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Entry version 186 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 1

Gene

CELSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.953

Transport Classification Database

More...
TCDBi
9.A.14.6.4 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 1
Alternative name(s):
Cadherin family member 9
Flamingo homolog 2
Short name:
hFmi2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELSR1
Synonyms:CDHF9, FMI2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1850 CELSR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604523 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 2469ExtracellularSequence analysisAdd BLAST2448
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2470 – 2490Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2491 – 2501CytoplasmicSequence analysisAdd BLAST11
Transmembranei2502 – 2522Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2523 – 2527ExtracellularSequence analysis5
Transmembranei2528 – 2548Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2549 – 2572CytoplasmicSequence analysisAdd BLAST24
Transmembranei2573 – 2593Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2594 – 2611ExtracellularSequence analysisAdd BLAST18
Transmembranei2612 – 2632Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2633 – 2655CytoplasmicSequence analysisAdd BLAST23
Transmembranei2656 – 2676Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2677 – 2683ExtracellularSequence analysis7
Transmembranei2684 – 2704Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2705 – 3014CytoplasmicSequence analysisAdd BLAST310

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neural tube defects (NTD)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
See also OMIM:182940
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067213773A → V in NTD; shows significantly reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs12170597Ensembl.1
Natural variantiVAR_0672152438R → Q in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs199688538Ensembl.1
Natural variantiVAR_0672172964S → L in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs6008777Ensembl.1
Natural variantiVAR_0672182983P → A in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs61741871Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9620

MalaCards human disease database

More...
MalaCardsi
CELSR1
MIMi182940 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000075275

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26393

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CELSR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22095551

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291421 – 3014Cadherin EGF LAG seven-pass G-type receptor 1Add BLAST2994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1287N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1307 ↔ 1318By similarity
Disulfide bondi1312 ↔ 1349By similarity
Disulfide bondi1351 ↔ 1360By similarity
Disulfide bondi1367 ↔ 1378By similarity
Disulfide bondi1372 ↔ 1387By similarity
Disulfide bondi1389 ↔ 1398By similarity
Disulfide bondi1407 ↔ 1418By similarity
Disulfide bondi1412 ↔ 1428By similarity
Disulfide bondi1430 ↔ 1440By similarity
Glycosylationi1576N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1620 ↔ 1646By similarity
Glycosylationi1623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1640N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1653 ↔ 1664By similarity
Disulfide bondi1658 ↔ 1673By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1666(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1675 ↔ 1684By similarity
Disulfide bondi1840 ↔ 1870By similarity
Disulfide bondi1876 ↔ 1887By similarity
Disulfide bondi1881 ↔ 1896By similarity
Modified residuei1889(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1898 ↔ 1907By similarity
Disulfide bondi1911 ↔ 1922By similarity
Disulfide bondi1916 ↔ 1934By similarity
Disulfide bondi1936 ↔ 1945By similarity
Disulfide bondi1953 ↔ 1966By similarity
Disulfide bondi1968 ↔ 1978By similarity
Glycosylationi1979N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1985 ↔ 2000By similarity
Disulfide bondi1987 ↔ 2003By similarity
Disulfide bondi2005 ↔ 2015By similarity
Disulfide bondi2024 ↔ 2033By similarity
Disulfide bondi2036 ↔ 2048By similarity
Glycosylationi2103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2523N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2761PhosphoserineBy similarity1
Modified residuei2764PhosphoserineCombined sources1
Modified residuei2871PhosphoserineBy similarity1
Modified residuei2873PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NYQ6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NYQ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYQ6

PeptideAtlas

More...
PeptideAtlasi
Q9NYQ6

PRoteomics IDEntifications database

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PRIDEi
Q9NYQ6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83263
83264 [Q9NYQ6-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1054

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000075275 Expressed in 155 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NYQ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NYQ6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052976
HPA060521

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114981, 24 interactors

Protein interaction database and analysis system

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IntActi
Q9NYQ6, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9NYQ6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NYQ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini246 – 353Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini354 – 459Cadherin 2PROSITE-ProRule annotationAdd BLAST106
Domaini460 – 565Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini566 – 687Cadherin 4PROSITE-ProRule annotationAdd BLAST122
Domaini688 – 789Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini790 – 892Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini893 – 999Cadherin 7PROSITE-ProRule annotationAdd BLAST107
Domaini1000 – 1101Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1106 – 1224Cadherin 9PROSITE-ProRule annotationAdd BLAST119
Domaini1303 – 1361EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1363 – 1399EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1403 – 1441EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1442 – 1646Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1649 – 1685EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1689 – 1870Laminin G-like 2PROSITE-ProRule annotationAdd BLAST182
Domaini1872 – 1907EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1908 – 1946EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1947 – 1979EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini1981 – 2016EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2003 – 2050Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2408 – 2460GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2659 – 2663Poly-Leu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYQ6

KEGG Orthology (KO)

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KOi
K04600

Identification of Orthologs from Complete Genome Data

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OMAi
YVVGWGI

Database of Orthologous Groups

More...
OrthoDBi
23882at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYQ6

TreeFam database of animal gene trees

More...
TreeFami
TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPPPPVLP VLLLLAAAAA LPAMGLRAAA WEPRVPGGTR AFALRPGCTY
60 70 80 90 100
AVGAACTPRA PRELLDVGRD GRLAGRRRVS GAGRPLPLQV RLVARSAPTA
110 120 130 140 150
LSRRLRARTH LPGCGARARL CGTGARLCGA LCFPVPGGCA AAQHSALAAP
160 170 180 190 200
TTLPACRCPP RPRPRCPGRP ICLPPGGSVR LRLLCALRRA AGAVRVGLAL
210 220 230 240 250
EAATAGTPSA SPSPSPPLPP NLPEARAGPA RRARRGTSGR GSLKFPMPNY
260 270 280 290 300
QVALFENEPA GTLILQLHAH YTIEGEEERV SYYMEGLFDE RSRGYFRIDS
310 320 330 340 350
ATGAVSTDSV LDRETKETHV LRVKAVDYST PPRSATTYIT VLVKDTNDHS
360 370 380 390 400
PVFEQSEYRE RVRENLEVGY EVLTIRASDR DSPINANLRY RVLGGAWDVF
410 420 430 440 450
QLNESSGVVS TRAVLDREEA AEYQLLVEAN DQGRNPGPLS ATATVYIEVE
460 470 480 490 500
DENDNYPQFS EQNYVVQVPE DVGLNTAVLR VQATDRDQGQ NAAIHYSILS
510 520 530 540 550
GNVAGQFYLH SLSGILDVIN PLDFEDVQKY SLSIKAQDGG RPPLINSSGV
560 570 580 590 600
VSVQVLDVND NEPIFVSSPF QATVLENVPL GYPVVHIQAV DADSGENARL
610 620 630 640 650
HYRLVDTAST FLGGGSAGPK NPAPTPDFPF QIHNSSGWIT VCAELDREEV
660 670 680 690 700
EHYSFGVEAV DHGSPPMSSS TSVSITVLDV NDNDPVFTQP TYELRLNEDA
710 720 730 740 750
AVGSSVLTLQ ARDRDANSVI TYQLTGGNTR NRFALSSQRG GGLITLALPL
760 770 780 790 800
DYKQEQQYVL AVTASDGTRS HTAHVLINVT DANTHRPVFQ SSHYTVSVSE
810 820 830 840 850
DRPVGTSIAT LSANDEDTGE NARITYVIQD PVPQFRIDPD SGTMYTMMEL
860 870 880 890 900
DYENQVAYTL TIMAQDNGIP QKSDTTTLEI LILDANDNAP QFLWDFYQGS
910 920 930 940 950
IFEDAPPSTS ILQVSATDRD SGPNGRLLYT FQGGDDGDGD FYIEPTSGVI
960 970 980 990 1000
RTQRRLDREN VAVYNLWALA VDRGSPTPLS ASVEIQVTIL DINDNAPMFE
1010 1020 1030 1040 1050
KDELELFVEE NNPVGSVVAK IRANDPDEGP NAQIMYQIVE GDMRHFFQLD
1060 1070 1080 1090 1100
LLNGDLRAMV ELDFEVRREY VLVVQATSAP LVSRATVHIL LVDQNDNPPV
1110 1120 1130 1140 1150
LPDFQILFNN YVTNKSNSFP TGVIGCIPAH DPDVSDSLNY TFVQGNELRL
1160 1170 1180 1190 1200
LLLDPATGEL QLSRDLDNNR PLEALMEVSV SDGIHSVTAF CTLRVTIITD
1210 1220 1230 1240 1250
DMLTNSITVR LENMSQEKFL SPLLALFVEG VAAVLSTTKD DVFVFNVQND
1260 1270 1280 1290 1300
TDVSSNILNV TFSALLPGGV RGQFFPSEDL QEQIYLNRTL LTTISTQRVL
1310 1320 1330 1340 1350
PFDDNICLRE PCENYMKCVS VLRFDSSAPF LSSTTVLFRP IHPINGLRCR
1360 1370 1380 1390 1400
CPPGFTGDYC ETEIDLCYSD PCGANGRCRS REGGYTCECF EDFTGEHCEV
1410 1420 1430 1440 1450
DARSGRCANG VCKNGGTCVN LLIGGFHCVC PPGEYERPYC EVTTRSFPPQ
1460 1470 1480 1490 1500
SFVTFRGLRQ RFHFTISLTF ATQERNGLLL YNGRFNEKHD FIALEIVDEQ
1510 1520 1530 1540 1550
VQLTFSAGET TTTVAPKVPS GVSDGRWHSV QVQYYNKPNI GHLGLPHGPS
1560 1570 1580 1590 1600
GEKMAVVTVD DCDTTMAVRF GKDIGNYSCA AQGTQTGSKK SLDLTGPLLL
1610 1620 1630 1640 1650
GGVPNLPEDF PVHNRQFVGC MRNLSVDGKN VDMAGFIANN GTREGCAARR
1660 1670 1680 1690 1700
NFCDGRRCQN GGTCVNRWNM YLCECPLRFG GKNCEQAMPH PQLFSGESVV
1710 1720 1730 1740 1750
SWSDLNIIIS VPWYLGLMFR TRKEDSVLME ATSGGPTSFR LQILNNYLQF
1760 1770 1780 1790 1800
EVSHGPSDVE SVMLSGLRVT DGEWHHLLIE LKNVKEDSEM KHLVTMTLDY
1810 1820 1830 1840 1850
GMDQNKADIG GMLPGLTVRS VVVGGASEDK VSVRRGFRGC MQGVRMGGTP
1860 1870 1880 1890 1900
TNVATLNMNN ALKVRVKDGC DVDDPCTSSP CPPNSRCHDA WEDYSCVCDK
1910 1920 1930 1940 1950
GYLGINCVDA CHLNPCENMG ACVRSPGSPQ GYVCECGPSH YGPYCENKLD
1960 1970 1980 1990 2000
LPCPRGWWGN PVCGPCHCAV SKGFDPDCNK TNGQCQCKEN YYKLLAQDTC
2010 2020 2030 2040 2050
LPCDCFPHGS HSRTCDMATG QCACKPGVIG RQCNRCDNPF AEVTTLGCEV
2060 2070 2080 2090 2100
IYNGCPKAFE AGIWWPQTKF GQPAAVPCPK GSVGNAVRHC SGEKGWLPPE
2110 2120 2130 2140 2150
LFNCTTISFV DLRAMNEKLS RNETQVDGAR ALQLVRALRS ATQHTGTLFG
2160 2170 2180 2190 2200
NDVRTAYQLL GHVLQHESWQ QGFDLAATQD ADFHEDVIHS GSALLAPATR
2210 2220 2230 2240 2250
AAWEQIQRSE GGTAQLLRRL EGYFSNVARN VRRTYLRPFV IVTANMILAV
2260 2270 2280 2290 2300
DIFDKFNFTG ARVPRFDTIH EEFPRELESS VSFPADFFRP PEEKEGPLLR
2310 2320 2330 2340 2350
PAGRRTTPQT TRPGPGTERE APISRRRRHP DDAGQFAVAL VIIYRTLGQL
2360 2370 2380 2390 2400
LPERYDPDRR SLRLPHRPII NTPMVSTLVY SEGAPLPRPL ERPVLVEFAL
2410 2420 2430 2440 2450
LEVEERTKPV CVFWNHSLAV GGTGGWSARG CELLSRNRTH VACQCSHTAS
2460 2470 2480 2490 2500
FAVLMDISRR ENGEVLPLKI VTYAAVSLSL AALLVAFVLL SLVRMLRSNL
2510 2520 2530 2540 2550
HSIHKHLAVA LFLSQLVFVI GINQTENPFL CTVVAILLHY IYMSTFAWTL
2560 2570 2580 2590 2600
VESLHVYRML TEVRNIDTGP MRFYYVVGWG IPAIVTGLAV GLDPQGYGNP
2610 2620 2630 2640 2650
DFCWLSLQDT LIWSFAGPIG AVIIINTVTS VLSAKVSCQR KHHYYGKKGI
2660 2670 2680 2690 2700
VSLLRTAFLL LLLISATWLL GLLAVNRDAL SFHYLFAIFS GLQGPFVLLF
2710 2720 2730 2740 2750
HCVLNQEVRK HLKGVLGGRK LHLEDSATTR ATLLTRSLNC NTTFGDGPDM
2760 2770 2780 2790 2800
LRTDLGESTA SLDSIVRDEG IQKLGVSSGL VRGSHGEPDA SLMPRSCKDP
2810 2820 2830 2840 2850
PGHDSDSDSE LSLDEQSSSY ASSHSSDSED DGVGAEEKWD PARGAVHSTP
2860 2870 2880 2890 2900
KGDAVANHVP AGWPDQSLAE SDSEDPSGKP RLKVETKVSV ELHREEQGSH
2910 2920 2930 2940 2950
RGEYPPDQES GGAARLASSQ PPEQRKGILK NKVTYPPPLT LTEQTLKGRL
2960 2970 2980 2990 3000
REKLADCEQS PTSSRTSSLG SGGPDCAITV KSPGREPGRD HLNGVAMNVR
3010
TGSAQADGSD SEKP
Length:3,014
Mass (Da):329,486
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC34691AD3A1DFF3A
GO
Isoform 2 (identifier: Q9NYQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1395-1397: GEH → EIS
     1398-3014: Missing.

Note: No experimental confirmation available.
Show »
Length:1,397
Mass (Da):152,365
Checksum:iEEB74A274AB73179
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7R9H0Y7R9_HUMAN
Cadherin EGF LAG seven-pass G-type ...
CELSR1
772Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti651E → D in AAH00059 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049464587I → V. Corresponds to variant dbSNP:rs34141466Ensembl.1
Natural variantiVAR_016094664S → W1 PublicationCorresponds to variant dbSNP:rs4823850Ensembl.1
Natural variantiVAR_067213773A → V in NTD; shows significantly reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs12170597Ensembl.1
Natural variantiVAR_0160951126C → R1 PublicationCorresponds to variant dbSNP:rs4823561Ensembl.1
Natural variantiVAR_0494651242V → I. Corresponds to variant dbSNP:rs6008842Ensembl.1
Natural variantiVAR_0494661894Y → H. Corresponds to variant dbSNP:rs34467708Ensembl.1
Natural variantiVAR_0494671994L → P. Corresponds to variant dbSNP:rs6008795Ensembl.1
Natural variantiVAR_0494681995L → P. Corresponds to variant dbSNP:rs6008794Ensembl.1
Natural variantiVAR_0494692045T → M. Corresponds to variant dbSNP:rs12169391Ensembl.1
Natural variantiVAR_0244792107I → V. Corresponds to variant dbSNP:rs4044210Ensembl.1
Natural variantiVAR_0494702219R → H. Corresponds to variant dbSNP:rs34267201Ensembl.1
Natural variantiVAR_0244802268T → A. Corresponds to variant dbSNP:rs6007897Ensembl.1
Natural variantiVAR_0672142312R → P Does not affect protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs7287089Ensembl.1
Natural variantiVAR_0672152438R → Q in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs199688538Ensembl.1
Natural variantiVAR_0672162739N → T Does not affect protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs148905592Ensembl.1
Natural variantiVAR_0494712797C → S. Corresponds to variant dbSNP:rs12165943Ensembl.1
Natural variantiVAR_0494722903E → Q. Corresponds to variant dbSNP:rs9615351Ensembl.1
Natural variantiVAR_0494732948G → S. Corresponds to variant dbSNP:rs35364389Ensembl.1
Natural variantiVAR_0672172964S → L in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs6008777Ensembl.1
Natural variantiVAR_0672182983P → A in NTD; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs61741871Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0020111395 – 1397GEH → EIS in isoform 2. 1 Publication3
Alternative sequenceiVSP_0020121398 – 3014Missing in isoform 2. 1 PublicationAdd BLAST1617

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231024 mRNA Translation: AAF61930.1
AL021392 Genomic DNA No translation available.
AL031588 Genomic DNA No translation available.
AL031597 Genomic DNA No translation available.
BC000059 mRNA Translation: AAH00059.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14076.1 [Q9NYQ6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055061.1, NM_014246.1 [Q9NYQ6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262738; ENSP00000262738; ENSG00000075275 [Q9NYQ6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9620

UCSC genome browser

More...
UCSCi
uc003bhw.1 human [Q9NYQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231024 mRNA Translation: AAF61930.1
AL021392 Genomic DNA No translation available.
AL031588 Genomic DNA No translation available.
AL031597 Genomic DNA No translation available.
BC000059 mRNA Translation: AAH00059.2
CCDSiCCDS14076.1 [Q9NYQ6-1]
RefSeqiNP_055061.1, NM_014246.1 [Q9NYQ6-1]

3D structure databases

SMRiQ9NYQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114981, 24 interactors
IntActiQ9NYQ6, 5 interactors
MINTiQ9NYQ6
STRINGi9606.ENSP00000262738

Protein family/group databases

MEROPSiP02.953
TCDBi9.A.14.6.4 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyConnecti1054
iPTMnetiQ9NYQ6
PhosphoSitePlusiQ9NYQ6

Polymorphism and mutation databases

BioMutaiCELSR1
DMDMi22095551

Proteomic databases

EPDiQ9NYQ6
jPOSTiQ9NYQ6
MaxQBiQ9NYQ6
PaxDbiQ9NYQ6
PeptideAtlasiQ9NYQ6
PRIDEiQ9NYQ6
ProteomicsDBi83263
83264 [Q9NYQ6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262738; ENSP00000262738; ENSG00000075275 [Q9NYQ6-1]
GeneIDi9620
KEGGihsa:9620
UCSCiuc003bhw.1 human [Q9NYQ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9620
DisGeNETi9620

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CELSR1
HGNCiHGNC:1850 CELSR1
HPAiHPA052976
HPA060521
MalaCardsiCELSR1
MIMi182940 phenotype
604523 gene
neXtProtiNX_Q9NYQ6
OpenTargetsiENSG00000075275
PharmGKBiPA26393

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000159839
HOGENOMiHOG000231346
InParanoidiQ9NYQ6
KOiK04600
OMAiYVVGWGI
OrthoDBi23882at2759
PhylomeDBiQ9NYQ6
TreeFamiTF323983

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CELSR1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CELSR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9620

Protein Ontology

More...
PROi
PR:Q9NYQ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000075275 Expressed in 155 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ9NYQ6 baseline and differential
GenevisibleiQ9NYQ6 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYQ6
Secondary accession number(s): O95722
, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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