BET1L

Functionⁱ

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functionⁱ

SNAP receptor activity
Source: HGNC
Inferred from direct assayⁱ
- 15215310

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ER to Golgi vesicle-mediated transport Source: Reactome
protein transport Source: UniProtKB-KW
regulation of retrograde vesicle-mediated transport, Golgi to ER
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17389686
retrograde transport, endosome to Golgi
Source: HGNC
Inferred from direct assayⁱ
- 15215310

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811438 Intra-Golgi traffic

Reactomeⁱ

R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BET1-like protein Alternative name(s): Golgi SNARE with a size of 15 kDa Short name: GOS-15 Short name: GS15 Vesicle transport protein GOS15
Gene namesⁱ	Name:BET1LImported Synonyms:GS15Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177951.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19348 BET1L
MIMⁱ	615417 gene
neXtProtⁱ	NX_Q9NYM9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 86	CytoplasmicSequence analysisAdd BLAST	86
Transmembraneⁱ	87 – 107	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	108 – 111	LumenalSequence analysis	4

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51272
Open Targets More...OpenTargetsⁱ	ENSG00000177951
PharmGKBⁱ	PA134970036

Polymorphism and mutation databases

BioMutaⁱ	BET1L
DMDMⁱ	74734714

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233056	1 – 111	BET1-like proteinAdd BLAST		111

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	9	PhosphoserineCombined sources		1
Modified residueⁱ	37	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NYM9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NYM9
PaxDbⁱ	Q9NYM9
PeptideAtlas More...PeptideAtlasⁱ	Q9NYM9
PRIDEⁱ	Q9NYM9
ProteomicsDBⁱ	83254
TopDownProteomicsⁱ	Q9NYM9

PTM databases

iPTMnetⁱ	Q9NYM9
PhosphoSitePlusⁱ	Q9NYM9
SwissPalmⁱ	Q9NYM9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177951 Expressed in 189 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_BET1L
ExpressionAtlasⁱ	Q9NYM9 baseline and differential
Genevisibleⁱ	Q9NYM9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039819

HPAⁱ

HPA039819

Interactionⁱ

Subunit structureⁱ

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

GO - Molecular functionⁱ

SNAP receptor activity
Source: HGNC
Inferred from direct assayⁱ
- 15215310

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119425, 11 interactors
IntActⁱ	Q9NYM9, 5 interactors
STRINGⁱ	9606.ENSP00000372210

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	15 – 77	t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		63

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3385 Eukaryota ENOG4111W10 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00570000079186
HOGENOMⁱ	HOG000290697
HOVERGENⁱ	HBG029661
InParanoidⁱ	Q9NYM9
KEGG Orthology (KO) More...KOⁱ	K08504
OMAⁱ	QNRYLDS
PhylomeDBⁱ	Q9NYM9
TreeFamⁱ	TF323307

Family and domain databases

InterProⁱ	View protein in InterPro IPR000727 T_SNARE_dom
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q9NYM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN 
        60         70         80         90        100
RYLDGMDSDF TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF 
       110 
ILSYFLSRAR T

Length:111

Mass (Da):12,388

Last modified:October 1, 2000 - v1

Checksum:ⁱ76E2C5099EC7EE5E

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PQJ6	E9PQJ6_HUMAN	BET1-like protein BET1-like protein	BET1L	88	Annotation score:
E9PHY4	E9PHY4_HUMAN	BET1-like protein BET1-like protein	BET1L	92	Annotation score:
A0A0C4DH16	A0A0C4DH16_HUMAN	BET1-like protein BET1-like protein	BET1L	102	Annotation score:
B8ZZS0	B8ZZS0_HUMAN	BET1-like protein BET1-like protein	BET1L	152	Annotation score:
H7BXT7	H7BXT7_HUMAN	BET1-like protein BET1-like protein	BET1L	58	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF234160 mRNA Translation: AAF37877.1 AK022958 mRNA Translation: BAG51142.1 BC008971 mRNA Translation: AAH08971.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41582.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001092257.1, NM_001098787.1
UniGeneⁱ	Hs.414418

Genome annotation databases

Ensemblⁱ	ENST00000382762; ENSP00000372210; ENSG00000177951
GeneIDⁱ	51272
KEGGⁱ	hsa:51272
UCSC genome browser More...UCSCⁱ	uc001loe.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYM9	BET1-like protein		HUMAN		88	UniRef100_Q9NYM9

Protein	Similar proteins		Species	Score	Length	Source
Q9NYM9	BET1-like protein		PONAB		111	UniRef90_Q9NYM9
BET1-like protein		BOVIN		111
BET1-like protein		HUMAN		88
BET1-like protein isoform X5		Enhydra lutris kenyoni		134
BET1L		CEREH		114
+38

Protein	Similar proteins		Species	Score	Length	Source
Q9NYM9	BET1-like protein		BOVIN		111	UniRef50_Q9NYM9
BET1-like protein		PONAB		111
BET1-like protein		HUMAN		88
BET1-like protein isoform X5		Enhydra lutris kenyoni		134
BET1L		CEREH		114
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF234160 mRNA Translation: AAF37877.1 AK022958 mRNA Translation: BAG51142.1 BC008971 mRNA Translation: AAH08971.1
CCDSⁱ	CCDS41582.1
RefSeqⁱ	NP_001092257.1, NM_001098787.1
UniGeneⁱ	Hs.414418

3D structure databases

ProteinModelPortalⁱ	Q9NYM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119425, 11 interactors
IntActⁱ	Q9NYM9, 5 interactors
STRINGⁱ	9606.ENSP00000372210

PTM databases

iPTMnetⁱ	Q9NYM9
PhosphoSitePlusⁱ	Q9NYM9
SwissPalmⁱ	Q9NYM9

Polymorphism and mutation databases

BioMutaⁱ	BET1L
DMDMⁱ	74734714

Proteomic databases

EPDⁱ	Q9NYM9
MaxQBⁱ	Q9NYM9
PaxDbⁱ	Q9NYM9
PeptideAtlasⁱ	Q9NYM9
PRIDEⁱ	Q9NYM9
ProteomicsDBⁱ	83254
TopDownProteomicsⁱ	Q9NYM9

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51272
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000382762; ENSP00000372210; ENSG00000177951
GeneIDⁱ	51272
KEGGⁱ	hsa:51272
UCSCⁱ	uc001loe.3 human

Organism-specific databases

CTDⁱ	51272
DisGeNETⁱ	51272
EuPathDBⁱ	HostDB:ENSG00000177951.17
GeneCardsⁱ	BET1L
HGNCⁱ	HGNC:19348 BET1L
HPAⁱ	HPA039819
MIMⁱ	615417 gene
neXtProtⁱ	NX_Q9NYM9
OpenTargetsⁱ	ENSG00000177951
PharmGKBⁱ	PA134970036
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3385 Eukaryota ENOG4111W10 LUCA
GeneTreeⁱ	ENSGT00570000079186
HOGENOMⁱ	HOG000290697
HOVERGENⁱ	HBG029661
InParanoidⁱ	Q9NYM9
KOⁱ	K08504
OMAⁱ	QNRYLDS
PhylomeDBⁱ	Q9NYM9
TreeFamⁱ	TF323307

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811438 Intra-Golgi traffic

Reactomeⁱ

R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSⁱ	BET1L human
GeneWikiⁱ	BET1L
GenomeRNAiⁱ	51272
Protein Ontology More...PROⁱ	PR:Q9NYM9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177951 Expressed in 189 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_BET1L
ExpressionAtlasⁱ	Q9NYM9 baseline and differential
Genevisibleⁱ	Q9NYM9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000727 T_SNARE_dom
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BET1L_HUMAN
Accessionⁱ	Q9NYM9Primary (citable) accession number: Q9NYM9 Secondary accession number(s): B3KMY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYM9 (BET1L_HUMAN)

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BET1-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytosol

Endosome

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ