UniProtKB - Q9NYL2 (M3K20_HUMAN)
Mitogen-activated protein kinase kinase kinase 20
MAP3K20
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 45 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 133 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 22 – 30 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- MAP kinase kinase kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- protein threonine kinase activity Source: RHEA
- RNA binding Source: UniProtKB
GO - Biological processi
- activation of JUN kinase activity Source: UniProtKB
- activation of MAPKK activity Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cell death Source: UniProtKB
- cell differentiation Source: UniProtKB
- cellular response to gamma radiation Source: UniProtKB
- cytoskeleton organization Source: Ensembl
- DNA damage checkpoint Source: UniProtKB
- embryonic digit morphogenesis Source: UniProtKB
- limb development Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of mitotic DNA damage checkpoint Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- stress-activated MAPK cascade Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NYL2 |
SignaLinki | Q9NYL2 |
SIGNORi | Q9NYL2 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase kinase kinase 20Imported (EC:2.7.11.25)Alternative name(s): Human cervical cancer suppressor gene 4 protein Short name: HCCS-4 Leucine zipper- and sterile alpha motif-containing kinase MLK-like mitogen-activated protein triple kinase Mitogen-activated protein kinase kinase kinase MLT Mixed lineage kinase-related kinase Short name: MLK-related kinase Short name: MRK Sterile alpha motif- and leucine zipper-containing kinase AZK |
Gene namesi | ORF Names:HCCS4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17797, MAP3K20 |
MIMi | 609479, gene |
neXtProti | NX_Q9NYL2 |
VEuPathDBi | HostDB:ENSG00000091436.16 |
Pathology & Biotechi
Involvement in diseasei
Split-foot malformation with mesoaxial polydactyly (SFMMP)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076448 | 368 | F → C in SFMMP; produces protein aggregation. 1 PublicationCorresponds to variant dbSNP:rs863225437EnsemblClinVar. | 1 |
Myopathy, centronuclear, 6, with fiber-type disproportion (CNM6)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080563 | 95 – 800 | Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST | 706 | |
Natural variantiVAR_080564 | 172 – 800 | Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST | 629 | |
Natural variantiVAR_082158 | 250 | R → W in CNM6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs763481300EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 45 | K → M: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 161 | T → A: Loss of autophosphorylation activity. 1 Publication | 1 | |
Mutagenesisi | 162 | T → A: Slight loss of autophosphorylation activity. 1 Publication | 1 | |
Mutagenesisi | 165 | S → A: Loss of autophosphorylation activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 51776 |
MalaCardsi | MAP3K20 |
MIMi | 616890, phenotype 617760, phenotype |
OpenTargetsi | ENSG00000091436 |
Orphaneti | 2020, Congenital fiber-type disproportion myopathy 488232, Split-foot malformation-mesoaxial polydactyly syndrome |
Miscellaneous databases
Pharosi | Q9NYL2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3886 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib |
DrugCentrali | Q9NYL2 |
GuidetoPHARMACOLOGYi | 2289 |
Genetic variation databases
BioMutai | MAP3K20 |
DMDMi | 313104215 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086338 | 2 – 800 | Mitogen-activated protein kinase kinase kinase 20Add BLAST | 799 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 161 | Phosphothreonine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 165 | Phosphoserine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 275 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 302 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 567 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 593 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 599 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 628 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 633 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 637 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 648 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 649 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 685 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 727 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 733 | PhosphoserineCombined sources | 1 | ||
Isoform 21 Publication (identifier: Q9NYL2-2) | |||||
Modified residuei | 339 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 429 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 434 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 454 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NYL2 |
jPOSTi | Q9NYL2 |
MassIVEi | Q9NYL2 |
MaxQBi | Q9NYL2 |
PaxDbi | Q9NYL2 |
PeptideAtlasi | Q9NYL2 |
PRIDEi | Q9NYL2 |
ProteomicsDBi | 83246 [Q9NYL2-1] 83247 [Q9NYL2-2] 83248 [Q9NYL2-3] |
PTM databases
iPTMneti | Q9NYL2 |
MetOSitei | Q9NYL2 |
PhosphoSitePlusi | Q9NYL2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000091436, Expressed in heart left ventricle and 234 other tissues |
ExpressionAtlasi | Q9NYL2, baseline and differential |
Genevisiblei | Q9NYL2, HS |
Organism-specific databases
HPAi | ENSG00000091436, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homodimer (PubMed:10924358, PubMed:26755636).
Interacts with PKN1 and ZNF33A (PubMed:12535642, PubMed:12761180).
Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20 (PubMed:21224381).
5 PublicationsBinary interactionsi
Hide detailsQ9NYL2
With | #Exp. | IntAct |
---|---|---|
RPS6KA5 [O75582] | 4 | EBI-602273,EBI-73869 |
YWHAZ [P63104] | 5 | EBI-602273,EBI-347088 |
ZNF567 [Q8N184] | 3 | EBI-602273,EBI-749400 |
Isoform 1 [Q9NYL2-1]
With | #Exp. | IntAct |
---|---|---|
PKN1 [Q16512] | 2 | EBI-687346,EBI-602382 |
Isoform 2 [Q9NYL2-2]
Protein-protein interaction databases
BioGRIDi | 119725, 54 interactors |
CORUMi | Q9NYL2 |
IntActi | Q9NYL2, 47 interactors |
MINTi | Q9NYL2 |
STRINGi | 9606.ENSP00000364361 |
Chemistry databases
BindingDBi | Q9NYL2 |
Miscellaneous databases
RNActi | Q9NYL2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NYL2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 277 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 339 – 410 | SAMPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 287 – 308 | Leucine-zipperAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00940000161352 |
HOGENOMi | CLU_019131_1_0_1 |
InParanoidi | Q9NYL2 |
OMAi | KALMMTG |
OrthoDBi | 938929at2759 |
PhylomeDBi | Q9NYL2 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI
60 70 80 90 100
EKEAEILSVL SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE
110 120 130 140 150
EMDMDHIMTW ATDVAKGMHY LHMEAPVKVI HRDLKSRNVV IAADGVLKIC
160 170 180 190 200
DFGASRFHNH TTHMSLVGTF PWMAPEVIQS LPVSETCDTY SYGVVLWEML
210 220 230 240 250
TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH QCWEADAKKR
260 270 280 290 300
PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD
310 320 330 340 350
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYCWVQQ
360 370 380 390 400
LVRKGDSSAE MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF
410 420 430 440 450
KSAIEKLTHD YINLFHFPPL IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT
460 470 480 490 500
GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT NLPDAEILKM TKPPFVMEKW
510 520 530 540 550
IVGIAKSQTV ECTVTYESDV RTPKSTKHVH SIQWSRTKPQ DEVKAVQLAI
560 570 580 590 600
QTLFTNSDGN PGSRSDSSAD CQWLDTLRMR QIASNTSLQR SQSNPILGSP
610 620 630 640 650
FFSHFDGQDS YAAAVRRPQV PIKYQQITPV NQSRSSSPTQ YGLTKNFSSL
660 670 680 690 700
HLNSRDSGFS SGNTDTSSER GRYSDRSRNK YGRGSISLNS SPRGRYSGKS
710 720 730 740 750
QHSTPSRGRY PGKFYRVSQS ALNPHQSPDF KRSPRDLHQP NTIPGMPLHP
760 770 780 790 800
ETDSRASEED SKVSEGGWTK VEYRKKPHRP SPAKTNKERA RGDHRGWRNF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J3F7 | C9J3F7_HUMAN | Mitogen-activated protein kinase ki... | MAP3K20 | 138 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 346 | C → W in AAF63490 (PubMed:10924358).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080563 | 95 – 800 | Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST | 706 | |
Natural variantiVAR_080564 | 172 – 800 | Missing in CNM6; decrease of protein abundance. 1 PublicationAdd BLAST | 629 | |
Natural variantiVAR_082158 | 250 | R → W in CNM6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs763481300EnsemblClinVar. | 1 | |
Natural variantiVAR_040806 | 267 | T → M1 PublicationCorresponds to variant dbSNP:rs6758025EnsemblClinVar. | 1 | |
Natural variantiVAR_040807 | 281 | A → T in an ovarian endometrioid sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040808 | 281 | A → V1 PublicationCorresponds to variant dbSNP:rs34683477Ensembl. | 1 | |
Natural variantiVAR_076448 | 368 | F → C in SFMMP; produces protein aggregation. 1 PublicationCorresponds to variant dbSNP:rs863225437EnsemblClinVar. | 1 | |
Natural variantiVAR_022827 | 531 | S → L5 PublicationsCorresponds to variant dbSNP:rs3769148Ensembl. | 1 | |
Natural variantiVAR_040809 | 580 | R → W1 PublicationCorresponds to variant dbSNP:rs7593622Ensembl. | 1 | |
Natural variantiVAR_040810 | 740 | P → T1 PublicationCorresponds to variant dbSNP:rs56202258Ensembl. | 1 | |
Natural variantiVAR_040811 | 773 | Y → H1 PublicationCorresponds to variant dbSNP:rs35608243Ensembl. | 1 | |
Natural variantiVAR_040812 | 784 | K → T2 PublicationsCorresponds to variant dbSNP:rs55830025EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051741 | 285 – 312 | CEIEA…LKERE → WVAPTAGHSVWLSKTITRLN EEVNQRSE in isoform 3. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_051742 | 313 – 800 | Missing in isoform 3. 1 PublicationAdd BLAST | 488 | |
Alternative sequenceiVSP_051743 | 332 – 455 | PSFEI…GPQDC → LPLAARMSEESYFESKTEES NSAEMSCQITATSNGEGHGM NPSLQAMMLMGFGDIFSMNK AGAVMHSGMQINMQAKQNSS KTTSKRRGKKVNMALGFSDF DLSEGDDDDDDDGEEEDNDM DNSE in isoform 2. 5 PublicationsAdd BLAST | 124 | |
Alternative sequenceiVSP_051744 | 456 – 800 | Missing in isoform 2. 5 PublicationsAdd BLAST | 345 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF238255 mRNA Translation: AAF63490.1 AB049733 mRNA Translation: BAB16444.1 AB049734 mRNA Translation: BAB16445.1 AF325454 mRNA Translation: AAK11615.1 AF480461 mRNA Translation: AAL85891.1 AF480462 mRNA Translation: AAL85892.1 AB030034 mRNA Translation: BAB12040.1 AF251441 mRNA Translation: AAF65822.1 AF465843 mRNA Translation: AAO33376.1 AK056310 mRNA Translation: BAG51674.1 AB208974 mRNA Translation: BAD92211.1 Different initiation. AC092573 Genomic DNA Translation: AAX82002.1 AC013461 Genomic DNA Translation: AAX93067.1 AC019046 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11164.1 BC001401 mRNA Translation: AAH01401.1 |
CCDSi | CCDS2251.1 [Q9NYL2-2] CCDS42777.1 [Q9NYL2-1] |
RefSeqi | NP_057737.2, NM_016653.2 [Q9NYL2-1] NP_598407.1, NM_133646.2 [Q9NYL2-2] XP_005246697.1, XM_005246640.2 [Q9NYL2-1] XP_016859812.1, XM_017004323.1 [Q9NYL2-2] XP_016859813.1, XM_017004324.1 [Q9NYL2-2] |
Genome annotation databases
Ensembli | ENST00000338983; ENSP00000340257; ENSG00000091436 [Q9NYL2-2] ENST00000375213; ENSP00000364361; ENSG00000091436 [Q9NYL2-1] ENST00000409176; ENSP00000387259; ENSG00000091436 [Q9NYL2-1] ENST00000539448; ENSP00000439414; ENSG00000091436 [Q9NYL2-2] |
GeneIDi | 51776 |
KEGGi | hsa:51776 |
UCSCi | uc002uhz.4, human [Q9NYL2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF238255 mRNA Translation: AAF63490.1 AB049733 mRNA Translation: BAB16444.1 AB049734 mRNA Translation: BAB16445.1 AF325454 mRNA Translation: AAK11615.1 AF480461 mRNA Translation: AAL85891.1 AF480462 mRNA Translation: AAL85892.1 AB030034 mRNA Translation: BAB12040.1 AF251441 mRNA Translation: AAF65822.1 AF465843 mRNA Translation: AAO33376.1 AK056310 mRNA Translation: BAG51674.1 AB208974 mRNA Translation: BAD92211.1 Different initiation. AC092573 Genomic DNA Translation: AAX82002.1 AC013461 Genomic DNA Translation: AAX93067.1 AC019046 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11164.1 BC001401 mRNA Translation: AAH01401.1 |
CCDSi | CCDS2251.1 [Q9NYL2-2] CCDS42777.1 [Q9NYL2-1] |
RefSeqi | NP_057737.2, NM_016653.2 [Q9NYL2-1] NP_598407.1, NM_133646.2 [Q9NYL2-2] XP_005246697.1, XM_005246640.2 [Q9NYL2-1] XP_016859812.1, XM_017004323.1 [Q9NYL2-2] XP_016859813.1, XM_017004324.1 [Q9NYL2-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5HES | X-ray | 2.14 | A/B | 5-309 | [»] | |
5X5O | X-ray | 1.87 | A | 5-309 | [»] | |
6JUT | X-ray | 2.10 | A | 5-309 | [»] | |
6JUU | X-ray | 1.90 | A | 5-309 | [»] | |
SMRi | Q9NYL2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119725, 54 interactors |
CORUMi | Q9NYL2 |
IntActi | Q9NYL2, 47 interactors |
MINTi | Q9NYL2 |
STRINGi | 9606.ENSP00000364361 |
Chemistry databases
BindingDBi | Q9NYL2 |
ChEMBLi | CHEMBL3886 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib |
DrugCentrali | Q9NYL2 |
GuidetoPHARMACOLOGYi | 2289 |
PTM databases
iPTMneti | Q9NYL2 |
MetOSitei | Q9NYL2 |
PhosphoSitePlusi | Q9NYL2 |
Genetic variation databases
BioMutai | MAP3K20 |
DMDMi | 313104215 |
Proteomic databases
EPDi | Q9NYL2 |
jPOSTi | Q9NYL2 |
MassIVEi | Q9NYL2 |
MaxQBi | Q9NYL2 |
PaxDbi | Q9NYL2 |
PeptideAtlasi | Q9NYL2 |
PRIDEi | Q9NYL2 |
ProteomicsDBi | 83246 [Q9NYL2-1] 83247 [Q9NYL2-2] 83248 [Q9NYL2-3] |
Protocols and materials databases
Antibodypediai | 2065, 301 antibodies |
DNASUi | 51776 |
Genome annotation databases
Ensembli | ENST00000338983; ENSP00000340257; ENSG00000091436 [Q9NYL2-2] ENST00000375213; ENSP00000364361; ENSG00000091436 [Q9NYL2-1] ENST00000409176; ENSP00000387259; ENSG00000091436 [Q9NYL2-1] ENST00000539448; ENSP00000439414; ENSG00000091436 [Q9NYL2-2] |
GeneIDi | 51776 |
KEGGi | hsa:51776 |
UCSCi | uc002uhz.4, human [Q9NYL2-1] |
Organism-specific databases
CTDi | 51776 |
DisGeNETi | 51776 |
GeneCardsi | MAP3K20 |
HGNCi | HGNC:17797, MAP3K20 |
HPAi | ENSG00000091436, Tissue enhanced (skeletal) |
MalaCardsi | MAP3K20 |
MIMi | 609479, gene 616890, phenotype 617760, phenotype |
neXtProti | NX_Q9NYL2 |
OpenTargetsi | ENSG00000091436 |
Orphaneti | 2020, Congenital fiber-type disproportion myopathy 488232, Split-foot malformation-mesoaxial polydactyly syndrome |
VEuPathDBi | HostDB:ENSG00000091436.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00940000161352 |
HOGENOMi | CLU_019131_1_0_1 |
InParanoidi | Q9NYL2 |
OMAi | KALMMTG |
OrthoDBi | 938929at2759 |
PhylomeDBi | Q9NYL2 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYL2 |
SignaLinki | Q9NYL2 |
SIGNORi | Q9NYL2 |
Miscellaneous databases
BioGRID-ORCSi | 51776, 7 hits in 980 CRISPR screens |
ChiTaRSi | MAP3K20, human |
GeneWikii | ZAK |
GenomeRNAii | 51776 |
Pharosi | Q9NYL2, Tchem |
PROi | PR:Q9NYL2 |
RNActi | Q9NYL2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091436, Expressed in heart left ventricle and 234 other tissues |
ExpressionAtlasi | Q9NYL2, baseline and differential |
Genevisiblei | Q9NYL2, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3K20_HUMAN | |
Accessioni | Q9NYL2Primary (citable) accession number: Q9NYL2 Secondary accession number(s): B3KPG2 Q9NYE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families