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Entry version 162 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

RB-associated KRAB zinc finger protein

Gene

RBAK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May repress E2F-dependent transcription. May promote AR-dependent transcription.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 505C2H2-type 9PROSITE-ProRule annotationAdd BLAST21
Zinc fingeri511 – 533C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RB-associated KRAB zinc finger protein
Alternative name(s):
RB-associated KRAB repressor
Short name:
hRBaK
Zinc finger protein 769
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBAK
Synonyms:ZNF769
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17680 RBAK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608191 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57786

Open Targets

More...
OpenTargetsi
ENSG00000146587

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400745

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYW8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBAK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761820

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169761 – 714RB-associated KRAB zinc finger proteinAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NYW8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NYW8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NYW8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYW8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYW8

PeptideAtlas

More...
PeptideAtlasi
Q9NYW8

PRoteomics IDEntifications database

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PRIDEi
Q9NYW8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
29813
83294 [Q9NYW8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NYW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146587 Expressed in 198 organ(s), highest expression level in amniotic fluid

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NYW8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071231

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121759, 16 interactors
1529617, 1 interactor

Database of interacting proteins

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DIPi
DIP-39336N

Protein interaction database and analysis system

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IntActi
Q9NYW8, 38 interactors

Molecular INTeraction database

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MINTi
Q9NYW8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NYW8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 260Required for interaction with RB11 PublicationAdd BLAST90
Regioni417 – 714Interaction with AR1 PublicationAdd BLAST298

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 505C2H2-type 9PROSITE-ProRule annotationAdd BLAST21
Zinc fingeri511 – 533C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYW8

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

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OMAi
SYYTIHY

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYW8

TreeFam database of animal gene trees

More...
TreeFami
TF350803

Family and domain databases

Conserved Domains Database

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CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTLQGPVSF KDVAVDFTQE EWQQLDPDEK ITYRDVMLEN YSHLVSVGYD
60 70 80 90 100
TTKPNVIIKL EQGEEPWIMG GEFPCQHSPE AWRVDDLIER IQENEDKHSR
110 120 130 140 150
QAACINSKTL TEEKENTFSQ IYMETSLVPS SIIAHNCVSC GKNLESISQL
160 170 180 190 200
ISSDGSYART KPDECNECGK TYHGEKMCEF NQNGDTYSHN EENILQKISI
210 220 230 240 250
LEKPFEYNEC MEALDNEAVF IAHKRAYIGE KPYEWNDSGP DFIQMSNFNA
260 270 280 290 300
YQRSQMEMKP FECSECGKSF CKKSKFIIHQ RAHTGEKPYE CNVCGKSFSQ
310 320 330 340 350
KGTLTVHRRS HLEEKPYKCN ECGKTFCQKL HLTQHLRTHS GEKPYECSEC
360 370 380 390 400
GKTFCQKTHL TLHQRNHSGE RPYPCNECGK SFSRKSALSD HQRTHTGEKL
410 420 430 440 450
YKCNECGKSY YRKSTLITHQ RTHTGEKPYQ CSECGKFFSR VSYLTIHYRS
460 470 480 490 500
HLEEKPYECN ECGKTFNLNS AFIRHRKVHT EEKSHECSEC GKFSQLYLTD
510 520 530 540 550
HHTAHLEEKP YECNECGKTF LVNSAFDGHQ PLPKGEKSYE CNVCGKLFNE
560 570 580 590 600
LSYYTEHYRS HSEEKPYGCS ECGKTFSHNS SLFRHQRVHT GEKPYECYEC
610 620 630 640 650
GKFFSQKSYL TIHHRIHSGE KPYECSKCGK VFSRMSNLTV HYRSHSGEKP
660 670 680 690 700
YECNECGKVF SQKSYLTVHY RTHSGEKPYE CNECGKKFHH RSAFNSHQRI
710
HRRGNMNVLD VENL
Length:714
Mass (Da):82,995
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36D90A6206118F8B
GO
Isoform 2 (identifier: Q9NYW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-113: EAWRVDDLIERIQENEDKHSRQAACINSKTLTEE → AALPAGHVAPAVAAAAAAPGRPGPHRQSRSPPGC
     114-714: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,251
Checksum:i57840FE5CD3D700C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti273K → E in BAF85758 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038438229G → E. Corresponds to variant dbSNP:rs35352738Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04480580 – 113EAWRV…TLTEE → AALPAGHVAPAVAAAAAAPG RPGPHRQSRSPPGC in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_044806114 – 714Missing in isoform 2. 1 PublicationAdd BLAST601

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF226869 mRNA Translation: AAF43389.1
BM929719 mRNA No translation available.
AK293069 mRNA Translation: BAF85758.1
AC092032 Genomic DNA Translation: AAQ93364.1
AC008167 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87321.1
BC136675 mRNA Translation: AAI36676.1
BC136676 mRNA Translation: AAI36677.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5337.1 [Q9NYW8-1]

NCBI Reference Sequences

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RefSeqi
NP_001191385.1, NM_001204456.1 [Q9NYW8-1]
NP_066986.1, NM_021163.3 [Q9NYW8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353796; ENSP00000275423; ENSG00000146587 [Q9NYW8-1]
ENST00000396912; ENSP00000380120; ENSG00000146587 [Q9NYW8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57786

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57786

UCSC genome browser

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UCSCi
uc003sns.1 human [Q9NYW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226869 mRNA Translation: AAF43389.1
BM929719 mRNA No translation available.
AK293069 mRNA Translation: BAF85758.1
AC092032 Genomic DNA Translation: AAQ93364.1
AC008167 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87321.1
BC136675 mRNA Translation: AAI36676.1
BC136676 mRNA Translation: AAI36677.1
CCDSiCCDS5337.1 [Q9NYW8-1]
RefSeqiNP_001191385.1, NM_001204456.1 [Q9NYW8-1]
NP_066986.1, NM_021163.3 [Q9NYW8-1]

3D structure databases

SMRiQ9NYW8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121759, 16 interactors
1529617, 1 interactor
DIPiDIP-39336N
IntActiQ9NYW8, 38 interactors
MINTiQ9NYW8
STRINGi9606.ENSP00000380120

PTM databases

iPTMnetiQ9NYW8
PhosphoSitePlusiQ9NYW8

Polymorphism and mutation databases

BioMutaiRBAK
DMDMi74761820

Proteomic databases

EPDiQ9NYW8
jPOSTiQ9NYW8
MassIVEiQ9NYW8
MaxQBiQ9NYW8
PaxDbiQ9NYW8
PeptideAtlasiQ9NYW8
PRIDEiQ9NYW8
ProteomicsDBi29813
83294 [Q9NYW8-1]

Genome annotation databases

EnsembliENST00000353796; ENSP00000275423; ENSG00000146587 [Q9NYW8-1]
ENST00000396912; ENSP00000380120; ENSG00000146587 [Q9NYW8-1]
GeneIDi57786
KEGGihsa:57786
UCSCiuc003sns.1 human [Q9NYW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57786
DisGeNETi57786

GeneCards: human genes, protein and diseases

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GeneCardsi
RBAK
HGNCiHGNC:17680 RBAK
HPAiHPA071231
MIMi608191 gene
neXtProtiNX_Q9NYW8
OpenTargetsiENSG00000146587
PharmGKBiPA162400745

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000154303
HOGENOMiHOG000234617
InParanoidiQ9NYW8
KOiK09228
OMAiSYYTIHY
OrthoDBi1318335at2759
PhylomeDBiQ9NYW8
TreeFamiTF350803

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBAK human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57786
PharosiQ9NYW8

Protein Ontology

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PROi
PR:Q9NYW8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000146587 Expressed in 198 organ(s), highest expression level in amniotic fluid
GenevisibleiQ9NYW8 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBAK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYW8
Secondary accession number(s): A6NDF2
, A8KAK4, B2RN44, B9EGS1, F8W6M7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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