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Protein

Taste receptor type 2 member 7

Gene

TAS2R7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
Taste receptor family B member 4
Short name:
TRB4
Gene namesi
Name:TAS2R7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121377.2
HGNCiHGNC:14913 TAS2R7
MIMi604793 gene
neXtProtiNX_Q9NYW3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 55CytoplasmicSequence analysisAdd BLAST25
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 128CytoplasmicSequence analysisAdd BLAST13
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 187ExtracellularSequence analysisAdd BLAST38
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 266ExtracellularSequence analysis10
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 318CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121377
PharmGKBiPA37925

Polymorphism and mutation databases

BioMutaiTAS2R7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822201 – 318Taste receptor type 2 member 7Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW3
PRIDEiQ9NYW3
ProteomicsDBi83289
TopDownProteomicsiQ9NYW3

PTM databases

iPTMnetiQ9NYW3
PhosphoSitePlusiQ9NYW3

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000121377 Expressed in 1 organ(s), highest expression level in Ammon's horn
CleanExiHS_TAS2R7
GenevisibleiQ9NYW3 HS

Interactioni

Protein-protein interaction databases

BioGridi119147, 17 interactors
STRINGi9606.ENSP00000240687

Structurei

3D structure databases

ProteinModelPortaliQ9NYW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAT Eukaryota
ENOG410YQIB LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW3
KOiK08474
OMAiTSSYFMP
OrthoDBiEOG091G0G0Q
PhylomeDBiQ9NYW3
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
IPR030053 TAS2R7
PANTHERiPTHR11394:SF58 PTHR11394:SF58, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS
60 70 80 90 100
LAISRICLLC VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA
110 120 130 140 150
TCLSIYYFFK IGNFFHPLFL WMKWRIDRVI SWILLGCVVL SVFISLPATE
160 170 180 190 200
NLNADFRFCV KAKRKTNLTW SCRVNKTQHA STKLFLNLAT LLPFCVCLMS
210 220 230 240 250
FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF LLLFIAYYLS
260 270 280 290 300
FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI
310
WKVMSILKGR KFQQHKQI
Length:318
Mass (Da):36,550
Last modified:October 1, 2000 - v1
Checksum:iF187ADB2D8274B8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062084263T → M. Corresponds to variant dbSNP:rs11838055Ensembl.1
Natural variantiVAR_021852263T → S. Corresponds to variant dbSNP:rs3759251Ensembl.1
Natural variantiVAR_024185304M → I. Corresponds to variant dbSNP:rs619381Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227133 Genomic DNA Translation: AAF43906.1
AY724936 Genomic DNA Translation: AAU21138.1
BC069091 mRNA Translation: AAH69091.1
BC093992 mRNA Translation: AAH93992.1
BC113561 mRNA Translation: AAI13562.1
CCDSiCCDS8631.1
RefSeqiNP_076408.1, NM_023919.2
UniGeneiHs.533754

Genome annotation databases

EnsembliENST00000240687; ENSP00000240687; ENSG00000121377
ENST00000574656; ENSP00000458498; ENSG00000273326
ENST00000613239; ENSP00000484743; ENSG00000274327
GeneIDi50837
KEGGihsa:50837
UCSCiuc001qyv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227133 Genomic DNA Translation: AAF43906.1
AY724936 Genomic DNA Translation: AAU21138.1
BC069091 mRNA Translation: AAH69091.1
BC093992 mRNA Translation: AAH93992.1
BC113561 mRNA Translation: AAI13562.1
CCDSiCCDS8631.1
RefSeqiNP_076408.1, NM_023919.2
UniGeneiHs.533754

3D structure databases

ProteinModelPortaliQ9NYW3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119147, 17 interactors
STRINGi9606.ENSP00000240687

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYW3
PhosphoSitePlusiQ9NYW3

Polymorphism and mutation databases

BioMutaiTAS2R7

Proteomic databases

PaxDbiQ9NYW3
PRIDEiQ9NYW3
ProteomicsDBi83289
TopDownProteomicsiQ9NYW3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240687; ENSP00000240687; ENSG00000121377
ENST00000574656; ENSP00000458498; ENSG00000273326
ENST00000613239; ENSP00000484743; ENSG00000274327
GeneIDi50837
KEGGihsa:50837
UCSCiuc001qyv.3 human

Organism-specific databases

CTDi50837
EuPathDBiHostDB:ENSG00000121377.2
GeneCardsiTAS2R7
HGNCiHGNC:14913 TAS2R7
MIMi604793 gene
neXtProtiNX_Q9NYW3
OpenTargetsiENSG00000121377
PharmGKBiPA37925
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAT Eukaryota
ENOG410YQIB LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW3
KOiK08474
OMAiTSSYFMP
OrthoDBiEOG091G0G0Q
PhylomeDBiQ9NYW3
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

GeneWikiiTAS2R7
GenomeRNAii50837
PROiPR:Q9NYW3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121377 Expressed in 1 organ(s), highest expression level in Ammon's horn
CleanExiHS_TAS2R7
GenevisibleiQ9NYW3 HS

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
IPR030053 TAS2R7
PANTHERiPTHR11394:SF58 PTHR11394:SF58, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R7_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW3
Secondary accession number(s): Q645Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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