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Protein

Taste receptor type 2 member 1

Gene

TAS2R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 1
Short name:
T2R1
Alternative name(s):
Taste receptor family B member 7
Short name:
TRB7
Gene namesi
Name:TAS2R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169777.6
HGNCiHGNC:14909 TAS2R1
MIMi604796 gene
neXtProtiNX_Q9NYW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 55CytoplasmicSequence analysisAdd BLAST25
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 81ExtracellularSequence analysis5
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini146 – 178ExtracellularSequence analysisAdd BLAST33
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 222CytoplasmicSequence analysisAdd BLAST23
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 257ExtracellularSequence analysisAdd BLAST14
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 299CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50834
OpenTargetsiENSG00000169777
PharmGKBiPA37921

Polymorphism and mutation databases

BioMutaiTAS2R1
DMDMi29839667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000821881 – 299Taste receptor type 2 member 1Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW7
PeptideAtlasiQ9NYW7
PRIDEiQ9NYW7
ProteomicsDBi83293

PTM databases

iPTMnetiQ9NYW7
PhosphoSitePlusiQ9NYW7

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000169777
CleanExiHS_TAS2R1
ExpressionAtlasiQ9NYW7 baseline and differential
GenevisibleiQ9NYW7 HS

Organism-specific databases

HPAiHPA051879

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371932

Structurei

3D structure databases

ProteinModelPortaliQ9NYW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0YF Eukaryota
ENOG410YMY3 LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW7
KOiK08474
OMAiWLKMRIS
OrthoDBiEOG091G0GD5
PhylomeDBiQ9NYW7
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC
60 70 80 90 100
LAVSRIFLQL FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG
110 120 130 140 150
VFYCAKVASV RHPLFIWLKM RISKLVPWMI LGSLLYVSMI CVFHSKYAGF
160 170 180 190 200
MVPYFLRKFF SQNATIQKED TLAIQIFSFV AEFSVPLLIF LFAVLLLIFS
210 220 230 240 250
LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH CMIKVFLSSL
260 270 280 290
KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ
Length:299
Mass (Da):34,333
Last modified:October 1, 2000 - v1
Checksum:iCFB17DD15645392C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020198111R → H. Corresponds to variant dbSNP:rs41469Ensembl.1
Natural variantiVAR_053340141C → Y. Corresponds to variant dbSNP:rs2234232Ensembl.1
Natural variantiVAR_020199206R → W. Corresponds to variant dbSNP:rs2234233Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227129 Genomic DNA Translation: AAF43902.1
AY724812 Genomic DNA Translation: AAU21051.1
BC101729 mRNA Translation: AAI01730.1
BC101731 mRNA Translation: AAI01732.1
CCDSiCCDS3876.1
RefSeqiNP_062545.1, NM_019599.2
UniGeneiHs.567492

Genome annotation databases

EnsembliENST00000382492; ENSP00000371932; ENSG00000169777
GeneIDi50834
KEGGihsa:50834
UCSCiuc003jem.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTA2R1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW7
Secondary accession number(s): Q646G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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