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Protein

Tropomodulin-3

Gene

TMOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-3
Alternative name(s):
Ubiquitous tropomodulin
Short name:
U-Tmod
Gene namesi
Name:TMOD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138594.12
HGNCiHGNC:11873 TMOD3
MIMi605112 gene
neXtProtiNX_Q9NYL9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29766
OpenTargetsiENSG00000138594
PharmGKBiPA36574

Polymorphism and mutation databases

BioMutaiTMOD3
DMDMi23396884

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861341 – 352Tropomodulin-3Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYL9
MaxQBiQ9NYL9
PaxDbiQ9NYL9
PeptideAtlasiQ9NYL9
PRIDEiQ9NYL9
ProteomicsDBi83252
TopDownProteomicsiQ9NYL9

2D gel databases

OGPiQ9NYL9

PTM databases

iPTMnetiQ9NYL9
PhosphoSitePlusiQ9NYL9
SwissPalmiQ9NYL9

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000138594
CleanExiHS_TMOD3
ExpressionAtlasiQ9NYL9 baseline and differential
GenevisibleiQ9NYL9 HS

Organism-specific databases

HPAiHPA001849

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118899, 129 interactors
IntActiQ9NYL9, 60 interactors
MINTiQ9NYL9
STRINGi9606.ENSP00000308753

Structurei

3D structure databases

ProteinModelPortaliQ9NYL9
SMRiQ9NYL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiQ9NYL9
KOiK10370
OMAiNTHVKNF
OrthoDBiEOG091G0C3H
PhylomeDBiQ9NYL9
TreeFamiTF315841

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030133 TMOD3
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF18 PTHR10901:SF18, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF
60 70 80 90 100
RQKNQTSKST TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP
110 120 130 140 150
KQKPVQTFTE EKVSLDPELE EALTSASDTE LCDLAAILGM HNLITNTKFC
160 170 180 190 200
NIMGSSNGVD QEHFSNVVKG EKILPVFDEP PNPTNVEESL KRTKENDAHL
210 220 230 240 250
VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN DPVATAFAEM
260 270 280 290 300
LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA
310 320 330 340 350
VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD

HQ
Length:352
Mass (Da):39,595
Last modified:October 1, 2000 - v1
Checksum:i8B7F2122C1BE9855
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27T → S in AAF31670 (PubMed:10662549).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237631 mRNA Translation: AAF45299.1
AF177171 mRNA Translation: AAF31670.1
AK312569 mRNA Translation: BAG35464.1
BC020542 mRNA Translation: AAH20542.1
AL137543 mRNA Translation: CAB70801.1
CCDSiCCDS10145.1
PIRiT46384
RefSeqiNP_055362.1, NM_014547.4
XP_016877576.1, XM_017022087.1
XP_016877577.1, XM_017022088.1
UniGeneiHs.4998

Genome annotation databases

EnsembliENST00000308580; ENSP00000308753; ENSG00000138594
GeneIDi29766
KEGGihsa:29766
UCSCiuc002abn.4 human

Similar proteinsi

Entry informationi

Entry nameiTMOD3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYL9
Secondary accession number(s): B2R6G7, Q9NT43, Q9NZR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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