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Entry version 181 (16 Oct 2019)
Sequence version 2 (05 May 2009)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

CELSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NYQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
Cadherin family member 11
Epidermal growth factor-like protein 1
Short name:
EGF-like protein 1
Flamingo homolog 1
Short name:
hFmi1
Multiple epidermal growth factor-like domains protein 2
Short name:
Multiple EGF-like domains protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELSR3
Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3230 CELSR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604264 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 2540ExtracellularSequence analysisAdd BLAST2508
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2541 – 2561Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2562 – 2572CytoplasmicSequence analysisAdd BLAST11
Transmembranei2573 – 2593Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2594 – 2601ExtracellularSequence analysis8
Transmembranei2602 – 2622Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2623 – 2643CytoplasmicSequence analysisAdd BLAST21
Transmembranei2644 – 2664Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2665 – 2681ExtracellularSequence analysisAdd BLAST17
Transmembranei2682 – 2702Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2703 – 2725CytoplasmicSequence analysisAdd BLAST23
Transmembranei2726 – 2746Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2747 – 2753ExtracellularSequence analysis7
Transmembranei2754 – 2774Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2775 – 3312CytoplasmicSequence analysisAdd BLAST538

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1951

Open Targets

More...
OpenTargetsi
ENSG00000008300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYQ7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CELSR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291833 – 3312Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi847N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1327N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1379 ↔ 1390By similarity
Disulfide bondi1384 ↔ 1421By similarity
Disulfide bondi1423 ↔ 1432By similarity
Disulfide bondi1439 ↔ 1450By similarity
Disulfide bondi1444 ↔ 1459By similarity
Disulfide bondi1461 ↔ 1470By similarity
Disulfide bondi1479 ↔ 1490By similarity
Disulfide bondi1484 ↔ 1500By similarity
Disulfide bondi1502 ↔ 1513By similarity
Glycosylationi1649N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1693 ↔ 1719By similarity
Glycosylationi1713N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1726 ↔ 1737By similarity
Disulfide bondi1731 ↔ 1746By similarity
Disulfide bondi1748 ↔ 1757By similarity
Glycosylationi1770N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1915 ↔ 1944By similarity
Disulfide bondi1950 ↔ 1961By similarity
Disulfide bondi1955 ↔ 1970By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1963(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1972 ↔ 1981By similarity
Disulfide bondi1985 ↔ 1996By similarity
Disulfide bondi1990 ↔ 2008By similarity
Disulfide bondi2010 ↔ 2019By similarity
Disulfide bondi2027 ↔ 2040By similarity
Disulfide bondi2042 ↔ 2052By similarity
Glycosylationi2053N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2059 ↔ 2074By similarity
Disulfide bondi2061 ↔ 2077By similarity
Disulfide bondi2079 ↔ 2089By similarity
Disulfide bondi2098 ↔ 2107By similarity
Disulfide bondi2110 ↔ 2122By similarity
Modified residuei2126PhosphotyrosineBy similarity1
Glycosylationi2177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2506N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3051PhosphotyrosineBy similarity1
Modified residuei3097PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NYQ7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NYQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NYQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYQ7

PeptideAtlas

More...
PeptideAtlasi
Q9NYQ7

PRoteomics IDEntifications database

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PRIDEi
Q9NYQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83265 [Q9NYQ7-1]
83266 [Q9NYQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NYQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000008300 Expressed in 149 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NYQ7 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA062866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-308417,EBI-389883

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108271, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NYQ7, 30 interactors

Molecular INTeraction database

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MINTi
Q9NYQ7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000164024

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYQ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini326 – 433Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini434 – 545Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini546 – 651Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini652 – 756Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini757 – 858Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini859 – 961Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini962 – 1067Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1068 – 1169Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1170 – 1265Cadherin 9PROSITE-ProRule annotationAdd BLAST96
Domaini1375 – 1433EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1435 – 1471EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1475 – 1514EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1515 – 1719Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1722 – 1758EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1764 – 1944Laminin G-like 2PROSITE-ProRule annotationAdd BLAST181
Domaini1946 – 1982EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1983 – 2020EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini2021 – 2053EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini2055 – 2090EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2077 – 2124Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2477 – 2529GPSPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYQ7

KEGG Orthology (KO)

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KOi
K04602

Identification of Orthologs from Complete Genome Data

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OMAi
QNMSQEH

Database of Orthologous Groups

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OrthoDBi
23882at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NYQ7

TreeFam database of animal gene trees

More...
TreeFami
TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

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Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT
60 70 80 90 100
GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG
110 120 130 140 150
PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR
160 170 180 190 200
GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG
210 220 230 240 250
TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR
260 270 280 290 300
TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA
310 320 330 340 350
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ
360 370 380 390 400
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY
410 420 430 440 450
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY
460 470 480 490 500
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR
510 520 530 540 550
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY
560 570 580 590 600
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG
610 620 630 640 650
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI
660 670 680 690 700
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV
710 720 730 740 750
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN
760 770 780 790 800
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN
810 820 830 840 850
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD
860 870 880 890 900
ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN
910 920 930 940 950
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM
960 970 980 990 1000
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF
1010 1020 1030 1040 1050
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP
1060 1070 1080 1090 1100
VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA
1110 1120 1130 1140 1150
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV
1160 1170 1180 1190 1200
SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP
1210 1220 1230 1240 1250
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD
1260 1270 1280 1290 1300
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA
1310 1320 1330 1340 1350
AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE
1360 1370 1380 1390 1400
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA
1410 1420 1430 1440 1450
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC
1460 1470 1480 1490 1500
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC
1510 1520 1530 1540 1550
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG
1560 1570 1580 1590 1600
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW
1610 1620 1630 1640 1650
HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY
1660 1670 1680 1690 1700
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID
1710 1720 1730 1740 1750
GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV
1760 1770 1780 1790 1800
GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG
1810 1820 1830 1840 1850
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD
1860 1870 1880 1890 1900
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL
1910 1920 1930 1940 1950
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC
1960 1970 1980 1990 2000
ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP
2010 2020 2030 2040 2050
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP
2060 2070 2080 2090 2100
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP
2110 2120 2130 2140 2150
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV
2160 2170 2180 2190 2200
PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL
2210 2220 2230 2240 2250
DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT
2260 2270 2280 2290 2300
ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE
2310 2320 2330 2340 2350
YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL
2360 2370 2380 2390 2400
FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE
2410 2420 2430 2440 2450
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH
2460 2470 2480 2490 2500
GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC
2510 2520 2530 2540 2550
ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS
2560 2570 2580 2590 2600
VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL
2610 2620 2630 2640 2650
VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW
2660 2670 2680 2690 2700
GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM
2710 2720 2730 2740 2750
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL
2760 2770 2780 2790 2800
AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP
2810 2820 2830 2840 2850
GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY
2860 2870 2880 2890 2900
LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL
2910 2920 2930 2940 2950
EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS
2960 2970 2980 2990 3000
YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL
3010 3020 3030 3040 3050
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI
3060 3070 3080 3090 3100
YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG
3110 3120 3130 3140 3150
SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR
3160 3170 3180 3190 3200
EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS
3210 3220 3230 3240 3250
REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL
3260 3270 3280 3290 3300
ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS
3310
PDSEVPRSEG HS
Length:3,312
Mass (Da):358,185
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E6B37787A9F0348
GO
Isoform 2 (identifier: Q9NYQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2158-2158: G → GLRGAG

Note: No experimental confirmation available.
Show »
Length:3,317
Mass (Da):358,640
Checksum:i2E19853A04982607
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13G → E in AAF61929 (PubMed:10716726).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020022157A → P. Corresponds to variant dbSNP:rs3733085Ensembl.1
Natural variantiVAR_020023805S → T. Corresponds to variant dbSNP:rs3821875Ensembl.1
Natural variantiVAR_0551011758Q → R. Corresponds to variant dbSNP:rs12107252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371252158G → GLRGAG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231023 mRNA Translation: AAF61929.1
AC121252 Genomic DNA No translation available.
AB011536 mRNA Translation: BAA32464.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2775.1 [Q9NYQ7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00250

NCBI Reference Sequences

More...
RefSeqi
NP_001398.2, NM_001407.2 [Q9NYQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1951

UCSC genome browser

More...
UCSCi
uc003cul.4 human [Q9NYQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231023 mRNA Translation: AAF61929.1
AC121252 Genomic DNA No translation available.
AB011536 mRNA Translation: BAA32464.1
CCDSiCCDS2775.1 [Q9NYQ7-1]
PIRiT00250
RefSeqiNP_001398.2, NM_001407.2 [Q9NYQ7-1]

3D structure databases

SMRiQ9NYQ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108271, 20 interactors
IntActiQ9NYQ7, 30 interactors
MINTiQ9NYQ7
STRINGi9606.ENSP00000164024

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ9NYQ7
PhosphoSitePlusiQ9NYQ7

Polymorphism and mutation databases

BioMutaiCELSR3
DMDMi229462826

Proteomic databases

EPDiQ9NYQ7
jPOSTiQ9NYQ7
MassIVEiQ9NYQ7
MaxQBiQ9NYQ7
PaxDbiQ9NYQ7
PeptideAtlasiQ9NYQ7
PRIDEiQ9NYQ7
ProteomicsDBi83265 [Q9NYQ7-1]
83266 [Q9NYQ7-2]

Genome annotation databases

EnsembliENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1]
GeneIDi1951
KEGGihsa:1951
UCSCiuc003cul.4 human [Q9NYQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1951
DisGeNETi1951

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CELSR3
HGNCiHGNC:3230 CELSR3
HPAiHPA062866
MIMi604264 gene
neXtProtiNX_Q9NYQ7
OpenTargetsiENSG00000008300
PharmGKBiPA26395

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000160077
HOGENOMiHOG000231346
InParanoidiQ9NYQ7
KOiK04602
OMAiQNMSQEH
OrthoDBi23882at2759
PhylomeDBiQ9NYQ7
TreeFamiTF323983

Enzyme and pathway databases

SignaLinkiQ9NYQ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CELSR3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CELSR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1951
PharosiQ9NYQ7

Protein Ontology

More...
PROi
PR:Q9NYQ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008300 Expressed in 149 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiQ9NYQ7 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYQ7
Secondary accession number(s): O75092
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 5, 2009
Last modified: October 16, 2019
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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