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UniProtKB - Q9NYL2 (M3K20_HUMAN)

Protein

Mitogen-activated protein kinase kinase kinase 20

Gene

MAP3K20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).5 Publications
Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45ATPPROSITE-ProRule annotation1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei133Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NYL2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NYL2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 20Imported (EC:2.7.11.25)
Alternative name(s):
Human cervical cancer suppressor gene 4 protein
Short name:
HCCS-4
Leucine zipper- and sterile alpha motif-containing kinase
MLK-like mitogen-activated protein triple kinase
Mitogen-activated protein kinase kinase kinase MLT
Mixed lineage kinase-related kinase
Short name:
MLK-related kinase
Short name:
MRK
Sterile alpha motif- and leucine zipper-containing kinase AZK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K20Imported
Synonyms:MLTK, ZAK1 Publication
ORF Names:HCCS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000091436.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:17797 MAP3K20

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609479 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NYL2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Split-foot malformation with mesoaxial polydactyly (SFMMP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss.
See also OMIM:616890
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076448368F → C in SFMMP; produces protein aggregation. 1 PublicationCorresponds to variant dbSNP:rs863225437EnsemblClinVar.1
Myopathy, centronuclear, 6, with fiber-type disproportion (CNM6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of centronuclear myopathy, a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. CNM6 is an autosomal recessive, slowly progressive form with onset in infancy or early childhood.
See also OMIM:617760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08056395 – 800Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST706
Natural variantiVAR_080564172 – 800Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST629

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi161T → A: Loss of autophosphorylation activity. 1 Publication1
Mutagenesisi162T → A: Slight loss of autophosphorylation activity. 1 Publication1
Mutagenesisi165S → A: Loss of autophosphorylation activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		51776

MalaCards human disease database

More...MalaCardsi		MAP3K20
MIMi616890 phenotype
617760 phenotype

Open Targets

More...OpenTargetsi		ENSG00000091436

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2020 Congenital fiber-type disproportion myopathy
488232 Split-foot malformation-mesoaxial polydactyly syndrome

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3886

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2289

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MLTK

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104215

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863382 – 800Mitogen-activated protein kinase kinase kinase 20Add BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei161Phosphothreonine; by autocatalysis1 Publication1
Modified residuei165Phosphoserine; by autocatalysis1 Publication1
Modified residuei275PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei628PhosphothreonineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Isoform 21 Publication (identifier: Q9NYL2-2)
Modified residuei339PhosphoserineCombined sources1 Publication1
Modified residuei429PhosphoserineCombined sources1 Publication1
Modified residuei434PhosphoserineCombined sources1 Publication1
Modified residuei454PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NYL2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NYL2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NYL2

PeptideAtlas

More...PeptideAtlasi		Q9NYL2

PRoteomics IDEntifications database

More...PRIDEi		Q9NYL2

ProteomicsDB human proteome resource

More...ProteomicsDBi		83246
83247 [Q9NYL2-2]
83248 [Q9NYL2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NYL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NYL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000091436 Expressed in 221 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NYL2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NYL2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017205

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:10924358, PubMed:26755636). Interacts with PKN1 and ZNF33A (PubMed:12535642, PubMed:12761180). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20 (PubMed:21224381).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119725, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NYL2

Protein interaction database and analysis system

More...IntActi		Q9NYL2, 41 interactors

Molecular INTeraction database

More...MINTi		Q9NYL2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364361

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NYL2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1800
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NYL2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NYL2

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini339 – 410SAMPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni287 – 308Leucine-zipperAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0192 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161352

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG080445

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NYL2

KEGG Orthology (KO)

More...KOi		K04424

Identification of Orthologs from Complete Genome Data

More...OMAi		QWRCEIE

Database of Orthologous Groups

More...OrthoDBi		EOG091G037E

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NYL2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR032938 MLTK
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR44496 PTHR44496, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9NYL2-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI 
        60         70         80         90        100
EKEAEILSVL SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE 
       110        120        130        140        150
EMDMDHIMTW ATDVAKGMHY LHMEAPVKVI HRDLKSRNVV IAADGVLKIC 
       160        170        180        190        200
DFGASRFHNH TTHMSLVGTF PWMAPEVIQS LPVSETCDTY SYGVVLWEML 
       210        220        230        240        250
TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH QCWEADAKKR 
       260        270        280        290        300
PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD 
       310        320        330        340        350
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYCWVQQ 
       360        370        380        390        400
LVRKGDSSAE MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF 
       410        420        430        440        450
KSAIEKLTHD YINLFHFPPL IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT 
       460        470        480        490        500
GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT NLPDAEILKM TKPPFVMEKW 
       510        520        530        540        550
IVGIAKSQTV ECTVTYESDV RTPKSTKHVH SIQWSRTKPQ DEVKAVQLAI 
       560        570        580        590        600
QTLFTNSDGN PGSRSDSSAD CQWLDTLRMR QIASNTSLQR SQSNPILGSP 
       610        620        630        640        650
FFSHFDGQDS YAAAVRRPQV PIKYQQITPV NQSRSSSPTQ YGLTKNFSSL 
       660        670        680        690        700
HLNSRDSGFS SGNTDTSSER GRYSDRSRNK YGRGSISLNS SPRGRYSGKS 
       710        720        730        740        750
QHSTPSRGRY PGKFYRVSQS ALNPHQSPDF KRSPRDLHQP NTIPGMPLHP 
       760        770        780        790        800
ETDSRASEED SKVSEGGWTK VEYRKKPHRP SPAKTNKERA RGDHRGWRNF
Length:800
Mass (Da):91,155
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2814509EC54B07A
GO
Isoform 21 Publication (identifier: Q9NYL2-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     332-455: PSFEIGAWTE...LKPGTGPQDC → LPLAARMSEE...EEDNDMDNSE
     456-800: Missing.

Show »
Length:455
Mass (Da):51,582
Checksum:iE87DB84A4D58B752
GO
Isoform 3 (identifier: Q9NYL2-3) [UniParc]FASTAAdd to basket
Also known as: HCCS-4

The sequence of this isoform differs from the canonical sequence as follows:
     285-312: CEIEATLERLKKLERDLSFKEQELKERE → WVAPTAGHSVWLSKTITRLNEEVNQRSE
     313-800: Missing.

Show »
Length:312
Mass (Da):35,468
Checksum:iB655E873246339FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4Q8H0D4Q8H0_HUMAN
Mitogen-activated protein kinase ki...
pk ZAK
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3F7C9J3F7_HUMAN
Mitogen-activated protein kinase ki...
MAP3K20
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92211 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346C → W in AAF63490 (PubMed:10924358).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08056395 – 800Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST706
Natural variantiVAR_080564172 – 800Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST629
Natural variantiVAR_040806267T → M1 PublicationCorresponds to variant dbSNP:rs6758025Ensembl.1
Natural variantiVAR_040807281A → T in an ovarian endometrioid sample; somatic mutation. 1 Publication1
Natural variantiVAR_040808281A → V1 PublicationCorresponds to variant dbSNP:rs34683477Ensembl.1
Natural variantiVAR_076448368F → C in SFMMP; produces protein aggregation. 1 PublicationCorresponds to variant dbSNP:rs863225437EnsemblClinVar.1
Natural variantiVAR_022827531S → L5 PublicationsCorresponds to variant dbSNP:rs3769148Ensembl.1
Natural variantiVAR_040809580R → W1 PublicationCorresponds to variant dbSNP:rs7593622Ensembl.1
Natural variantiVAR_040810740P → T1 PublicationCorresponds to variant dbSNP:rs56202258Ensembl.1
Natural variantiVAR_040811773Y → H1 PublicationCorresponds to variant dbSNP:rs35608243Ensembl.1
Natural variantiVAR_040812784K → T2 PublicationsCorresponds to variant dbSNP:rs55830025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051741285 – 312CEIEA…LKERE → WVAPTAGHSVWLSKTITRLN EEVNQRSE in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_051742313 – 800Missing in isoform 3. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_051743332 – 455PSFEI…GPQDC → LPLAARMSEESYFESKTEES NSAEMSCQITATSNGEGHGM NPSLQAMMLMGFGDIFSMNK AGAVMHSGMQINMQAKQNSS KTTSKRRGKKVNMALGFSDF DLSEGDDDDDDDGEEEDNDM DNSE in isoform 2. 5 PublicationsAdd BLAST124
Alternative sequenceiVSP_051744456 – 800Missing in isoform 2. 5 PublicationsAdd BLAST345

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF238255 mRNA Translation: AAF63490.1
AB049733 mRNA Translation: BAB16444.1
AB049734 mRNA Translation: BAB16445.1
AF325454 mRNA Translation: AAK11615.1
AF480461 mRNA Translation: AAL85891.1
AF480462 mRNA Translation: AAL85892.1
AB030034 mRNA Translation: BAB12040.1
AF251441 mRNA Translation: AAF65822.1
AF465843 mRNA Translation: AAO33376.1
AK056310 mRNA Translation: BAG51674.1
AB208974 mRNA Translation: BAD92211.1 Different initiation.
AC092573 Genomic DNA Translation: AAX82002.1
AC013461 Genomic DNA Translation: AAX93067.1
AC019046 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11164.1
BC001401 mRNA Translation: AAH01401.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2251.1 [Q9NYL2-2]
CCDS42777.1 [Q9NYL2-1]

NCBI Reference Sequences

More...RefSeqi		NP_057737.2, NM_016653.2 [Q9NYL2-1]
NP_598407.1, NM_133646.2 [Q9NYL2-2]
XP_005246697.1, XM_005246640.2 [Q9NYL2-1]
XP_016859812.1, XM_017004323.1 [Q9NYL2-2]
XP_016859813.1, XM_017004324.1 [Q9NYL2-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.444451

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338983; ENSP00000340257; ENSG00000091436 [Q9NYL2-2]
ENST00000375213; ENSP00000364361; ENSG00000091436 [Q9NYL2-1]
ENST00000409176; ENSP00000387259; ENSG00000091436 [Q9NYL2-1]
ENST00000539448; ENSP00000439414; ENSG00000091436 [Q9NYL2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51776

UCSC genome browser

More...UCSCi		uc002uhz.4 human [Q9NYL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238255 mRNA Translation: AAF63490.1
AB049733 mRNA Translation: BAB16444.1
AB049734 mRNA Translation: BAB16445.1
AF325454 mRNA Translation: AAK11615.1
AF480461 mRNA Translation: AAL85891.1
AF480462 mRNA Translation: AAL85892.1
AB030034 mRNA Translation: BAB12040.1
AF251441 mRNA Translation: AAF65822.1
AF465843 mRNA Translation: AAO33376.1
AK056310 mRNA Translation: BAG51674.1
AB208974 mRNA Translation: BAD92211.1 Different initiation.
AC092573 Genomic DNA Translation: AAX82002.1
AC013461 Genomic DNA Translation: AAX93067.1
AC019046 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11164.1
BC001401 mRNA Translation: AAH01401.1
CCDSiCCDS2251.1 [Q9NYL2-2]
CCDS42777.1 [Q9NYL2-1]
RefSeqiNP_057737.2, NM_016653.2 [Q9NYL2-1]
NP_598407.1, NM_133646.2 [Q9NYL2-2]
XP_005246697.1, XM_005246640.2 [Q9NYL2-1]
XP_016859812.1, XM_017004323.1 [Q9NYL2-2]
XP_016859813.1, XM_017004324.1 [Q9NYL2-2]
UniGeneiHs.444451

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HESX-ray2.14A/B5-309[»]
5X5OX-ray1.87A5-309[»]
ProteinModelPortaliQ9NYL2
SMRiQ9NYL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119725, 44 interactors
CORUMiQ9NYL2
IntActiQ9NYL2, 41 interactors
MINTiQ9NYL2
STRINGi9606.ENSP00000364361

Chemistry databases

BindingDBiQ9NYL2
ChEMBLiCHEMBL3886
GuidetoPHARMACOLOGYi2289

PTM databases

iPTMnetiQ9NYL2
PhosphoSitePlusiQ9NYL2

Polymorphism and mutation databases

BioMutaiMLTK
DMDMi313104215

Proteomic databases

EPDiQ9NYL2
MaxQBiQ9NYL2
PaxDbiQ9NYL2
PeptideAtlasiQ9NYL2
PRIDEiQ9NYL2
ProteomicsDBi83246
83247 [Q9NYL2-2]
83248 [Q9NYL2-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51776
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338983; ENSP00000340257; ENSG00000091436 [Q9NYL2-2]
ENST00000375213; ENSP00000364361; ENSG00000091436 [Q9NYL2-1]
ENST00000409176; ENSP00000387259; ENSG00000091436 [Q9NYL2-1]
ENST00000539448; ENSP00000439414; ENSG00000091436 [Q9NYL2-2]
GeneIDi51776
KEGGihsa:51776
UCSCiuc002uhz.4 human [Q9NYL2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51776
DisGeNETi51776
EuPathDBiHostDB:ENSG00000091436.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP3K20

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0030332
HGNCiHGNC:17797 MAP3K20
HPAiHPA017205
MalaCardsiMAP3K20
MIMi609479 gene
616890 phenotype
617760 phenotype
neXtProtiNX_Q9NYL2
OpenTargetsiENSG00000091436
Orphaneti2020 Congenital fiber-type disproportion myopathy
488232 Split-foot malformation-mesoaxial polydactyly syndrome

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000161352
HOVERGENiHBG080445
InParanoidiQ9NYL2
KOiK04424
OMAiQWRCEIE
OrthoDBiEOG091G037E
PhylomeDBiQ9NYL2

Enzyme and pathway databases

SignaLinkiQ9NYL2
SIGNORiQ9NYL2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZAK human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZAK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51776

Protein Ontology

More...PROi		PR:Q9NYL2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000091436 Expressed in 221 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ9NYL2 baseline and differential
GenevisibleiQ9NYL2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR032938 MLTK
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR44496 PTHR44496, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYL2
Secondary accession number(s): B3KPG2
, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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