UniProtKB - Q9NYJ7 (DLL3_HUMAN)

BLAST

>sp|Q9NYJ7|DLL3_HUMAN Delta-like protein 3 OS=Homo sapiens OX=9606 GN=DLL3 PE=1 SV=1
MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF
RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF
SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP
PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL
EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC
PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ
PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG
FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP
PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL
PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREVATPLFPPLHTGRA
GQRQHLLFPYPSSILSVK

Align

Format
Add to basket Added to basket
History
Entry version 173 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Delta-like protein 3

Gene

DLL3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).By similarity

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
Notch binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10742114

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

compartment pattern specification Source: Ensembl
negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
paraxial mesoderm development Source: Ensembl
skeletal system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10742114
somitogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Notch signaling pathway

Enzyme and pathway databases

SignaLinkⁱ	Q9NYJ7
SIGNORⁱ	Q9NYJ7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta-like protein 3 Alternative name(s): Drosophila Delta homolog 3 Short name: Delta3
Gene namesⁱ	Name:DLL3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090932.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2909 DLL3
MIMⁱ	602768 gene
neXtProtⁱ	NX_Q9NYJ7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 492	ExtracellularSequence analysisAdd BLAST	466
Transmembraneⁱ	493 – 513	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	514 – 618	CytoplasmicSequence analysisAdd BLAST	105

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spondylocostal dysostosis 1, autosomal recessive (SCDO1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_009952	385	G → D in SCDO1. 1 PublicationCorresponds to variant dbSNP:rs104894674EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10683
GeneReviewsⁱ	DLL3
MalaCards human disease database More...MalaCardsⁱ	DLL3
MIMⁱ	277300 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000090932
Orphanetⁱ	2311 Autosomal recessive spondylocostal dysostosis
PharmGKBⁱ	PA27365

Polymorphism and mutation databases

BioMutaⁱ	DLL3
DMDMⁱ	12229810

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000007509	27 – 618	Delta-like protein 3Add BLAST		592

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	220 ↔ 231	PROSITE-ProRule annotation
Disulfide bondⁱ	224 ↔ 237	PROSITE-ProRule annotation
Disulfide bondⁱ	239 ↔ 248	PROSITE-ProRule annotation
Disulfide bondⁱ	278 ↔ 289	PROSITE-ProRule annotation
Disulfide bondⁱ	283 ↔ 298	PROSITE-ProRule annotation
Disulfide bondⁱ	300 ↔ 309	PROSITE-ProRule annotation
Disulfide bondⁱ	316 ↔ 327	PROSITE-ProRule annotation
Disulfide bondⁱ	321 ↔ 339	PROSITE-ProRule annotation
Disulfide bondⁱ	341 ↔ 350	PROSITE-ProRule annotation
Disulfide bondⁱ	357 ↔ 368	PROSITE-ProRule annotation
Disulfide bondⁱ	362 ↔ 377	PROSITE-ProRule annotation
Disulfide bondⁱ	379 ↔ 388	PROSITE-ProRule annotation
Disulfide bondⁱ	395 ↔ 406	PROSITE-ProRule annotation
Disulfide bondⁱ	400 ↔ 415	PROSITE-ProRule annotation
Disulfide bondⁱ	417 ↔ 426	PROSITE-ProRule annotation
Disulfide bondⁱ	433 ↔ 444	PROSITE-ProRule annotation
Disulfide bondⁱ	438 ↔ 453	PROSITE-ProRule annotation
Disulfide bondⁱ	455 ↔ 464	PROSITE-ProRule annotation

Post-translational modificationⁱ

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

Keywords - PTMⁱ

Disulfide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9NYJ7
PeptideAtlas More...PeptideAtlasⁱ	Q9NYJ7
PRIDEⁱ	Q9NYJ7
ProteomicsDBⁱ	83237

PTM databases

iPTMnetⁱ	Q9NYJ7
PhosphoSitePlusⁱ	Q9NYJ7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090932 Expressed in 41 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_DLL3
ExpressionAtlasⁱ	Q9NYJ7 baseline and differential
Genevisibleⁱ	Q9NYJ7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056533

HPAⁱ

HPA056533

Interactionⁱ

Subunit structureⁱ

Can bind and activate Notch-1 or another Notch receptor.By similarity

GO - Molecular functionⁱ

Notch binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10742114

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000205143

STRINGⁱ

9606.ENSP00000205143

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYJ7
SMRⁱ	Q9NYJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	176 – 215	DSLAdd BLAST	40
Domainⁱ	216 – 249	EGF-like 1PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	274 – 310	EGF-like 2PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	312 – 351	EGF-like 3PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	353 – 389	EGF-like 4PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	391 – 427	EGF-like 5PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	429 – 465	EGF-like 6PROSITE-ProRule annotationAdd BLAST	37

Domainⁱ

The DSL domain is required for binding to the Notch receptor.

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1217 Eukaryota ENOG410XP6K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150895
HOGENOMⁱ	HOG000267024
HOVERGENⁱ	HBG007139
InParanoidⁱ	Q9NYJ7
KEGG Orthology (KO) More...KOⁱ	K06051
OMAⁱ	GPWARDI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G058A
PhylomeDBⁱ	Q9NYJ7
TreeFamⁱ	TF351835

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR009030 Growth_fac_rcpt_cys_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 4 hits PF12661 hEGF, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 6 hits SM00179 EGF_CA, 5 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 6 hits PS01186 EGF_2, 6 hits PS50026 EGF_3, 6 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NYJ7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC 
        60         70         80         90        100
SARLPCRLFF RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD 
       110        120        130        140        150
LPLPDGLLQV PFRDAWPGTF SFIIETWREE LGDQIGGPAW SLLARVAGRR 
       160        170        180        190        200
RLAAGGPWAR DIQRAGAWEL RFSYRARCEP PAVGTACTRL CRPRSAPSRC 
       210        220        230        240        250
GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL EGWTGPLCTV 
       260        270        280        290        300
PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC 
       310        320        330        340        350
PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC 
       360        370        380        390        400
EKRVDRCSLQ PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC 
       410        420        430        440        450
ANGGTCVEGG GAHRCSCALG FGGRDCRERA DPCAARPCAH GGRCYAHFSG 
       460        470        480        490        500
LVCACAPGYM GARCEFPVHP DGASALPAAP PGLRPGDPQR YLLPPALGLL 
       510        520        530        540        550
VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL PDALNNLRTQ 
       560        570        580        590        600
EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREVATP LFPPLHTGRA 
       610 
GQRQHLLFPY PSSILSVK

Length:618

Mass (Da):64,618

Last modified:October 1, 2000 - v1

Checksum:ⁱ58A9BC0A7DEAD1A0

Isoform 2 (identifier: Q9NYJ7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
587-618: VATPLFPPLHTGRAGQRQHLLFPYPSSILSVK → A

« Hide

        10         20         30         40         50
MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC 
        60         70         80         90        100
SARLPCRLFF RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD 
       110        120        130        140        150
LPLPDGLLQV PFRDAWPGTF SFIIETWREE LGDQIGGPAW SLLARVAGRR 
       160        170        180        190        200
RLAAGGPWAR DIQRAGAWEL RFSYRARCEP PAVGTACTRL CRPRSAPSRC 
       210        220        230        240        250
GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL EGWTGPLCTV 
       260        270        280        290        300
PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC 
       310        320        330        340        350
PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC 
       360        370        380        390        400
EKRVDRCSLQ PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC 
       410        420        430        440        450
ANGGTCVEGG GAHRCSCALG FGGRDCRERA DPCAARPCAH GGRCYAHFSG 
       460        470        480        490        500
LVCACAPGYM GARCEFPVHP DGASALPAAP PGLRPGDPQR YLLPPALGLL 
       510        520        530        540        550
VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL PDALNNLRTQ 
       560        570        580 
EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREA

Note: No experimental confirmation available.

Show »

Length:587

Mass (Da):61,178

Checksum:ⁱ66503288EABBFECE

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R177	M0R177_HUMAN		Delta-like protein 3 Delta-like protein 3	DLL3	220	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	318	D → N in BAC11535 (PubMed:16303743).Curated		1
Sequence conflictⁱ	435	A → V in BAC11535 (PubMed:16303743).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_046782	115	A → T1 PublicationCorresponds to variant dbSNP:rs71647811Ensembl.	1
Natural variantⁱVAR_046783	142	L → Q1 PublicationCorresponds to variant dbSNP:rs55741253EnsemblClinVar.	1
Natural variantⁱVAR_046784	172	F → C2 PublicationsCorresponds to variant dbSNP:rs8107127EnsemblClinVar.	1
Natural variantⁱVAR_016776	218	L → P2 PublicationsCorresponds to variant dbSNP:rs1110627EnsemblClinVar.	1
Natural variantⁱVAR_009952	385	G → D in SCDO1. 1 PublicationCorresponds to variant dbSNP:rs104894674EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045249	587 – 618	VATPL…ILSVK → A in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF241373 AF241372 Genomic DNA Translation: AAF62542.1 AK075302 mRNA Translation: BAC11535.1 AC011500 Genomic DNA No translation available. BC000218 mRNA Translation: AAH00218.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12537.1 [Q9NYJ7-2] CCDS12538.1 [Q9NYJ7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_058637.1, NM_016941.3 [Q9NYJ7-1] NP_982353.1, NM_203486.2 [Q9NYJ7-2]
UniGeneⁱ	Hs.127792

Genome annotation databases

Ensemblⁱ	ENST00000205143; ENSP00000205143; ENSG00000090932 [Q9NYJ7-1] ENST00000356433; ENSP00000348810; ENSG00000090932 [Q9NYJ7-2]
GeneIDⁱ	10683
KEGGⁱ	hsa:10683
UCSC genome browser More...UCSCⁱ	uc002olw.3 human [Q9NYJ7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYJ7	Uncharacterized protein		NOMLE		619	UniRef90_Q9NYJ7
Uncharacterized protein		RHIBE		618
Uncharacterized protein		RHIRO		618
Delta like canonical Notch ligand 3		GORGO		618
Uncharacterized protein		CERAT		618
+37

Protein	Similar proteins		Species	Score	Length	Source
Q9NYJ7	Uncharacterized protein		NOMLE		619	UniRef50_Q9NYJ7
Uncharacterized protein		MACFA		618
DLL3 isoform 4		PANTR		618
Delta like canonical Notch ligand 3		GORGO		618
Uncharacterized protein		RHIBE		618
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF241373 AF241372 Genomic DNA Translation: AAF62542.1 AK075302 mRNA Translation: BAC11535.1 AC011500 Genomic DNA No translation available. BC000218 mRNA Translation: AAH00218.1
CCDSⁱ	CCDS12537.1 [Q9NYJ7-2] CCDS12538.1 [Q9NYJ7-1]
RefSeqⁱ	NP_058637.1, NM_016941.3 [Q9NYJ7-1] NP_982353.1, NM_203486.2 [Q9NYJ7-2]
UniGeneⁱ	Hs.127792

3D structure databases

ProteinModelPortalⁱ	Q9NYJ7
SMRⁱ	Q9NYJ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000205143

STRINGⁱ

9606.ENSP00000205143

PTM databases

iPTMnetⁱ	Q9NYJ7
PhosphoSitePlusⁱ	Q9NYJ7

Polymorphism and mutation databases

BioMutaⁱ	DLL3
DMDMⁱ	12229810

Proteomic databases

PaxDbⁱ	Q9NYJ7
PeptideAtlasⁱ	Q9NYJ7
PRIDEⁱ	Q9NYJ7
ProteomicsDBⁱ	83237

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10683
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000205143; ENSP00000205143; ENSG00000090932 [Q9NYJ7-1] ENST00000356433; ENSP00000348810; ENSG00000090932 [Q9NYJ7-2]
GeneIDⁱ	10683
KEGGⁱ	hsa:10683
UCSCⁱ	uc002olw.3 human [Q9NYJ7-1]

Organism-specific databases

CTDⁱ	10683
DisGeNETⁱ	10683
EuPathDBⁱ	HostDB:ENSG00000090932.10
GeneCardsⁱ	DLL3
GeneReviewsⁱ	DLL3
HGNCⁱ	HGNC:2909 DLL3
HPAⁱ	HPA056533
MalaCardsⁱ	DLL3
MIMⁱ	277300 phenotype 602768 gene
neXtProtⁱ	NX_Q9NYJ7
OpenTargetsⁱ	ENSG00000090932
Orphanetⁱ	2311 Autosomal recessive spondylocostal dysostosis
PharmGKBⁱ	PA27365
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1217 Eukaryota ENOG410XP6K LUCA
GeneTreeⁱ	ENSGT00930000150895
HOGENOMⁱ	HOG000267024
HOVERGENⁱ	HBG007139
InParanoidⁱ	Q9NYJ7
KOⁱ	K06051
OMAⁱ	GPWARDI
OrthoDBⁱ	EOG091G058A
PhylomeDBⁱ	Q9NYJ7
TreeFamⁱ	TF351835

Enzyme and pathway databases

SignaLinkⁱ	Q9NYJ7
SIGNORⁱ	Q9NYJ7

Miscellaneous databases

ChiTaRSⁱ	DLL3 human
GeneWikiⁱ	DLL3
GenomeRNAiⁱ	10683
Protein Ontology More...PROⁱ	PR:Q9NYJ7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090932 Expressed in 41 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_DLL3
ExpressionAtlasⁱ	Q9NYJ7 baseline and differential
Genevisibleⁱ	Q9NYJ7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR009030 Growth_fac_rcpt_cys_sf
Pfamⁱ	View protein in Pfam PF00008 EGF, 4 hits PF12661 hEGF, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 6 hits SM00179 EGF_CA, 5 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 6 hits PS01186 EGF_2, 6 hits PS50026 EGF_3, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DLL3_HUMAN
Accessionⁱ	Q9NYJ7Primary (citable) accession number: Q9NYJ7 Secondary accession number(s): E9PFG2, Q8NBS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYJ7 (DLL3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Delta-like protein 3

DLL3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ