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UniProtKB - Q9NYF8 (BCLF1_HUMAN)

Entry version 174 (31 Jul 2019)
Sequence version 2 (24 May 2004)
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Protein

Bcl-2-associated transcription factor 1

Gene

BCLAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-associated transcription factor 1
Short name:
Btf
Alternative name(s):
BCLAF1 and THRAP3 family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCLAF1
Synonyms:BTF, KIAA0164
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16863 BCLAF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612588 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NYF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9774

Open Targets

More...OpenTargetsi		ENSG00000029363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134868035

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCLAF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		47605556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648881 – 920Bcl-2-associated transcription factor 1Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1
Modified residuei177PhosphoserineCombined sources1 Publication1
Modified residuei181PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei196PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei219PhosphotyrosineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1 Publication1
Modified residuei284PhosphotyrosineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1 Publication1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei332N6-acetyllysine; alternateBy similarity1
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei341PhosphothreonineCombined sources1
Modified residuei355PhosphothreonineCombined sources1
Modified residuei383PhosphotyrosineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei402PhosphothreonineCombined sources1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei421N6-acetyllysine; alternateBy similarity1
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei422PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei431PhosphothreonineCombined sources1
Modified residuei437N6-acetyllysine; alternateCombined sources1
Cross-linki437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei450PhosphoserineCombined sources1
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei472PhosphoserineCombined sources1
Modified residuei475N6-acetyllysineBy similarity1
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei494PhosphothreonineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Cross-linki501Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei502PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1 Publication1
Modified residuei525PhosphoserineCombined sources1
Modified residuei531PhosphoserineCombined sources1 Publication1
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki548Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei559PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei566PhosphothreonineCombined sources1
Cross-linki567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei578PhosphoserineCombined sources1
Cross-linki580Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki580Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei648PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1 Publication1
Modified residuei660PhosphoserineCombined sources1
Modified residuei661PhosphothreonineCombined sources1
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei690PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Cross-linki778Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki784Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei803CitrullineBy similarity1
Modified residuei809Omega-N-methylarginineCombined sources1
Cross-linki831Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki831Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki911Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 4 (identifier: Q9NYF8-4)
Modified residuei339PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NYF8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NYF8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NYF8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NYF8

PeptideAtlas

More...PeptideAtlasi		Q9NYF8

PRoteomics IDEntifications database

More...PRIDEi		Q9NYF8

ProteomicsDB human proteome resource

More...ProteomicsDBi		83221 [Q9NYF8-1]
83222 [Q9NYF8-2]
83223 [Q9NYF8-3]
83224 [Q9NYF8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NYF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NYF8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NYF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000029363 Expressed in 242 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NYF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NYF8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA006484
HPA006669
HPA027770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Bcl-2 related proteins, EMD, with the adenovirus E1B 19 kDa protein and with DNA.

Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.

Component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115118, 131 interactors

Protein interaction database and analysis system

More...IntActi		Q9NYF8, 81 interactors

Molecular INTeraction database

More...MINTi		Q9NYF8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435210

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi141 – 148Poly-Ser8
Compositional biasi749 – 763Poly-SerAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCLAF1/THRAP3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJCD Eukaryota
ENOG4110X68 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183163

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NYF8

KEGG Orthology (KO)

More...KOi		K13087

Identification of Orthologs from Complete Genome Data

More...OMAi		QDEQKDT

Database of Orthologous Groups

More...OrthoDBi		380969at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NYF8

TreeFam database of animal gene trees

More...TreeFami		TF335939

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026668 Bcl-2_assoc_TF1
IPR029199 THRAP3_BCLAF1

The PANTHER Classification System

More...PANTHERi		PTHR15268 PTHR15268, 1 hit
PTHR15268:SF4 PTHR15268:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15440 THRAP3_BCLAF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD 
        60         70         80         90        100
RMYSRDYRRD YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR 
       110        120        130        140        150
HSRSPRRGRS RSRSPKRRSV SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY 
       160        170        180        190        200
SKSPVSKRRG SQEKQTKKAE GEPQEESPLK SKSQEEPKDT FEHDPSESID 
       210        220        230        240        250
EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS SCSDAPMLST 
       260        270        280        290        300
VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS 
       310        320        330        340        350
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKRF TDEESRVFLL 
       360        370        380        390        400
DRGNTRDKEA SKEKGSEKGR AEGEWEDQEA LDYFSDKESG KQKFNDSEGD 
       410        420        430        440        450
DTEETEDYRQ FRKSVLADQG KSFATASHRN TEEEGLKYKS KVSLKGNRES 
       460        470        480        490        500
DGFREEKNYK LKETGYVVER PSTTKDKHKE EDKNSERITV KKETQSPEQV 
       510        520        530        540        550
KSEKLKDLFD YSPPLHKNLD AREKSTFREE SPLRIKMIAS DSHRPEVKLK 
       560        570        580        590        600
MAPVPLDDSN RPASLTKDRL LASTLVHSVK KEQEFRSIFD HIKLPQASKS 
       610        620        630        640        650
TSESFIQHIV SLVHHVKEQY FKSAAMTLNE RFTSYQKATE EHSTRQKSPE 
       660        670        680        690        700
IHRRIDISPS TLRKHTRLAG EERVFKEENQ KGDKKLRCDS ADLRHDIDRR 
       710        720        730        740        750
RKERSKERGD SKGSRESSGS RKQEKTPKDY KEYKSYKDDS KHKREQDHSR 
       760        770        780        790        800
SSSSSASPSS PSSREEKESK KEREEEFKTH HEMKEYSGFA GVSRPRGTFF 
       810        820        830        840        850
RIRGRGRARG VFAGTNTGPN NSNTTFQKRP KEEEWDPEYT PKSKKYFLHD 
       860        870        880        890        900
DRDDGVDYWA KRGRGRGTFQ RGRGRFNFKK SGSSPKWTHD KYQGDGIVED 
       910        920
EEETMENNEE KKDRRKEEKE
Length:920
Mass (Da):106,122
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8892B98E54F52C20
GO
Isoform 2 (identifier: Q9NYF8-2) [UniParc]FASTAAdd to basket
Also known as: Btf-l

The sequence of this isoform differs from the canonical sequence as follows:
     35-36: Missing.

Show »
Length:918
Mass (Da):105,948
Checksum:i8DD27EC0EC8FBFC5
GO
Isoform 3 (identifier: Q9NYF8-3) [UniParc]FASTAAdd to basket
Also known as: Btf-s, BP-1

The sequence of this isoform differs from the canonical sequence as follows:
     35-36: Missing.
     800-848: Missing.

Show »
Length:869
Mass (Da):100,232
Checksum:i6A11356844C6EF40
GO
Isoform 4 (identifier: Q9NYF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-511: Missing.

Show »
Length:747
Mass (Da):85,937
Checksum:i85CDAF9B406FAE0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK91E9PK91_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
871Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK09E9PK09_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKI6E9PKI6_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
752Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJA7E9PJA7_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQN2E9PQN2_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
750Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF14H0YF14_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF63H0YF63_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ43A0A1W2PQ43_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
703Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF00H0YF00_HUMAN
Bcl-2-associated transcription fact...
BCLAF1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47687 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH47887 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH56894 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH63846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA11481 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → A in AAF64304 (PubMed:10330179).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05959166G → A. Corresponds to variant dbSNP:rs9942517Ensembl.1
Natural variantiVAR_050692209S → C. Corresponds to variant dbSNP:rs6940018Ensembl.1
Natural variantiVAR_050693459Y → D. Corresponds to variant dbSNP:rs1967446Ensembl.1
Natural variantiVAR_050694461L → H. Corresponds to variant dbSNP:rs1967445Ensembl.1
Natural variantiVAR_050695629N → S. Corresponds to variant dbSNP:rs7381749Ensembl.1
Natural variantiVAR_050696875R → C. Corresponds to variant dbSNP:rs34541670Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01036935 – 36Missing in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_010371339 – 511Missing in isoform 4. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_010370800 – 848Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF249273 mRNA Translation: AAF64304.1
D79986 mRNA Translation: BAA11481.2 Different initiation.
AL121713 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47950.1
CH471051 Genomic DNA Translation: EAW47951.1
BC047687 mRNA Translation: AAH47687.1 Sequence problems.
BC047887 mRNA Translation: AAH47887.1 Sequence problems.
BC056894 mRNA Translation: AAH56894.1 Sequence problems.
BC063846 mRNA Translation: AAH63846.1 Sequence problems.
BC132780 mRNA Translation: AAI32781.1
BC144281 mRNA Translation: AAI44282.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47485.1 [Q9NYF8-4]
CCDS47486.1 [Q9NYF8-3]
CCDS5177.1 [Q9NYF8-1]
CCDS75525.1 [Q9NYF8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001070908.1, NM_001077440.1 [Q9NYF8-3]
NP_001070909.1, NM_001077441.1 [Q9NYF8-4]
NP_001287967.1, NM_001301038.1 [Q9NYF8-2]
NP_055554.1, NM_014739.2 [Q9NYF8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000353331; ENSP00000229446; ENSG00000029363 [Q9NYF8-3]
ENST00000392348; ENSP00000376159; ENSG00000029363 [Q9NYF8-3]
ENST00000527759; ENSP00000434826; ENSG00000029363 [Q9NYF8-2]
ENST00000530767; ENSP00000436501; ENSG00000029363 [Q9NYF8-4]
ENST00000531224; ENSP00000435210; ENSG00000029363 [Q9NYF8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9774

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9774

UCSC genome browser

More...UCSCi		uc003qgw.2 human [Q9NYF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249273 mRNA Translation: AAF64304.1
D79986 mRNA Translation: BAA11481.2 Different initiation.
AL121713 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47950.1
CH471051 Genomic DNA Translation: EAW47951.1
BC047687 mRNA Translation: AAH47687.1 Sequence problems.
BC047887 mRNA Translation: AAH47887.1 Sequence problems.
BC056894 mRNA Translation: AAH56894.1 Sequence problems.
BC063846 mRNA Translation: AAH63846.1 Sequence problems.
BC132780 mRNA Translation: AAI32781.1
BC144281 mRNA Translation: AAI44282.1
CCDSiCCDS47485.1 [Q9NYF8-4]
CCDS47486.1 [Q9NYF8-3]
CCDS5177.1 [Q9NYF8-1]
CCDS75525.1 [Q9NYF8-2]
RefSeqiNP_001070908.1, NM_001077440.1 [Q9NYF8-3]
NP_001070909.1, NM_001077441.1 [Q9NYF8-4]
NP_001287967.1, NM_001301038.1 [Q9NYF8-2]
NP_055554.1, NM_014739.2 [Q9NYF8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi115118, 131 interactors
IntActiQ9NYF8, 81 interactors
MINTiQ9NYF8
STRINGi9606.ENSP00000435210

PTM databases

iPTMnetiQ9NYF8
PhosphoSitePlusiQ9NYF8
SwissPalmiQ9NYF8

Polymorphism and mutation databases

BioMutaiBCLAF1
DMDMi47605556

Proteomic databases

EPDiQ9NYF8
jPOSTiQ9NYF8
MaxQBiQ9NYF8
PaxDbiQ9NYF8
PeptideAtlasiQ9NYF8
PRIDEiQ9NYF8
ProteomicsDBi83221 [Q9NYF8-1]
83222 [Q9NYF8-2]
83223 [Q9NYF8-3]
83224 [Q9NYF8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353331; ENSP00000229446; ENSG00000029363 [Q9NYF8-3]
ENST00000392348; ENSP00000376159; ENSG00000029363 [Q9NYF8-3]
ENST00000527759; ENSP00000434826; ENSG00000029363 [Q9NYF8-2]
ENST00000530767; ENSP00000436501; ENSG00000029363 [Q9NYF8-4]
ENST00000531224; ENSP00000435210; ENSG00000029363 [Q9NYF8-1]
GeneIDi9774
KEGGihsa:9774
UCSCiuc003qgw.2 human [Q9NYF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9774
DisGeNETi9774

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCLAF1
HGNCiHGNC:16863 BCLAF1
HPAiHPA006484
HPA006669
HPA027770
MIMi612588 gene
neXtProtiNX_Q9NYF8
OpenTargetsiENSG00000029363
PharmGKBiPA134868035

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJCD Eukaryota
ENOG4110X68 LUCA
GeneTreeiENSGT00950000183163
InParanoidiQ9NYF8
KOiK13087
OMAiQDEQKDT
OrthoDBi380969at2759
PhylomeDBiQ9NYF8
TreeFamiTF335939

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCLAF1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCLAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9774

Protein Ontology

More...PROi		PR:Q9NYF8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000029363 Expressed in 242 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9NYF8 baseline and differential
GenevisibleiQ9NYF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026668 Bcl-2_assoc_TF1
IPR029199 THRAP3_BCLAF1
PANTHERiPTHR15268 PTHR15268, 1 hit
PTHR15268:SF4 PTHR15268:SF4, 1 hit
PfamiView protein in Pfam
PF15440 THRAP3_BCLAF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCLF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYF8
Secondary accession number(s): A2RU75
, B7ZM58, E1P586, Q14673, Q86WU6, Q86WY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 31, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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