TLR7

Functionⁱ

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

double-stranded RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16111635
drug binding Source: Ensembl
signaling pattern recognition receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
single-stranded RNA binding Source: UniProtKB
siRNA binding Source: UniProtKB
transmembrane signaling receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
defense response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16188996
I-kappaB kinase/NF-kappaB signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
I-kappaB phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19740627
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
innate immune response Source: UniProtKB-KW
microglial cell activation Source: Ensembl
MyD88-dependent toll-like receptor signaling pathway Source: InterPro
positive regulation of chemokine production
Source: BHF-UCL
Inferred from direct assayⁱ
- 19740627
positive regulation of inflammatory response
Source: BHF-UCL
Inferred by curatorⁱ
- 19740627
positive regulation of interferon-alpha biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16286015
positive regulation of interferon-beta biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16286015
positive regulation of interferon-gamma biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16286015
positive regulation of interleukin-6 production
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of interleukin-8 biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16188996
positive regulation of interleukin-8 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 19740627
positive regulation of NIK/NF-kappaB signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 19740627
regulation of protein phosphorylation Source: Ensembl
toll-like receptor 7 signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
toll-like receptor 9 signaling pathway Source: Reactome
toll-like receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome

Reactomeⁱ

R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Toll-like receptor 7
Gene namesⁱ	Name:TLR7 ORF Names:UNQ248/PRO285
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196664.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15631 TLR7
MIMⁱ	300365 gene
neXtProtⁱ	NX_Q9NYK1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 839	ExtracellularSequence analysisAdd BLAST	813
Transmembraneⁱ	840 – 860	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	861 – 1049	CytoplasmicSequence analysisAdd BLAST	189

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51284
Open Targets More...OpenTargetsⁱ	ENSG00000196664
PharmGKBⁱ	PA38008

Chemistry databases

ChEMBLⁱ	CHEMBL5936
Drug and drug target database More...DrugBankⁱ	DB05127 ANA971 DB01611 Hydroxychloroquine DB00724 Imiquimod DB04860 Isatoribine DB05475 SCV-07
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1757

Polymorphism and mutation databases

BioMutaⁱ	TLR7
DMDMⁱ	20140876

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000034733	27 – 1049	Toll-like receptor 7Add BLAST		1023

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	66	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	69	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	202	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	215	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	361	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	413	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	488	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	523	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	534	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	590	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	679	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	720	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	799	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9NYK1
PeptideAtlas More...PeptideAtlasⁱ	Q9NYK1
PRIDEⁱ	Q9NYK1
ProteomicsDBⁱ	83240

PTM databases

GlyConnectⁱ	1817
iPTMnetⁱ	Q9NYK1
PhosphoSitePlusⁱ	Q9NYK1

Expressionⁱ

Tissue specificityⁱ

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Gene expression databases

Bgeeⁱ	ENSG00000196664 Expressed in 113 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TLR7
ExpressionAtlasⁱ	Q9NYK1 baseline and differential
Genevisibleⁱ	Q9NYK1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059613

HPAⁱ

HPA059613

Interactionⁱ

Subunit structureⁱ

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Interacts with SMPDL3B (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	119436, 2 interactors
IntActⁱ	Q9NYK1, 11 interactors
STRINGⁱ	9606.ENSP00000370034

Chemistry databases

BindingDBⁱ

Q9NYK1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYK1
SMRⁱ	Q9NYK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 64	LRR 1Add BLAST	22
Repeatⁱ	65 – 87	LRR 2Add BLAST	23
Repeatⁱ	110 – 126	LRR 3Add BLAST	17
Repeatⁱ	127 – 149	LRR 4Add BLAST	23
Repeatⁱ	151 – 170	LRR 5Add BLAST	20
Repeatⁱ	171 – 195	LRR 6Add BLAST	25
Repeatⁱ	203 – 226	LRR 7Add BLAST	24
Repeatⁱ	228 – 247	LRR 8Add BLAST	20
Repeatⁱ	248 – 275	LRR 9Add BLAST	28
Repeatⁱ	289 – 312	LRR 10Add BLAST	24
Repeatⁱ	314 – 337	LRR 11Add BLAST	24
Repeatⁱ	339 – 368	LRR 12Add BLAST	30
Repeatⁱ	369 – 392	LRR 13Add BLAST	24
Repeatⁱ	396 – 419	LRR 14Add BLAST	24
Repeatⁱ	421 – 443	LRR 15Add BLAST	23
Repeatⁱ	492 – 515	LRR 16Add BLAST	24
Repeatⁱ	516 – 540	LRR 17Add BLAST	25
Repeatⁱ	541 – 564	LRR 18Add BLAST	24
Repeatⁱ	566 – 588	LRR 19Add BLAST	23
Repeatⁱ	595 – 618	LRR 20Add BLAST	24
Repeatⁱ	619 – 644	LRR 21Add BLAST	26
Repeatⁱ	649 – 672	LRR 22Add BLAST	24
Repeatⁱ	674 – 697	LRR 23Add BLAST	24
Repeatⁱ	698 – 721	LRR 24Add BLAST	24
Repeatⁱ	723 – 745	LRR 25Add BLAST	23
Repeatⁱ	746 – 769	LRR 26Add BLAST	24
Repeatⁱ	772 – 795	LRR 27Add BLAST	24
Domainⁱ	889 – 1036	TIRPROSITE-ProRule annotationAdd BLAST	148

Sequence similaritiesⁱ

Belongs to the Toll-like receptor family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4641 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119006
HOGENOMⁱ	HOG000230468
HOVERGENⁱ	HBG018601
InParanoidⁱ	Q9NYK1
KEGG Orthology (KO) More...KOⁱ	K05404
OMAⁱ	MLNFTKN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G023M
PhylomeDBⁱ	Q9NYK1
TreeFamⁱ	TF325595

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR026906 LRR_5 IPR032675 LRR_dom_sf IPR000157 TIR_dom IPR026880 TLR7 IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR44312:SF1 PTHR44312:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13306 LRR_5, 1 hit PF13855 LRR_8, 3 hits PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 12 hits SM00082 LRRCT, 1 hit SM00255 TIR, 1 hit
SUPFAMⁱ	SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 18 hits PS50104 TIR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9NYK1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD 
        60         70         80         90        100
CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC 
       110        120        130        140        150
VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL 
       160        170        180        190        200
QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF 
       210        220        230        240        250
LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ 
       260        270        280        290        300
LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN 
       310        320        330        340        350
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN 
       360        370        380        390        400
FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE 
       410        420        430        440        450
VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART 
       460        470        480        490        500
SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL 
       510        520        530        540        550
SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS 
       560        570        580        590        600
NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK 
       610        620        630        640        650
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL 
       660        670        680        690        700
KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN 
       710        720        730        740        750
LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR 
       760        770        780        790        800
YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH 
       810        820        830        840        850
TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS 
       860        870        880        890        900
LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK 
       910        920        930        940        950
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS 
       960        970        980        990       1000
KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF 
      1010       1020       1030       1040 
LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV

Length:1,049

Mass (Da):120,922

Last modified:October 1, 2000 - v1

Checksum:ⁱ8C701E9E437F2721

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	725	L → H in AAF78035 (PubMed:11022120).Curated		1
Sequence conflictⁱ	738	L → P in AAF78035 (PubMed:11022120).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034554	11	Q → L1 PublicationCorresponds to variant dbSNP:rs179008Ensembl.		1
Natural variantⁱVAR_024665	448	A → V. Corresponds to variant dbSNP:rs5743781Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF240467 mRNA Translation: AAF60188.1 AF245702 mRNA Translation: AAF78035.1 DQ022185 Genomic DNA Translation: AAZ99026.1 AY358292 mRNA Translation: AAQ88659.1 BC033651 mRNA Translation: AAH33651.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14151.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057646.1, NM_016562.3
UniGeneⁱ	Hs.659215

Genome annotation databases

Ensemblⁱ	ENST00000380659; ENSP00000370034; ENSG00000196664
GeneIDⁱ	51284
KEGGⁱ	hsa:51284
UCSC genome browser More...UCSCⁱ	uc004cvc.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYK1	TLR7		HUMAN		1049	UniRef100_Q9NYK1
Toll-like receptor 7 (Fragment)		HUMAN		26

Protein	Similar proteins		Species	Score	Length	Source
Q9NYK1	TLR7		HUMAN		1049	UniRef90_Q9NYK1
Toll like receptor 7		AOTNA		1049
TLR7 isoform 1		PANTR		1049
Toll-like receptor 7 (Fragment)		Pan troglodytes verus		1048
Toll-like receptor 7	)	MACMU		1049
+50

Protein	Similar proteins		Species	Score	Length	Source
Q9NYK1	Toll-like receptor 7		MOUSE		1050	UniRef50_Q9NYK1
TLR7		HUMAN		1049
Uncharacterized protein		NOMLE		1049
Toll-like receptor 7	)	MACMU		1049
Toll-like receptor 7		MACFA		1049
+648

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF240467 mRNA Translation: AAF60188.1 AF245702 mRNA Translation: AAF78035.1 DQ022185 Genomic DNA Translation: AAZ99026.1 AY358292 mRNA Translation: AAQ88659.1 BC033651 mRNA Translation: AAH33651.1
CCDSⁱ	CCDS14151.1
RefSeqⁱ	NP_057646.1, NM_016562.3
UniGeneⁱ	Hs.659215

3D structure databases

ProteinModelPortalⁱ	Q9NYK1
SMRⁱ	Q9NYK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119436, 2 interactors
IntActⁱ	Q9NYK1, 11 interactors
STRINGⁱ	9606.ENSP00000370034

Chemistry databases

BindingDBⁱ	Q9NYK1
ChEMBLⁱ	CHEMBL5936
DrugBankⁱ	DB05127 ANA971 DB01611 Hydroxychloroquine DB00724 Imiquimod DB04860 Isatoribine DB05475 SCV-07
GuidetoPHARMACOLOGYⁱ	1757

PTM databases

GlyConnectⁱ	1817
iPTMnetⁱ	Q9NYK1
PhosphoSitePlusⁱ	Q9NYK1

Polymorphism and mutation databases

BioMutaⁱ	TLR7
DMDMⁱ	20140876

Proteomic databases

PaxDbⁱ	Q9NYK1
PeptideAtlasⁱ	Q9NYK1
PRIDEⁱ	Q9NYK1
ProteomicsDBⁱ	83240

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51284
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000380659; ENSP00000370034; ENSG00000196664
GeneIDⁱ	51284
KEGGⁱ	hsa:51284
UCSCⁱ	uc004cvc.4 human

Organism-specific databases

CTDⁱ	51284
DisGeNETⁱ	51284
EuPathDBⁱ	HostDB:ENSG00000196664.4
GeneCardsⁱ	TLR7
HGNCⁱ	HGNC:15631 TLR7
HPAⁱ	HPA059613
MIMⁱ	300365 gene
neXtProtⁱ	NX_Q9NYK1
OpenTargetsⁱ	ENSG00000196664
PharmGKBⁱ	PA38008
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4641 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00760000119006
HOGENOMⁱ	HOG000230468
HOVERGENⁱ	HBG018601
InParanoidⁱ	Q9NYK1
KOⁱ	K05404
OMAⁱ	MLNFTKN
OrthoDBⁱ	EOG091G023M
PhylomeDBⁱ	Q9NYK1
TreeFamⁱ	TF325595

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome

Reactomeⁱ

R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

ChiTaRSⁱ	TLR7 human
GeneWikiⁱ	TLR_7
GenomeRNAiⁱ	51284
Protein Ontology More...PROⁱ	PR:Q9NYK1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196664 Expressed in 113 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TLR7
ExpressionAtlasⁱ	Q9NYK1 baseline and differential
Genevisibleⁱ	Q9NYK1 HS

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR026906 LRR_5 IPR032675 LRR_dom_sf IPR000157 TIR_dom IPR026880 TLR7 IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR44312:SF1 PTHR44312:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF13306 LRR_5, 1 hit PF13855 LRR_8, 3 hits PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 12 hits SM00082 LRRCT, 1 hit SM00255 TIR, 1 hit
SUPFAMⁱ	SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 18 hits PS50104 TIR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TLR7_HUMAN
Accessionⁱ	Q9NYK1Primary (citable) accession number: Q9NYK1 Secondary accession number(s): D1CS69, Q9NR98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYK1 (TLR7_HUMAN)

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Toll-like receptor 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endoplasmic reticulum

Endosome

Other locations

Endoplasmic reticulum

Endosome

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ