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Protein

Taste receptor type 2 member 10

Gene

TAS2R10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.1 Publication

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 10
Short name:
T2R10
Alternative name(s):
Taste receptor family B member 2
Short name:
TRB2
Gene namesi
Name:TAS2R10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121318.2
HGNCiHGNC:14918 TAS2R10
MIMi604791 gene
neXtProtiNX_Q9NYW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini28 – 42CytoplasmicSequence analysisAdd BLAST15
Transmembranei43 – 63Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini64 – 100ExtracellularSequence analysisAdd BLAST37
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 126CytoplasmicSequence analysis5
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 179ExtracellularSequence analysisAdd BLAST32
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 227CytoplasmicSequence analysisAdd BLAST27
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 257ExtracellularSequence analysis9
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 307CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50839
OpenTargetsiENSG00000121318
PharmGKBiPA37928

Polymorphism and mutation databases

BioMutaiTAS2R10
DMDMi311033532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822381 – 307Taste receptor type 2 member 10Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW0
PeptideAtlasiQ9NYW0
PRIDEiQ9NYW0
ProteomicsDBi83286

PTM databases

iPTMnetiQ9NYW0
PhosphoSitePlusiQ9NYW0

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000121318
CleanExiHS_TAS2R10
GenevisibleiQ9NYW0 HS

Interactioni

Protein-protein interaction databases

IntActiQ9NYW0, 4 interactors
STRINGi9606.ENSP00000240619

Structurei

3D structure databases

ProteinModelPortaliQ9NYW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMNH Eukaryota
ENOG410Z4AM LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW0
KOiK08474
OMAiLIISLWR
OrthoDBiEOG091G0KU9
PhylomeDBiQ9NYW0
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL
60 70 80 90 100
AISRIFLIWI IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT
110 120 130 140 150
SLSIFYFLKI ANFSNYIFLW LKSRTNMVLP FMIVFLLISS LLNFAYIAKI
160 170 180 190 200
LNDYKTKNDT VWDLNMYKSE YFIKQILLNL GVIFFFTLSL ITCIFLIISL
210 220 230 240 250
WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF IGMAIEISCF
260 270 280 290 300
TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK

RKNLRVT
Length:307
Mass (Da):35,365
Last modified:November 2, 2010 - v3
Checksum:i058DD69A55AE71C6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030009156T → M2 PublicationsCorresponds to variant dbSNP:rs597468Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227136 Genomic DNA Translation: AAF43909.1
AY724946 Genomic DNA Translation: AAU21148.1
AC006518 Genomic DNA No translation available.
BC069089 mRNA Translation: AAH69089.1
BC101762 mRNA Translation: AAI01763.1
BC101764 mRNA Translation: AAI01765.1
CCDSiCCDS8634.1
RefSeqiNP_076410.1, NM_023921.1
UniGeneiHs.533756

Genome annotation databases

EnsembliENST00000240619; ENSP00000240619; ENSG00000121318
ENST00000576159; ENSP00000461683; ENSG00000272805
ENST00000611256; ENSP00000482990; ENSG00000277238
GeneIDi50839
KEGGihsa:50839
UCSCiuc001qyy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT2R10_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW0
Secondary accession number(s): Q3MIM9, Q6NTD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 2, 2010
Last modified: July 18, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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