UniProtKB - Q9NYQ7 (CELR3_HUMAN)
Protein
Cadherin EGF LAG seven-pass G-type receptor 3
Gene
CELSR3
Organism
Homo sapiens (Human)
Status
Functioni
Receptor that may have an important role in cell/cell signaling during nervous system formation.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G protein-coupled receptor activity Source: GDB
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GDB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- multicellular organism development Source: UniProtKB-KW
- Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9NYQ7 |
SignaLinki | Q9NYQ7 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin EGF LAG seven-pass G-type receptor 3Alternative name(s): Cadherin family member 11 Epidermal growth factor-like protein 1 Short name: EGF-like protein 1 Flamingo homolog 1 Short name: hFmi1 Multiple epidermal growth factor-like domains protein 2 Short name: Multiple EGF-like domains protein 2 |
Gene namesi | Name:CELSR3 Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3230, CELSR3 |
MIMi | 604264, gene |
neXtProti | NX_Q9NYQ7 |
VEuPathDBi | HostDB:ENSG00000008300.14 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GDB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 2540 | ExtracellularSequence analysisAdd BLAST | 2508 | |
Transmembranei | 2541 – 2561 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2562 – 2572 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 2573 – 2593 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2594 – 2601 | ExtracellularSequence analysis | 8 | |
Transmembranei | 2602 – 2622 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2623 – 2643 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 2644 – 2664 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2665 – 2681 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 2682 – 2702 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2703 – 2725 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 2726 – 2746 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2747 – 2753 | ExtracellularSequence analysis | 7 | |
Transmembranei | 2754 – 2774 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2775 – 3312 | CytoplasmicSequence analysisAdd BLAST | 538 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1951 |
OpenTargetsi | ENSG00000008300 |
PharmGKBi | PA26395 |
Miscellaneous databases
Pharosi | Q9NYQ7, Tbio |
Genetic variation databases
BioMutai | CELSR3 |
DMDMi | 229462826 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000012918 | 33 – 3312 | Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST | 3280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 632 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 847 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1317 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1327 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1379 ↔ 1390 | By similarity | ||
Disulfide bondi | 1384 ↔ 1421 | By similarity | ||
Disulfide bondi | 1423 ↔ 1432 | By similarity | ||
Disulfide bondi | 1439 ↔ 1450 | By similarity | ||
Disulfide bondi | 1444 ↔ 1459 | By similarity | ||
Disulfide bondi | 1461 ↔ 1470 | By similarity | ||
Disulfide bondi | 1479 ↔ 1490 | By similarity | ||
Disulfide bondi | 1484 ↔ 1500 | By similarity | ||
Disulfide bondi | 1502 ↔ 1513 | By similarity | ||
Glycosylationi | 1649 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1693 ↔ 1719 | By similarity | ||
Glycosylationi | 1713 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1726 ↔ 1737 | By similarity | ||
Disulfide bondi | 1731 ↔ 1746 | By similarity | ||
Disulfide bondi | 1748 ↔ 1757 | By similarity | ||
Glycosylationi | 1770 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1915 ↔ 1944 | By similarity | ||
Disulfide bondi | 1950 ↔ 1961 | By similarity | ||
Disulfide bondi | 1955 ↔ 1970 | By similarity | ||
Modified residuei | 1963 | (3R)-3-hydroxyaspartateSequence analysis | 1 | |
Disulfide bondi | 1972 ↔ 1981 | By similarity | ||
Disulfide bondi | 1985 ↔ 1996 | By similarity | ||
Disulfide bondi | 1990 ↔ 2008 | By similarity | ||
Disulfide bondi | 2010 ↔ 2019 | By similarity | ||
Disulfide bondi | 2027 ↔ 2040 | By similarity | ||
Disulfide bondi | 2042 ↔ 2052 | By similarity | ||
Glycosylationi | 2053 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2059 ↔ 2074 | By similarity | ||
Disulfide bondi | 2061 ↔ 2077 | By similarity | ||
Disulfide bondi | 2079 ↔ 2089 | By similarity | ||
Disulfide bondi | 2098 ↔ 2107 | By similarity | ||
Disulfide bondi | 2110 ↔ 2122 | By similarity | ||
Modified residuei | 2126 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 2177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2386 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2506 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 3051 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 3097 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, PhosphoproteinProteomic databases
EPDi | Q9NYQ7 |
jPOSTi | Q9NYQ7 |
MassIVEi | Q9NYQ7 |
MaxQBi | Q9NYQ7 |
PaxDbi | Q9NYQ7 |
PeptideAtlasi | Q9NYQ7 |
PRIDEi | Q9NYQ7 |
ProteomicsDBi | 83265 [Q9NYQ7-1] 83266 [Q9NYQ7-2] |
PTM databases
GlyGeni | Q9NYQ7, 15 sites |
iPTMneti | Q9NYQ7 |
PhosphoSitePlusi | Q9NYQ7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000008300, Expressed in cerebellar hemisphere and 170 other tissues |
Genevisiblei | Q9NYQ7, HS |
Organism-specific databases
HPAi | ENSG00000008300, Tissue enhanced (brain, pituitary gland) |
Interactioni
Binary interactionsi
Q9NYQ7
With | #Exp. | IntAct |
---|---|---|
NCK1 [P16333] | 2 | EBI-308417,EBI-389883 |
Protein-protein interaction databases
BioGRIDi | 108271, 22 interactors |
IntActi | Q9NYQ7, 30 interactors |
MINTi | Q9NYQ7 |
STRINGi | 9606.ENSP00000164024 |
Miscellaneous databases
RNActi | Q9NYQ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 326 – 433 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 434 – 545 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 546 – 651 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 652 – 756 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 757 – 858 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 859 – 961 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 962 – 1067 | Cadherin 7PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 1068 – 1169 | Cadherin 8PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1170 – 1265 | Cadherin 9PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1375 – 1433 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1435 – 1471 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1475 – 1514 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1515 – 1719 | Laminin G-like 1PROSITE-ProRule annotationAdd BLAST | 205 | |
Domaini | 1722 – 1758 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1764 – 1944 | Laminin G-like 2PROSITE-ProRule annotationAdd BLAST | 181 | |
Domaini | 1946 – 1982 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1983 – 2020 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 2021 – 2053 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 2055 – 2090 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2077 – 2124 | Laminin EGF-likePROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 2477 – 2529 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000160077 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q9NYQ7 |
OMAi | WTARDCD |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q9NYQ7 |
TreeFami | TF323983 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR002049, Laminin_EGF IPR001791, Laminin_G |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 8 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT
60 70 80 90 100
GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG
110 120 130 140 150
PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR
160 170 180 190 200
GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG
210 220 230 240 250
TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR
260 270 280 290 300
TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA
310 320 330 340 350
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ
360 370 380 390 400
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY
410 420 430 440 450
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY
460 470 480 490 500
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR
510 520 530 540 550
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY
560 570 580 590 600
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG
610 620 630 640 650
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI
660 670 680 690 700
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV
710 720 730 740 750
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN
760 770 780 790 800
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN
810 820 830 840 850
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD
860 870 880 890 900
ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN
910 920 930 940 950
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM
960 970 980 990 1000
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF
1010 1020 1030 1040 1050
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP
1060 1070 1080 1090 1100
VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA
1110 1120 1130 1140 1150
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV
1160 1170 1180 1190 1200
SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP
1210 1220 1230 1240 1250
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD
1260 1270 1280 1290 1300
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA
1310 1320 1330 1340 1350
AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE
1360 1370 1380 1390 1400
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA
1410 1420 1430 1440 1450
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC
1460 1470 1480 1490 1500
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC
1510 1520 1530 1540 1550
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG
1560 1570 1580 1590 1600
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW
1610 1620 1630 1640 1650
HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY
1660 1670 1680 1690 1700
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID
1710 1720 1730 1740 1750
GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV
1760 1770 1780 1790 1800
GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG
1810 1820 1830 1840 1850
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD
1860 1870 1880 1890 1900
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL
1910 1920 1930 1940 1950
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC
1960 1970 1980 1990 2000
ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP
2010 2020 2030 2040 2050
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP
2060 2070 2080 2090 2100
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP
2110 2120 2130 2140 2150
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV
2160 2170 2180 2190 2200
PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL
2210 2220 2230 2240 2250
DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT
2260 2270 2280 2290 2300
ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE
2310 2320 2330 2340 2350
YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL
2360 2370 2380 2390 2400
FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE
2410 2420 2430 2440 2450
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH
2460 2470 2480 2490 2500
GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC
2510 2520 2530 2540 2550
ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS
2560 2570 2580 2590 2600
VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL
2610 2620 2630 2640 2650
VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW
2660 2670 2680 2690 2700
GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM
2710 2720 2730 2740 2750
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL
2760 2770 2780 2790 2800
AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP
2810 2820 2830 2840 2850
GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY
2860 2870 2880 2890 2900
LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL
2910 2920 2930 2940 2950
EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS
2960 2970 2980 2990 3000
YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL
3010 3020 3030 3040 3050
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI
3060 3070 3080 3090 3100
YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG
3110 3120 3130 3140 3150
SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR
3160 3170 3180 3190 3200
EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS
3210 3220 3230 3240 3250
REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL
3260 3270 3280 3290 3300
ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS
3310
PDSEVPRSEG HS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | G → E in AAF61929 (PubMed:10716726).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020022 | 157 | A → P. Corresponds to variant dbSNP:rs3733085Ensembl. | 1 | |
Natural variantiVAR_020023 | 805 | S → T. Corresponds to variant dbSNP:rs3821875Ensembl. | 1 | |
Natural variantiVAR_055101 | 1758 | Q → R1 PublicationCorresponds to variant dbSNP:rs12107252Ensembl. | 1 | |
Natural variantiVAR_083108 | 2136 | G → D Found in a patient with epileptic encephalopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777163EnsemblClinVar. | 1 | |
Natural variantiVAR_083109 | 2630 | M → I1 PublicationCorresponds to variant dbSNP:rs149614835EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037125 | 2158 | G → GLRGAG in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF231023 mRNA Translation: AAF61929.1 AC121252 Genomic DNA No translation available. AB011536 mRNA Translation: BAA32464.1 |
CCDSi | CCDS2775.1 [Q9NYQ7-1] |
PIRi | T00250 |
RefSeqi | NP_001398.2, NM_001407.2 [Q9NYQ7-1] |
Genome annotation databases
Ensembli | ENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1] |
GeneIDi | 1951 |
KEGGi | hsa:1951 |
UCSCi | uc003cul.4, human [Q9NYQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF231023 mRNA Translation: AAF61929.1 AC121252 Genomic DNA No translation available. AB011536 mRNA Translation: BAA32464.1 |
CCDSi | CCDS2775.1 [Q9NYQ7-1] |
PIRi | T00250 |
RefSeqi | NP_001398.2, NM_001407.2 [Q9NYQ7-1] |
3D structure databases
SMRi | Q9NYQ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108271, 22 interactors |
IntActi | Q9NYQ7, 30 interactors |
MINTi | Q9NYQ7 |
STRINGi | 9606.ENSP00000164024 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9NYQ7, 15 sites |
iPTMneti | Q9NYQ7 |
PhosphoSitePlusi | Q9NYQ7 |
Genetic variation databases
BioMutai | CELSR3 |
DMDMi | 229462826 |
Proteomic databases
EPDi | Q9NYQ7 |
jPOSTi | Q9NYQ7 |
MassIVEi | Q9NYQ7 |
MaxQBi | Q9NYQ7 |
PaxDbi | Q9NYQ7 |
PeptideAtlasi | Q9NYQ7 |
PRIDEi | Q9NYQ7 |
ProteomicsDBi | 83265 [Q9NYQ7-1] 83266 [Q9NYQ7-2] |
Protocols and materials databases
Antibodypediai | 13269, 305 antibodies |
Genome annotation databases
Ensembli | ENST00000164024; ENSP00000164024; ENSG00000008300 [Q9NYQ7-1] |
GeneIDi | 1951 |
KEGGi | hsa:1951 |
UCSCi | uc003cul.4, human [Q9NYQ7-1] |
Organism-specific databases
CTDi | 1951 |
DisGeNETi | 1951 |
GeneCardsi | CELSR3 |
HGNCi | HGNC:3230, CELSR3 |
HPAi | ENSG00000008300, Tissue enhanced (brain, pituitary gland) |
MIMi | 604264, gene |
neXtProti | NX_Q9NYQ7 |
OpenTargetsi | ENSG00000008300 |
PharmGKBi | PA26395 |
VEuPathDBi | HostDB:ENSG00000008300.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000160077 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q9NYQ7 |
OMAi | WTARDCD |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q9NYQ7 |
TreeFami | TF323983 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYQ7 |
SignaLinki | Q9NYQ7 |
Miscellaneous databases
BioGRID-ORCSi | 1951, 12 hits in 990 CRISPR screens |
ChiTaRSi | CELSR3, human |
GeneWikii | CELSR3 |
GenomeRNAii | 1951 |
Pharosi | Q9NYQ7, Tbio |
PROi | PR:Q9NYQ7 |
RNActi | Q9NYQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008300, Expressed in cerebellar hemisphere and 170 other tissues |
Genevisiblei | Q9NYQ7, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR002049, Laminin_EGF IPR001791, Laminin_G |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 8 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CELR3_HUMAN | |
Accessioni | Q9NYQ7Primary (citable) accession number: Q9NYQ7 Secondary accession number(s): O75092 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2002 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families