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Entry version 177 (26 Feb 2020)
Sequence version 2 (16 Apr 2002)
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Protein

Zinc finger protein 226

Gene

ZNF226

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 226
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF226
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13019 ZNF226

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYT6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000167380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYT6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF226

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20178347

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474671 – 803Zinc finger protein 226Add BLAST803

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NYT6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NYT6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NYT6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYT6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYT6

PeptideAtlas

More...
PeptideAtlasi
Q9NYT6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYT6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74878
83275 [Q9NYT6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167380 Expressed in corpus callosum and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYT6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYT6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034353
HPA006145

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113552, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NYT6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000465121

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NYT6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYT6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162119

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYT6

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRPNDYE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYT6

TreeFam database of animal gene trees

More...
TreeFami
TF350845

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP
60 70 80 90 100
PFKQDVSPIE RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC
110 120 130 140 150
WQIWQQIAND LTRCQDSMIN NSQCHKQGDF PYQVGTELSI QISEDENYIV
160 170 180 190 200
NKADGPNNTG NPEFPILRTQ DSWRKTFLTE SQRLNRDQQI SIKNKLCQCK
210 220 230 240 250
KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD HNSMIHTGQK
260 270 280 290 300
SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK
310 320 330 340 350
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL
360 370 380 390 400
NVHCKVHTAE KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF
410 420 430 440 450
SRNSHLQSHQ RVHTGEKPYK CEECGKGFIC SSNLYIHQRV HTGEKPYKCE
460 470 480 490 500
ECGKGFSRPS SLQAHQGVHT GEKSYICTVC GKGFTLSSNL QAHQRVHTGE
510 520 530 540 550
KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF SQSSYLQIHQ
560 570 580 590 600
KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA
610 620 630 640 650
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK
660 670 680 690 700
SFGRSAHLQA HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK
710 720 730 740 750
CGECGKYFSQ ASSLQLHQSV HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT
760 770 780 790 800
GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD KSYKSNRGGK NIRESTQEKK

SIK
Length:803
Mass (Da):91,921
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i256DE75551A932A8
GO
Isoform 2 (identifier: Q9NYT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-94: GEKNQSKLITVQDRES → DTLLVKALLLYDLAQT
     95-803: Missing.

Show »
Length:94
Mass (Da):10,797
Checksum:i8CEB536281389870
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL77K7EL77_HUMAN
Zinc finger protein 226
ZNF226
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPU4K7EPU4_HUMAN
Zinc finger protein 226
ZNF226
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESM6K7ESM6_HUMAN
Zinc finger protein 226
ZNF226
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKQ6K7EKQ6_HUMAN
Zinc finger protein 226
ZNF226
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELA3K7ELA3_HUMAN
Zinc finger protein 226
ZNF226
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELM4K7ELM4_HUMAN
Zinc finger protein 226
ZNF226
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQC3K7EQC3_HUMAN
Zinc finger protein 226
ZNF226
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK05K7EK05_HUMAN
Zinc finger protein 226
ZNF226
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERY1K7ERY1_HUMAN
Zinc finger protein 226
ZNF226
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ66K7EJ66_HUMAN
Zinc finger protein 226
ZNF226
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195K → E in AAF34786 (PubMed:12743021).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04685379 – 94GEKNQ…QDRES → DTLLVKALLLYDLAQT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04685495 – 803Missing in isoform 2. 1 PublicationAdd BLAST709

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF228418 mRNA Translation: AAF34786.1
AK023091 mRNA Translation: BAB14398.1
AC074331 Genomic DNA Translation: AAF88103.1
AC138470 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57259.1
BC017786 mRNA Translation: AAH17786.1
BC024197 mRNA Translation: AAH24197.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46102.1 [Q9NYT6-1]
CCDS46103.1 [Q9NYT6-2]

NCBI Reference Sequences

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RefSeqi
NP_001027544.1, NM_001032372.1 [Q9NYT6-1]
NP_001027545.1, NM_001032373.1 [Q9NYT6-1]
NP_001027546.1, NM_001032374.1 [Q9NYT6-2]
NP_001139692.1, NM_001146220.2 [Q9NYT6-2]
NP_001306017.1, NM_001319088.1 [Q9NYT6-1]
NP_001306018.1, NM_001319089.1 [Q9NYT6-1]
NP_001306019.1, NM_001319090.1 [Q9NYT6-1]
NP_057003.2, NM_015919.3 [Q9NYT6-2]
NP_057528.2, NM_016444.2 [Q9NYT6-1]
XP_005259284.1, XM_005259227.2 [Q9NYT6-1]
XP_006723430.1, XM_006723367.3 [Q9NYT6-1]
XP_006723431.1, XM_006723368.3 [Q9NYT6-1]
XP_006723432.1, XM_006723369.2 [Q9NYT6-1]
XP_016882751.1, XM_017027262.1 [Q9NYT6-1]
XP_016882754.1, XM_017027265.1 [Q9NYT6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300823; ENSP00000300823; ENSG00000167380 [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380 [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380 [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380 [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380 [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380 [Q9NYT6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7769

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7769

UCSC genome browser

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UCSCi
uc002oyn.4 human [Q9NYT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228418 mRNA Translation: AAF34786.1
AK023091 mRNA Translation: BAB14398.1
AC074331 Genomic DNA Translation: AAF88103.1
AC138470 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57259.1
BC017786 mRNA Translation: AAH17786.1
BC024197 mRNA Translation: AAH24197.1
CCDSiCCDS46102.1 [Q9NYT6-1]
CCDS46103.1 [Q9NYT6-2]
RefSeqiNP_001027544.1, NM_001032372.1 [Q9NYT6-1]
NP_001027545.1, NM_001032373.1 [Q9NYT6-1]
NP_001027546.1, NM_001032374.1 [Q9NYT6-2]
NP_001139692.1, NM_001146220.2 [Q9NYT6-2]
NP_001306017.1, NM_001319088.1 [Q9NYT6-1]
NP_001306018.1, NM_001319089.1 [Q9NYT6-1]
NP_001306019.1, NM_001319090.1 [Q9NYT6-1]
NP_057003.2, NM_015919.3 [Q9NYT6-2]
NP_057528.2, NM_016444.2 [Q9NYT6-1]
XP_005259284.1, XM_005259227.2 [Q9NYT6-1]
XP_006723430.1, XM_006723367.3 [Q9NYT6-1]
XP_006723431.1, XM_006723368.3 [Q9NYT6-1]
XP_006723432.1, XM_006723369.2 [Q9NYT6-1]
XP_016882751.1, XM_017027262.1 [Q9NYT6-1]
XP_016882754.1, XM_017027265.1 [Q9NYT6-2]

3D structure databases

SMRiQ9NYT6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113552, 4 interactors
IntActiQ9NYT6, 1 interactor
STRINGi9606.ENSP00000465121

PTM databases

iPTMnetiQ9NYT6
PhosphoSitePlusiQ9NYT6

Polymorphism and mutation databases

BioMutaiZNF226
DMDMi20178347

Proteomic databases

EPDiQ9NYT6
jPOSTiQ9NYT6
MassIVEiQ9NYT6
MaxQBiQ9NYT6
PaxDbiQ9NYT6
PeptideAtlasiQ9NYT6
PRIDEiQ9NYT6
ProteomicsDBi74878
83275 [Q9NYT6-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7769

Genome annotation databases

EnsembliENST00000300823; ENSP00000300823; ENSG00000167380 [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380 [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380 [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380 [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380 [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380 [Q9NYT6-1]
GeneIDi7769
KEGGihsa:7769
UCSCiuc002oyn.4 human [Q9NYT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7769

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF226
HGNCiHGNC:13019 ZNF226
HPAiCAB034353
HPA006145
neXtProtiNX_Q9NYT6
OpenTargetsiENSG00000167380
PharmGKBiPA37598

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162119
HOGENOMiCLU_002678_17_1_1
InParanoidiQ9NYT6
KOiK09228
OMAiYRPNDYE
OrthoDBi1318335at2759
PhylomeDBiQ9NYT6
TreeFamiTF350845

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF226 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7769
PharosiQ9NYT6 Tdark

Protein Ontology

More...
PROi
PR:Q9NYT6
RNActiQ9NYT6 protein

Gene expression databases

BgeeiENSG00000167380 Expressed in corpus callosum and 208 other tissues
ExpressionAtlasiQ9NYT6 baseline and differential
GenevisibleiQ9NYT6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN226_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYT6
Secondary accession number(s): Q8WWE6, Q96TE6, Q9NS44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 16, 2002
Last modified: February 26, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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