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Protein

UDP-glucose:glycoprotein glucosyltransferase 2

Gene

UGGT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).By similarity

Caution

Has no enzymatic activity towards unfolded RNase B or thyroglobulin.1 Publication

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-901032 ER Quality Control Compartment (ERQC)
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 2 (EC:2.4.1.-)
Short name:
UGT2
Short name:
hUGT2
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase 2
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:UGGT2
Synonyms:UGCGL2, UGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102595.18
HGNCiHGNC:15664 UGGT2
MIMi605898 gene
neXtProtiNX_Q9NYU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi55757
OpenTargetsiENSG00000102595
PharmGKBiPA38015

Polymorphism and mutation databases

BioMutaiUGGT2
DMDMi311033544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001227428 – 1516UDP-glucose:glycoprotein glucosyltransferase 2Add BLAST1489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi950N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1289PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NYU1
MaxQBiQ9NYU1
PaxDbiQ9NYU1
PeptideAtlasiQ9NYU1
PRIDEiQ9NYU1
ProteomicsDBi83276

PTM databases

GlyConnecti1872
iPTMnetiQ9NYU1
PhosphoSitePlusiQ9NYU1

Expressioni

Tissue specificityi

Higher levels in kidney, pancreas, heart, and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000102595 Expressed in 207 organ(s), highest expression level in intestine
CleanExiHS_UGCGL2
ExpressionAtlasiQ9NYU1 baseline and differential
GenevisibleiQ9NYU1 HS

Organism-specific databases

HPAiHPA047955

Interactioni

Subunit structurei

Interacts with METTL23.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-1054215,EBI-743771

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120875, 13 interactors
IntActiQ9NYU1, 7 interactors
MINTiQ9NYU1
STRINGi9606.ENSP00000365938

Structurei

3D structure databases

ProteinModelPortaliQ9NYU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1220 – 1516GlucosyltransferaseAdd BLAST297

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1513 – 1516Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1879 Eukaryota
ENOG410XRK6 LUCA
GeneTreeiENSGT00390000004600
HOGENOMiHOG000184622
HOVERGENiHBG079469
InParanoidiQ9NYU1
KOiK11718
OMAiKSEDIYQ
OrthoDBiEOG091G010F
PhylomeDBiQ9NYU1
TreeFamiTF300320

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
PF06427 UDP-g_GGTase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAKATNVV RLLLGSTALW LSQLGSGTVA ASKSVTAHLA AKWPETPLLL
60 70 80 90 100
EASEFMAEES NEKFWQFLET VQELAIYKQT ESDYSYYNLI LKKAGQFLDN
110 120 130 140 150
LHINLLKFAF SIRAYSPAIQ MFQQIAADEP PPDGCNAFVV IHKKHTCKIN
160 170 180 190 200
EIKKLLKKAA SRTRPYLFKG DHKFPTNKEN LPVVILYAEM GTRTFSAFHK
210 220 230 240 250
VLSEKAQNEE ILYVLRHYIQ KPSSRKMYLS GYGVELAIKS TEYKALDDTQ
260 270 280 290 300
VKTVTNTTVE DETETNEVQG FLFGKLKEIY SDLRDNLTAF QKYLIESNKQ
310 320 330 340 350
MMPLKVWELQ DLSFQAASQI MSAPVYDSIK LMKDISQNFP IKARSLTRIA
360 370 380 390 400
VNQHMREEIK ENQKDLQVRF KIQPGDARLF INGLRVDMDV YDAFSILDML
410 420 430 440 450
KLEGKMMNGL RNLGINGEDM SKFLKLNSHI WEYTYVLDIR HSSIMWINDL
460 470 480 490 500
ENDDLYITWP TSCQKLLKPV FPGSVPSIRR NFHNLVLFID PAQEYTLDFI
510 520 530 540 550
KLADVFYSHE VPLRIGFVFI LNTDDEVDGA NDAGVALWRA FNYIAEEFDI
560 570 580 590 600
SEAFISIVHM YQKVKKDQNI LTVDNVKSVL QNTFPHANIW DILGIHSKYD
610 620 630 640 650
EERKAGASFY KMTGLGPLPQ ALYNGEPFKH EEMNIKELKM AVLQRMMDAS
660 670 680 690 700
VYLQREVFLG TLNDRTNAID FLMDRNNVVP RINTLILRTN QQYLNLISTS
710 720 730 740 750
VTADVEDFST FFFLDSQDKS AVIAKNMYYL TQDDESIISA VTLWIIADFD
760 770 780 790 800
KPSGRKLLFN ALKHMKTSVH SRLGIIYNPT SKINEENTAI SRGILAAFLT
810 820 830 840 850
QKNMFLRSFL GQLAKEEIAT AIYSGDKIKT FLIEGMDKNA FEKKYNTVGV
860 870 880 890 900
NIFRTHQLFC QDVLKLRPGE MGIVSNGRFL GPLDEDFYAE DFYLLEKITF
910 920 930 940 950
SNLGEKIKGI VENMGINANN MSDFIMKVDA LMSSVPKRAS RYDVTFLREN
960 970 980 990 1000
HSVIKTNPQE NDMFFNVIAI VDPLTREAQK MAQLLVVLGK IINMKIKLFM
1010 1020 1030 1040 1050
NCRGRLSEAP LESFYRFVLE PELMSGANDV SSLGPVAKFL DIPESPLLIL
1060 1070 1080 1090 1100
NMITPEGWLV ETVHSNCDLD NIHLKDTEKT VTAEYELEYL LLEGQCFDKV
1110 1120 1130 1140 1150
TEQPPRGLQF TLGTKNKPAV VDTIVMAHHG YFQLKANPGA WILRLHQGKS
1160 1170 1180 1190 1200
EDIYQIVGHE GTDSQADLED IIVVLNSFKS KILKVKVKKE TDKIKEDILT
1210 1220 1230 1240 1250
DEDEKTKGLW DSIKSFTVSL HKENKKEKDV LNIFSVASGH LYERFLRIMM
1260 1270 1280 1290 1300
LSVLRNTKTP VKFWLLKNYL SPTFKEVIPH MAKEYGFRYE LVQYRWPRWL
1310 1320 1330 1340 1350
RQQTERQRII WGYKILFLDV LFPLAVDKII FVDADQIVRH DLKELRDFDL
1360 1370 1380 1390 1400
DGAPYGYTPF CDSRREMDGY RFWKTGYWAS HLLRRKYHIS ALYVVDLKKF
1410 1420 1430 1440 1450
RRIGAGDRLR SQYQALSQDP NSLSNLDQDL PNNMIYQVAI KSLPQDWLWC
1460 1470 1480 1490 1500
ETWCDDESKQ RAKTIDLCNN PKTKESKLKA AARIVPEWVE YDAEIRQLLD
1510
HLENKKQDTI LTHDEL
Length:1,516
Mass (Da):174,735
Last modified:November 2, 2010 - v4
Checksum:iBD216896ECA54E4F
GO
Isoform 2 (identifier: Q9NYU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: E → S
     279-1516: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):31,425
Checksum:i8B2126D4F7309389
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NP03A6NP03_HUMAN
UDP-glucose:glycoprotein glucosyltr...
UGGT2
280Annotation score:
E7EMU6E7EMU6_HUMAN
UDP-glucose:glycoprotein glucosyltr...
UGGT2
372Annotation score:
A0A1W2PQ18A0A1W2PQ18_HUMAN
UDP-glucose:glycoprotein glucosyltr...
UGGT2
280Annotation score:
A0A087WYR2A0A087WYR2_HUMAN
UDP-glucose:glycoprotein glucosyltr...
UGGT2
278Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030006323A → T1 PublicationCorresponds to variant dbSNP:rs12863903Ensembl.1
Natural variantiVAR_030007328S → A3 PublicationsCorresponds to variant dbSNP:rs816142Ensembl.1
Natural variantiVAR_055849821A → T1 PublicationCorresponds to variant dbSNP:rs33949518Ensembl.1
Natural variantiVAR_061196865K → R. Corresponds to variant dbSNP:rs35060832Ensembl.1
Natural variantiVAR_055850924F → I. Corresponds to variant dbSNP:rs35780499Ensembl.1
Natural variantiVAR_030008994M → L2 PublicationsCorresponds to variant dbSNP:rs12876018Ensembl.1
Natural variantiVAR_0558511274F → L. Corresponds to variant dbSNP:rs9525072Ensembl.1
Natural variantiVAR_0611971285Y → F. Corresponds to variant dbSNP:rs35123499Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056319278E → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_056320279 – 1516Missing in isoform 2. 1 PublicationAdd BLAST1238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA Translation: AAF66233.2
AL136104 Genomic DNA No translation available.
AL158192 Genomic DNA No translation available.
AL607038 Genomic DNA No translation available.
AL162500 Genomic DNA No translation available.
BC032302 mRNA Translation: AAH32302.1
BC125233 mRNA Translation: AAI25234.1
AL133051 mRNA Translation: CAB61378.1
CCDSiCCDS9480.1 [Q9NYU1-1]
PIRiT42654
RefSeqiNP_064506.3, NM_020121.3 [Q9NYU1-1]
UniGeneiHs.193226
Hs.656444

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595 [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595 [Q9NYU1-1]
ENST00000621375; ENSP00000482021; ENSG00000102595 [Q9NYU1-2]
GeneIDi55757
KEGGihsa:55757
UCSCiuc001vmt.5 human [Q9NYU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA Translation: AAF66233.2
AL136104 Genomic DNA No translation available.
AL158192 Genomic DNA No translation available.
AL607038 Genomic DNA No translation available.
AL162500 Genomic DNA No translation available.
BC032302 mRNA Translation: AAH32302.1
BC125233 mRNA Translation: AAI25234.1
AL133051 mRNA Translation: CAB61378.1
CCDSiCCDS9480.1 [Q9NYU1-1]
PIRiT42654
RefSeqiNP_064506.3, NM_020121.3 [Q9NYU1-1]
UniGeneiHs.193226
Hs.656444

3D structure databases

ProteinModelPortaliQ9NYU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120875, 13 interactors
IntActiQ9NYU1, 7 interactors
MINTiQ9NYU1
STRINGi9606.ENSP00000365938

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

PTM databases

GlyConnecti1872
iPTMnetiQ9NYU1
PhosphoSitePlusiQ9NYU1

Polymorphism and mutation databases

BioMutaiUGGT2
DMDMi311033544

Proteomic databases

EPDiQ9NYU1
MaxQBiQ9NYU1
PaxDbiQ9NYU1
PeptideAtlasiQ9NYU1
PRIDEiQ9NYU1
ProteomicsDBi83276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595 [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595 [Q9NYU1-1]
ENST00000621375; ENSP00000482021; ENSG00000102595 [Q9NYU1-2]
GeneIDi55757
KEGGihsa:55757
UCSCiuc001vmt.5 human [Q9NYU1-1]

Organism-specific databases

CTDi55757
DisGeNETi55757
EuPathDBiHostDB:ENSG00000102595.18
GeneCardsiUGGT2
H-InvDBiHIX0011410
HGNCiHGNC:15664 UGGT2
HPAiHPA047955
MIMi605898 gene
neXtProtiNX_Q9NYU1
OpenTargetsiENSG00000102595
PharmGKBiPA38015
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1879 Eukaryota
ENOG410XRK6 LUCA
GeneTreeiENSGT00390000004600
HOGENOMiHOG000184622
HOVERGENiHBG079469
InParanoidiQ9NYU1
KOiK11718
OMAiKSEDIYQ
OrthoDBiEOG091G010F
PhylomeDBiQ9NYU1
TreeFamiTF300320

Enzyme and pathway databases

UniPathwayi
UPA00378

ReactomeiR-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRSiUGGT2 human
GenomeRNAii55757
PROiPR:Q9NYU1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102595 Expressed in 207 organ(s), highest expression level in intestine
CleanExiHS_UGCGL2
ExpressionAtlasiQ9NYU1 baseline and differential
GenevisibleiQ9NYU1 HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
PF06427 UDP-g_GGTase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUGGG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYU1
Secondary accession number(s): A6NKL4
, Q08AD0, Q5JQR8, Q8N5K0, Q9UFC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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