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Protein

BET1-like protein

Gene

BET1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
BET1-like protein
Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name:
GOS-15
Short name:
GS15
Vesicle transport protein GOS15
Gene namesi
Name:BET1LImported
Synonyms:GS15Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177951.17
HGNCiHGNC:19348 BET1L
MIMi615417 gene
neXtProtiNX_Q9NYM9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini108 – 111LumenalSequence analysis4

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51272
OpenTargetsiENSG00000177951
PharmGKBiPA134970036

Polymorphism and mutation databases

BioMutaiBET1L
DMDMi74734714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330561 – 111BET1-like proteinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYM9
MaxQBiQ9NYM9
PaxDbiQ9NYM9
PeptideAtlasiQ9NYM9
PRIDEiQ9NYM9
ProteomicsDBi83254
TopDownProteomicsiQ9NYM9

PTM databases

iPTMnetiQ9NYM9
PhosphoSitePlusiQ9NYM9
SwissPalmiQ9NYM9

Expressioni

Gene expression databases

BgeeiENSG00000177951 Expressed in 189 organ(s), highest expression level in adenohypophysis
CleanExiHS_BET1L
ExpressionAtlasiQ9NYM9 baseline and differential
GenevisibleiQ9NYM9 HS

Organism-specific databases

HPAiHPA039819

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119425, 11 interactors
IntActiQ9NYM9, 5 interactors
STRINGi9606.ENSP00000372210

Structurei

3D structure databases

ProteinModelPortaliQ9NYM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 77t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiQ9NYM9
KOiK08504
OMAiQNRYLDS
PhylomeDBiQ9NYM9
TreeFamiTF323307

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9NYM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN
60 70 80 90 100
RYLDGMDSDF TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF
110
ILSYFLSRAR T
Length:111
Mass (Da):12,388
Last modified:October 1, 2000 - v1
Checksum:i76E2C5099EC7EE5E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQJ6E9PQJ6_HUMAN
BET1-like protein
BET1L
88Annotation score:
E9PHY4E9PHY4_HUMAN
BET1-like protein
BET1L
92Annotation score:
A0A0C4DH16A0A0C4DH16_HUMAN
BET1-like protein
BET1L
102Annotation score:
B8ZZS0B8ZZS0_HUMAN
BET1-like protein
BET1L
152Annotation score:
H7BXT7H7BXT7_HUMAN
BET1-like protein
BET1L
58Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234160 mRNA Translation: AAF37877.1
AK022958 mRNA Translation: BAG51142.1
BC008971 mRNA Translation: AAH08971.1
CCDSiCCDS41582.1
RefSeqiNP_001092257.1, NM_001098787.1
UniGeneiHs.414418

Genome annotation databases

EnsembliENST00000382762; ENSP00000372210; ENSG00000177951
GeneIDi51272
KEGGihsa:51272
UCSCiuc001loe.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234160 mRNA Translation: AAF37877.1
AK022958 mRNA Translation: BAG51142.1
BC008971 mRNA Translation: AAH08971.1
CCDSiCCDS41582.1
RefSeqiNP_001092257.1, NM_001098787.1
UniGeneiHs.414418

3D structure databases

ProteinModelPortaliQ9NYM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119425, 11 interactors
IntActiQ9NYM9, 5 interactors
STRINGi9606.ENSP00000372210

PTM databases

iPTMnetiQ9NYM9
PhosphoSitePlusiQ9NYM9
SwissPalmiQ9NYM9

Polymorphism and mutation databases

BioMutaiBET1L
DMDMi74734714

Proteomic databases

EPDiQ9NYM9
MaxQBiQ9NYM9
PaxDbiQ9NYM9
PeptideAtlasiQ9NYM9
PRIDEiQ9NYM9
ProteomicsDBi83254
TopDownProteomicsiQ9NYM9

Protocols and materials databases

DNASUi51272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382762; ENSP00000372210; ENSG00000177951
GeneIDi51272
KEGGihsa:51272
UCSCiuc001loe.3 human

Organism-specific databases

CTDi51272
DisGeNETi51272
EuPathDBiHostDB:ENSG00000177951.17
GeneCardsiBET1L
HGNCiHGNC:19348 BET1L
HPAiHPA039819
MIMi615417 gene
neXtProtiNX_Q9NYM9
OpenTargetsiENSG00000177951
PharmGKBiPA134970036
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiQ9NYM9
KOiK08504
OMAiQNRYLDS
PhylomeDBiQ9NYM9
TreeFamiTF323307

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiBET1L human
GeneWikiiBET1L
GenomeRNAii51272
PROiPR:Q9NYM9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177951 Expressed in 189 organ(s), highest expression level in adenohypophysis
CleanExiHS_BET1L
ExpressionAtlasiQ9NYM9 baseline and differential
GenevisibleiQ9NYM9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBET1L_HUMAN
AccessioniPrimary (citable) accession number: Q9NYM9
Secondary accession number(s): B3KMY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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