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Entry version 174 (08 May 2019)
Sequence version 2 (18 May 2010)
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Protein

Protocadherin Fat 2

Gene

FAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 2
Short name:
hFat2
Alternative name(s):
Cadherin family member 8
Multiple epidermal growth factor-like domains protein 1
Short name:
Multiple EGF-like domains protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAT2
Synonyms:CDHF8, KIAA0811, MEGF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3596 FAT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604269 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 4048ExtracellularSequence analysisAdd BLAST4030
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4049 – 4069HelicalSequence analysisAdd BLAST21
Topological domaini4070 – 4349CytoplasmicSequence analysisAdd BLAST280

Keywords - Cellular componenti

Cell junction, Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 45 (SCA45)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA45 is a slowly progressive, autosomal dominant form with onset in adulthood.
See also OMIM:617769
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0806653586K → N in SCA45; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770597316EnsemblClinVar.1
Natural variantiVAR_0806663649R → Q in SCA45; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201335279EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...
DisGeNETi
2196

MalaCards human disease database

More...
MalaCardsi
FAT2
MIMi617769 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000086570

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28009

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434503

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000401819 – 4349Protocadherin Fat 2Add BLAST4331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1904N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3873N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3904N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3912 ↔ 3944By similarity
Disulfide bondi3951 ↔ 3962By similarity
Disulfide bondi3956 ↔ 3972By similarity
Disulfide bondi3974 ↔ 3983By similarity
Glycosylationi3989N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3990 ↔ 4001By similarity
Disulfide bondi3995 ↔ 4010By similarity
Disulfide bondi4012 ↔ 4021By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NYQ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NYQ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYQ8

PeptideAtlas

More...
PeptideAtlasi
Q9NYQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYQ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83267

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086570 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NYQ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYQ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033680

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261800

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NYQ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 256Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini363 – 458Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini459 – 564Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini565 – 669Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini716 – 820Cadherin 6PROSITE-ProRule annotationAdd BLAST105
Domaini821 – 925Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini926 – 1032Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1033 – 1137Cadherin 9PROSITE-ProRule annotationAdd BLAST105
Domaini1138 – 1242Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1243 – 1346Cadherin 11PROSITE-ProRule annotationAdd BLAST104
Domaini1350 – 1448Cadherin 12PROSITE-ProRule annotationAdd BLAST99
Domaini1449 – 1555Cadherin 13PROSITE-ProRule annotationAdd BLAST107
Domaini1556 – 1660Cadherin 14PROSITE-ProRule annotationAdd BLAST105
Domaini1661 – 1758Cadherin 15PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1872Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1969 – 2070Cadherin 17PROSITE-ProRule annotationAdd BLAST102
Domaini2071 – 2171Cadherin 18PROSITE-ProRule annotationAdd BLAST101
Domaini2172 – 2272Cadherin 19PROSITE-ProRule annotationAdd BLAST101
Domaini2273 – 2379Cadherin 20PROSITE-ProRule annotationAdd BLAST107
Domaini2380 – 2481Cadherin 21PROSITE-ProRule annotationAdd BLAST102
Domaini2482 – 2585Cadherin 22PROSITE-ProRule annotationAdd BLAST104
Domaini2586 – 2691Cadherin 23PROSITE-ProRule annotationAdd BLAST106
Domaini2692 – 2797Cadherin 24PROSITE-ProRule annotationAdd BLAST106
Domaini2798 – 2906Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2907 – 3011Cadherin 26PROSITE-ProRule annotationAdd BLAST105
Domaini3012 – 3113Cadherin 27PROSITE-ProRule annotationAdd BLAST102
Domaini3114 – 3218Cadherin 28PROSITE-ProRule annotationAdd BLAST105
Domaini3219 – 3321Cadherin 29PROSITE-ProRule annotationAdd BLAST103
Domaini3322 – 3426Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3427 – 3531Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3532 – 3642Cadherin 32PROSITE-ProRule annotationAdd BLAST111
Domaini3773 – 3944Laminin G-likePROSITE-ProRule annotationAdd BLAST172
Domaini3947 – 3984EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3986 – 4022EGF-like 2PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3297 – 3302Poly-Ser6

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000046499

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYQ8

KEGG Orthology (KO)

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KOi
K16506

Identification of Orthologs from Complete Genome Data

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OMAi
MVRDQEM

Database of Orthologous Groups

More...
OrthoDBi
12779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYQ8

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 29 hits
PF00008 EGF, 2 hits
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 33 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00282 LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 33 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 14 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NYQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT
60 70 80 90 100
YVESFEKMGI YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK
110 120 130 140 150
SSNTALLNRE VRDSYTLIIQ ATEKTLELEA LTRVVVHILD QNDLKPLFSP
160 170 180 190 200
PSYRVTISED MPLKSPICKV TATDADLGQN AEFYYAFNTR SEMFAIHPTS
210 220 230 240 250
GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA ALVVHVEPAL
260 270 280 290 300
RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF
310 320 330 340 350
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF
360 370 380 390 400
HLPPSKLSSL KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS
410 420 430 440 450
SENVGFKLNA RTGLITTTKL MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD
460 470 480 490 500
CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV TATDRDHGEN GYVTYSIAGP
510 520 530 540 550
KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS PFRREKEVSI
560 570 580 590 600
FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE
610 620 630 640 650
IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS
660 670 680 690 700
PTTLNITVVK DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT
710 720 730 740 750
SLSTYQINHY TPQFEDHFPQ SIDVLESVPI NTPLARLAAT DPDAGFNGKL
760 770 780 790 800
VYVIADGNEE GCFDIELETG LLTVAAPLDY EATNFYILNV TVYDLGTPQK
810 820 830 840 850
SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA ELTTKDADSE
860 870 880 890 900
DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS
910 920 930 940 950
KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS
960 970 980 990 1000
DPDLGPAGEV RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW
1010 1020 1030 1040 1050
ASDGGRPLAR RTLCHVEVIV LDVNENLHPP HFASFVHQGQ VQENSPSGTQ
1060 1070 1080 1090 1100
VIVVAAQDDD SGLDGELQYF LRAGTGLAAF SINQDTGMIQ TLAPLDREFA
1110 1120 1130 1140 1150
SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA VFYPSIQEDA
1160 1170 1180 1190 1200
PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL
1210 1220 1230 1240 1250
DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR
1260 1270 1280 1290 1300
LPERLSPVSP GPVYRLVASD LDEGLNGRVT YSIEDSDEEA FSIDLVTGVV
1310 1320 1330 1340 1350
SSSSTFTAGE YNILTIKATD SGQPPLSASV RLHIEWIPWP RPSSIPLAFD
1360 1370 1380 1390 1400
ETYYSFTVME TDPVNHMVGV ISVEGRPGLF WFNISGGDKD MDFDIEKTTG
1410 1420 1430 1440 1450
SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN INHHRPQFLE
1460 1470 1480 1490 1500
TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD
1510 1520 1530 1540 1550
PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL
1560 1570 1580 1590 1600
HPPRFTQLHY EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE
1610 1620 1630 1640 1650
GFFNINALLG IITLAQKLDQ ANHAPHTLTV KAEDQGSPQW HDLATVIIHV
1660 1670 1680 1690 1700
YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL LVSAMSPSEV TYELREGNKD
1710 1720 1730 1740 1750
GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT DVMVVVDIID
1760 1770 1780 1790 1800
ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL
1810 1820 1830 1840 1850
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL
1860 1870 1880 1890 1900
FAPRPAQVII HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED
1910 1920 1930 1940 1950
SEVNYSIKTG NADEAVTIHP VTGSISVLNP AFLGLSRKLT IRASDGLYQD
1960 1970 1980 1990 2000
TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN LQDRKALVIL GAQGNHLNDT
2010 2020 2030 2040 2050
LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV EVRDNRTPQR
2060 2070 2080 2090 2100
VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG
2110 2120 2130 2140 2150
TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT
2160 2170 2180 2190 2200
PSLQSEEEVL VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG
2210 2220 2230 2240 2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKTKHV FTVRATDTAL
2260 2270 2280 2290 2300
GSFSEATVEV LVEDVNDNPP TFSQLVYTTS ISEGLPAQTP VIQLLASDQD
2310 2320 2330 2340 2350
SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE AQQHFHVKVR
2360 2370 2380 2390 2400
AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK
2410 2420 2430 2440 2450
VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY
2460 2470 2480 2490 2500
NLRVGASDGV FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV
2510 2520 2530 2540 2550
IDLLAIDKDS GPYGTIDYTI INKLASEKFS INPNGQIATL QKLDRENSTE
2560 2570 2580 2590 2600
RVIAIKVMAR DGGGRVAFCT VKIILTDEND NPPQFKASEY TVSIQSNVSK
2610 2620 2630 2640 2650
DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT GVVKVKDSLV
2660 2670 2680 2690 2700
GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA
2710 2720 2730 2740 2750
PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK
2760 2770 2780 2790 2800
VRKPMDHEST KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD
2810 2820 2830 2840 2850
PYKAVLTENM PVGTSVIQVT AIDKDTGRDG QVSYRLSADP GSNVHELFAI
2860 2870 2880 2890 2900
DSESGWITTL QELDCETCQT YHFHVVAYDH GQTIQLSSQA LVQVSITDEN
2910 2920 2930 2940 2950
DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR QVTCYITEGD
2960 2970 2980 2990 3000
PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF
3010 3020 3030 3040 3050
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL
3060 3070 3080 3090 3100
HGPGAHEFKL DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT
3110 3120 3130 3140 3150
LHVEDVNDNA PRFFPSHCAV AVFDNTTVKT PVAVVFARDP DQGANAQVVY
3160 3170 3180 3190 3200
SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ APLELTVRAS DLGTPIPLST
3210 3220 3230 3240 3250
LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL ATLTRPGAEK
3260 3270 3280 3290 3300
TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS
3310 3320 3330 3340 3350
LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG
3360 3370 3380 3390 3400
PLNSDITYSL IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD
3410 3420 3430 3440 3450
SGQPPLHEDT DIAIQVADVN DNPPRFFQLN YSTTVQENSP IGSKVLQLIL
3460 3470 3480 3490 3500
SDPDSPENGP PYSFRITKGN NGSAFRVTPD GWLVTAEGLS RRAQEWYQLQ
3510 3520 3530 3540 3550
IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV GEDEFQGGMV
3560 3570 3580 3590 3600
GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF
3610 3620 3630 3640 3650
NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN
3660 3670 3680 3690 3700
LQRFLSHKLD IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA
3710 3720 3730 3740 3750
SIITHSAKEM EHSVGVQMRS AMPMVPCQGP TCQGQICHNT VHLDPKVGPT
3760 3770 3780 3790 3800
YSTARLSILT PRHHLQRSCS CNGTATRFSG QSYVRYRAPA ARNWHIHFYL
3810 3820 3830 3840 3850
KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN LSSQRHVNDH
3860 3870 3880 3890 3900
EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH
3910 3920 3930 3940 3950
SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY
3960 3970 3980 3990 4000
CSQNTCLNGG KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT
4010 4020 4030 4040 4050
CILSPKGASC NCPHPYTGDR CEMEARGCSE GHCLVTPEIQ RGDWGQQELL
4060 4070 4080 4090 4100
IITVAVAFII ISTVGLLFYC RRCKSHKPVA MEDPDLLARS VGVDTQAMPA
4110 4120 4130 4140 4150
IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV VCSVPPRLPP
4160 4170 4180 4190 4200
AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ
4210 4220 4230 4240 4250
GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED
4260 4270 4280 4290 4300
LMPSRPPSPR ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM
4310 4320 4330 4340
RLSRAGPSYA VCEVEGAPLA GQGQPRVPPN YEGSDMVESD YGSCEEVMF
Length:4,349
Mass (Da):479,317
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCEDBB52E252A996
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBK2H0YBK2_HUMAN
Protocadherin Fat 2
FAT2
1,122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1287D → Y in AAF61928 (PubMed:10716726).Curated1
Sequence conflicti1303S → N in AAF61928 (PubMed:10716726).Curated1
Sequence conflicti4160E → G in BAA32463 (PubMed:9693030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055595201G → A. Corresponds to variant dbSNP:rs11739693Ensembl.1
Natural variantiVAR_055596248P → S. Corresponds to variant dbSNP:rs3734061Ensembl.1
Natural variantiVAR_055597574R → C. Corresponds to variant dbSNP:rs1432862Ensembl.1
Natural variantiVAR_055598686F → S. Corresponds to variant dbSNP:rs9324700Ensembl.1
Natural variantiVAR_055599992R → Q. Corresponds to variant dbSNP:rs3734056Ensembl.1
Natural variantiVAR_0556001004G → S. Corresponds to variant dbSNP:rs3734055Ensembl.1
Natural variantiVAR_0556011164P → L. Corresponds to variant dbSNP:rs2304053Ensembl.1
Natural variantiVAR_0610761181Y → H. Corresponds to variant dbSNP:rs6872614Ensembl.1
Natural variantiVAR_0582861295L → P. Corresponds to variant dbSNP:rs35640822Ensembl.1
Natural variantiVAR_0556021462V → M. Corresponds to variant dbSNP:rs2278371Ensembl.1
Natural variantiVAR_0556031515G → S. Corresponds to variant dbSNP:rs2278370Ensembl.1
Natural variantiVAR_0556041571G → S. Corresponds to variant dbSNP:rs10044879Ensembl.1
Natural variantiVAR_0556051895R → W. Corresponds to variant dbSNP:rs34464977Ensembl.1
Natural variantiVAR_0556062054G → A. Corresponds to variant dbSNP:rs34493925Ensembl.1
Natural variantiVAR_0610772428F → S. Corresponds to variant dbSNP:rs6892335Ensembl.1
Natural variantiVAR_0556072907A → T. Corresponds to variant dbSNP:rs3734053Ensembl.1
Natural variantiVAR_0556083318R → Q. Corresponds to variant dbSNP:rs7718054Ensembl.1
Natural variantiVAR_0556093318R → W. Corresponds to variant dbSNP:rs2304024Ensembl.1
Natural variantiVAR_0556103514L → S. Corresponds to variant dbSNP:rs2053028Ensembl.1
Natural variantiVAR_0806653586K → N in SCA45; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770597316EnsemblClinVar.1
Natural variantiVAR_0556113631M → I. Corresponds to variant dbSNP:rs6650971Ensembl.1
Natural variantiVAR_0806663649R → Q in SCA45; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201335279EnsemblClinVar.1
Natural variantiVAR_0556123664A → G. Corresponds to variant dbSNP:rs35963695Ensembl.1
Natural variantiVAR_0556133953Q → H. Corresponds to variant dbSNP:rs2304029Ensembl.1
Natural variantiVAR_0556144117P → L1 PublicationCorresponds to variant dbSNP:rs1105168Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231022 mRNA Translation: AAF61928.1
AB011535 mRNA Translation: BAA32463.1
AL157443 mRNA Translation: CAB75663.1
AC011337 Genomic DNA No translation available.
AC011374 Genomic DNA No translation available.
AC034205 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4317.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46927

NCBI Reference Sequences

More...
RefSeqi
NP_001438.1, NM_001447.2
XP_006714824.1, XM_006714761.3
XP_011535902.1, XM_011537600.2
XP_011535905.1, XM_011537603.2
XP_016864713.1, XM_017009224.1
XP_016864714.1, XM_017009225.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261800; ENSP00000261800; ENSG00000086570

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2196

UCSC genome browser

More...
UCSCi
uc003lue.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231022 mRNA Translation: AAF61928.1
AB011535 mRNA Translation: BAA32463.1
AL157443 mRNA Translation: CAB75663.1
AC011337 Genomic DNA No translation available.
AC011374 Genomic DNA No translation available.
AC034205 Genomic DNA No translation available.
CCDSiCCDS4317.1
PIRiT46927
RefSeqiNP_001438.1, NM_001447.2
XP_006714824.1, XM_006714761.3
XP_011535902.1, XM_011537600.2
XP_011535905.1, XM_011537603.2
XP_016864713.1, XM_017009224.1
XP_016864714.1, XM_017009225.1

3D structure databases

SMRiQ9NYQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261800

PTM databases

iPTMnetiQ9NYQ8
PhosphoSitePlusiQ9NYQ8

Polymorphism and mutation databases

BioMutaiFAT2
DMDMi296434503

Proteomic databases

EPDiQ9NYQ8
jPOSTiQ9NYQ8
MaxQBiQ9NYQ8
PaxDbiQ9NYQ8
PeptideAtlasiQ9NYQ8
PRIDEiQ9NYQ8
ProteomicsDBi83267

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261800; ENSP00000261800; ENSG00000086570
GeneIDi2196
KEGGihsa:2196
UCSCiuc003lue.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2196
DisGeNETi2196

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAT2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005330
HGNCiHGNC:3596 FAT2
HPAiCAB033680
MalaCardsiFAT2
MIMi604269 gene
617769 phenotype
neXtProtiNX_Q9NYQ8
OpenTargetsiENSG00000086570
PharmGKBiPA28009

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000158507
HOGENOMiHOG000046499
InParanoidiQ9NYQ8
KOiK16506
OMAiMVRDQEM
OrthoDBi12779at2759
PhylomeDBiQ9NYQ8
TreeFamiTF316403

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2196

Protein Ontology

More...
PROi
PR:Q9NYQ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086570 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9NYQ8 baseline and differential
GenevisibleiQ9NYQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 29 hits
PF00008 EGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 33 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00282 LamG, 1 hit
SUPFAMiSSF49313 SSF49313, 33 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 14 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYQ8
Secondary accession number(s): O75091, Q9NSR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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