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Protein

Taste receptor type 2 member 8

Gene

TAS2R8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 8
Short name:
T2R8
Alternative name(s):
Taste receptor family B member 5
Short name:
TRB5
Gene namesi
Name:TAS2R8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121314.2
HGNCiHGNC:14915 TAS2R8
MIMi604794 gene
neXtProtiNX_Q9NYW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 50CytoplasmicSequence analysisAdd BLAST22
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 82ExtracellularSequence analysisAdd BLAST11
Transmembranei83 – 103Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini104 – 131CytoplasmicSequence analysisAdd BLAST28
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 184ExtracellularSequence analysisAdd BLAST32
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 239CytoplasmicSequence analysisAdd BLAST34
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 266ExtracellularSequence analysis6
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121314
PharmGKBiPA37926

Chemistry databases

ChEMBLiCHEMBL3988599

Polymorphism and mutation databases

BioMutaiTAS2R8
DMDMi29839662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822271 – 309Taste receptor type 2 member 8Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW2
PeptideAtlasiQ9NYW2
PRIDEiQ9NYW2
ProteomicsDBi83288

PTM databases

iPTMnetiQ9NYW2
PhosphoSitePlusiQ9NYW2

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000121314 Expressed in 2 organ(s), highest expression level in heart
CleanExiHS_TAS2R8
GenevisibleiQ9NYW2 HS

Interactioni

Protein-protein interaction databases

BioGridi119146, 1 interactor
IntActiQ9NYW2, 1 interactor
STRINGi9606.ENSP00000240615

Chemistry databases

BindingDBiQ9NYW2

Structurei

3D structure databases

ProteinModelPortaliQ9NYW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAT Eukaryota
ENOG410YQIB LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW2
KOiK08474
OMAiNWIDWIK
OrthoDBiEOG091G0G0Q
PhylomeDBiQ9NYW2
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSPADNIFI ILITGEFILG ILGNGYIALV NWIDWIKKKK ISTVDYILTN
60 70 80 90 100
LVIARICLIS VMVVNGIVIV LNPDVYTKNK QQIVIFTFWT FANYLNMWIT
110 120 130 140 150
TCLNVFYFLK IASSSHPLFL WLKWKIDMVV HWILLGCFAI SLLVSLIAAI
160 170 180 190 200
VLSCDYRFHA IAKHKRNITE MFHVSKIPYF EPLTLFNLFA IVPFIVSLIS
210 220 230 240 250
FFLLVRSLWR HTKQIKLYAT GSRDPSTEVH VRAIKTMTSF IFFFFLYYIS
260 270 280 290 300
SILMTFSYLM TKYKLAVEFG EIAAILYPLG HSLILIVLNN KLRQTFVRML

TCRKIACMI
Length:309
Mass (Da):35,877
Last modified:October 1, 2000 - v1
Checksum:i5E3D94B726A52413
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024186308M → V1 PublicationCorresponds to variant dbSNP:rs2537817Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227134 Genomic DNA Translation: AAF43907.1
AY724935 Genomic DNA Translation: AAU21137.1
BC069084 mRNA Translation: AAH69084.1
BC069551 mRNA Translation: AAH69551.1
BC096701 mRNA Translation: AAH96701.1
BC096735 mRNA Translation: AAH96735.1
BC098353 mRNA Translation: AAH98353.1
CCDSiCCDS8632.1
RefSeqiNP_076407.1, NM_023918.1
UniGeneiHs.533755

Genome annotation databases

EnsembliENST00000240615; ENSP00000240615; ENSG00000121314
ENST00000572823; ENSP00000461158; ENSG00000272712
ENST00000610444; ENSP00000484163; ENSG00000277316
GeneIDi50836
KEGGihsa:50836
UCSCiuc010shh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227134 Genomic DNA Translation: AAF43907.1
AY724935 Genomic DNA Translation: AAU21137.1
BC069084 mRNA Translation: AAH69084.1
BC069551 mRNA Translation: AAH69551.1
BC096701 mRNA Translation: AAH96701.1
BC096735 mRNA Translation: AAH96735.1
BC098353 mRNA Translation: AAH98353.1
CCDSiCCDS8632.1
RefSeqiNP_076407.1, NM_023918.1
UniGeneiHs.533755

3D structure databases

ProteinModelPortaliQ9NYW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119146, 1 interactor
IntActiQ9NYW2, 1 interactor
STRINGi9606.ENSP00000240615

Chemistry databases

BindingDBiQ9NYW2
ChEMBLiCHEMBL3988599

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYW2
PhosphoSitePlusiQ9NYW2

Polymorphism and mutation databases

BioMutaiTAS2R8
DMDMi29839662

Proteomic databases

PaxDbiQ9NYW2
PeptideAtlasiQ9NYW2
PRIDEiQ9NYW2
ProteomicsDBi83288

Protocols and materials databases

DNASUi50836
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240615; ENSP00000240615; ENSG00000121314
ENST00000572823; ENSP00000461158; ENSG00000272712
ENST00000610444; ENSP00000484163; ENSG00000277316
GeneIDi50836
KEGGihsa:50836
UCSCiuc010shh.3 human

Organism-specific databases

CTDi50836
EuPathDBiHostDB:ENSG00000121314.2
GeneCardsiTAS2R8
HGNCiHGNC:14915 TAS2R8
MIMi604794 gene
neXtProtiNX_Q9NYW2
OpenTargetsiENSG00000121314
PharmGKBiPA37926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAT Eukaryota
ENOG410YQIB LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW2
KOiK08474
OMAiNWIDWIK
OrthoDBiEOG091G0G0Q
PhylomeDBiQ9NYW2
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

GeneWikiiTAS2R8
GenomeRNAii50836
PROiPR:Q9NYW2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121314 Expressed in 2 organ(s), highest expression level in heart
CleanExiHS_TAS2R8
GenevisibleiQ9NYW2 HS

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R8_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW2
Secondary accession number(s): Q4KN29, Q645Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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