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UniProtKB - Q9NYQ7 (CELR3_HUMAN)

Entry version 177 (08 May 2019)
Sequence version 2 (05 May 2009)
Previous versions | rss
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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

CELSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NYQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
Cadherin family member 11
Epidermal growth factor-like protein 1
Short name:
EGF-like protein 1
Flamingo homolog 1
Short name:
hFmi1
Multiple epidermal growth factor-like domains protein 2
Short name:
Multiple EGF-like domains protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELSR3
Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3230 CELSR3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604264 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NYQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 2540ExtracellularSequence analysisAdd BLAST2508
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2541 – 2561Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2562 – 2572CytoplasmicSequence analysisAdd BLAST11
Transmembranei2573 – 2593Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2594 – 2601ExtracellularSequence analysis8
Transmembranei2602 – 2622Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2623 – 2643CytoplasmicSequence analysisAdd BLAST21
Transmembranei2644 – 2664Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2665 – 2681ExtracellularSequence analysisAdd BLAST17
Transmembranei2682 – 2702Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2703 – 2725CytoplasmicSequence analysisAdd BLAST23
Transmembranei2726 – 2746Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2747 – 2753ExtracellularSequence analysis7
Transmembranei2754 – 2774Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2775 – 3312CytoplasmicSequence analysisAdd BLAST538

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1951

Open Targets

More...OpenTargetsi		ENSG00000008300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26395

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CELSR3

Domain mapping of disease mutations (DMDM)

More...DMDMi		229462826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291833 – 3312Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi847N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1327N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1379 ↔ 1390By similarity
Disulfide bondi1384 ↔ 1421By similarity
Disulfide bondi1423 ↔ 1432By similarity
Disulfide bondi1439 ↔ 1450By similarity
Disulfide bondi1444 ↔ 1459By similarity
Disulfide bondi1461 ↔ 1470By similarity
Disulfide bondi1479 ↔ 1490By similarity
Disulfide bondi1484 ↔ 1500By similarity
Disulfide bondi1502 ↔ 1513By similarity
Glycosylationi1649N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1693 ↔ 1719By similarity
Glycosylationi1713N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1726 ↔ 1737By similarity
Disulfide bondi1731 ↔ 1746By similarity
Disulfide bondi1748 ↔ 1757By similarity
Glycosylationi1770N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1915 ↔ 1944By similarity
Disulfide bondi1950 ↔ 1961By similarity
Disulfide bondi1955 ↔ 1970By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1963(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1972 ↔ 1981By similarity
Disulfide bondi1985 ↔ 1996By similarity
Disulfide bondi1990 ↔ 2008By similarity
Disulfide bondi2010 ↔ 2019By similarity
Disulfide bondi2027 ↔ 2040By similarity
Disulfide bondi2042 ↔ 2052By similarity
Glycosylationi2053N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2059 ↔ 2074By similarity
Disulfide bondi2061 ↔ 2077By similarity
Disulfide bondi2079 ↔ 2089By similarity
Disulfide bondi2098 ↔ 2107By similarity
Disulfide bondi2110 ↔ 2122By similarity
Modified residuei2126PhosphotyrosineBy similarity1
Glycosylationi2177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2506N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3051PhosphotyrosineBy similarity1
Modified residuei3097PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NYQ7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NYQ7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NYQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NYQ7

PeptideAtlas

More...PeptideAtlasi		Q9NYQ7

PRoteomics IDEntifications database

More...PRIDEi		Q9NYQ7

ProteomicsDB human proteome resource

More...ProteomicsDBi		83265
83266 [Q9NYQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NYQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NYQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000008300 Expressed in 149 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NYQ7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA062866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-308417,EBI-389883

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108271, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q9NYQ7, 19 interactors

Molecular INTeraction database

More...MINTi		Q9NYQ7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000164024

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NYQ7

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini326 – 433Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini434 – 545Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini546 – 651Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini652 – 756Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini757 – 858Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini859 – 961Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini962 – 1067Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1068 – 1169Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1170 – 1265Cadherin 9PROSITE-ProRule annotationAdd BLAST96
Domaini1375 – 1433EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1435 – 1471EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1475 – 1514EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1515 – 1719Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1722 – 1758EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1764 – 1944Laminin G-like 2PROSITE-ProRule annotationAdd BLAST181
Domaini1946 – 1982EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1983 – 2020EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini2021 – 2053EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini2055 – 2090EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2077 – 2124Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2477 – 2529GPSPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231346

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NYQ7

KEGG Orthology (KO)

More...KOi		K04602

Identification of Orthologs from Complete Genome Data

More...OMAi		DGGFRCQ

Database of Orthologous Groups

More...OrthoDBi		23882at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NYQ7

TreeFam database of animal gene trees

More...TreeFami		TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT 
        60         70         80         90        100
GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG 
       110        120        130        140        150
PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR 
       160        170        180        190        200
GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG 
       210        220        230        240        250
TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR 
       260        270        280        290        300
TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 
       310        320        330        340        350
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ 
       360        370        380        390        400
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY 
       410        420        430        440        450
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY 
       460        470        480        490        500
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR 
       510        520        530        540        550
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY 
       560        570        580        590        600
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 
       610        620        630        640        650
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI 
       660        670        680        690        700
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV 
       710        720        730        740        750
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN 
       760        770        780        790        800
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN 
       810        820        830        840        850
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD 
       860        870        880        890        900
ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 
       910        920        930        940        950
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM 
       960        970        980        990       1000
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF 
      1010       1020       1030       1040       1050
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP 
      1060       1070       1080       1090       1100
VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA 
      1110       1120       1130       1140       1150
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV 
      1160       1170       1180       1190       1200
SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 
      1210       1220       1230       1240       1250
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD 
      1260       1270       1280       1290       1300
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA 
      1310       1320       1330       1340       1350
AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE 
      1360       1370       1380       1390       1400
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA 
      1410       1420       1430       1440       1450
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC 
      1460       1470       1480       1490       1500
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 
      1510       1520       1530       1540       1550
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG 
      1560       1570       1580       1590       1600
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW 
      1610       1620       1630       1640       1650
HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY 
      1660       1670       1680       1690       1700
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID 
      1710       1720       1730       1740       1750
GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV 
      1760       1770       1780       1790       1800
GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 
      1810       1820       1830       1840       1850
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD 
      1860       1870       1880       1890       1900
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL 
      1910       1920       1930       1940       1950
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC 
      1960       1970       1980       1990       2000
ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP 
      2010       2020       2030       2040       2050
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP 
      2060       2070       2080       2090       2100
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 
      2110       2120       2130       2140       2150
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV 
      2160       2170       2180       2190       2200
PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL 
      2210       2220       2230       2240       2250
DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT 
      2260       2270       2280       2290       2300
ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE 
      2310       2320       2330       2340       2350
YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL 
      2360       2370       2380       2390       2400
FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 
      2410       2420       2430       2440       2450
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH 
      2460       2470       2480       2490       2500
GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC 
      2510       2520       2530       2540       2550
ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS 
      2560       2570       2580       2590       2600
VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL 
      2610       2620       2630       2640       2650
VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW 
      2660       2670       2680       2690       2700
GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 
      2710       2720       2730       2740       2750
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL 
      2760       2770       2780       2790       2800
AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP 
      2810       2820       2830       2840       2850
GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY 
      2860       2870       2880       2890       2900
LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL 
      2910       2920       2930       2940       2950
EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS 
      2960       2970       2980       2990       3000
YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 
      3010       3020       3030       3040       3050
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI 
      3060       3070       3080       3090       3100
YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG 
      3110       3120       3130       3140       3150
SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR 
      3160       3170       3180       3190       3200
EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS 
      3210       3220       3230       3240       3250
REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL 
      3260       3270       3280       3290       3300
ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS 
      3310 
PDSEVPRSEG HS
Length:3,312
Mass (Da):358,185
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E6B37787A9F0348
GO
Isoform 2 (identifier: Q9NYQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2158-2158: G → GLRGAG

Note: No experimental confirmation available.
Show »
Length:3,317
Mass (Da):358,640
Checksum:i2E19853A04982607
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13G → E in AAF61929 (PubMed:10716726).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020022157A → P. Corresponds to variant dbSNP:rs3733085Ensembl.1
Natural variantiVAR_020023805S → T. Corresponds to variant dbSNP:rs3821875Ensembl.1
Natural variantiVAR_0551011758Q → R. Corresponds to variant dbSNP:rs12107252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371252158G → GLRGAG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF231023 mRNA Translation: AAF61929.1
AC121252 Genomic DNA No translation available.
AB011536 mRNA Translation: BAA32464.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2775.1 [Q9NYQ7-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00250

NCBI Reference Sequences

More...RefSeqi		NP_001398.2, NM_001407.2 [Q9NYQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1951

UCSC genome browser

More...UCSCi		uc003cul.4 human [Q9NYQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231023 mRNA Translation: AAF61929.1
AC121252 Genomic DNA No translation available.
AB011536 mRNA Translation: BAA32464.1
CCDSiCCDS2775.1 [Q9NYQ7-1]
PIRiT00250
RefSeqiNP_001398.2, NM_001407.2 [Q9NYQ7-1]

3D structure databases

SMRiQ9NYQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108271, 19 interactors
IntActiQ9NYQ7, 19 interactors
MINTiQ9NYQ7
STRINGi9606.ENSP00000164024

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ9NYQ7
PhosphoSitePlusiQ9NYQ7

Polymorphism and mutation databases

BioMutaiCELSR3
DMDMi229462826

Proteomic databases

EPDiQ9NYQ7
jPOSTiQ9NYQ7
MaxQBiQ9NYQ7
PaxDbiQ9NYQ7
PeptideAtlasiQ9NYQ7
PRIDEiQ9NYQ7
ProteomicsDBi83265
83266 [Q9NYQ7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1]
GeneIDi1951
KEGGihsa:1951
UCSCiuc003cul.4 human [Q9NYQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1951
DisGeNETi1951

GeneCards: human genes, protein and diseases

More...GeneCardsi		CELSR3

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0200467
HGNCiHGNC:3230 CELSR3
HPAiHPA062866
MIMi604264 gene
neXtProtiNX_Q9NYQ7
OpenTargetsiENSG00000008300
PharmGKBiPA26395

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000160077
HOGENOMiHOG000231346
InParanoidiQ9NYQ7
KOiK04602
OMAiDGGFRCQ
OrthoDBi23882at2759
PhylomeDBiQ9NYQ7
TreeFamiTF323983

Enzyme and pathway databases

SignaLinkiQ9NYQ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CELSR3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CELSR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1951

Protein Ontology

More...PROi		PR:Q9NYQ7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000008300 Expressed in 149 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiQ9NYQ7 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYQ7
Secondary accession number(s): O75092
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 5, 2009
Last modified: May 8, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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