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Protein

NF-kappa-B inhibitor-interacting Ras-like protein 1

Gene

NKIRAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-933542 TRAF6 mediated NF-kB activation
SignaLinkiQ9NYS0

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-interacting Ras-like protein 1
Alternative name(s):
I-kappa-B-interacting Ras-like protein 1
Short name:
Kappa B-Ras protein 1
Short name:
KappaB-Ras1
Gene namesi
Name:NKIRAS1
Synonyms:KBRAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000197885.10
HGNCiHGNC:17899 NKIRAS1
MIMi604496 gene
neXtProtiNX_Q9NYS0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38T → A: Loss of function. 1 Publication1

Organism-specific databases

DisGeNETi28512
OpenTargetsiENSG00000197885
PharmGKBiPA134958823

Polymorphism and mutation databases

BioMutaiNKIRAS1
DMDMi74753075

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256751 – 192NF-kappa-B inhibitor-interacting Ras-like protein 1Add BLAST192

Proteomic databases

EPDiQ9NYS0
MaxQBiQ9NYS0
PaxDbiQ9NYS0
PeptideAtlasiQ9NYS0
PRIDEiQ9NYS0
ProteomicsDBi83272

PTM databases

iPTMnetiQ9NYS0
PhosphoSitePlusiQ9NYS0

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000197885
CleanExiHS_NKIRAS1
ExpressionAtlasiQ9NYS0 baseline and differential
GenevisibleiQ9NYS0 HS

Organism-specific databases

HPAiHPA062521

Interactioni

Subunit structurei

Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).3 Publications

Protein-protein interaction databases

BioGridi118389, 7 interactors
IntActiQ9NYS0, 1 interactor
STRINGi9606.ENSP00000373411

Structurei

3D structure databases

ProteinModelPortaliQ9NYS0
SMRiQ9NYS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 93Interactions with NFKBIA and NFKBIBAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Domaini

In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3883 Eukaryota
ENOG4110VES LUCA
GeneTreeiENSGT00390000006495
HOGENOMiHOG000230991
HOVERGENiHBG105089
InParanoidiQ9NYS0
KOiK17197
OMAiLPKHYYS
OrthoDBiEOG091G0IH8
PhylomeDBiQ9NYS0
TreeFamiTF314483

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD
60 70 80 90 100
RGVKEQLHLY DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL
110 120 130 140 150
KKEIDKFKDK KEVAIVVLGN KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT
160 170 180 190
VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP GRKNKGNSNS EN
Length:192
Mass (Da):21,643
Last modified:October 1, 2000 - v1
Checksum:i84948448BE0853B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95Q → R in BAB55341 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229839 mRNA Translation: AAF34998.1
AK027749 mRNA Translation: BAB55341.1
DQ314881 Genomic DNA Translation: ABC40740.1
BC066940 mRNA Translation: AAH66940.1
BC012145 mRNA Translation: AAH12145.1
CCDSiCCDS33717.1
RefSeqiNP_065078.1, NM_020345.3
XP_005265133.1, XM_005265076.3
XP_005265134.1, XM_005265077.4
XP_005265135.1, XM_005265078.3
UniGeneiHs.173202

Genome annotation databases

EnsembliENST00000388759; ENSP00000373411; ENSG00000197885
ENST00000416026; ENSP00000394214; ENSG00000197885
ENST00000421515; ENSP00000392307; ENSG00000197885
ENST00000425478; ENSP00000400385; ENSG00000197885
ENST00000443659; ENSP00000393785; ENSG00000197885
ENST00000614374; ENSP00000483749; ENSG00000197885
GeneIDi28512
KEGGihsa:28512
UCSCiuc003ccj.4 human

Similar proteinsi

Entry informationi

Entry nameiKBRS1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYS0
Secondary accession number(s): Q96K18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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