UniProtKB - Q9NYM9 (BET1L_HUMAN)
Protein
BET1-like protein
Gene
BET1L
Organism
Homo sapiens (Human)
Status
Functioni
Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity
GO - Molecular functioni
- SNAP receptor activity Source: HGNC-UCL
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- protein transport Source: UniProtKB-KW
- regulation of retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
- retrograde transport, endosome to Golgi Source: HGNC-UCL
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NYM9 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic |
Names & Taxonomyi
Protein namesi | Recommended name: BET1-like proteinAlternative name(s): Golgi SNARE with a size of 15 kDa Short name: GOS-15 Short name: GS15 Vesicle transport protein GOS15 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19348, BET1L |
MIMi | 615417, gene |
neXtProti | NX_Q9NYM9 |
VEuPathDBi | HostDB:ENSG00000177951.17 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity
- trans-Golgi network membrane By similarity
Note: Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks.By similarity
Cytosol
- cytosol Source: GOC
Endosome
- endosome Source: HGNC-UCL
Golgi apparatus
- Golgi apparatus Source: HGNC-UCL
- Golgi membrane Source: Reactome
- Golgi trans cisterna Source: GO_Central
- integral component of Golgi membrane Source: InterPro
Other locations
- membrane Source: UniProtKB
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 86 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Transmembranei | 87 – 107 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 111 | LumenalSequence analysis | 4 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51272 |
OpenTargetsi | ENSG00000177951 |
PharmGKBi | PA134970036 |
Miscellaneous databases
Pharosi | Q9NYM9, Tbio |
Genetic variation databases
BioMutai | BET1L |
DMDMi | 74734714 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233056 | 1 – 111 | BET1-like proteinAdd BLAST | 111 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 | |
Modified residuei | 37 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NYM9 |
jPOSTi | Q9NYM9 |
MassIVEi | Q9NYM9 |
MaxQBi | Q9NYM9 |
PaxDbi | Q9NYM9 |
PeptideAtlasi | Q9NYM9 |
PRIDEi | Q9NYM9 |
ProteomicsDBi | 83254 |
TopDownProteomicsi | Q9NYM9 |
PTM databases
iPTMneti | Q9NYM9 |
PhosphoSitePlusi | Q9NYM9 |
SwissPalmi | Q9NYM9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177951, Expressed in adenohypophysis and 206 other tissues |
ExpressionAtlasi | Q9NYM9, baseline and differential |
Genevisiblei | Q9NYM9, HS |
Organism-specific databases
HPAi | ENSG00000177951, Low tissue specificity |
Interactioni
Subunit structurei
Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.
By similarityProtein-protein interaction databases
BioGRIDi | 119425, 25 interactors |
IntActi | Q9NYM9, 8 interactors |
STRINGi | 9606.ENSP00000372210 |
Miscellaneous databases
RNActi | Q9NYM9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 77 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000160208 |
InParanoidi | Q9NYM9 |
OMAi | CYVSIGL |
OrthoDBi | 1536545at2759 |
PhylomeDBi | Q9NYM9 |
TreeFami | TF323307 |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9NYM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN
60 70 80 90 100
RYLDGMDSDF TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF
110
ILSYFLSRAR T
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZS0 | B8ZZS0_HUMAN | BET1-like protein | BET1L | 152 | Annotation score: | ||
E9PQJ6 | E9PQJ6_HUMAN | BET1-like protein | BET1L | 88 | Annotation score: | ||
E9PHY4 | E9PHY4_HUMAN | BET1-like protein | BET1L | 92 | Annotation score: | ||
A0A0C4DH16 | A0A0C4DH16_HUMAN | BET1-like protein | BET1L | 102 | Annotation score: | ||
H7BXT7 | H7BXT7_HUMAN | BET1-like protein | BET1L | 58 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF234160 mRNA Translation: AAF37877.1 AK022958 mRNA Translation: BAG51142.1 BC008971 mRNA Translation: AAH08971.1 |
CCDSi | CCDS41582.1 |
RefSeqi | NP_001092257.1, NM_001098787.1 |
Genome annotation databases
Ensembli | ENST00000382762; ENSP00000372210; ENSG00000177951 |
GeneIDi | 51272 |
KEGGi | hsa:51272 |
UCSCi | uc001loe.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF234160 mRNA Translation: AAF37877.1 AK022958 mRNA Translation: BAG51142.1 BC008971 mRNA Translation: AAH08971.1 |
CCDSi | CCDS41582.1 |
RefSeqi | NP_001092257.1, NM_001098787.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119425, 25 interactors |
IntActi | Q9NYM9, 8 interactors |
STRINGi | 9606.ENSP00000372210 |
PTM databases
iPTMneti | Q9NYM9 |
PhosphoSitePlusi | Q9NYM9 |
SwissPalmi | Q9NYM9 |
Genetic variation databases
BioMutai | BET1L |
DMDMi | 74734714 |
Proteomic databases
EPDi | Q9NYM9 |
jPOSTi | Q9NYM9 |
MassIVEi | Q9NYM9 |
MaxQBi | Q9NYM9 |
PaxDbi | Q9NYM9 |
PeptideAtlasi | Q9NYM9 |
PRIDEi | Q9NYM9 |
ProteomicsDBi | 83254 |
TopDownProteomicsi | Q9NYM9 |
Protocols and materials databases
Antibodypediai | 41928, 37 antibodies |
DNASUi | 51272 |
Genome annotation databases
Ensembli | ENST00000382762; ENSP00000372210; ENSG00000177951 |
GeneIDi | 51272 |
KEGGi | hsa:51272 |
UCSCi | uc001loe.3, human |
Organism-specific databases
CTDi | 51272 |
DisGeNETi | 51272 |
GeneCardsi | BET1L |
HGNCi | HGNC:19348, BET1L |
HPAi | ENSG00000177951, Low tissue specificity |
MIMi | 615417, gene |
neXtProti | NX_Q9NYM9 |
OpenTargetsi | ENSG00000177951 |
PharmGKBi | PA134970036 |
VEuPathDBi | HostDB:ENSG00000177951.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000160208 |
InParanoidi | Q9NYM9 |
OMAi | CYVSIGL |
OrthoDBi | 1536545at2759 |
PhylomeDBi | Q9NYM9 |
TreeFami | TF323307 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYM9 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic |
Miscellaneous databases
BioGRID-ORCSi | 51272, 6 hits in 873 CRISPR screens |
ChiTaRSi | BET1L, human |
GeneWikii | BET1L |
GenomeRNAii | 51272 |
Pharosi | Q9NYM9, Tbio |
PROi | PR:Q9NYM9 |
RNActi | Q9NYM9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177951, Expressed in adenohypophysis and 206 other tissues |
ExpressionAtlasi | Q9NYM9, baseline and differential |
Genevisiblei | Q9NYM9, HS |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BET1L_HUMAN | |
Accessioni | Q9NYM9Primary (citable) accession number: Q9NYM9 Secondary accession number(s): B3KMY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot