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Protein

Palmitoyltransferase ZDHHC3

Gene

ZDHHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).By similarity2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC3Curated (EC:2.3.1.2252 Publications)
Alternative name(s):
Protein DHHC1Imported
Zinc finger DHHC domain-containing protein 3Imported
Short name:
DHHC-3Imported
Gene namesi
Name:ZDHHC3Imported
ORF Names:HSD49Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163812.13
HGNCiHGNC:18470 ZDHHC3
neXtProtiNX_Q9NYG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 72ExtracellularSequence analysis4
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 171CytoplasmicSequence analysisAdd BLAST78
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 214ExtracellularSequence analysisAdd BLAST22
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 299CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi299V → VEKKNR, VKKKEK or VKGKRD: Impaired localization leading to localization to the endoplasmic reticulum. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000163812
PharmGKBiPA38544

Polymorphism and mutation databases

BioMutaiZDHHC3
DMDMi476007823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004220641 – 299Palmitoyltransferase ZDHHC3Add BLAST299

Post-translational modificationi

Autopalmitoylated.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NYG2
MaxQBiQ9NYG2
PeptideAtlasiQ9NYG2
PRIDEiQ9NYG2
ProteomicsDBi83225
83226 [Q9NYG2-2]

PTM databases

iPTMnetiQ9NYG2
PhosphoSitePlusiQ9NYG2
SwissPalmiQ9NYG2

Expressioni

Gene expression databases

BgeeiENSG00000163812 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_ZDHHC3
ExpressionAtlasiQ9NYG2 baseline and differential
GenevisibleiQ9NYG2 HS

Organism-specific databases

HPAiCAB012465
HPA016616

Interactioni

Protein-protein interaction databases

BioGridi119455, 7 interactors
IntActiQ9NYG2, 4 interactors
MINTiQ9NYG2

Structurei

3D structure databases

ProteinModelPortaliQ9NYG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 177DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00880000137864
HOGENOMiHOG000234755
HOVERGENiHBG056583
InParanoidiQ9NYG2
KOiK20029
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV
60 70 80 90 100
TWFLVLYAEF VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT
110 120 130 140 150
DPGAVPKGNA TKEFIESLQL KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI
160 170 180 190 200
RKMDHHCPWV NNCVGENNQK YFVLFTMYIA LISLHALIMV GFHFLHCFEE
210 220 230 240 250
DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH SICTDETGIE
260 270 280 290
QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV
Length:299
Mass (Da):34,170
Last modified:April 3, 2013 - v2
Checksum:i345A960FCB46E0E1
GO
Isoform 2 (identifier: Q9NYG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-204: K → TYGLNREEMAETGISLHEKMQPLNFSSTE

Show »
Length:327
Mass (Da):37,338
Checksum:i3982186DE17725F7
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNU5C9JNU5_HUMAN
Palmitoyltransferase
ZDHHC3
44Annotation score:
F8W6M3F8W6M3_HUMAN
Palmitoyltransferase
ZDHHC3
333Annotation score:
C9JIA9C9JIA9_HUMAN
Palmitoyltransferase
ZDHHC3
95Annotation score:
H0Y6A5H0Y6A5_HUMAN
Palmitoyltransferase
ZDHHC3
195Annotation score:
H7C365H7C365_HUMAN
Palmitoyltransferase ZDHHC3
ZDHHC3
111Annotation score:
H7C1U6H7C1U6_HUMAN
Palmitoyltransferase ZDHHC3
ZDHHC3
60Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006934204K → TYGLNREEMAETGISLHEKM QPLNFSSTE in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA Translation: AAF63570.1
AF441791 mRNA Translation: AAL34547.1
BC015467 mRNA Translation: AAH15467.1
AY605661 mRNA Translation: AAV83779.1
CCDSiCCDS2724.1 [Q9NYG2-2]
CCDS46811.1 [Q9NYG2-1]
RefSeqiNP_001128651.1, NM_001135179.1 [Q9NYG2-1]
NP_057682.1, NM_016598.2 [Q9NYG2-2]
XP_016862055.1, XM_017006566.1
XP_016862056.1, XM_017006567.1
UniGeneiHs.61430

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812 [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812 [Q9NYG2-1]
ENST00000628351; ENSP00000486386; ENSG00000280674 [Q9NYG2-1]
ENST00000630389; ENSP00000485706; ENSG00000280674 [Q9NYG2-2]
GeneIDi51304
KEGGihsa:51304
UCSCiuc003cod.4 human [Q9NYG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA Translation: AAF63570.1
AF441791 mRNA Translation: AAL34547.1
BC015467 mRNA Translation: AAH15467.1
AY605661 mRNA Translation: AAV83779.1
CCDSiCCDS2724.1 [Q9NYG2-2]
CCDS46811.1 [Q9NYG2-1]
RefSeqiNP_001128651.1, NM_001135179.1 [Q9NYG2-1]
NP_057682.1, NM_016598.2 [Q9NYG2-2]
XP_016862055.1, XM_017006566.1
XP_016862056.1, XM_017006567.1
UniGeneiHs.61430

3D structure databases

ProteinModelPortaliQ9NYG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119455, 7 interactors
IntActiQ9NYG2, 4 interactors
MINTiQ9NYG2

PTM databases

iPTMnetiQ9NYG2
PhosphoSitePlusiQ9NYG2
SwissPalmiQ9NYG2

Polymorphism and mutation databases

BioMutaiZDHHC3
DMDMi476007823

Proteomic databases

EPDiQ9NYG2
MaxQBiQ9NYG2
PeptideAtlasiQ9NYG2
PRIDEiQ9NYG2
ProteomicsDBi83225
83226 [Q9NYG2-2]

Protocols and materials databases

DNASUi51304
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812 [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812 [Q9NYG2-1]
ENST00000628351; ENSP00000486386; ENSG00000280674 [Q9NYG2-1]
ENST00000630389; ENSP00000485706; ENSG00000280674 [Q9NYG2-2]
GeneIDi51304
KEGGihsa:51304
UCSCiuc003cod.4 human [Q9NYG2-1]

Organism-specific databases

CTDi51304
EuPathDBiHostDB:ENSG00000163812.13
GeneCardsiZDHHC3
HGNCiHGNC:18470 ZDHHC3
HPAiCAB012465
HPA016616
neXtProtiNX_Q9NYG2
OpenTargetsiENSG00000163812
PharmGKBiPA38544
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137864
HOGENOMiHOG000234755
HOVERGENiHBG056583
InParanoidiQ9NYG2
KOiK20029
TreeFamiTF319798

Miscellaneous databases

ChiTaRSiZDHHC3 human
GeneWikiiZDHHC3
GenomeRNAii51304
PROiPR:Q9NYG2

Gene expression databases

BgeeiENSG00000163812 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_ZDHHC3
ExpressionAtlasiQ9NYG2 baseline and differential
GenevisibleiQ9NYG2 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYG2
Secondary accession number(s): Q53A17, Q96BL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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