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Protein

UDP-glucose:glycoprotein glucosyltransferase 1

Gene

UGGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.1 Publication

Cofactori

Ca2+1 Publication, Mn2+1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-901032 ER Quality Control Compartment (ERQC)
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 1 (EC:2.4.1.-)
Short name:
UGT1
Short name:
hUGT1
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:UGGT1
Synonyms:GT, UGCGL1, UGGT, UGT11 Publication, UGTRBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136731.12
HGNCiHGNC:15663 UGGT1
MIMi605897 gene
neXtProtiNX_Q9NYU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1452 – 1457Missing : Inactive. 6
Mutagenesisi1452D → A: Inactive. 1 Publication1
Mutagenesisi1453Q → A: 4% active. 1 Publication1
Mutagenesisi1454D → A: Inactive. 1 Publication1
Mutagenesisi1455L → A: 2% active. 1 Publication1
Mutagenesisi1456P → A: 41% active. 1 Publication1
Mutagenesisi1457N → A: 7% active. 1 Publication1

Organism-specific databases

DisGeNETi56886
OpenTargetsiENSG00000136731
PharmGKBiPA38014

Polymorphism and mutation databases

BioMutaiUGGT1
DMDMi224471872

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42By similarityAdd BLAST42
ChainiPRO_000001227143 – 1555UDP-glucose:glycoprotein glucosyltransferase 1Add BLAST1513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1228N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1277PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NYU2
MaxQBiQ9NYU2
PaxDbiQ9NYU2
PeptideAtlasiQ9NYU2
PRIDEiQ9NYU2
ProteomicsDBi83277
83278 [Q9NYU2-2]

PTM databases

iPTMnetiQ9NYU2
PhosphoSitePlusiQ9NYU2
SwissPalmiQ9NYU2

Expressioni

Tissue specificityi

Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.1 Publication

Inductioni

By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment.1 Publication

Gene expression databases

BgeeiENSG00000136731
CleanExiHS_UGCGL1
ExpressionAtlasiQ9NYU2 baseline and differential
GenevisibleiQ9NYU2 HS

Organism-specific databases

HPAiHPA012761
HPA015127

Interactioni

Subunit structurei

Monomer as well as in a tight complex with SELENOF (By similarity). Interacts with METTL23.By similarity1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121217, 62 interactors
IntActiQ9NYU2, 36 interactors
STRINGi9606.ENSP00000259253

Structurei

3D structure databases

ProteinModelPortaliQ9NYU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1244 – 1555GlucosyltransferaseBy similarityAdd BLAST312

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1552 – 1555Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.By similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1879 Eukaryota
ENOG410XRK6 LUCA
GeneTreeiENSGT00390000004600
HOGENOMiHOG000184622
HOVERGENiHBG079469
InParanoidiQ9NYU2
KOiK11718
OMAiTEMEGFR
OrthoDBiEOG091G010F
PhylomeDBiQ9NYU2
TreeFamiTF300320

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF06427 UDP-g_GGTase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCKGDASGA CAAGALPVTG VCYKMGVLVV LTVLWLFSSV KADSKAITTS
60 70 80 90 100
LTTKWFSTPL LLEASEFLAE DSQEKFWNFV EASQNIGSSD HDGTDYSYYH
110 120 130 140 150
AILEAAFQFL SPLQQNLFKF CLSLRSYSAT IQAFQQIAAD EPPPEGCNSF
160 170 180 190 200
FSVHGKKTCE SDTLEALLLT ASERPKPLLF KGDHRYPSSN PESPVVIFYS
210 220 230 240 250
EIGSEEFSNF HRQLISKSNA GKINYVFRHY IFNPRKEPVY LSGYGVELAI
260 270 280 290 300
KSTEYKAKDD TQVKGTEVNT TVIGENDPID EVQGFLFGKL RDLHPDLEGQ
310 320 330 340 350
LKELRKHLVE STNEMAPLKV WQLQDLSFQT AARILASPVE LALVVMKDLS
360 370 380 390 400
QNFPTKARAI TKTAVSSELR TEVEENQKYF KGTLGLQPGD SALFINGLHM
410 420 430 440 450
DLDTQDIFSL FDVLRNEARV MEGLHRLGIE GLSLHNVLKL NIQPSEADYA
460 470 480 490 500
VDIRSPAISW VNNLEVDSRY NSWPSSLQEL LRPTFPGVIR QIRKNLHNMV
510 520 530 540 550
FIVDPAHETT AELMNTAEMF LSNHIPLRIG FIFVVNDSED VDGMQDAGVA
560 570 580 590 600
VLRAYNYVAQ EVDDYHAFQT LTHIYNKVRT GEKVKVEHVV SVLEKKYPYV
610 620 630 640 650
EVNSILGIDS AYDRNRKEAR GYYEQTGVGP LPVVLFNGMP FEREQLDPDE
660 670 680 690 700
LETITMHKIL ETTTFFQRAV YLGELPHDQD VVEYIMNQPN VVPRINSRIL
710 720 730 740 750
TAERDYLDLT ASNNFFVDDY ARFTILDSQG KTAAVANSMN YLTKKGMSSK
760 770 780 790 800
EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD AIKHQKSSNN VRISMINNPA
810 820 830 840 850
KEISYENTQI SRAIWAALQT QTSNAAKNFI TKMAKEGAAE ALAAGADIAE
860 870 880 890 900
FSVGGMDFSL FKEVFESSKM DFILSHAVYC RDVLKLKKGQ RAVISNGRII
910 920 930 940 950
GPLEDSELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV
960 970 980 990 1000
DALLSAQPKG DPRIEYQFFE DRHSAIKLRP KEGETYFDVV AVVDPVTREA
1010 1020 1030 1040 1050
QRLAPLLLVL AQLINMNLRV FMNCQSKLSD MPLKSFYRYV LEPEISFTSD
1060 1070 1080 1090 1100
NSFAKGPIAK FLDMPQSPLF TLNLNTPESW MVESVRTPYD LDNIYLEEVD
1110 1120 1130 1140 1150
SVVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP VIVDTIVMAN
1160 1170 1180 1190 1200
LGYFQLKANP GAWILRLRKG RSEDIYRIYS HDGTDSPPDA DEVVIVLNNF
1210 1220 1230 1240 1250
KSKIIKVKVQ KKADMVNEDL LSDGTSENES GFWDSFKWGF TGQKTEEVKQ
1260 1270 1280 1290 1300
DKDDIINIFS VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK
1310 1320 1330 1340 1350
EFIPYMANEY NFQYELVQYK WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV
1360 1370 1380 1390 1400
VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY GYTPFCDSRR EMDGYRFWKS
1410 1420 1430 1440 1450
GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG LSQDPNSLSN
1460 1470 1480 1490 1500
LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE
1510 1520 1530 1540 1550
PKLEAAVRIV PEWQDYDQEI KQLQIRFQKE KETGALYKEK TKEPSREGPQ

KREEL
Length:1,555
Mass (Da):177,190
Last modified:March 3, 2009 - v3
Checksum:i0A5274A4A65152D3
GO
Isoform 2 (identifier: Q9NYU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:1,531
Mass (Da):174,977
Checksum:iC3EDD499D6043569
GO

Sequence cautioni

The sequence AAY14885 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB14632 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1487A → T in BAB14632 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365081 – 24Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227905 mRNA Translation: AAF66232.1
AC017079 Genomic DNA Translation: AAY14735.1
AC108059 Genomic DNA Translation: AAY14885.1 Sequence problems.
BC041098 mRNA Translation: AAH41098.1
AK023671 mRNA Translation: BAB14632.1 Different initiation.
CCDSiCCDS2154.1 [Q9NYU2-1]
RefSeqiNP_064505.1, NM_020120.3 [Q9NYU2-1]
UniGeneiHs.743306

Genome annotation databases

EnsembliENST00000259253; ENSP00000259253; ENSG00000136731 [Q9NYU2-1]
GeneIDi56886
KEGGihsa:56886
UCSCiuc002tps.4 human [Q9NYU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUGGG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYU2
Secondary accession number(s): Q53QP2
, Q53SL3, Q8IW30, Q9H8I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 3, 2009
Last modified: July 18, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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