Hao2

Functionⁱ

Has 2-hydroxyacid oxidase activity. Most active on medium-chain substrates.

Caution

Was originally thought to originate from human.1 Publication

Catalytic activityⁱ

(S)-2-hydroxy acid + O₂ = 2-oxo acid + H₂O₂.

Cofactorⁱ

FMN

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	128	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	130	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	156	FMNPROSITE-ProRule annotation	1
Binding siteⁱ	165	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	224	FMNPROSITE-ProRule annotation	1
Active siteⁱ	248	Proton acceptorPROSITE-ProRule annotation	1
Binding siteⁱ	251	SubstratePROSITE-ProRule annotation	1
Binding siteⁱ	303	FMNPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	279 – 303	FMNPROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

(S)-2-hydroxy-acid oxidase activity Source: MGI
FMN binding Source: MGI
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: MGI
medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
signaling receptor binding Source: MGI
very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Flavoprotein, FMN

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390918 Peroxisomal lipid metabolism R-MMU-9033241 Peroxisomal protein import

Reactomeⁱ

R-MMU-390918 Peroxisomal lipid metabolism
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hydroxyacid oxidase 2 (EC:1.1.3.15) Short name: HAOX2 Alternative name(s): (S)-2-hydroxy-acid oxidase, peroxisomal Medium chain alpha-hydroxy acid oxidase Medium-chain L-2-hydroxy acid oxidase
Gene namesⁱ	Name:Hao2 Synonyms:Hao3, Haox2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:96012 Hao2

Keywords - Cellular componentⁱ

Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206321	1 – 353	Hydroxyacid oxidase 2Add BLAST		353

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	171	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NYQ2
PaxDbⁱ	Q9NYQ2
PRIDEⁱ	Q9NYQ2

PTM databases

iPTMnetⁱ	Q9NYQ2
PhosphoSitePlusⁱ	Q9NYQ2

Expressionⁱ

Tissue specificityⁱ

Pancreas.

Gene expression databases

Bgeeⁱ	ENSMUSG00000027870 Expressed in 66 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_HAO3
Genevisibleⁱ	Q9NYQ2 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer or homooctamer.By similarity

GO - Molecular functionⁱ

signaling receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000029464

STRINGⁱ

10090.ENSMUSP00000029464

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYQ2
SMRⁱ	Q9NYQ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 353	FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST		352

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	351 – 353	Microbody targeting signalSequence analysis		3

Sequence similaritiesⁱ

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0538 Eukaryota COG1304 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018717
HOGENOMⁱ	HOG000217463
HOVERGENⁱ	HBG051881
InParanoidⁱ	Q9NYQ2
KEGG Orthology (KO) More...KOⁱ	K11517
OMAⁱ	KNEFHTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ADA
PhylomeDBⁱ	Q9NYQ2
TreeFamⁱ	TF313363

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NYQ2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLCLADFK AQAQKQLSKT SWDFIEGEAD DGITYNDNLA AFRRIRLRPR 
        60         70         80         90        100
YLRDVSKIDT RTTIQGQEIN APICISPTAF HSIAWADGEK STAKAAQKAN 
       110        120        130        140        150
ICYVISSYAS YTVEDIVAAA PGGLHWFQLY VQPDWDINKQ MVQRIEALGF 
       160        170        180        190        200
KALVVTVDAP VLGNRRGNKR SLLDLEANIK LKDLRSPGES KSGLPTPLSM 
       210        220        230        240        250
PSSSSCWNDL PLLQSMTRLP IILKGILTKE DAELAVKHNI RGIIVSNHGG 
       260        270        280        290        300
RQLDEVPASI DALREVVAAV NGKIEVYMDG GVRTGNDVLK ALALGARCIF 
       310        320        330        340        350
LGRPIIWGLA CKGEDGVKEV LDILKEELHT CMALSGCRSV AEISPDLIQF 

SRL

Length:353

Mass (Da):38,700

Last modified:October 1, 2000 - v1

Checksum:ⁱ0604D529F69DE3C7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	164	N → H in CAB96380 (Ref. 3) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF231918 mRNA Translation: AAF40201.1 AF272947 mRNA Translation: AAF81795.1 AJ251820 mRNA Translation: CAB96380.1 AK078908 mRNA Translation: BAC37452.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17671.1
NCBI Reference Sequences More...RefSeqⁱ	NP_062418.3, NM_019545.4 XP_011238471.1, XM_011240169.2
UniGeneⁱ	Mm.281874

Genome annotation databases

Ensemblⁱ	ENSMUST00000029464; ENSMUSP00000029464; ENSMUSG00000027870
GeneIDⁱ	56185
KEGGⁱ	mmu:56185
UCSC genome browser More...UCSCⁱ	uc008qqj.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYQ2	Uncharacterized protein		MOUSE		353	UniRef90_Q9NYQ2
UPI000A30BF19		MUSPA		353
UPI000A3197D9		MUSCR		353
Uncharacterized protein		MOUSE		353
Hydroxyacid oxidase (Glycolate oxidase) 3		MOUSE		353

Protein	Similar proteins		Species	Score	Length	Source
Q9NYQ2	Uncharacterized protein		MOUSE		353	UniRef50_Q9NYQ2
hydroxyacid oxidase 2 isoform X3		MESAU		313
Hydroxyacid oxidase 2		NEOVI		353
Hydroxyacid oxidase 2		MUSPF		366
hydroxyacid oxidase 2 isoform X1		Enhydra lutris kenyoni		353
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF231918 mRNA Translation: AAF40201.1 AF272947 mRNA Translation: AAF81795.1 AJ251820 mRNA Translation: CAB96380.1 AK078908 mRNA Translation: BAC37452.1
CCDSⁱ	CCDS17671.1
RefSeqⁱ	NP_062418.3, NM_019545.4 XP_011238471.1, XM_011240169.2
UniGeneⁱ	Mm.281874

3D structure databases

ProteinModelPortalⁱ	Q9NYQ2
SMRⁱ	Q9NYQ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000029464

STRINGⁱ

10090.ENSMUSP00000029464

PTM databases

iPTMnetⁱ	Q9NYQ2
PhosphoSitePlusⁱ	Q9NYQ2

Proteomic databases

MaxQBⁱ	Q9NYQ2
PaxDbⁱ	Q9NYQ2
PRIDEⁱ	Q9NYQ2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029464; ENSMUSP00000029464; ENSMUSG00000027870
GeneIDⁱ	56185
KEGGⁱ	mmu:56185
UCSCⁱ	uc008qqj.2 mouse

Organism-specific databases

CTDⁱ	51179
MGIⁱ	MGI:96012 Hao2

Phylogenomic databases

eggNOGⁱ	KOG0538 Eukaryota COG1304 LUCA
GeneTreeⁱ	ENSGT00390000018717
HOGENOMⁱ	HOG000217463
HOVERGENⁱ	HBG051881
InParanoidⁱ	Q9NYQ2
KOⁱ	K11517
OMAⁱ	KNEFHTS
OrthoDBⁱ	EOG091G0ADA
PhylomeDBⁱ	Q9NYQ2
TreeFamⁱ	TF313363

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390918 Peroxisomal lipid metabolism R-MMU-9033241 Peroxisomal protein import

Reactomeⁱ

R-MMU-390918 Peroxisomal lipid metabolism
R-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	Hao2 mouse
Protein Ontology More...PROⁱ	PR:Q9NYQ2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027870 Expressed in 66 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_HAO3
Genevisibleⁱ	Q9NYQ2 MM

Family and domain databases

CDDⁱ	cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS
Pfamⁱ	View protein in Pfam PF01070 FMN_dh, 1 hit
PIRSFⁱ	PIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HAOX2_MOUSE
Accessionⁱ	Q9NYQ2Primary (citable) accession number: Q9NYQ2 Secondary accession number(s): Q9JHS7, Q9JI00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYQ2 (HAOX2_MOUSE)

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Hydroxyacid oxidase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Mitochondrion

Peroxisome

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ