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Protein

NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene

NKIRAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-interacting Ras-like protein 2
Alternative name(s):
I-kappa-B-interacting Ras-like protein 2
Short name:
Kappa B-Ras protein 2
Short name:
KappaB-Ras2
Gene namesi
Name:NKIRAS2
Synonyms:KBRAS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168256.17
HGNCiHGNC:17898 NKIRAS2
MIMi604497 gene
neXtProtiNX_Q9NYR9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi28511
OpenTargetsiENSG00000168256
PharmGKBiPA134968907

Polymorphism and mutation databases

BioMutaiNKIRAS2
DMDMi74734716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256791 – 191NF-kappa-B inhibitor-interacting Ras-like protein 2Add BLAST191

Proteomic databases

EPDiQ9NYR9
MaxQBiQ9NYR9
PaxDbiQ9NYR9
PeptideAtlasiQ9NYR9
PRIDEiQ9NYR9
ProteomicsDBi83269
83270 [Q9NYR9-2]
83271 [Q9NYR9-3]

PTM databases

iPTMnetiQ9NYR9
PhosphoSitePlusiQ9NYR9

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000168256 Expressed in 225 organ(s), highest expression level in heart left ventricle
CleanExiHS_NKIRAS2
ExpressionAtlasiQ9NYR9 baseline and differential
GenevisibleiQ9NYR9 HS

Organism-specific databases

HPAiHPA062861

Interactioni

Subunit structurei

Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.1 Publication

Protein-protein interaction databases

BioGridi118388, 14 interactors
IntActiQ9NYR9, 4 interactors
MINTiQ9NYR9
STRINGi9606.ENSP00000303580

Structurei

3D structure databases

ProteinModelPortaliQ9NYR9
SMRiQ9NYR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 191Small GTPase-likeAdd BLAST191

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Domaini

In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3883 Eukaryota
ENOG4110VES LUCA
GeneTreeiENSGT00390000006495
HOGENOMiHOG000230991
HOVERGENiHBG105089
InParanoidiQ9NYR9
KOiK17197
PhylomeDBiQ9NYR9
TreeFamiTF314483

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD
60 70 80 90 100
RGVREQVRFY DTRGLRDGAE LPRHCFSCTD GYVLVYSTDS RESFQRVELL
110 120 130 140 150
KKEIDKSKDK KEVTIVVLGN KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS
160 170 180 190
VADRRSLLEP FVYLASKMTQ PQSKSAFPLS RKNKGSGSLD G
Length:191
Mass (Da):21,508
Last modified:October 1, 2000 - v1
Checksum:i27429230DA563342
GO
Isoform 2 (identifier: Q9NYR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-34: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):21,292
Checksum:i4857EEA02F788F38
GO
Isoform 3 (identifier: Q9NYR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-112: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,910
Checksum:i8B874EC8C7EF28E4
GO
Isoform 4 (identifier: Q9NYR9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-97: VRFYDTRGLR...TDSRESFQRV → IAESLFSVWS...TSVTYRSSGV
     98-191: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):10,770
Checksum:i4049375BE44AF8A5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXP1H7BXP1_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
229Annotation score:
K7ERG2K7ERG2_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
140Annotation score:
K7ELL8K7ELL8_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
58Annotation score:
K7ER26K7ER26_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
46Annotation score:
K7EKE9K7EKE9_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
42Annotation score:
A0A0A0MTA0A0A0A0MTA0_HUMAN
NF-kappa-B inhibitor-interacting Ra...
NKIRAS2
41Annotation score:

Sequence cautioni

The sequence BAB55006 differs from that shown. Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01741233 – 34Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_04315157 – 112Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_04487357 – 97VRFYD…SFQRV → IAESLFSVWSCSRRRLTNPR TRRRSPSWSLATSVTYRSSG V in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04487498 – 191Missing in isoform 4. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229840 mRNA Translation: AAF34999.1
AK027265 mRNA Translation: BAB55006.1 Sequence problems.
AK054571 mRNA Translation: BAG51392.1
AK297975 mRNA Translation: BAG60285.1
DB126967 mRNA No translation available.
AL137682 mRNA Translation: CAB70873.2
DQ314882 Genomic DNA Translation: ABC40741.1
AC105024 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60791.1
BC007450 mRNA Translation: AAH07450.1
BC063498 mRNA Translation: AAH63498.1
CCDSiCCDS11415.1 [Q9NYR9-1]
CCDS45679.1 [Q9NYR9-3]
CCDS45680.1 [Q9NYR9-4]
PIRiT46440
RefSeqiNP_001001349.1, NM_001001349.2 [Q9NYR9-1]
NP_001138399.1, NM_001144927.1 [Q9NYR9-1]
NP_001138400.1, NM_001144928.1 [Q9NYR9-3]
NP_001138401.1, NM_001144929.1 [Q9NYR9-4]
NP_060065.2, NM_017595.5 [Q9NYR9-1]
XP_005257308.1, XM_005257251.1 [Q9NYR9-1]
UniGeneiHs.632252

Genome annotation databases

EnsembliENST00000307641; ENSP00000303580; ENSG00000168256 [Q9NYR9-1]
ENST00000393880; ENSP00000377458; ENSG00000168256 [Q9NYR9-1]
ENST00000393881; ENSP00000377459; ENSG00000168256 [Q9NYR9-1]
ENST00000393885; ENSP00000377463; ENSG00000168256 [Q9NYR9-1]
ENST00000449471; ENSP00000401976; ENSG00000168256 [Q9NYR9-3]
ENST00000479407; ENSP00000465633; ENSG00000168256 [Q9NYR9-4]
GeneIDi28511
KEGGihsa:28511
UCSCiuc002hyq.4 human [Q9NYR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229840 mRNA Translation: AAF34999.1
AK027265 mRNA Translation: BAB55006.1 Sequence problems.
AK054571 mRNA Translation: BAG51392.1
AK297975 mRNA Translation: BAG60285.1
DB126967 mRNA No translation available.
AL137682 mRNA Translation: CAB70873.2
DQ314882 Genomic DNA Translation: ABC40741.1
AC105024 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60791.1
BC007450 mRNA Translation: AAH07450.1
BC063498 mRNA Translation: AAH63498.1
CCDSiCCDS11415.1 [Q9NYR9-1]
CCDS45679.1 [Q9NYR9-3]
CCDS45680.1 [Q9NYR9-4]
PIRiT46440
RefSeqiNP_001001349.1, NM_001001349.2 [Q9NYR9-1]
NP_001138399.1, NM_001144927.1 [Q9NYR9-1]
NP_001138400.1, NM_001144928.1 [Q9NYR9-3]
NP_001138401.1, NM_001144929.1 [Q9NYR9-4]
NP_060065.2, NM_017595.5 [Q9NYR9-1]
XP_005257308.1, XM_005257251.1 [Q9NYR9-1]
UniGeneiHs.632252

3D structure databases

ProteinModelPortaliQ9NYR9
SMRiQ9NYR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118388, 14 interactors
IntActiQ9NYR9, 4 interactors
MINTiQ9NYR9
STRINGi9606.ENSP00000303580

PTM databases

iPTMnetiQ9NYR9
PhosphoSitePlusiQ9NYR9

Polymorphism and mutation databases

BioMutaiNKIRAS2
DMDMi74734716

Proteomic databases

EPDiQ9NYR9
MaxQBiQ9NYR9
PaxDbiQ9NYR9
PeptideAtlasiQ9NYR9
PRIDEiQ9NYR9
ProteomicsDBi83269
83270 [Q9NYR9-2]
83271 [Q9NYR9-3]

Protocols and materials databases

DNASUi28511
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307641; ENSP00000303580; ENSG00000168256 [Q9NYR9-1]
ENST00000393880; ENSP00000377458; ENSG00000168256 [Q9NYR9-1]
ENST00000393881; ENSP00000377459; ENSG00000168256 [Q9NYR9-1]
ENST00000393885; ENSP00000377463; ENSG00000168256 [Q9NYR9-1]
ENST00000449471; ENSP00000401976; ENSG00000168256 [Q9NYR9-3]
ENST00000479407; ENSP00000465633; ENSG00000168256 [Q9NYR9-4]
GeneIDi28511
KEGGihsa:28511
UCSCiuc002hyq.4 human [Q9NYR9-1]

Organism-specific databases

CTDi28511
DisGeNETi28511
EuPathDBiHostDB:ENSG00000168256.17
GeneCardsiNKIRAS2
HGNCiHGNC:17898 NKIRAS2
HPAiHPA062861
MIMi604497 gene
neXtProtiNX_Q9NYR9
OpenTargetsiENSG00000168256
PharmGKBiPA134968907
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3883 Eukaryota
ENOG4110VES LUCA
GeneTreeiENSGT00390000006495
HOGENOMiHOG000230991
HOVERGENiHBG105089
InParanoidiQ9NYR9
KOiK17197
PhylomeDBiQ9NYR9
TreeFamiTF314483

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-933542 TRAF6 mediated NF-kB activation

Miscellaneous databases

ChiTaRSiNKIRAS2 human
GeneWikiiNKIRAS2
GenomeRNAii28511
PROiPR:Q9NYR9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168256 Expressed in 225 organ(s), highest expression level in heart left ventricle
CleanExiHS_NKIRAS2
ExpressionAtlasiQ9NYR9 baseline and differential
GenevisibleiQ9NYR9 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKBRS2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYR9
Secondary accession number(s): A6NCZ5
, B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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