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Entry version 148 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Taste receptor type 2 member 9

Gene

TAS2R9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).By similarity

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NYW1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Taste receptor type 2 member 9
Short name:
T2R9
Alternative name(s):
Taste receptor family B member 6
Short name:
TRB6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAS2R9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121381.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14917, TAS2R9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604795, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 32Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini33 – 52CytoplasmicSequence analysisAdd BLAST20
Transmembranei53 – 72Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini73 – 86ExtracellularSequence analysisAdd BLAST14
Transmembranei87 – 109Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini110 – 128CytoplasmicSequence analysisAdd BLAST19
Transmembranei129 – 146Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini147 – 180ExtracellularSequence analysisAdd BLAST34
Transmembranei181 – 203Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini204 – 234CytoplasmicSequence analysisAdd BLAST31
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 261ExtracellularSequence analysis4
Transmembranei262 – 284Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini285 – 312CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50835

Open Targets

More...
OpenTargetsi
ENSG00000121381

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37927

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYW1, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3309110

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAS2R9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29839661

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000822321 – 312Taste receptor type 2 member 9Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYW1

PeptideAtlas

More...
PeptideAtlasi
Q9NYW1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYW1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83287

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NYW1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121381, Expressed in sural nerve and 9 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYW1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000121381, Tissue enhanced (enhanced)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240691

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NYW1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NYW1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SY8P, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186648

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072337_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYW1

KEGG Orthology (KO)

More...
KOi
K08474

Identification of Orthologs from Complete Genome Data

More...
OMAi
IGIWGNG

Database of Orthologous Groups

More...
OrthoDBi
1010573at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYW1

TreeFam database of animal gene trees

More...
TreeFami
TF335891

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017452, GPCR_Rhodpsn_7TM
IPR007960, T2R

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05296, TAS2R, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NYW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS
60 70 80 90 100
LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT
110 120 130 140 150
SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND
160 170 180 190 200
DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL
210 220 230 240 250
LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV
260 270 280 290 300
MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
310
KCFLRRRKPF VP
Length:312
Mass (Da):35,611
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCE66F1E31051F49
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053345170K → Q. Corresponds to variant dbSNP:rs11054043Ensembl.1
Natural variantiVAR_020204187V → A2 PublicationsCorresponds to variant dbSNP:rs3741845Ensembl.1
Natural variantiVAR_053346238L → V. Corresponds to variant dbSNP:rs11054042Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF227135 Genomic DNA Translation: AAF43908.1
AY724954 Genomic DNA Translation: AAU21150.1
BC069066 mRNA Translation: AAH69066.1
BC095519 mRNA Translation: AAH95519.1
AB199063 Genomic DNA Translation: BAD97966.1
AB199064 Genomic DNA Translation: BAD97967.1
AB199065 Genomic DNA Translation: BAD97968.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8633.1

NCBI Reference Sequences

More...
RefSeqi
NP_076406.1, NM_023917.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240691; ENSP00000240691; ENSG00000121381
ENST00000573524; ENSP00000460247; ENSG00000273086
ENST00000616297; ENSP00000480069; ENSG00000273713

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50835

UCSC genome browser

More...
UCSCi
uc001qyx.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA Translation: AAF43908.1
AY724954 Genomic DNA Translation: AAU21150.1
BC069066 mRNA Translation: AAH69066.1
BC095519 mRNA Translation: AAH95519.1
AB199063 Genomic DNA Translation: BAD97966.1
AB199064 Genomic DNA Translation: BAD97967.1
AB199065 Genomic DNA Translation: BAD97968.1
CCDSiCCDS8633.1
RefSeqiNP_076406.1, NM_023917.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000240691

Chemistry databases

BindingDBiQ9NYW1
ChEMBLiCHEMBL3309110

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniQ9NYW1, 1 site
iPTMnetiQ9NYW1
PhosphoSitePlusiQ9NYW1

Polymorphism and mutation databases

BioMutaiTAS2R9
DMDMi29839661

Proteomic databases

PaxDbiQ9NYW1
PeptideAtlasiQ9NYW1
PRIDEiQ9NYW1
ProteomicsDBi83287

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23398, 101 antibodies

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381
ENST00000573524; ENSP00000460247; ENSG00000273086
ENST00000616297; ENSP00000480069; ENSG00000273713
GeneIDi50835
KEGGihsa:50835
UCSCiuc001qyx.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50835
DisGeNETi50835
EuPathDBiHostDB:ENSG00000121381.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAS2R9
HGNCiHGNC:14917, TAS2R9
HPAiENSG00000121381, Tissue enhanced (enhanced)
MIMi604795, gene
neXtProtiNX_Q9NYW1
OpenTargetsiENSG00000121381
PharmGKBiPA37927

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SY8P, Eukaryota
GeneTreeiENSGT00960000186648
HOGENOMiCLU_072337_3_0_1
InParanoidiQ9NYW1
KOiK08474
OMAiIGIWGNG
OrthoDBi1010573at2759
PhylomeDBiQ9NYW1
TreeFamiTF335891

Enzyme and pathway databases

PathwayCommonsiQ9NYW1
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
50835, 2 hits in 863 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAS2R9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50835
PharosiQ9NYW1, Tdark

Protein Ontology

More...
PROi
PR:Q9NYW1
RNActiQ9NYW1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121381, Expressed in sural nerve and 9 other tissues
GenevisibleiQ9NYW1, HS

Family and domain databases

InterProiView protein in InterPro
IPR017452, GPCR_Rhodpsn_7TM
IPR007960, T2R
PfamiView protein in Pfam
PF05296, TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTA2R9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7
, Q50KT0, Q50KT1, Q645W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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