HAO2

Functionⁱ

Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Catalytic activityⁱ

(S)-2-hydroxy acid + O₂ = 2-oxo acid + H₂O₂.

Cofactorⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	128	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	130	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	156	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	165	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	222	FMNPROSITE-ProRule annotation	1
Active siteⁱ	246	Proton acceptorPROSITE-ProRule annotation	1
Binding siteⁱ	249	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	301	FMNPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	277 – 301	FMNPROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

(S)-2-hydroxy-acid oxidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10777549
FMN binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10777549
medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365
very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid catabolic process Source: Reactome
fatty acid oxidation
Source: UniProtKB
Inferred from direct assayⁱ
- 10777549
protein targeting to peroxisome Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Flavoprotein, FMN

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390918 Peroxisomal lipid metabolism R-HSA-9033241 Peroxisomal protein import

Reactomeⁱ

R-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9033241 Peroxisomal protein import

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hydroxyacid oxidase 2 (EC:1.1.3.15) Short name: HAOX2 Alternative name(s): (S)-2-hydroxy-acid oxidase, peroxisomal Cell growth-inhibiting gene 16 protein Long chain alpha-hydroxy acid oxidase Long-chain L-2-hydroxy acid oxidase
Gene namesⁱ	Name:HAO2 Synonyms:HAOX2 ORF Names:GIG16
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116882.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4810 HAO2
MIMⁱ	605176 gene
neXtProtⁱ	NX_Q9NYQ3

Keywords - Cellular componentⁱ

Peroxisome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51179
Open Targets More...OpenTargetsⁱ	ENSG00000116882
PharmGKBⁱ	PA29186

Chemistry databases

ChEMBLⁱ	CHEMBL2169732
Drug and drug target database More...DrugBankⁱ	DB03247 Riboflavin Monophosphate

Polymorphism and mutation databases

BioMutaⁱ	HAO2
DMDMⁱ	13124287

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206320	1 – 351	Hydroxyacid oxidase 2Add BLAST		351

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	178	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9NYQ3
PeptideAtlas More...PeptideAtlasⁱ	Q9NYQ3
PRIDEⁱ	Q9NYQ3
ProteomicsDBⁱ	83262

PTM databases

iPTMnetⁱ	Q9NYQ3
PhosphoSitePlusⁱ	Q9NYQ3

Expressionⁱ

Tissue specificityⁱ

Liver and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000116882 Expressed in 73 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_HAO2
ExpressionAtlasⁱ	Q9NYQ3 baseline and differential
Genevisibleⁱ	Q9NYQ3 HS

Interactionⁱ

Subunit structureⁱ

Homotetramer or homooctamer.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SEC14L4	Q9UDX3	4	EBI-8803200,EBI-10320311

With

Entry

#Exp.

IntAct

Notes

SEC14L4

Q9UDX3

4

EBI-8803200,EBI-10320311

GO - Molecular functionⁱ

signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119356, 25 interactors
IntActⁱ	Q9NYQ3, 2 interactors
STRINGⁱ	9606.ENSP00000316339

Chemistry databases

BindingDBⁱ

Q9NYQ3

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYQ3
SMRⁱ	Q9NYQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 351	FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST		350

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	349 – 351	Microbody targeting signalSequence analysis		3

Sequence similaritiesⁱ

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0538 Eukaryota COG1304 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018717
HOGENOMⁱ	HOG000217463
HOVERGENⁱ	HBG051881
InParanoidⁱ	Q9NYQ3
KEGG Orthology (KO) More...KOⁱ	K11517
OMAⁱ	KNEFHTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ADA
PhylomeDBⁱ	Q9NYQ3
TreeFamⁱ	TF313363

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NYQ3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVCLTDFQ AHAREQLSKS TRDFIEGGAD DSITRDDNIA AFKRIRLRPR 
        60         70         80         90        100
YLRDVSEVDT RTTIQGEEIS APICIAPTGF HCLVWPDGEM STARAAQAAG 
       110        120        130        140        150
ICYITSTFAS CSLEDIVIAA PEGLRWFQLY VHPDLQLNKQ LIQRVESLGF 
       160        170        180        190        200
KALVITLDTP VCGNRRHDIR NQLRRNLTLT DLQSPKKGNA IPYFQMTPIS 
       210        220        230        240        250
TSLCWNDLSW FQSITRLPII LKGILTKEDA ELAVKHNVQG IIVSNHGGRQ 
       260        270        280        290        300
LDEVLASIDA LTEVVAAVKG KIEVYLDGGV RTGNDVLKAL ALGAKCIFLG 
       310        320        330        340        350
RPILWGLACK GEHGVKEVLN ILTNEFHTSM ALTGCRSVAE INRNLVQFSR 

L

Length:351

Mass (Da):38,839

Last modified:October 1, 2000 - v1

Checksum:ⁱ7330DE44E282947D

GO

Isoform 2 (identifier: Q9NYQ3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MEDKMWSECEGPEM

« Hide

        10         20         30         40         50
MEDKMWSECE GPEMSLVCLT DFQAHAREQL SKSTRDFIEG GADDSITRDD 
        60         70         80         90        100
NIAAFKRIRL RPRYLRDVSE VDTRTTIQGE EISAPICIAP TGFHCLVWPD 
       110        120        130        140        150
GEMSTARAAQ AAGICYITST FASCSLEDIV IAAPEGLRWF QLYVHPDLQL 
       160        170        180        190        200
NKQLIQRVES LGFKALVITL DTPVCGNRRH DIRNQLRRNL TLTDLQSPKK 
       210        220        230        240        250
GNAIPYFQMT PISTSLCWND LSWFQSITRL PIILKGILTK EDAELAVKHN 
       260        270        280        290        300
VQGIIVSNHG GRQLDEVLAS IDALTEVVAA VKGKIEVYLD GGVRTGNDVL 
       310        320        330        340        350
KALALGAKCI FLGRPILWGL ACKGEHGVKE VLNILTNEFH TSMALTGCRS 
       360 
VAEINRNLVQ FSRL

Note: No experimental confirmation available.

Show »

Length:364

Mass (Da):40,391

Checksum:ⁱ13F52C5D431E8B2E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5QP02	Q5QP02_HUMAN		Hydroxyacid oxidase 2 Hydroxyacid oxidase 2	HAO2	186	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	80	F → Y in AAF14000 (Ref. 2) Curated		1
Sequence conflictⁱ	292 – 294	LGA → HED in AAF14000 (Ref. 2) Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049087	15	E → K. Corresponds to variant dbSNP:rs34638261Ensembl.		1
Natural variantⁱVAR_049088	221	L → M. Corresponds to variant dbSNP:rs6661625Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055095	1	M → MEDKMWSECEGPEM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF231917 mRNA Translation: AAF40200.1 AF203975 mRNA Translation: AAF14000.1 AY513277 mRNA Translation: AAT08030.1 AK298289 mRNA Translation: BAG60549.1 AL139346 Genomic DNA No translation available. AL359553 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56698.1 CH471122 Genomic DNA Translation: EAW56699.1 BC020863 mRNA Translation: AAH20863.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS76196.1 [Q9NYQ3-2] CCDS901.1 [Q9NYQ3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005783.2, NM_001005783.2 [Q9NYQ3-2] NP_057611.1, NM_016527.3 [Q9NYQ3-1]
UniGeneⁱ	Hs.659767

Genome annotation databases

Ensemblⁱ	ENST00000325945; ENSP00000316339; ENSG00000116882 [Q9NYQ3-1] ENST00000361035; ENSP00000354314; ENSG00000116882 [Q9NYQ3-2] ENST00000622548; ENSP00000483507; ENSG00000116882 [Q9NYQ3-1]
GeneIDⁱ	51179
KEGGⁱ	hsa:51179
UCSC genome browser More...UCSCⁱ	uc001ehq.1 human [Q9NYQ3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYQ3	Isoform 2 of Hydroxyacid oxidase 2		HUMAN		364	UniRef100_Q9NYQ3
Uncharacterized protein		PANPA		351

Protein	Similar proteins		Species	Score	Length	Source
Q9NYQ3	Isoform 2 of Hydroxyacid oxidase 2		HUMAN		364	UniRef90_Q9NYQ3
Uncharacterized protein		PANPA		351
Uncharacterized protein		RHIRO		367
Uncharacterized protein		MACFA		364
Uncharacterized protein		MACNE		364
+49

Protein	Similar proteins		Species	Score	Length	Source
Q9NYQ3	Hydroxyacid oxidase 2	)	RAT		353	UniRef50_Q9NYQ3
Hydroxyacid oxidase 2		BOVIN		353
Isoform 2 of Hydroxyacid oxidase 2		HUMAN		364
Uncharacterized protein		PANPA		351
Uncharacterized protein		RHIRO		367
+334

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF231917 mRNA Translation: AAF40200.1 AF203975 mRNA Translation: AAF14000.1 AY513277 mRNA Translation: AAT08030.1 AK298289 mRNA Translation: BAG60549.1 AL139346 Genomic DNA No translation available. AL359553 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56698.1 CH471122 Genomic DNA Translation: EAW56699.1 BC020863 mRNA Translation: AAH20863.1
CCDSⁱ	CCDS76196.1 [Q9NYQ3-2] CCDS901.1 [Q9NYQ3-1]
RefSeqⁱ	NP_001005783.2, NM_001005783.2 [Q9NYQ3-2] NP_057611.1, NM_016527.3 [Q9NYQ3-1]
UniGeneⁱ	Hs.659767

3D structure databases

ProteinModelPortalⁱ	Q9NYQ3
SMRⁱ	Q9NYQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119356, 25 interactors
IntActⁱ	Q9NYQ3, 2 interactors
STRINGⁱ	9606.ENSP00000316339

Chemistry databases

BindingDBⁱ	Q9NYQ3
ChEMBLⁱ	CHEMBL2169732
DrugBankⁱ	DB03247 Riboflavin Monophosphate

PTM databases

iPTMnetⁱ	Q9NYQ3
PhosphoSitePlusⁱ	Q9NYQ3

Polymorphism and mutation databases

BioMutaⁱ	HAO2
DMDMⁱ	13124287

Proteomic databases

PaxDbⁱ	Q9NYQ3
PeptideAtlasⁱ	Q9NYQ3
PRIDEⁱ	Q9NYQ3
ProteomicsDBⁱ	83262

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51179
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325945; ENSP00000316339; ENSG00000116882 [Q9NYQ3-1] ENST00000361035; ENSP00000354314; ENSG00000116882 [Q9NYQ3-2] ENST00000622548; ENSP00000483507; ENSG00000116882 [Q9NYQ3-1]
GeneIDⁱ	51179
KEGGⁱ	hsa:51179
UCSCⁱ	uc001ehq.1 human [Q9NYQ3-1]

Organism-specific databases

CTDⁱ	51179
DisGeNETⁱ	51179
EuPathDBⁱ	HostDB:ENSG00000116882.14
GeneCardsⁱ	HAO2
HGNCⁱ	HGNC:4810 HAO2
MIMⁱ	605176 gene
neXtProtⁱ	NX_Q9NYQ3
OpenTargetsⁱ	ENSG00000116882
PharmGKBⁱ	PA29186
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0538 Eukaryota COG1304 LUCA
GeneTreeⁱ	ENSGT00390000018717
HOGENOMⁱ	HOG000217463
HOVERGENⁱ	HBG051881
InParanoidⁱ	Q9NYQ3
KOⁱ	K11517
OMAⁱ	KNEFHTS
OrthoDBⁱ	EOG091G0ADA
PhylomeDBⁱ	Q9NYQ3
TreeFamⁱ	TF313363

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390918 Peroxisomal lipid metabolism R-HSA-9033241 Peroxisomal protein import

Reactomeⁱ

R-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	HAO2 human
GenomeRNAiⁱ	51179
Protein Ontology More...PROⁱ	PR:Q9NYQ3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116882 Expressed in 73 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_HAO2
ExpressionAtlasⁱ	Q9NYQ3 baseline and differential
Genevisibleⁱ	Q9NYQ3 HS

Family and domain databases

CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS
Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HAOX2_HUMAN
Accessionⁱ	Q9NYQ3Primary (citable) accession number: Q9NYQ3 Secondary accession number(s): Q2TU86, Q5QP00, Q9UJS6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYQ3 (HAOX2_HUMAN)

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Hydroxyacid oxidase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Cytosol

Peroxisome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ