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Protein

Taste receptor type 2 member 5

Gene

TAS2R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 5
Short name:
T2R5
Gene namesi
Name:TAS2R5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127366.5
HGNCiHGNC:14912 TAS2R5
MIMi605062 gene
neXtProtiNX_Q9NYW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 45CytoplasmicSequence analysisAdd BLAST23
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 82ExtracellularSequence analysisAdd BLAST16
Transmembranei83 – 103Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini104 – 127CytoplasmicSequence analysisAdd BLAST24
Transmembranei128 – 148Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini149 – 175ExtracellularSequence analysisAdd BLAST27
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 223CytoplasmicSequence analysisAdd BLAST27
Transmembranei224 – 244Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini245 – 253ExtracellularSequence analysis9
Transmembranei254 – 274Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini275 – 299CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127366
PharmGKBiPA37924

Polymorphism and mutation databases

BioMutaiTAS2R5
DMDMi29839664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822121 – 299Taste receptor type 2 member 5Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW4
PeptideAtlasiQ9NYW4
PRIDEiQ9NYW4
ProteomicsDBi83290

PTM databases

iPTMnetiQ9NYW4
PhosphoSitePlusiQ9NYW4

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000127366 Expressed in 89 organ(s), highest expression level in right uterine tube
CleanExiHS_TAS2R5
ExpressionAtlasiQ9NYW4 baseline and differential
GenevisibleiQ9NYW4 HS

Interactioni

Protein-protein interaction databases

IntActiQ9NYW4, 5 interactors
STRINGi9606.ENSP00000247883

Structurei

3D structure databases

ProteinModelPortaliQ9NYW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKQ4 Eukaryota
ENOG41119UC LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098555
InParanoidiQ9NYW4
KOiK08474
OMAiCRFLLQW
OrthoDBiEOG091G0FNQ
PhylomeDBiQ9NYW4
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG
60 70 80 90 100
LAGCRFLLQW LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS
110 120 130 140 150
VFYCKKITTF DRPAYLWLKQ RAYNLSLWCL LGYFIINLLL TVQIGLTFYH
160 170 180 190 200
PPQGNSSIRY PFESWQYLYA FQLNSGSYLP LVVFLVSSGM LIVSLYTHHK
210 220 230 240 250
KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF SITSKTYPPD
260 270 280 290
LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP
Length:299
Mass (Da):34,505
Last modified:October 1, 2000 - v1
Checksum:iF85064A07E9018C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05334320G → S. Corresponds to variant dbSNP:rs2234013Ensembl.1
Natural variantiVAR_02020326S → I. Corresponds to variant dbSNP:rs2227264Ensembl.1
Natural variantiVAR_034537113P → L. Corresponds to variant dbSNP:rs2234014Ensembl.1
Natural variantiVAR_034538167Y → C. Corresponds to variant dbSNP:rs34529840Ensembl.1
Natural variantiVAR_024184213R → Q. Corresponds to variant dbSNP:rs2234015Ensembl.1
Natural variantiVAR_053344294R → L. Corresponds to variant dbSNP:rs2234016Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227132 Genomic DNA Translation: AAF43905.1
AY724966 Genomic DNA Translation: AAU21159.1
AC004979 Genomic DNA Translation: AAS02040.1
BC069509 mRNA Translation: AAH69509.1
BC101586 mRNA Translation: AAI01587.1
BC101588 mRNA Translation: AAI01589.1
CCDSiCCDS5869.1
RefSeqiNP_061853.1, NM_018980.2
UniGeneiHs.675370

Genome annotation databases

EnsembliENST00000247883; ENSP00000247883; ENSG00000127366
GeneIDi54429
KEGGihsa:54429
UCSCiuc003vwr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227132 Genomic DNA Translation: AAF43905.1
AY724966 Genomic DNA Translation: AAU21159.1
AC004979 Genomic DNA Translation: AAS02040.1
BC069509 mRNA Translation: AAH69509.1
BC101586 mRNA Translation: AAI01587.1
BC101588 mRNA Translation: AAI01589.1
CCDSiCCDS5869.1
RefSeqiNP_061853.1, NM_018980.2
UniGeneiHs.675370

3D structure databases

ProteinModelPortaliQ9NYW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NYW4, 5 interactors
STRINGi9606.ENSP00000247883

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYW4
PhosphoSitePlusiQ9NYW4

Polymorphism and mutation databases

BioMutaiTAS2R5
DMDMi29839664

Proteomic databases

PaxDbiQ9NYW4
PeptideAtlasiQ9NYW4
PRIDEiQ9NYW4
ProteomicsDBi83290

Protocols and materials databases

DNASUi54429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247883; ENSP00000247883; ENSG00000127366
GeneIDi54429
KEGGihsa:54429
UCSCiuc003vwr.2 human

Organism-specific databases

CTDi54429
EuPathDBiHostDB:ENSG00000127366.5
GeneCardsiTAS2R5
HGNCiHGNC:14912 TAS2R5
MIMi605062 gene
neXtProtiNX_Q9NYW4
OpenTargetsiENSG00000127366
PharmGKBiPA37924
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQ4 Eukaryota
ENOG41119UC LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098555
InParanoidiQ9NYW4
KOiK08474
OMAiCRFLLQW
OrthoDBiEOG091G0FNQ
PhylomeDBiQ9NYW4
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

GeneWikiiTAS2R5
GenomeRNAii54429
PROiPR:Q9NYW4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127366 Expressed in 89 organ(s), highest expression level in right uterine tube
CleanExiHS_TAS2R5
ExpressionAtlasiQ9NYW4 baseline and differential
GenevisibleiQ9NYW4 HS

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R5_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW4
Secondary accession number(s): Q645W0, Q75MV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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