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Protein

PH and SEC7 domain-containing protein 3

Gene

PSD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor for ARF6.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 3
Alternative name(s):
Epididymis tissue protein Li 20mP
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D
Short name:
Exchange factor for ARF6 D
Hepatocellular carcinoma-associated antigen 67
Pleckstrin homology and SEC7 domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSD3
Synonyms:EFA6D, EFA6R, HCA67, KIAA0942
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000156011.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19093 PSD3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23362

Open Targets

More...
OpenTargetsi
ENSG00000156011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394629

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160332377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001202051 – 1048PH and SEC7 domain-containing protein 3Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei1009PhosphoserineBy similarity1
Modified residuei1011PhosphoserineBy similarity1
Modified residuei1012PhosphoserineBy similarity1
Modified residuei1014PhosphoserineBy similarity1
Modified residuei1020PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NYI0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NYI0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NYI0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NYI0

PeptideAtlas

More...
PeptideAtlasi
Q9NYI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYI0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83232
83233 [Q9NYI0-2]
83234 [Q9NYI0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NYI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NYI0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NYI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000156011 Expressed in 231 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_PSD3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYI0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002455

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116943, 8 interactors

Protein interaction database and analysis system

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IntActi
Q9NYI0, 23 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000324127

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NYI0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYI0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini534 – 734SEC7PROSITE-ProRule annotationAdd BLAST201
Domaini785 – 898PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili922 – 952Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0932 Eukaryota
COG5307 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115732

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108299

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYI0

KEGG Orthology (KO)

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KOi
K12494

Identification of Orthologs from Complete Genome Data

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OMAi
EILWLQK

Database of Orthologous Groups

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OrthoDBi
301851at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NYI0

TreeFam database of animal gene trees

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TreeFami
TF319755

Family and domain databases

Conserved Domains Database

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CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01369 Sec7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGRSAAAET FVWVNNASAH SQSVAKAKYE FLFGRSEGKA PDTSDHGGST
60 70 80 90 100
LLPPNVTNEF PEYGTMEEGG EGLRASLEFD GEALPCHPQE QQGVQPLTGC
110 120 130 140 150
HSGLDSVTEG PKDVREAPSQ SHLKEQSLQP IDSLISALKA TEARIISGTL
160 170 180 190 200
QATKVLDQDA VSSFSVQQVE KELDTASRKT QRVNKTLPAG QKNLPEIPLS
210 220 230 240 250
AEVTTEESFY LSIQKDLTAL LTGDTQAEIS QIMNNGRKGA VCVQEPSCPL
260 270 280 290 300
ASLGSSAVTC HSAGSVGFLK EQRSALGREH PGGCDRSSSM GRPGRVKHVE
310 320 330 340 350
FQGVEILWTG GDKRETQHPI DFETSLQRTA SPDSKESSKV PRHLISSAGL
360 370 380 390 400
CNSSSLTENV WDESWKAPSE RPGTSSGTFS PVRLDESGED EVFLQENKQH
410 420 430 440 450
LEKTPKPERD RERISEQEEH VKGEDEDILG PGYTEDSTDV YSSQFETILD
460 470 480 490 500
NTSLYYSAES LETLYSEPDS YFSFEMPLTP MIQQRIKEGG QFLERTSGGG
510 520 530 540 550
HQDILSVSAD GGIVMGYSSG VTNGLNDASD SIYTKGTPEI AFWGSNAGVK
560 570 580 590 600
TTRLEAHSEM GSTEILEKET PENLSNGTSS NVEAAKRLAK RLYQLDRFKR
610 620 630 640 650
SDVAKHLGKN NEFSKLVAEE YLKFFDFTGM TLDQSLRYFF KAFSLVGETQ
660 670 680 690 700
ERERVLIHFS NRYFYCNPDT IASQDGVHCL TCAIMLLNTD LHGHVNIGKK
710 720 730 740 750
MTCQEFIANL QGVNEGVDFS KDLLKALYNS IKNEKLEWAV DDEEKKKSPS
760 770 780 790 800
ESTEEKANGT HPKTISRIGS TTNPFLDIPH DPNAAVYKSG FLARKIHADM
810 820 830 840 850
DGKKTPRGKR GWKTFYAVLK GTVLYLQKDE YKPEKALSEE DLKNAVSVHH
860 870 880 890 900
ALASKATDYE KKPNVFKLKT ADWRVLLFQT QSPEEMQGWI NKINCVAAVF
910 920 930 940 950
SAPPFPAAIG SQKKFSRPLL PATTTKLSQE EQLKSHESKL KQITTELAEH
960 970 980 990 1000
RSYPPDKKVK AKDVDEYKLK DHYLEFEKTR YEMYVSILKE GGKELLSNDE
1010 1020 1030 1040
SEAAGLKKSH SSPSLNPDTS PITAKVKRNV SERKDHRPET PSIKQKVT
Length:1,048
Mass (Da):116,034
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE879B65AB390162
GO
Isoform 2 (identifier: Q9NYI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     695-695: Missing.

Show »
Length:1,047
Mass (Da):115,934
Checksum:i4DED4BCE8BA62E89
GO
Isoform 3 (identifier: Q9NYI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-534: Missing.
     535-545: KGTPEIAFWGS → MGSSWCLYGCC
     695-695: Missing.

Show »
Length:513
Mass (Da):58,077
Checksum:i1B78E20F34C4FD65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJ29E5RJ29_HUMAN
PH and SEC7 domain-containing prote...
PSD3
982Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DKF8B4DKF8_HUMAN
PH and SEC7 domain-containing prote...
PSD3 hCG_28251
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJE4E5RJE4_HUMAN
PH and SEC7 domain-containing prote...
PSD3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC20H0YC20_HUMAN
PH and SEC7 domain-containing prote...
PSD3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFG7E5RFG7_HUMAN
PH and SEC7 domain-containing prote...
PSD3
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAQ7H0YAQ7_HUMAN
PH and SEC7 domain-containing prote...
PSD3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH02E5RH02_HUMAN
PH and SEC7 domain-containing prote...
PSD3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXD8A0A087WXD8_HUMAN
PH and SEC7 domain-containing prote...
PSD3
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1Z0A0A087X1Z0_HUMAN
PH and SEC7 domain-containing prote...
PSD3
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIH3E5RIH3_HUMAN
PH and SEC7 domain-containing prote...
PSD3
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF61269 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH75044 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH75045 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA76786 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036947186T → M. Corresponds to variant dbSNP:rs7016219Ensembl.1
Natural variantiVAR_036948186T → P. Corresponds to variant dbSNP:rs7003060Ensembl.1
Natural variantiVAR_036949293P → L. Corresponds to variant dbSNP:rs13263453Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291551 – 534Missing in isoform 3. 1 PublicationAdd BLAST534
Alternative sequenceiVSP_029156535 – 545KGTPEIAFWGS → MGSSWCLYGCC in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023029695Missing in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB023159 mRNA Translation: BAA76786.2 Different initiation.
GU727648 mRNA Translation: ADU87649.1
AC009884 Genomic DNA No translation available.
AC087821 Genomic DNA No translation available.
AC090420 Genomic DNA No translation available.
AC100800 Genomic DNA No translation available.
AC120051 Genomic DNA No translation available.
AF519767 mRNA Translation: AAM74203.1
AF243495 mRNA Translation: AAF61269.2 Different initiation.
BC075044 mRNA Translation: AAH75044.1 Different initiation.
BC075045 mRNA Translation: AAH75045.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34854.1 [Q9NYI0-3]
CCDS43720.1 [Q9NYI0-2]

NCBI Reference Sequences

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RefSeqi
NP_056125.3, NM_015310.3 [Q9NYI0-2]
NP_996792.1, NM_206909.2 [Q9NYI0-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.434255

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000286485; ENSP00000286485; ENSG00000156011 [Q9NYI0-3]
ENST00000327040; ENSP00000324127; ENSG00000156011 [Q9NYI0-2]
ENST00000440756; ENSP00000401704; ENSG00000156011 [Q9NYI0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23362

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23362

UCSC genome browser

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UCSCi
uc003wyy.4 human [Q9NYI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023159 mRNA Translation: BAA76786.2 Different initiation.
GU727648 mRNA Translation: ADU87649.1
AC009884 Genomic DNA No translation available.
AC087821 Genomic DNA No translation available.
AC090420 Genomic DNA No translation available.
AC100800 Genomic DNA No translation available.
AC120051 Genomic DNA No translation available.
AF519767 mRNA Translation: AAM74203.1
AF243495 mRNA Translation: AAF61269.2 Different initiation.
BC075044 mRNA Translation: AAH75044.1 Different initiation.
BC075045 mRNA Translation: AAH75045.1 Different initiation.
CCDSiCCDS34854.1 [Q9NYI0-3]
CCDS43720.1 [Q9NYI0-2]
RefSeqiNP_056125.3, NM_015310.3 [Q9NYI0-2]
NP_996792.1, NM_206909.2 [Q9NYI0-3]
UniGeneiHs.434255

3D structure databases

ProteinModelPortaliQ9NYI0
SMRiQ9NYI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116943, 8 interactors
IntActiQ9NYI0, 23 interactors
STRINGi9606.ENSP00000324127

PTM databases

iPTMnetiQ9NYI0
PhosphoSitePlusiQ9NYI0
SwissPalmiQ9NYI0

Polymorphism and mutation databases

BioMutaiPSD3
DMDMi160332377

Proteomic databases

EPDiQ9NYI0
jPOSTiQ9NYI0
MaxQBiQ9NYI0
PaxDbiQ9NYI0
PeptideAtlasiQ9NYI0
PRIDEiQ9NYI0
ProteomicsDBi83232
83233 [Q9NYI0-2]
83234 [Q9NYI0-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23362
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286485; ENSP00000286485; ENSG00000156011 [Q9NYI0-3]
ENST00000327040; ENSP00000324127; ENSG00000156011 [Q9NYI0-2]
ENST00000440756; ENSP00000401704; ENSG00000156011 [Q9NYI0-1]
GeneIDi23362
KEGGihsa:23362
UCSCiuc003wyy.4 human [Q9NYI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23362
DisGeNETi23362
EuPathDBiHostDB:ENSG00000156011.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PSD3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0007347
HGNCiHGNC:19093 PSD3
HPAiHPA002455
MIMi614440 gene
neXtProtiNX_Q9NYI0
OpenTargetsiENSG00000156011
PharmGKBiPA128394629

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000156591
HOGENOMiHOG000115732
HOVERGENiHBG108299
InParanoidiQ9NYI0
KOiK12494
OMAiEILWLQK
OrthoDBi301851at2759
PhylomeDBiQ9NYI0
TreeFamiTF319755

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PSD3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23362

Protein Ontology

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PROi
PR:Q9NYI0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156011 Expressed in 231 organ(s), highest expression level in cerebellum
CleanExiHS_PSD3
ExpressionAtlasiQ9NYI0 baseline and differential
GenevisibleiQ9NYI0 HS

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYI0
Secondary accession number(s): A6NFQ4
, E9KL50, Q6B003, Q9Y2F1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 13, 2007
Last modified: January 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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