):20,072
Last modified:October 31, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8385992500B6C447
GO
Isoform 2 (identifier: Q9NYY1-2) [UniParc]FASTAAdd to basket
Also known as: IL-20S, ex4-del, Short

The sequence of this isoform differs from the canonical sequence as follows:
     127-151: Missing.

Note: Lung-specific.
Show »
Length:151
Mass (Da):17,144
Checksum:i417BF88DDD9E5DCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → D in AAF36679 (PubMed:11163236).Curated1
Sequence conflicti126C → S in AAQ88686 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049577107R → Q. Corresponds to variant dbSNP:rs35856950Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054904127 – 151Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF224266 mRNA Translation: AAF36679.1
AY876922 mRNA Translation: AAW78348.1
AY358320 mRNA Translation: AAQ88686.1
AF402002 Genomic DNA Translation: AAK84423.1
AC098935 Genomic DNA No translation available.
BC069311 mRNA Translation: AAH69311.1
BC069364 mRNA Translation: AAH69364.1
BC069398 mRNA Translation: AAH69398.1
BC069425 mRNA Translation: AAH69425.1
BC069449 mRNA Translation: AAH69449.1
BC069487 mRNA Translation: AAH69487.1
BC069523 mRNA Translation: AAH69523.1
BC069559 mRNA Translation: AAH69559.1
BC074948 mRNA Translation: AAH74948.1
BC074949 mRNA Translation: AAH74949.1
BC117386 mRNA Translation: AAI17387.1
BC117390 mRNA Translation: AAI17391.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1470.1 [Q9NYY1-1]

NCBI Reference Sequences

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RefSeqi
NP_061194.2, NM_018724.3 [Q9NYY1-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.272373

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367096; ENSP00000356063; ENSG00000162891 [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891 [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891 [Q9NYY1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
50604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50604

UCSC genome browser

More...
UCSCi
uc001her.4 human [Q9NYY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224266 mRNA Translation: AAF36679.1
AY876922 mRNA Translation: AAW78348.1
AY358320 mRNA Translation: AAQ88686.1
AF402002 Genomic DNA Translation: AAK84423.1
AC098935 Genomic DNA No translation available.
BC069311 mRNA Translation: AAH69311.1
BC069364 mRNA Translation: AAH69364.1
BC069398 mRNA Translation: AAH69398.1
BC069425 mRNA Translation: AAH69425.1
BC069449 mRNA Translation: AAH69449.1
BC069487 mRNA Translation: AAH69487.1
BC069523 mRNA Translation: AAH69523.1
BC069559 mRNA Translation: AAH69559.1
BC074948 mRNA Translation: AAH74948.1
BC074949 mRNA Translation: AAH74949.1
BC117386 mRNA Translation: AAI17387.1
BC117390 mRNA Translation: AAI17391.1
CCDSiCCDS1470.1 [Q9NYY1-1]
RefSeqiNP_061194.2, NM_018724.3 [Q9NYY1-1]
UniGeneiHs.272373

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortaliQ9NYY1
SMRiQ9NYY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119086, 9 interactors
IntActiQ9NYY1, 3 interactors
STRINGi9606.ENSP00000356063

Chemistry databases

ChEMBLiCHEMBL3713449

PTM databases

iPTMnetiQ9NYY1
PhosphoSitePlusiQ9NYY1

Polymorphism and mutation databases

BioMutaiIL20
DMDMi38258955

Proteomic databases

PaxDbiQ9NYY1
PeptideAtlasiQ9NYY1
PRIDEiQ9NYY1
ProteomicsDBi83298

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
50604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891 [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891 [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891 [Q9NYY1-2]
GeneIDi50604
KEGGihsa:50604
UCSCiuc001her.4 human [Q9NYY1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50604
DisGeNETi50604
EuPathDBiHostDB:ENSG00000162891.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL20
HGNCiHGNC:6002 IL20
HPAiCAB025802
MIMi605619 gene
neXtProtiNX_Q9NYY1
OpenTargetsiENSG00000162891
PharmGKBiPA29817

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IW76 Eukaryota
ENOG410YMTB LUCA
GeneTreeiENSGT00410000025637
HOGENOMiHOG000113033
HOVERGENiHBG108002
InParanoidiQ9NYY1
KOiK22667
OMAiRDSVQAK
OrthoDBi1189017at2759
PhylomeDBiQ9NYY1
TreeFamiTF333253

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9NYY1
SIGNORiQ9NYY1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50604

Protein Ontology

More...
PROi
PR:Q9NYY1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162891 Expressed in 43 organ(s), highest expression level in omental fat pad
CleanExiHS_IL20
GenevisibleiQ9NYY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
IPR020442 IL-20
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01935 INTRLEUKIN20
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q2THG6, Q96QZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 31, 2003
Last modified: January 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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