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Protein

Pleckstrin-2

Gene

PLEK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:PLEK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100558.8
HGNCiHGNC:19238 PLEK2
MIMi608007 gene
neXtProtiNX_Q9NYT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26499
OpenTargetsiENSG00000100558
PharmGKBiPA134963543

Polymorphism and mutation databases

BioMutaiPLEK2
DMDMi20532216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538621 – 353Pleckstrin-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei120PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NYT0
MaxQBiQ9NYT0
PaxDbiQ9NYT0
PeptideAtlasiQ9NYT0
PRIDEiQ9NYT0
ProteomicsDBi83274

PTM databases

iPTMnetiQ9NYT0
PhosphoSitePlusiQ9NYT0

Expressioni

Gene expression databases

BgeeiENSG00000100558 Expressed in 140 organ(s), highest expression level in right adrenal gland
CleanExiHS_PLEK2
ExpressionAtlasiQ9NYT0 baseline and differential
GenevisibleiQ9NYT0 HS

Organism-specific databases

HPAiHPA001208

Interactioni

Protein-protein interaction databases

BioGridi117708, 4 interactors
STRINGi9606.ENSP00000216446

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NYT0
SMRiQ9NYT0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NYT0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 104PH 1PROSITE-ProRule annotationAdd BLAST101
Domaini139 – 225DEPPROSITE-ProRule annotationAdd BLAST87
Domaini247 – 353PH 2PROSITE-ProRule annotationAdd BLAST107

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2 Eukaryota
ENOG410ZHY3 LUCA
GeneTreeiENSGT00390000006543
HOGENOMiHOG000294078
HOVERGENiHBG001361
InParanoidiQ9NYT0
KOiK19993
OMAiMDWIDAI
OrthoDBiEOG091G09EY
PhylomeDBiQ9NYT0
TreeFamiTF332246

Family and domain databases

CDDicd04444 DEP_PLEK2, 1 hit
Gene3Di1.10.10.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037370 Pleckstrin
IPR037369 PLEK2_DEP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12092 PTHR12092, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NYT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR
60 70 80 90 100
ILLDGCTITC PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT
110 120 130 140 150
GAIHAGQPGK VQQLHSLRNS FKLPPHISLH RIVDKMHDSN TGIRSSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS NSFTASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS TVELSGTVVK
260 270 280 290 300
QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):39,971
Last modified:October 1, 2000 - v1
Checksum:iCE355BF917F2385E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ64H0YJ64_HUMAN
Pleckstrin-2
PLEK2
204Annotation score:
H0YJD0H0YJD0_HUMAN
Pleckstrin-2
PLEK2
127Annotation score:
G3V337G3V337_HUMAN
Pleckstrin-2
PLEK2
77Annotation score:
H0YIZ5H0YIZ5_HUMAN
Pleckstrin-2
PLEK2
117Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05050480T → M. Corresponds to variant dbSNP:rs34300264Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA Translation: AAF34791.1
BC001226 mRNA Translation: AAH01226.1
BC008056 mRNA Translation: AAH08056.2
CCDSiCCDS9782.1
RefSeqiNP_057529.1, NM_016445.2
UniGeneiHs.170473

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558
GeneIDi26499
KEGGihsa:26499
UCSCiuc001xjh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA Translation: AAF34791.1
BC001226 mRNA Translation: AAH01226.1
BC008056 mRNA Translation: AAH08056.2
CCDSiCCDS9782.1
RefSeqiNP_057529.1, NM_016445.2
UniGeneiHs.170473

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1GNMR-A238-353[»]
ProteinModelPortaliQ9NYT0
SMRiQ9NYT0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117708, 4 interactors
STRINGi9606.ENSP00000216446

PTM databases

iPTMnetiQ9NYT0
PhosphoSitePlusiQ9NYT0

Polymorphism and mutation databases

BioMutaiPLEK2
DMDMi20532216

Proteomic databases

EPDiQ9NYT0
MaxQBiQ9NYT0
PaxDbiQ9NYT0
PeptideAtlasiQ9NYT0
PRIDEiQ9NYT0
ProteomicsDBi83274

Protocols and materials databases

DNASUi26499
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558
GeneIDi26499
KEGGihsa:26499
UCSCiuc001xjh.2 human

Organism-specific databases

CTDi26499
DisGeNETi26499
EuPathDBiHostDB:ENSG00000100558.8
GeneCardsiPLEK2
HGNCiHGNC:19238 PLEK2
HPAiHPA001208
MIMi608007 gene
neXtProtiNX_Q9NYT0
OpenTargetsiENSG00000100558
PharmGKBiPA134963543
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGI2 Eukaryota
ENOG410ZHY3 LUCA
GeneTreeiENSGT00390000006543
HOGENOMiHOG000294078
HOVERGENiHBG001361
InParanoidiQ9NYT0
KOiK19993
OMAiMDWIDAI
OrthoDBiEOG091G09EY
PhylomeDBiQ9NYT0
TreeFamiTF332246

Miscellaneous databases

ChiTaRSiPLEK2 human
EvolutionaryTraceiQ9NYT0
GeneWikiiPLEK2
GenomeRNAii26499
PROiPR:Q9NYT0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100558 Expressed in 140 organ(s), highest expression level in right adrenal gland
CleanExiHS_PLEK2
ExpressionAtlasiQ9NYT0 baseline and differential
GenevisibleiQ9NYT0 HS

Family and domain databases

CDDicd04444 DEP_PLEK2, 1 hit
Gene3Di1.10.10.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037370 Pleckstrin
IPR037369 PLEK2_DEP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12092 PTHR12092, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLEK2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYT0
Secondary accession number(s): Q96JT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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