Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 226

Gene

ZNF226

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 226
Gene namesi
Name:ZNF226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167380.16
HGNCiHGNC:13019 ZNF226
neXtProtiNX_Q9NYT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167380
PharmGKBiPA37598

Polymorphism and mutation databases

BioMutaiZNF226
DMDMi20178347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474671 – 803Zinc finger protein 226Add BLAST803

Proteomic databases

EPDiQ9NYT6
MaxQBiQ9NYT6
PaxDbiQ9NYT6
PeptideAtlasiQ9NYT6
PRIDEiQ9NYT6
ProteomicsDBi83275

PTM databases

iPTMnetiQ9NYT6
PhosphoSitePlusiQ9NYT6

Expressioni

Gene expression databases

BgeeiENSG00000167380 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF226
ExpressionAtlasiQ9NYT6 baseline and differential
GenevisibleiQ9NYT6 HS

Organism-specific databases

HPAiCAB034353
HPA006145

Interactioni

Protein-protein interaction databases

BioGridi113552, 3 interactors
STRINGi9606.ENSP00000336719

Structurei

3D structure databases

ProteinModelPortaliQ9NYT6
SMRiQ9NYT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NYT6
KOiK09228
OMAiHRVHKSE
OrthoDBiEOG091G02KC
PhylomeDBiQ9NYT6
TreeFamiTF350845

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 17 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP
60 70 80 90 100
PFKQDVSPIE RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC
110 120 130 140 150
WQIWQQIAND LTRCQDSMIN NSQCHKQGDF PYQVGTELSI QISEDENYIV
160 170 180 190 200
NKADGPNNTG NPEFPILRTQ DSWRKTFLTE SQRLNRDQQI SIKNKLCQCK
210 220 230 240 250
KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD HNSMIHTGQK
260 270 280 290 300
SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK
310 320 330 340 350
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL
360 370 380 390 400
NVHCKVHTAE KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF
410 420 430 440 450
SRNSHLQSHQ RVHTGEKPYK CEECGKGFIC SSNLYIHQRV HTGEKPYKCE
460 470 480 490 500
ECGKGFSRPS SLQAHQGVHT GEKSYICTVC GKGFTLSSNL QAHQRVHTGE
510 520 530 540 550
KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF SQSSYLQIHQ
560 570 580 590 600
KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA
610 620 630 640 650
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK
660 670 680 690 700
SFGRSAHLQA HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK
710 720 730 740 750
CGECGKYFSQ ASSLQLHQSV HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT
760 770 780 790 800
GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD KSYKSNRGGK NIRESTQEKK

SIK
Length:803
Mass (Da):91,921
Last modified:April 16, 2002 - v2
Checksum:i256DE75551A932A8
GO
Isoform 2 (identifier: Q9NYT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-94: GEKNQSKLITVQDRES → DTLLVKALLLYDLAQT
     95-803: Missing.

Note: No experimental confirmation available.
Show »
Length:94
Mass (Da):10,797
Checksum:i8CEB536281389870
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPU4K7EPU4_HUMAN
Zinc finger protein 226
ZNF226
60Annotation score:
K7EKQ6K7EKQ6_HUMAN
Zinc finger protein 226
ZNF226
72Annotation score:
K7EL77K7EL77_HUMAN
Zinc finger protein 226
ZNF226
66Annotation score:
K7EQC3K7EQC3_HUMAN
Zinc finger protein 226
ZNF226
153Annotation score:
K7ELM4K7ELM4_HUMAN
Zinc finger protein 226
ZNF226
139Annotation score:
K7ESM6K7ESM6_HUMAN
Zinc finger protein 226
ZNF226
127Annotation score:
K7EK05K7EK05_HUMAN
Zinc finger protein 226
ZNF226
89Annotation score:
K7ELA3K7ELA3_HUMAN
Zinc finger protein 226
ZNF226
89Annotation score:
K7ERY1K7ERY1_HUMAN
Zinc finger protein 226
ZNF226
27Annotation score:
K7EJ66K7EJ66_HUMAN
Zinc finger protein 226
ZNF226
114Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195K → E in AAF34786 (PubMed:12743021).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04685379 – 94GEKNQ…QDRES → DTLLVKALLLYDLAQT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04685495 – 803Missing in isoform 2. 1 PublicationAdd BLAST709

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228418 mRNA Translation: AAF34786.1
AK023091 mRNA Translation: BAB14398.1
AC074331 Genomic DNA Translation: AAF88103.1
AC138470 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57259.1
BC017786 mRNA Translation: AAH17786.1
BC024197 mRNA Translation: AAH24197.1
CCDSiCCDS46102.1 [Q9NYT6-1]
CCDS46103.1 [Q9NYT6-2]
RefSeqiNP_001027544.1, NM_001032372.1 [Q9NYT6-1]
NP_001027545.1, NM_001032373.1 [Q9NYT6-1]
NP_001027546.1, NM_001032374.1 [Q9NYT6-2]
NP_001139692.1, NM_001146220.2 [Q9NYT6-2]
NP_001306017.1, NM_001319088.1 [Q9NYT6-1]
NP_001306018.1, NM_001319089.1 [Q9NYT6-1]
NP_001306019.1, NM_001319090.1 [Q9NYT6-1]
NP_057003.2, NM_015919.3 [Q9NYT6-2]
NP_057528.2, NM_016444.2 [Q9NYT6-1]
XP_005259284.1, XM_005259227.2 [Q9NYT6-1]
XP_006723430.1, XM_006723367.3 [Q9NYT6-1]
XP_006723431.1, XM_006723368.3 [Q9NYT6-1]
XP_006723432.1, XM_006723369.2 [Q9NYT6-1]
XP_016882751.1, XM_017027262.1 [Q9NYT6-1]
XP_016882754.1, XM_017027265.1 [Q9NYT6-2]
UniGeneiHs.145956

Genome annotation databases

EnsembliENST00000300823; ENSP00000300823; ENSG00000167380 [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380 [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380 [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380 [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380 [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380 [Q9NYT6-1]
GeneIDi7769
KEGGihsa:7769
UCSCiuc002oyn.4 human [Q9NYT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228418 mRNA Translation: AAF34786.1
AK023091 mRNA Translation: BAB14398.1
AC074331 Genomic DNA Translation: AAF88103.1
AC138470 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57259.1
BC017786 mRNA Translation: AAH17786.1
BC024197 mRNA Translation: AAH24197.1
CCDSiCCDS46102.1 [Q9NYT6-1]
CCDS46103.1 [Q9NYT6-2]
RefSeqiNP_001027544.1, NM_001032372.1 [Q9NYT6-1]
NP_001027545.1, NM_001032373.1 [Q9NYT6-1]
NP_001027546.1, NM_001032374.1 [Q9NYT6-2]
NP_001139692.1, NM_001146220.2 [Q9NYT6-2]
NP_001306017.1, NM_001319088.1 [Q9NYT6-1]
NP_001306018.1, NM_001319089.1 [Q9NYT6-1]
NP_001306019.1, NM_001319090.1 [Q9NYT6-1]
NP_057003.2, NM_015919.3 [Q9NYT6-2]
NP_057528.2, NM_016444.2 [Q9NYT6-1]
XP_005259284.1, XM_005259227.2 [Q9NYT6-1]
XP_006723430.1, XM_006723367.3 [Q9NYT6-1]
XP_006723431.1, XM_006723368.3 [Q9NYT6-1]
XP_006723432.1, XM_006723369.2 [Q9NYT6-1]
XP_016882751.1, XM_017027262.1 [Q9NYT6-1]
XP_016882754.1, XM_017027265.1 [Q9NYT6-2]
UniGeneiHs.145956

3D structure databases

ProteinModelPortaliQ9NYT6
SMRiQ9NYT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113552, 3 interactors
STRINGi9606.ENSP00000336719

PTM databases

iPTMnetiQ9NYT6
PhosphoSitePlusiQ9NYT6

Polymorphism and mutation databases

BioMutaiZNF226
DMDMi20178347

Proteomic databases

EPDiQ9NYT6
MaxQBiQ9NYT6
PaxDbiQ9NYT6
PeptideAtlasiQ9NYT6
PRIDEiQ9NYT6
ProteomicsDBi83275

Protocols and materials databases

DNASUi7769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300823; ENSP00000300823; ENSG00000167380 [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380 [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380 [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380 [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380 [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380 [Q9NYT6-1]
GeneIDi7769
KEGGihsa:7769
UCSCiuc002oyn.4 human [Q9NYT6-1]

Organism-specific databases

CTDi7769
EuPathDBiHostDB:ENSG00000167380.16
GeneCardsiZNF226
HGNCiHGNC:13019 ZNF226
HPAiCAB034353
HPA006145
neXtProtiNX_Q9NYT6
OpenTargetsiENSG00000167380
PharmGKBiPA37598
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NYT6
KOiK09228
OMAiHRVHKSE
OrthoDBiEOG091G02KC
PhylomeDBiQ9NYT6
TreeFamiTF350845

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF226 human
GenomeRNAii7769
PROiPR:Q9NYT6

Gene expression databases

BgeeiENSG00000167380 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF226
ExpressionAtlasiQ9NYT6 baseline and differential
GenevisibleiQ9NYT6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 17 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN226_HUMAN
AccessioniPrimary (citable) accession number: Q9NYT6
Secondary accession number(s): Q8WWE6, Q96TE6, Q9NS44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 16, 2002
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again