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Protein

U3 small nucleolar RNA-associated protein 6 homolog

Gene

UTP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 6 homolog
Alternative name(s):
Hepatocellular carcinoma-associated antigen 66
Multiple hat domains protein
Gene namesi
Name:UTP6
Synonyms:C17orf40, HCA66, MHAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108651.9
HGNCiHGNC:18279 UTP6
neXtProtiNX_Q9NYH9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55813
OpenTargetsiENSG00000108651
PharmGKBiPA142672224

Polymorphism and mutation databases

BioMutaiUTP6
DMDMi134047946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057541 – 597U3 small nucleolar RNA-associated protein 6 homologAdd BLAST597

Proteomic databases

EPDiQ9NYH9
MaxQBiQ9NYH9
PaxDbiQ9NYH9
PeptideAtlasiQ9NYH9
PRIDEiQ9NYH9
ProteomicsDBi83231

2D gel databases

SWISS-2DPAGEiQ9NYH9

PTM databases

iPTMnetiQ9NYH9
PhosphoSitePlusiQ9NYH9
SwissPalmiQ9NYH9

Expressioni

Gene expression databases

BgeeiENSG00000108651 Expressed in 216 organ(s), highest expression level in testis
CleanExiHS_UTP6
ExpressionAtlasiQ9NYH9 baseline and differential
GenevisibleiQ9NYH9 HS

Organism-specific databases

HPAiHPA025936
HPA055806

Interactioni

Protein-protein interaction databases

BioGridi120923, 35 interactors
IntActiQ9NYH9, 15 interactors
MINTiQ9NYH9
STRINGi9606.ENSP00000261708

Structurei

3D structure databases

ProteinModelPortaliQ9NYH9
SMRiQ9NYH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati121 – 153HAT 1Add BLAST33
Repeati156 – 188HAT 2Add BLAST33
Repeati304 – 335HAT 3Add BLAST32
Repeati488 – 520HAT 4Add BLAST33
Repeati524 – 557HAT 5Add BLAST34

Sequence similaritiesi

Belongs to the UTP6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2396 Eukaryota
COG5191 LUCA
GeneTreeiENSGT00390000016493
HOGENOMiHOG000285956
HOVERGENiHBG051886
InParanoidiQ9NYH9
KOiK14557
OMAiEKEQESC
OrthoDBiEOG091G09F4
PhylomeDBiQ9NYH9
TreeFamiTF323957

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR013949 Utp6
PfamiView protein in Pfam
PF08640 U3_assoc_6, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NYH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF
60 70 80 90 100
KEDFINYVQY EINLLELIQR RRTRIGYSFK KDEIENSIVH RVQGVFQRAS
110 120 130 140 150
AKWKDDVQLW LSYVAFCKKW ATKTRLSKVF SAMLAIHSNK PALWIMAAKW
160 170 180 190 200
EMEDRLSSES ARQLFLRALR FHPECPKLYK EYFRMELMHA EKLRKEKEEF
210 220 230 240 250
EKASMDVENP DYSEEILKGE LAWIIYKNSV SIIKGAEFHV SLLSIAQLFD
260 270 280 290 300
FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQTEE QPTTKQAKAV
310 320 330 340 350
EVGRKEERCC AVYEEAVKTL PTEAMWKCYI TFCLERFTKK SNSGFLRGKR
360 370 380 390 400
LERTMTVFRK AHELKLLSEC QYKQLSVSLL CYNFLREALE VAVAGTELFR
410 420 430 440 450
DSGTMWQLKL QVLIESKSPD IAMLFEEAFV HLKPQVCLPL WISWAEWSEG
460 470 480 490 500
AKSQEDTEAV FKKALLAVIG ADSVTLKNKY LDWAYRSGGY KKARAVFKSL
510 520 530 540 550
QESRPFSVDF FRKMIQFEKE QESCNMANIR EYYERALREF GSADSDLWMD
560 570 580 590
YMKEELNHPL GRPENCGQIY WRAMKMLQGE SAEAFVAKHA MHQTGHL
Length:597
Mass (Da):70,194
Last modified:March 20, 2007 - v2
Checksum:iB5254063791E52FF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRR8J3KRR8_HUMAN
U3 small nucleolar RNA-associated p...
UTP6
61Annotation score:
J3QSA7J3QSA7_HUMAN
U3 small nucleolar RNA-associated p...
UTP6
29Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03122235K → R. Corresponds to variant dbSNP:rs16967042Ensembl.1
Natural variantiVAR_02666869Q → R2 PublicationsCorresponds to variant dbSNP:rs3760454Ensembl.1
Natural variantiVAR_049322134L → V. Corresponds to variant dbSNP:rs34859443Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244135 mRNA Translation: AAF66244.1
AF334386 mRNA Translation: AAO15382.1
BC015454 mRNA Translation: AAH15454.1
BC035325 mRNA Translation: AAH35325.1
AJ272197 mRNA Translation: CAB77268.1
CCDSiCCDS11269.1
RefSeqiNP_060898.2, NM_018428.2
UniGeneiHs.589862

Genome annotation databases

EnsembliENST00000261708; ENSP00000261708; ENSG00000108651
GeneIDi55813
KEGGihsa:55813
UCSCiuc002hgr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244135 mRNA Translation: AAF66244.1
AF334386 mRNA Translation: AAO15382.1
BC015454 mRNA Translation: AAH15454.1
BC035325 mRNA Translation: AAH35325.1
AJ272197 mRNA Translation: CAB77268.1
CCDSiCCDS11269.1
RefSeqiNP_060898.2, NM_018428.2
UniGeneiHs.589862

3D structure databases

ProteinModelPortaliQ9NYH9
SMRiQ9NYH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120923, 35 interactors
IntActiQ9NYH9, 15 interactors
MINTiQ9NYH9
STRINGi9606.ENSP00000261708

PTM databases

iPTMnetiQ9NYH9
PhosphoSitePlusiQ9NYH9
SwissPalmiQ9NYH9

Polymorphism and mutation databases

BioMutaiUTP6
DMDMi134047946

2D gel databases

SWISS-2DPAGEiQ9NYH9

Proteomic databases

EPDiQ9NYH9
MaxQBiQ9NYH9
PaxDbiQ9NYH9
PeptideAtlasiQ9NYH9
PRIDEiQ9NYH9
ProteomicsDBi83231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261708; ENSP00000261708; ENSG00000108651
GeneIDi55813
KEGGihsa:55813
UCSCiuc002hgr.4 human

Organism-specific databases

CTDi55813
DisGeNETi55813
EuPathDBiHostDB:ENSG00000108651.9
GeneCardsiUTP6
HGNCiHGNC:18279 UTP6
HPAiHPA025936
HPA055806
neXtProtiNX_Q9NYH9
OpenTargetsiENSG00000108651
PharmGKBiPA142672224
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2396 Eukaryota
COG5191 LUCA
GeneTreeiENSGT00390000016493
HOGENOMiHOG000285956
HOVERGENiHBG051886
InParanoidiQ9NYH9
KOiK14557
OMAiEKEQESC
OrthoDBiEOG091G09F4
PhylomeDBiQ9NYH9
TreeFamiTF323957

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUTP6 human
GeneWikiiUTP6
GenomeRNAii55813
PROiPR:Q9NYH9

Gene expression databases

BgeeiENSG00000108651 Expressed in 216 organ(s), highest expression level in testis
CleanExiHS_UTP6
ExpressionAtlasiQ9NYH9 baseline and differential
GenevisibleiQ9NYH9 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR013949 Utp6
PfamiView protein in Pfam
PF08640 U3_assoc_6, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SUPFAMiSSF48452 SSF48452, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUTP6_HUMAN
AccessioniPrimary (citable) accession number: Q9NYH9
Secondary accession number(s): Q8IX96, Q96BL2, Q9NQ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 20, 2007
Last modified: October 10, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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