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Entry version 129 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

RNA polymerase I-specific transcription initiation factor RRN3

Gene

RRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NYV6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN3
Alternative name(s):
Transcription initiation factor IA
Short name:
TIF-IA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RRN3
Synonyms:TIFIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30346 RRN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605121 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi411 – 415Missing : Abolishes interaction with TAF1B and TAF1C. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
54700

Open Targets

More...
OpenTargetsi
ENSG00000085721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134878601

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RRN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74719591

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114261 – 651RNA polymerase I-specific transcription initiation factor RRN3Add BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei170PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei200Phosphothreonine; by MAPK91 Publication1
Modified residuei640PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NYV6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NYV6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYV6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYV6

PeptideAtlas

More...
PeptideAtlasi
Q9NYV6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYV6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
5679
5920
61783
83282 [Q9NYV6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085721 Expressed in 208 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYV6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120102, 32 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NYV6

Protein interaction database and analysis system

More...
IntActi
Q9NYV6, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9NYV6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000198767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYV6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni500 – 651Interaction with TWISTNB1 PublicationAdd BLAST152
Regioni557 – 651Interaction with EIF3L1 PublicationAdd BLAST95

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRN3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2434 Eukaryota
ENOG410XRJJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236344

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYV6

KEGG Orthology (KO)

More...
KOi
K15216

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLKVCSP

Database of Orthologous Groups

More...
OrthoDBi
855834at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYV6

TreeFam database of animal gene trees

More...
TreeFami
TF312979

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007991 RNA_pol_I_trans_ini_fac_RRN3

The PANTHER Classification System

More...
PANTHERi
PTHR12790 PTHR12790, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05327 RRN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV
60 70 80 90 100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM
110 120 130 140 150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM
160 170 180 190 200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST
210 220 230 240 250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK
260 270 280 290 300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP
310 320 330 340 350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI
360 370 380 390 400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR
410 420 430 440 450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV
460 470 480 490 500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN
510 520 530 540 550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ
560 570 580 590 600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI
610 620 630 640 650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP

L
Length:651
Mass (Da):74,107
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC646DC6677C49895
GO
Isoform 2 (identifier: Q9NYV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-305: DEDEETEHETKAGPERLDQ → VSSLLMKVEMKFIIKGGNS
     306-651: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):34,472
Checksum:i1745373E5CC8CE7B
GO
Isoform 3 (identifier: Q9NYV6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:618
Mass (Da):70,876
Checksum:i1D119D4C3DADB659
GO
Isoform 4 (identifier: Q9NYV6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.
     223-255: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):53,315
Checksum:iFCAE200CD69B3663
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H148F5H148_HUMAN
RNA polymerase I-specific transcrip...
RRN3
621Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMT1H3BMT1_HUMAN
RNA polymerase I-specific transcrip...
RRN3
638Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051886348I → M. Corresponds to variant dbSNP:rs2941256Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565191 – 149Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_0565201 – 33Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_056521223 – 255Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_056338287 – 305DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_056339306 – 651Missing in isoform 2. 1 PublicationAdd BLAST346

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ272050 mRNA Translation: CAC07955.1
AF227156 mRNA Translation: AAF66160.1
AK303405 mRNA Translation: BAG64459.1
AK304856 mRNA Translation: BAG65594.1
AK314769 mRNA Translation: BAG37307.1
AC139256 Genomic DNA No translation available.
CH471301 Genomic DNA Translation: EAW54754.1
BC071868 mRNA Translation: AAH71868.1
BC104660 mRNA Translation: AAI04661.1
BC132688 mRNA Translation: AAI32689.1
BC132690 mRNA Translation: AAI32691.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10559.1 [Q9NYV6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060897.3, NM_018427.4 [Q9NYV6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000198767; ENSP00000198767; ENSG00000085721 [Q9NYV6-1]
ENST00000327307; ENSP00000318484; ENSG00000085721 [Q9NYV6-3]
ENST00000564131; ENSP00000454238; ENSG00000085721 [Q9NYV6-2]
ENST00000616334; ENSP00000480743; ENSG00000278494 [Q9NYV6-1]
ENST00000632541; ENSP00000488651; ENSG00000278494 [Q9NYV6-3]
ENST00000634151; ENSP00000487821; ENSG00000278494 [Q9NYV6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54700

UCSC genome browser

More...
UCSCi
uc002dde.4 human [Q9NYV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272050 mRNA Translation: CAC07955.1
AF227156 mRNA Translation: AAF66160.1
AK303405 mRNA Translation: BAG64459.1
AK304856 mRNA Translation: BAG65594.1
AK314769 mRNA Translation: BAG37307.1
AC139256 Genomic DNA No translation available.
CH471301 Genomic DNA Translation: EAW54754.1
BC071868 mRNA Translation: AAH71868.1
BC104660 mRNA Translation: AAI04661.1
BC132688 mRNA Translation: AAI32689.1
BC132690 mRNA Translation: AAI32691.1
CCDSiCCDS10559.1 [Q9NYV6-1]
RefSeqiNP_060897.3, NM_018427.4 [Q9NYV6-1]

3D structure databases

SMRiQ9NYV6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120102, 32 interactors
CORUMiQ9NYV6
IntActiQ9NYV6, 4 interactors
MINTiQ9NYV6
STRINGi9606.ENSP00000198767

PTM databases

iPTMnetiQ9NYV6
PhosphoSitePlusiQ9NYV6

Polymorphism and mutation databases

BioMutaiRRN3
DMDMi74719591

Proteomic databases

EPDiQ9NYV6
jPOSTiQ9NYV6
MaxQBiQ9NYV6
PaxDbiQ9NYV6
PeptideAtlasiQ9NYV6
PRIDEiQ9NYV6
ProteomicsDBi5679
5920
61783
83282 [Q9NYV6-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54700
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000198767; ENSP00000198767; ENSG00000085721 [Q9NYV6-1]
ENST00000327307; ENSP00000318484; ENSG00000085721 [Q9NYV6-3]
ENST00000564131; ENSP00000454238; ENSG00000085721 [Q9NYV6-2]
ENST00000616334; ENSP00000480743; ENSG00000278494 [Q9NYV6-1]
ENST00000632541; ENSP00000488651; ENSG00000278494 [Q9NYV6-3]
ENST00000634151; ENSP00000487821; ENSG00000278494 [Q9NYV6-2]
GeneIDi54700
KEGGihsa:54700
UCSCiuc002dde.4 human [Q9NYV6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54700
DisGeNETi54700

GeneCards: human genes, protein and diseases

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GeneCardsi
RRN3
HGNCiHGNC:30346 RRN3
HPAiHPA049837
MIMi605121 gene
neXtProtiNX_Q9NYV6
OpenTargetsiENSG00000085721
PharmGKBiPA134878601

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2434 Eukaryota
ENOG410XRJJ LUCA
GeneTreeiENSGT00390000001488
HOGENOMiHOG000236344
InParanoidiQ9NYV6
KOiK15216
OMAiPLKVCSP
OrthoDBi855834at2759
PhylomeDBiQ9NYV6
TreeFamiTF312979

Enzyme and pathway databases

ReactomeiR-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
SIGNORiQ9NYV6

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RRN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54700

Protein Ontology

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PROi
PR:Q9NYV6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000085721 Expressed in 208 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9NYV6 baseline and differential
GenevisibleiQ9NYV6 HS

Family and domain databases

InterProiView protein in InterPro
IPR007991 RNA_pol_I_trans_ini_fac_RRN3
PANTHERiPTHR12790 PTHR12790, 1 hit
PfamiView protein in Pfam
PF05327 RRN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYV6
Secondary accession number(s): A2RTY9
, B4E0J7, B4E3T2, Q3MHU9, Q6IPL4, Q9H4F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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