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UniProtKB - Q9NYW7 (TA2R1_HUMAN)
Protein
Taste receptor type 2 member 1
Gene
TAS2R1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Miscellaneous
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
GO - Molecular functioni
- bitter taste receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
- taste receptor activity Source: UniProtKB
GO - Biological processi
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction, Taste |
Enzyme and pathway databases
PathwayCommonsi | Q9NYW7 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
Names & Taxonomyi
Protein namesi | Recommended name: Taste receptor type 2 member 1Short name: T2R1 Alternative name(s): Taste receptor family B member 7 Short name: TRB7 |
Gene namesi | Name:TAS2R1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14909, TAS2R1 |
MIMi | 604796, gene |
neXtProti | NX_Q9NYW7 |
VEuPathDBi | HostDB:ENSG00000169777 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | ExtracellularSequence analysis | 9 | |
Transmembranei | 10 – 30 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 55 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 56 – 76 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 81 | ExtracellularSequence analysis | 5 | |
Transmembranei | 82 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 124 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 125 – 145 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 178 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 179 – 199 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 222 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 223 – 243 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 257 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 258 – 278 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 299 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 50834 |
OpenTargetsi | ENSG00000169777 |
PharmGKBi | PA37921 |
Miscellaneous databases
Pharosi | Q9NYW7, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523475 |
Genetic variation databases
BioMutai | TAS2R1 |
DMDMi | 29839667 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082188 | 1 – 299 | Taste receptor type 2 member 1Add BLAST | 299 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9NYW7 |
PaxDbi | Q9NYW7 |
PeptideAtlasi | Q9NYW7 |
PRIDEi | Q9NYW7 |
PTM databases
GlyGeni | Q9NYW7, 1 site |
iPTMneti | Q9NYW7 |
PhosphoSitePlusi | Q9NYW7 |
Expressioni
Tissue specificityi
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Gene expression databases
Bgeei | ENSG00000169777, Expressed in right testis and 31 other tissues |
ExpressionAtlasi | Q9NYW7, baseline and differential |
Genevisiblei | Q9NYW7, HS |
Organism-specific databases
HPAi | ENSG00000169777, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000371932 |
Chemistry databases
BindingDBi | Q9NYW7 |
Miscellaneous databases
RNActi | Q9NYW7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor T2R family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S2SI, Eukaryota |
GeneTreei | ENSGT00960000186638 |
HOGENOMi | CLU_072337_1_1_1 |
InParanoidi | Q9NYW7 |
OMAi | KHRKMAP |
OrthoDBi | 1010573at2759 |
PhylomeDBi | Q9NYW7 |
TreeFami | TF335891 |
Family and domain databases
InterProi | View protein in InterPro IPR007960, TAS2R |
Pfami | View protein in Pfam PF05296, TAS2R, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NYW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC
60 70 80 90 100
LAVSRIFLQL FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG
110 120 130 140 150
VFYCAKVASV RHPLFIWLKM RISKLVPWMI LGSLLYVSMI CVFHSKYAGF
160 170 180 190 200
MVPYFLRKFF SQNATIQKED TLAIQIFSFV AEFSVPLLIF LFAVLLLIFS
210 220 230 240 250
LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH CMIKVFLSSL
260 270 280 290
KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KPZ8 | U3KPZ8_HUMAN | Taste receptor type 2 member 1 | TAS2R1 | 61 | Annotation score: | ||
U3KQT0 | U3KQT0_HUMAN | Taste receptor type 2 member 1 | TAS2R1 | 155 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020198 | 111 | R → H. Corresponds to variant dbSNP:rs41469Ensembl. | 1 | |
Natural variantiVAR_053340 | 141 | C → Y. Corresponds to variant dbSNP:rs2234232EnsemblClinVar. | 1 | |
Natural variantiVAR_020199 | 206 | R → W. Corresponds to variant dbSNP:rs2234233Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF227129 Genomic DNA Translation: AAF43902.1 AY724812 Genomic DNA Translation: AAU21051.1 BC101729 mRNA Translation: AAI01730.1 BC101731 mRNA Translation: AAI01732.1 |
CCDSi | CCDS3876.1 |
RefSeqi | NP_062545.1, NM_019599.2 |
Genome annotation databases
Ensembli | ENST00000382492; ENSP00000371932; ENSG00000169777 |
GeneIDi | 50834 |
KEGGi | hsa:50834 |
MANE-Selecti | ENST00000382492.4; ENSP00000371932.2; NM_019599.3; NP_062545.1 |
UCSCi | uc003jem.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF227129 Genomic DNA Translation: AAF43902.1 AY724812 Genomic DNA Translation: AAU21051.1 BC101729 mRNA Translation: AAI01730.1 BC101731 mRNA Translation: AAI01732.1 |
CCDSi | CCDS3876.1 |
RefSeqi | NP_062545.1, NM_019599.2 |
3D structure databases
SMRi | Q9NYW7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000371932 |
Chemistry databases
BindingDBi | Q9NYW7 |
ChEMBLi | CHEMBL4523475 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9NYW7, 1 site |
iPTMneti | Q9NYW7 |
PhosphoSitePlusi | Q9NYW7 |
Genetic variation databases
BioMutai | TAS2R1 |
DMDMi | 29839667 |
Proteomic databases
MassIVEi | Q9NYW7 |
PaxDbi | Q9NYW7 |
PeptideAtlasi | Q9NYW7 |
PRIDEi | Q9NYW7 |
Protocols and materials databases
Antibodypediai | 22446, 124 antibodies from 23 providers |
DNASUi | 50834 |
Genome annotation databases
Ensembli | ENST00000382492; ENSP00000371932; ENSG00000169777 |
GeneIDi | 50834 |
KEGGi | hsa:50834 |
MANE-Selecti | ENST00000382492.4; ENSP00000371932.2; NM_019599.3; NP_062545.1 |
UCSCi | uc003jem.2, human |
Organism-specific databases
CTDi | 50834 |
DisGeNETi | 50834 |
GeneCardsi | TAS2R1 |
HGNCi | HGNC:14909, TAS2R1 |
HPAi | ENSG00000169777, Tissue enriched (testis) |
MIMi | 604796, gene |
neXtProti | NX_Q9NYW7 |
OpenTargetsi | ENSG00000169777 |
PharmGKBi | PA37921 |
VEuPathDBi | HostDB:ENSG00000169777 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2SI, Eukaryota |
GeneTreei | ENSGT00960000186638 |
HOGENOMi | CLU_072337_1_1_1 |
InParanoidi | Q9NYW7 |
OMAi | KHRKMAP |
OrthoDBi | 1010573at2759 |
PhylomeDBi | Q9NYW7 |
TreeFami | TF335891 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYW7 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
Miscellaneous databases
BioGRID-ORCSi | 50834, 5 hits in 1025 CRISPR screens |
GeneWikii | TAS2R1 |
GenomeRNAii | 50834 |
Pharosi | Q9NYW7, Tbio |
PROi | PR:Q9NYW7 |
RNActi | Q9NYW7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169777, Expressed in right testis and 31 other tissues |
ExpressionAtlasi | Q9NYW7, baseline and differential |
Genevisiblei | Q9NYW7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007960, TAS2R |
Pfami | View protein in Pfam PF05296, TAS2R, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TA2R1_HUMAN | |
Accessioni | Q9NYW7Primary (citable) accession number: Q9NYW7 Secondary accession number(s): Q646G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families