Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Taste receptor type 2 member 16

Gene

TAS2R16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.2 Publications

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.
Confers bitter perception of salicin to non-taster mice.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Gene namesi
Name:TAS2R16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128519.3
HGNCiHGNC:14921 TAS2R16
MIMi604867 gene
neXtProtiNX_Q9NYV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 41CytoplasmicSequence analysisAdd BLAST19
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 125CytoplasmicSequence analysisAdd BLAST20
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 182ExtracellularSequence analysisAdd BLAST36
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 228CytoplasmicSequence analysisAdd BLAST25
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 291CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50833
MalaCardsiTAS2R16
MIMi617956 phenotype
OpenTargetsiENSG00000128519
PharmGKBiPA37931

Chemistry databases

ChEMBLiCHEMBL3309106

Polymorphism and mutation databases

BioMutaiTAS2R16
DMDMi29839657

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822621 – 291Taste receptor type 2 member 16Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYV7
PeptideAtlasiQ9NYV7
PRIDEiQ9NYV7
ProteomicsDBi83283

PTM databases

iPTMnetiQ9NYV7
PhosphoSitePlusiQ9NYV7

Expressioni

Tissue specificityi

Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).1 Publication

Gene expression databases

BgeeiENSG00000128519 Expressed in 6 organ(s), highest expression level in muscle tissue
CleanExiHS_TAS2R16
GenevisibleiQ9NYV7 HS

Interactioni

Subunit structurei

Interacts with RTP3 and RTP4.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000249284

Chemistry databases

BindingDBiQ9NYV7

Structurei

3D structure databases

ProteinModelPortaliQ9NYV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNW Eukaryota
ENOG41119UD LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098568
InParanoidiQ9NYV7
KOiK08474
OMAiCVTIIPS
OrthoDBiEOG091G0HIR
PhylomeDBiQ9NYV7
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI
60 70 80 90 100
SLGISRFCLQ WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT
110 120 130 140 150
VFYCIKVSSF THHIFLWLRW RILRLFPWIL LGSLMITCVT IIPSAIGNYI
160 170 180 190 200
QIQLLTMEHL PRNSTVTDKL ENFHQYQFQA HTVALVIPFI LFLASTIFLM
210 220 230 240 250
ASLTKQIQHH STGHCNPSMK ARFTALRSLA VLFIVFTSYF LTILITIIGT
260 270 280 290
LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C
Length:291
Mass (Da):33,986
Last modified:October 1, 2000 - v1
Checksum:i0693085F23D57D73
GO

Polymorphismi

Genetic variation in TAS2R16 influences sensitivity to beta-glucopyranoside tasting [MIMi:617956]. Variant Asn-172 results in greater receptor activation in response to bitter beta-glucopyranoside compounds including salicin, arbutin and amygdalin compared to Lys-172 (PubMed:16051168). Variant Lys-172 may influence risk of alcohol dependence (PubMed:16385453).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080835101V → M1 Publication1
Natural variantiVAR_080836114I → V1 Publication1
Natural variantiVAR_080837116L → P1 Publication1
Natural variantiVAR_080838161P → S1 Publication1
Natural variantiVAR_034539172N → K Associated with susceptibility to alcoholism. 2 PublicationsCorresponds to variant dbSNP:rs846664EnsemblClinVar.1
Natural variantiVAR_080839177Q → P1 Publication1
Natural variantiVAR_080840216N → D1 Publication1
Natural variantiVAR_080841221A → V1 Publication1
Natural variantiVAR_020205222R → H4 PublicationsCorresponds to variant dbSNP:rs860170Ensembl.1
Natural variantiVAR_080842235V → M1 Publication1
Natural variantiVAR_080843240F → V1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227139 Genomic DNA Translation: AAF43912.1
AY724962 Genomic DNA Translation: AAU21158.1
AC004838 Genomic DNA Translation: AAP21892.1
CH236947 Genomic DNA Translation: EAL24338.1
BC095524 mRNA Translation: AAH95524.1
CCDSiCCDS5785.1
RefSeqiNP_058641.1, NM_016945.2
UniGeneiHs.272395

Genome annotation databases

EnsembliENST00000249284; ENSP00000249284; ENSG00000128519
GeneIDi50833
KEGGihsa:50833
UCSCiuc003vkl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227139 Genomic DNA Translation: AAF43912.1
AY724962 Genomic DNA Translation: AAU21158.1
AC004838 Genomic DNA Translation: AAP21892.1
CH236947 Genomic DNA Translation: EAL24338.1
BC095524 mRNA Translation: AAH95524.1
CCDSiCCDS5785.1
RefSeqiNP_058641.1, NM_016945.2
UniGeneiHs.272395

3D structure databases

ProteinModelPortaliQ9NYV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000249284

Chemistry databases

BindingDBiQ9NYV7
ChEMBLiCHEMBL3309106

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYV7
PhosphoSitePlusiQ9NYV7

Polymorphism and mutation databases

BioMutaiTAS2R16
DMDMi29839657

Proteomic databases

PaxDbiQ9NYV7
PeptideAtlasiQ9NYV7
PRIDEiQ9NYV7
ProteomicsDBi83283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249284; ENSP00000249284; ENSG00000128519
GeneIDi50833
KEGGihsa:50833
UCSCiuc003vkl.2 human

Organism-specific databases

CTDi50833
DisGeNETi50833
EuPathDBiHostDB:ENSG00000128519.3
GeneCardsiTAS2R16
HGNCiHGNC:14921 TAS2R16
MalaCardsiTAS2R16
MIMi604867 gene
617956 phenotype
neXtProtiNX_Q9NYV7
OpenTargetsiENSG00000128519
PharmGKBiPA37931
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKNW Eukaryota
ENOG41119UD LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098568
InParanoidiQ9NYV7
KOiK08474
OMAiCVTIIPS
OrthoDBiEOG091G0HIR
PhylomeDBiQ9NYV7
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

GeneWikiiTAS2R16
GenomeRNAii50833
PROiPR:Q9NYV7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128519 Expressed in 6 organ(s), highest expression level in muscle tissue
CleanExiHS_TAS2R16
GenevisibleiQ9NYV7 HS

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2R16_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV7
Secondary accession number(s): A4D0X2
, Q502V3, Q549U8, Q645W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again