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Entry version 180 (13 Nov 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Anaphase-promoting complex subunit 11

Gene

ANAPC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi23Zinc 1By similarity1
Metal bindingi26Zinc 1By similarity1
Metal bindingi34Zinc 3By similarity1
Metal bindingi37Zinc 3By similarity1
Metal bindingi44Zinc 3By similarity1
Metal bindingi51Zinc 2By similarity1
Metal bindingi53Zinc 2By similarity1
Metal bindingi56Zinc 1By similarity1
Metal bindingi58Zinc 3By similarity1
Metal bindingi59Zinc 1By similarity1
Metal bindingi73Zinc 2By similarity1
Metal bindingi76Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri34 – 77RING-typePROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NYG5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 11
Short name:
APC11
Alternative name(s):
Cyclosome subunit 11
Hepatocellular carcinoma-associated RING finger protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC11
ORF Names:HSPC214
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14452 ANAPC11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614534 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYG5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi23C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi26C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi34C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi37C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi44C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi51C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi53H → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi56H → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi58H → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi59C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi73C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1
Mutagenesisi76C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51529

Open Targets

More...
OpenTargetsi
ENSG00000141552

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24787

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYG5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANAPC11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
19924286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000557471 – 84Anaphase-promoting complex subunit 11Add BLAST84

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NYG5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NYG5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NYG5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYG5

PeptideAtlas

More...
PeptideAtlasi
Q9NYG5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYG5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83227 [Q9NYG5-1]
83228 [Q9NYG5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYG5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141552 Expressed in 92 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYG5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYG5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021989
HPA027838

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:10922056, PubMed:25043029).

Interacts with the cullin domain of ANAPC2 (PubMed:11739784).

Interacts with UBE2D2 (PubMed:11739784).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NZC7-54EBI-12224467,EBI-12040603

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119591, 36 interactors

Database of interacting proteins

More...
DIPi
DIP-52741N

Protein interaction database and analysis system

More...
IntActi
Q9NYG5, 41 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYG5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain coordinates an additional third zinc ion.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RING-box family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 77RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000171951

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYG5

KEGG Orthology (KO)

More...
KOi
K03358

Identification of Orthologs from Complete Genome Data

More...
OMAi
SELVHRT

Database of Orthologous Groups

More...
OrthoDBi
1283603at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYG5

TreeFam database of animal gene trees

More...
TreeFami
TF354219

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024991 Apc11
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12861 zf-ANAPC11, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ
60 70 80
CSHCFHMHCI LKWLHAQQVQ QHCPMCRQEW KFKE
Length:84
Mass (Da):9,841
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEACBD5A54FDC11AE
GO
Isoform 2 (identifier: Q9NYG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-84: KVPGDDCPLV...MCRQEWKFKE → PLHGESISRC...PDLALAGGAS

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):20,644
Checksum:iE28CB66699B5B937
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QS46J3QS46_HUMAN
Anaphase-promoting complex subunit ...
ANAPC11
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSK3J3KSK3_HUMAN
Anaphase-promoting complex subunit ...
ANAPC11
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL35J3QL35_HUMAN
Anaphase-promoting complex subunit ...
ANAPC11
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1B5A0A087X1B5_HUMAN
Anaphase-promoting complex subunit ...
ANAPC11
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36134 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01234738 – 84KVPGD…WKFKE → PLHGESISRCLGWCPQPVPV LGGRAHPQVPINTASPTPGQ HTGSLMSREESSRSPDPTPP ALDQETSSLLRCTSPWCLDH SCDLFGITDQVSADGPRACR QGARRRLPAGVGPVLPLLPH ALHPQVAARTAGAAALPHVP PGMEVQGVRPDLALAGGAS in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF247565 mRNA Translation: AAF65816.1
AF247789 mRNA Translation: AAL95694.1
AF151048 mRNA Translation: AAF36134.1 Frameshift.
AC145207 Genomic DNA No translation available.
BC000607 mRNA Translation: AAH00607.2
BC066308 mRNA Translation: AAH66308.1
BC095454 mRNA Translation: AAH95454.1
BC104641 mRNA Translation: AAI04642.1
BC171892 mRNA Translation: AAI71892.1
BC171898 mRNA Translation: AAI71898.1
BC171899 mRNA Translation: AAI71899.1
BC171900 mRNA Translation: AAI71900.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11789.1 [Q9NYG5-1]
CCDS32769.1 [Q9NYG5-2]

NCBI Reference Sequences

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RefSeqi
NP_001002244.1, NM_001002244.2 [Q9NYG5-2]
NP_001002245.1, NM_001002245.2 [Q9NYG5-1]
NP_001002246.1, NM_001002246.2 [Q9NYG5-1]
NP_001002247.1, NM_001002247.2 [Q9NYG5-1]
NP_001002248.1, NM_001002248.2 [Q9NYG5-1]
NP_001002249.1, NM_001002249.2 [Q9NYG5-1]
NP_001276343.1, NM_001289414.1 [Q9NYG5-1]
NP_001276344.1, NM_001289415.1 [Q9NYG5-1]
NP_001276345.1, NM_001289416.1 [Q9NYG5-1]
NP_001276346.1, NM_001289417.1 [Q9NYG5-1]
NP_001276349.1, NM_001289420.1
NP_057560.8, NM_016476.11 [Q9NYG5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344877; ENSP00000339695; ENSG00000141552 [Q9NYG5-1]
ENST00000357385; ENSP00000349957; ENSG00000141552 [Q9NYG5-2]
ENST00000392376; ENSP00000376181; ENSG00000141552 [Q9NYG5-1]
ENST00000571024; ENSP00000461648; ENSG00000141552 [Q9NYG5-1]
ENST00000571570; ENSP00000458143; ENSG00000141552 [Q9NYG5-1]
ENST00000571874; ENSP00000459200; ENSG00000141552 [Q9NYG5-1]
ENST00000572639; ENSP00000460678; ENSG00000141552 [Q9NYG5-1]
ENST00000572851; ENSP00000458265; ENSG00000141552 [Q9NYG5-1]
ENST00000574924; ENSP00000460064; ENSG00000141552 [Q9NYG5-1]
ENST00000575195; ENSP00000458515; ENSG00000141552 [Q9NYG5-1]
ENST00000577747; ENSP00000463567; ENSG00000141552 [Q9NYG5-1]
ENST00000578550; ENSP00000464615; ENSG00000141552 [Q9NYG5-1]
ENST00000579978; ENSP00000463640; ENSG00000141552 [Q9NYG5-1]
ENST00000583839; ENSP00000463598; ENSG00000141552 [Q9NYG5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51529

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51529

UCSC genome browser

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UCSCi
uc002kbv.3 human [Q9NYG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247565 mRNA Translation: AAF65816.1
AF247789 mRNA Translation: AAL95694.1
AF151048 mRNA Translation: AAF36134.1 Frameshift.
AC145207 Genomic DNA No translation available.
BC000607 mRNA Translation: AAH00607.2
BC066308 mRNA Translation: AAH66308.1
BC095454 mRNA Translation: AAH95454.1
BC104641 mRNA Translation: AAI04642.1
BC171892 mRNA Translation: AAI71892.1
BC171898 mRNA Translation: AAI71898.1
BC171899 mRNA Translation: AAI71899.1
BC171900 mRNA Translation: AAI71900.1
CCDSiCCDS11789.1 [Q9NYG5-1]
CCDS32769.1 [Q9NYG5-2]
RefSeqiNP_001002244.1, NM_001002244.2 [Q9NYG5-2]
NP_001002245.1, NM_001002245.2 [Q9NYG5-1]
NP_001002246.1, NM_001002246.2 [Q9NYG5-1]
NP_001002247.1, NM_001002247.2 [Q9NYG5-1]
NP_001002248.1, NM_001002248.2 [Q9NYG5-1]
NP_001002249.1, NM_001002249.2 [Q9NYG5-1]
NP_001276343.1, NM_001289414.1 [Q9NYG5-1]
NP_001276344.1, NM_001289415.1 [Q9NYG5-1]
NP_001276345.1, NM_001289416.1 [Q9NYG5-1]
NP_001276346.1, NM_001289417.1 [Q9NYG5-1]
NP_001276349.1, NM_001289420.1
NP_057560.8, NM_016476.11 [Q9NYG5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MT5NMR-A17-84[»]
4R2YX-ray1.76A/B/C/D17-84[»]
4UI9electron microscopy3.60B1-84[»]
5A31electron microscopy4.30B1-84[»]
5G04electron microscopy4.00B1-84[»]
5G05electron microscopy3.40B1-84[»]
5JG6X-ray2.00A/D17-84[»]
5KHRelectron microscopy6.10B1-84[»]
5KHUelectron microscopy4.80B1-84[»]
5L9Telectron microscopy6.40B1-84[»]
5L9Uelectron microscopy6.40B1-84[»]
5LCWelectron microscopy4.00B1-84[»]
6Q6Gelectron microscopy3.20C1-84[»]
6Q6Helectron microscopy3.20C1-84[»]
SMRiQ9NYG5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119591, 36 interactors
DIPiDIP-52741N
IntActiQ9NYG5, 41 interactors

PTM databases

iPTMnetiQ9NYG5
PhosphoSitePlusiQ9NYG5

Polymorphism and mutation databases

BioMutaiANAPC11
DMDMi19924286

Proteomic databases

EPDiQ9NYG5
jPOSTiQ9NYG5
MassIVEiQ9NYG5
MaxQBiQ9NYG5
PeptideAtlasiQ9NYG5
PRIDEiQ9NYG5
ProteomicsDBi83227 [Q9NYG5-1]
83228 [Q9NYG5-2]

Genome annotation databases

EnsembliENST00000344877; ENSP00000339695; ENSG00000141552 [Q9NYG5-1]
ENST00000357385; ENSP00000349957; ENSG00000141552 [Q9NYG5-2]
ENST00000392376; ENSP00000376181; ENSG00000141552 [Q9NYG5-1]
ENST00000571024; ENSP00000461648; ENSG00000141552 [Q9NYG5-1]
ENST00000571570; ENSP00000458143; ENSG00000141552 [Q9NYG5-1]
ENST00000571874; ENSP00000459200; ENSG00000141552 [Q9NYG5-1]
ENST00000572639; ENSP00000460678; ENSG00000141552 [Q9NYG5-1]
ENST00000572851; ENSP00000458265; ENSG00000141552 [Q9NYG5-1]
ENST00000574924; ENSP00000460064; ENSG00000141552 [Q9NYG5-1]
ENST00000575195; ENSP00000458515; ENSG00000141552 [Q9NYG5-1]
ENST00000577747; ENSP00000463567; ENSG00000141552 [Q9NYG5-1]
ENST00000578550; ENSP00000464615; ENSG00000141552 [Q9NYG5-1]
ENST00000579978; ENSP00000463640; ENSG00000141552 [Q9NYG5-1]
ENST00000583839; ENSP00000463598; ENSG00000141552 [Q9NYG5-1]
GeneIDi51529
KEGGihsa:51529
UCSCiuc002kbv.3 human [Q9NYG5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51529
DisGeNETi51529

GeneCards: human genes, protein and diseases

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GeneCardsi
ANAPC11
HGNCiHGNC:14452 ANAPC11
HPAiHPA021989
HPA027838
MIMi614534 gene
neXtProtiNX_Q9NYG5
OpenTargetsiENSG00000141552
PharmGKBiPA24787

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000164946
HOGENOMiHOG000171951
InParanoidiQ9NYG5
KOiK03358
OMAiSELVHRT
OrthoDBi1283603at2759
PhylomeDBiQ9NYG5
TreeFamiTF354219

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ9NYG5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANAPC11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANAPC11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51529
PharosiQ9NYG5

Protein Ontology

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PROi
PR:Q9NYG5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141552 Expressed in 92 organ(s), highest expression level in testis
ExpressionAtlasiQ9NYG5 baseline and differential
GenevisibleiQ9NYG5 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR024991 Apc11
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12861 zf-ANAPC11, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYG5
Secondary accession number(s): A8MTT2
, B7ZW64, Q502X9, Q9BW64, Q9P0R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: November 13, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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