UniProtKB - Q9NYF8 (BCLF1_HUMAN)
(max 400 entries)x
Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
- BLAST
>sp|Q9NYF8|BCLF1_HUMAN Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2 MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRD YRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSV SSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLK SKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSS SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRS PAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEA SKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQG KSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKE EDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIAS DSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKS TSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPS TLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGS RKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTH HEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYT PKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVED EEETMENNEEKKDRRKEEKE
- Align
Protein
Bcl-2-associated transcription factor 1
Gene
BCLAF1
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.11"Regulation of cyclin D1 RNA stability by SNIP1."
Bracken C.P., Wall S.J., Barre B., Panov K.I., Ajuh P.M., Perkins N.D.
Cancer Res. 68:7621-7628(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, IDENTIFICATION IN THE SNARP COMPLEX.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- RNA binding Source: UniProtKBInferred from high throughput direct assayi
GO - Biological processi
- apoptotic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
- cellular response to leukemia inhibitory factor Source: Ensembl
- negative regulation of transcription, DNA-templated Source: MGIInferred from direct assayi
- positive regulation of apoptotic process Source: MGIInferred from direct assayi
- positive regulation of DNA-templated transcription, initiation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKBInferred from mutant phenotypei
- positive regulation of response to DNA damage stimulus Source: UniProtKBInferred from mutant phenotypei
- regulation of DNA-templated transcription in response to stress Source: UniProtKBInferred from mutant phenotypei
- transcription, DNA-templated Source: UniProtKB-KW
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Bcl-2-associated transcription factor 1Short name: Btf Alternative name(s): BCLAF1 and THRAP3 family member 1 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:BCLAF1 Synonyms:BTF, KIAA0164 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000029363.15 |
Human Gene Nomenclature Database More...HGNCi | HGNC:16863 BCLAF1 |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 612588 gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q9NYF8 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Nucleus
- Nucleus
- Nucleus speckle 1 Publication
Manual assertion based on experiment ini
- Ref.21"Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle."
Horiuchi K., Kawamura T., Iwanari H., Ohashi R., Naito M., Kodama T., Hamakubo T.
J. Biol. Chem. 288:33292-33302(2013) [PubMed] [Europe PMC] [Abstract]Cited for: IDENTIFICATION IN A MACOM-LIKE COMPLEX, SUBCELLULAR LOCATION.
- nucleoplasm 1 Publication
Manual assertion based on experiment ini
- Ref.21"Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle."
Horiuchi K., Kawamura T., Iwanari H., Ohashi R., Naito M., Kodama T., Hamakubo T.
J. Biol. Chem. 288:33292-33302(2013) [PubMed] [Europe PMC] [Abstract]Cited for: IDENTIFICATION IN A MACOM-LIKE COMPLEX, SUBCELLULAR LOCATION.
Other locations
Nucleus
- nuclear speck Source: UniProtKBInferred from direct assayi
- nucleoplasm Source: UniProtKBInferred from direct assayi
- nucleus Source: MGIInferred from direct assayi
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Nucleus<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Organism-specific databases
DisGeNET More...DisGeNETi | 9774 |
Open Targets More...OpenTargetsi | ENSG00000029363 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA134868035 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | BCLAF1 |
Domain mapping of disease mutations (DMDM) More...DMDMi | 47605556 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000064888 | 1 – 920 | Bcl-2-associated transcription factor 1Add BLAST | 920 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
|---|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 102 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 104 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 152 | N6-acetyllysineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 177 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Modified residuei | 181 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki | 188 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 196 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 198 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 219 | PhosphotyrosineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 222 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 259 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 262 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 264 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 268 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Modified residuei | 284 | PhosphotyrosineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 285 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 290 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Modified residuei | 297 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 300 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 315 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 332 | N6-acetyllysine; alternateBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | ||
| Cross-linki | 332 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 341 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 355 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 383 | PhosphotyrosineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 385 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 389 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 397 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 402 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 421 | N6-acetyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toi | 1 | ||
| Cross-linki | 421 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 422 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 427 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 431 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 437 | N6-acetyllysine; alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 437 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 450 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 457 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 462 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 472 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 475 | N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toi | 1 | ||
| Cross-linki | 491 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 492 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 494 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 496 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 501 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 502 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 512 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Modified residuei | 525 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 531 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Cross-linki | 536 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 548 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 550 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 559 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 564 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 566 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 567 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 578 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 580 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 580 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 593 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 599 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 622 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 648 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 658 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
Manual assertion based on experiment ini
| 1 | ||
| Modified residuei | 660 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 661 | PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 690 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Modified residuei | 760 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 778 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 784 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Modified residuei | 803 | CitrullineBy similarity | 1 | ||
| Modified residuei | 809 | Omega-N-methylarginineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
| Cross-linki | 831 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 831 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Cross-linki | 911 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources Manual assertion inferred from combination of experimental and computational evidencei
| |||
| Isoform 4 (identifier: Q9NYF8-4) | |||||
| Modified residuei | 339 | PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidencei
| 1 | ||
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Citrullinated by PADI4.By similarity
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | Q9NYF8 |
MaxQB - The MaxQuant DataBase More...MaxQBi | Q9NYF8 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q9NYF8 |
PeptideAtlas More...PeptideAtlasi | Q9NYF8 |
PRoteomics IDEntifications database More...PRIDEi | Q9NYF8 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 83221 83222 [Q9NYF8-2] 83223 [Q9NYF8-3] 83224 [Q9NYF8-4] |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q9NYF8 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q9NYF8 |
SwissPalm database of S-palmitoylation events More...SwissPalmi | Q9NYF8 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Ubiquitous.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000029363 Expressed in 242 organ(s), highest expression level in substantia nigra |
CleanEx database of gene expression profiles More...CleanExi | HS_BCLAF1 |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q9NYF8 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q9NYF8 HS |
Organism-specific databases
Human Protein Atlas More...HPAi | HPA006484 HPA006669 HPA027770 |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Interacts with Bcl-2 related proteins, EMD, with the adenovirus E1B 19 kDa protein and with DNA. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.3 Publications
Manual assertion based on experiment ini
- Ref.7"Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy."
Haraguchi T., Holaska J.M., Yamane M., Koujin T., Hashiguchi N., Mori C., Wilson K.L., Hiraoka Y.
Eur. J. Biochem. 271:1035-1045(2004) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH EMD. - Ref.11"Regulation of cyclin D1 RNA stability by SNIP1."
Bracken C.P., Wall S.J., Barre B., Panov K.I., Ajuh P.M., Perkins N.D.
Cancer Res. 68:7621-7628(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, IDENTIFICATION IN THE SNARP COMPLEX. - Ref.21"Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle."
Horiuchi K., Kawamura T., Iwanari H., Ohashi R., Naito M., Kodama T., Hamakubo T.
J. Biol. Chem. 288:33292-33302(2013) [PubMed] [Europe PMC] [Abstract]Cited for: IDENTIFICATION IN A MACOM-LIKE COMPLEX, SUBCELLULAR LOCATION.
<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
| With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| BCL2 | P10415 | 2 | EBI-437804,EBI-77694 | |
| EMD | P50402 | 3 | EBI-437804,EBI-489887 |
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 115118, 120 interactors |
Protein interaction database and analysis system More...IntActi | Q9NYF8, 75 interactors |
Molecular INTeraction database More...MINTi | Q9NYF8 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000435210 |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q9NYF8 |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 141 – 148 | Poly-Ser | 8 | |
| Compositional biasi | 749 – 763 | Poly-SerAdd BLAST | 15 |
<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Belongs to the BCLAF1/THRAP3 family.Curated
Phylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | ENOG410IJCD Eukaryota ENOG4110X68 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00530000063211 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG050681 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q9NYF8 |
KEGG Orthology (KO) More...KOi | K13087 |
Identification of Orthologs from Complete Genome Data More...OMAi | TSHRNTE |
Database of Orthologous Groups More...OrthoDBi | EOG091G03HU |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q9NYF8 |
TreeFam database of animal gene trees More...TreeFami | TF335939 |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR026668 Bcl-2_assoc_TF1 IPR029199 THRAP3_BCLAF1 |
The PANTHER Classification System More...PANTHERi | PTHR15268 PTHR15268, 1 hit PTHR15268:SF4 PTHR15268:SF4, 1 hit |
Pfam protein domain database More...Pfami | View protein in Pfam PF15440 THRAP3_BCLAF1, 1 hit |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NYF8-1) [UniParc]FASTAAdd to basketAdded to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
« Hide
Show »10 20 30 40 50
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD
60 70 80 90 100
RMYSRDYRRD YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR
110 120 130 140 150
HSRSPRRGRS RSRSPKRRSV SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY
160 170 180 190 200
SKSPVSKRRG SQEKQTKKAE GEPQEESPLK SKSQEEPKDT FEHDPSESID
210 220 230 240 250
EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS SCSDAPMLST
260 270 280 290 300
VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS
310 320 330 340 350
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKRF TDEESRVFLL
360 370 380 390 400
DRGNTRDKEA SKEKGSEKGR AEGEWEDQEA LDYFSDKESG KQKFNDSEGD
410 420 430 440 450
DTEETEDYRQ FRKSVLADQG KSFATASHRN TEEEGLKYKS KVSLKGNRES
460 470 480 490 500
DGFREEKNYK LKETGYVVER PSTTKDKHKE EDKNSERITV KKETQSPEQV
510 520 530 540 550
KSEKLKDLFD YSPPLHKNLD AREKSTFREE SPLRIKMIAS DSHRPEVKLK
560 570 580 590 600
MAPVPLDDSN RPASLTKDRL LASTLVHSVK KEQEFRSIFD HIKLPQASKS
610 620 630 640 650
TSESFIQHIV SLVHHVKEQY FKSAAMTLNE RFTSYQKATE EHSTRQKSPE
660 670 680 690 700
IHRRIDISPS TLRKHTRLAG EERVFKEENQ KGDKKLRCDS ADLRHDIDRR
710 720 730 740 750
RKERSKERGD SKGSRESSGS RKQEKTPKDY KEYKSYKDDS KHKREQDHSR
760 770 780 790 800
SSSSSASPSS PSSREEKESK KEREEEFKTH HEMKEYSGFA GVSRPRGTFF
810 820 830 840 850
RIRGRGRARG VFAGTNTGPN NSNTTFQKRP KEEEWDPEYT PKSKKYFLHD
860 870 880 890 900
DRDDGVDYWA KRGRGRGTFQ RGRGRFNFKK SGSSPKWTHD KYQGDGIVED
910 920
EEETMENNEE KKDRRKEEKE
Length:920
Mass (Da):106,122
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i8892B98E54F52C20
Isoform 2 (identifier: Q9NYF8-2) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Btf-l
The sequence of this isoform differs from the canonical sequence as follows:
35-36: Missing.
« Hide
Show »10 20 30 40 50
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYRSRSRT YSRSRSRDRM
60 70 80 90 100
YSRDYRRDYR NNRGMRRPYG YRGRGRGYYQ GGGGRYHRGG YRPVWNRRHS
110 120 130 140 150
RSPRRGRSRS RSPKRRSVSS QRSRSRSRRS YRSSRSPRSS SSRSSSPYSK
160 170 180 190 200
SPVSKRRGSQ EKQTKKAEGE PQEESPLKSK SQEEPKDTFE HDPSESIDEF
210 220 230 240 250
NKSSATSGDI WPGLSAYDNS PRSPHSPSPI ATPPSQSSSC SDAPMLSTVH
260 270 280 290 300
SAKNTPSQHS HSIQHSPERS GSGSVGNGSS RYSPSQNSPI HHIPSRRSPA
310 320 330 340 350
KTIAPQNAPR DESRGRSSFY PDGGDQETAK TGKFLKRFTD EESRVFLLDR
360 370 380 390 400
GNTRDKEASK EKGSEKGRAE GEWEDQEALD YFSDKESGKQ KFNDSEGDDT
410 420 430 440 450
EETEDYRQFR KSVLADQGKS FATASHRNTE EEGLKYKSKV SLKGNRESDG
460 470 480 490 500
FREEKNYKLK ETGYVVERPS TTKDKHKEED KNSERITVKK ETQSPEQVKS
510 520 530 540 550
EKLKDLFDYS PPLHKNLDAR EKSTFREESP LRIKMIASDS HRPEVKLKMA
560 570 580 590 600
PVPLDDSNRP ASLTKDRLLA STLVHSVKKE QEFRSIFDHI KLPQASKSTS
610 620 630 640 650
ESFIQHIVSL VHHVKEQYFK SAAMTLNERF TSYQKATEEH STRQKSPEIH
660 670 680 690 700
RRIDISPSTL RKHTRLAGEE RVFKEENQKG DKKLRCDSAD LRHDIDRRRK
710 720 730 740 750
ERSKERGDSK GSRESSGSRK QEKTPKDYKE YKSYKDDSKH KREQDHSRSS
760 770 780 790 800
SSSASPSSPS SREEKESKKE REEEFKTHHE MKEYSGFAGV SRPRGTFFRI
810 820 830 840 850
RGRGRARGVF AGTNTGPNNS NTTFQKRPKE EEWDPEYTPK SKKYFLHDDR
860 870 880 890 900
DDGVDYWAKR GRGRGTFQRG RGRFNFKKSG SSPKWTHDKY QGDGIVEDEE
910
ETMENNEEKK DRRKEEKE
Isoform 3 (identifier: Q9NYF8-3) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Btf-s, BP-1
The sequence of this isoform differs from the canonical sequence as follows:
35-36: Missing.
800-848: Missing.
« Hide
Show »10 20 30 40 50
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYRSRSRT YSRSRSRDRM
60 70 80 90 100
YSRDYRRDYR NNRGMRRPYG YRGRGRGYYQ GGGGRYHRGG YRPVWNRRHS
110 120 130 140 150
RSPRRGRSRS RSPKRRSVSS QRSRSRSRRS YRSSRSPRSS SSRSSSPYSK
160 170 180 190 200
SPVSKRRGSQ EKQTKKAEGE PQEESPLKSK SQEEPKDTFE HDPSESIDEF
210 220 230 240 250
NKSSATSGDI WPGLSAYDNS PRSPHSPSPI ATPPSQSSSC SDAPMLSTVH
260 270 280 290 300
SAKNTPSQHS HSIQHSPERS GSGSVGNGSS RYSPSQNSPI HHIPSRRSPA
310 320 330 340 350
KTIAPQNAPR DESRGRSSFY PDGGDQETAK TGKFLKRFTD EESRVFLLDR
360 370 380 390 400
GNTRDKEASK EKGSEKGRAE GEWEDQEALD YFSDKESGKQ KFNDSEGDDT
410 420 430 440 450
EETEDYRQFR KSVLADQGKS FATASHRNTE EEGLKYKSKV SLKGNRESDG
460 470 480 490 500
FREEKNYKLK ETGYVVERPS TTKDKHKEED KNSERITVKK ETQSPEQVKS
510 520 530 540 550
EKLKDLFDYS PPLHKNLDAR EKSTFREESP LRIKMIASDS HRPEVKLKMA
560 570 580 590 600
PVPLDDSNRP ASLTKDRLLA STLVHSVKKE QEFRSIFDHI KLPQASKSTS
610 620 630 640 650
ESFIQHIVSL VHHVKEQYFK SAAMTLNERF TSYQKATEEH STRQKSPEIH
660 670 680 690 700
RRIDISPSTL RKHTRLAGEE RVFKEENQKG DKKLRCDSAD LRHDIDRRRK
710 720 730 740 750
ERSKERGDSK GSRESSGSRK QEKTPKDYKE YKSYKDDSKH KREQDHSRSS
760 770 780 790 800
SSSASPSSPS SREEKESKKE REEEFKTHHE MKEYSGFAGV SRPRGTFHDD
810 820 830 840 850
RDDGVDYWAK RGRGRGTFQR GRGRFNFKKS GSSPKWTHDK YQGDGIVEDE
860
EETMENNEEK KDRRKEEKE
Isoform 4 (identifier: Q9NYF8-4) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
339-511: Missing.
« Hide
Show »10 20 30 40 50
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD
60 70 80 90 100
RMYSRDYRRD YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR
110 120 130 140 150
HSRSPRRGRS RSRSPKRRSV SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY
160 170 180 190 200
SKSPVSKRRG SQEKQTKKAE GEPQEESPLK SKSQEEPKDT FEHDPSESID
210 220 230 240 250
EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS SCSDAPMLST
260 270 280 290 300
VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS
310 320 330 340 350
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKSP PLHKNLDARE
360 370 380 390 400
KSTFREESPL RIKMIASDSH RPEVKLKMAP VPLDDSNRPA SLTKDRLLAS
410 420 430 440 450
TLVHSVKKEQ EFRSIFDHIK LPQASKSTSE SFIQHIVSLV HHVKEQYFKS
460 470 480 490 500
AAMTLNERFT SYQKATEEHS TRQKSPEIHR RIDISPSTLR KHTRLAGEER
510 520 530 540 550
VFKEENQKGD KKLRCDSADL RHDIDRRRKE RSKERGDSKG SRESSGSRKQ
560 570 580 590 600
EKTPKDYKEY KSYKDDSKHK REQDHSRSSS SSASPSSPSS REEKESKKER
610 620 630 640 650
EEEFKTHHEM KEYSGFAGVS RPRGTFFRIR GRGRARGVFA GTNTGPNNSN
660 670 680 690 700
TTFQKRPKEE EWDPEYTPKS KKYFLHDDRD DGVDYWAKRG RGRGTFQRGR
710 720 730 740
GRFNFKKSGS SPKWTHDKYQ GDGIVEDEEE TMENNEEKKD RRKEEKE
<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| Entry | Entry name | Protein names | Gene names | Length | Annotation | ||
|---|---|---|---|---|---|---|---|
| E9PK91 | E9PK91_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 871 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| E9PK09 | E9PK09_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 725 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| E9PKI6 | E9PKI6_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 752 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| H0YF63 | H0YF63_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 126 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| H0YF14 | H0YF14_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 187 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| E9PJA7 | E9PJA7_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 467 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| E9PQN2 | E9PQN2_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 750 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| H0YF00 | H0YF00_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 118 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
| A0A1W2PQ43 | A0A1W2PQ43_HUMAN | Bcl-2-associated transcription fact... Bcl-2-associated transcription factor 1 | BCLAF1 | 703 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
The sequence AAH47687 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH47887 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH56894 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH63846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA11481 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 4 | S → A in AAF64304 (PubMed:10330179).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059591 | 66 | G → A. Corresponds to variant dbSNP:rs9942517Ensembl. | 1 | |
| Natural variantiVAR_050692 | 209 | S → C. Corresponds to variant dbSNP:rs6940018Ensembl. | 1 | |
| Natural variantiVAR_050693 | 459 | Y → D. Corresponds to variant dbSNP:rs1967446Ensembl. | 1 | |
| Natural variantiVAR_050694 | 461 | L → H. Corresponds to variant dbSNP:rs1967445Ensembl. | 1 | |
| Natural variantiVAR_050695 | 629 | N → S. Corresponds to variant dbSNP:rs7381749Ensembl. | 1 | |
| Natural variantiVAR_050696 | 875 | R → C. Corresponds to variant dbSNP:rs34541670Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010369 | 35 – 36 | Missing in isoform 2 and isoform 3. 2 Publications <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 2 | |
| Alternative sequenceiVSP_010371 | 339 – 511 | Missing in isoform 4. 1 Publication Manual assertion based on opinion ini
| 173 | |
| Alternative sequenceiVSP_010370 | 800 – 848 | Missing in isoform 3. 1 Publication Manual assertion based on opinion ini
| 49 |
Sequence databases
| Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AF249273 mRNA Translation: AAF64304.1 D79986 mRNA Translation: BAA11481.2 Different initiation. AL121713 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47950.1 CH471051 Genomic DNA Translation: EAW47951.1 BC047687 mRNA Translation: AAH47687.1 Sequence problems. BC047887 mRNA Translation: AAH47887.1 Sequence problems. BC056894 mRNA Translation: AAH56894.1 Sequence problems. BC063846 mRNA Translation: AAH63846.1 Sequence problems. BC132780 mRNA Translation: AAI32781.1 BC144281 mRNA Translation: AAI44282.1 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS47485.1 [Q9NYF8-4] CCDS47486.1 [Q9NYF8-3] CCDS5177.1 [Q9NYF8-1] CCDS75525.1 [Q9NYF8-2] |
NCBI Reference Sequences More...RefSeqi | NP_001070908.1, NM_001077440.1 [Q9NYF8-3] NP_001070909.1, NM_001077441.1 [Q9NYF8-4] NP_001287967.1, NM_001301038.1 [Q9NYF8-2] NP_055554.1, NM_014739.2 [Q9NYF8-1] |
UniGene gene-oriented nucleotide sequence clusters More...UniGenei | Hs.486542 |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000353331; ENSP00000229446; ENSG00000029363 [Q9NYF8-3] ENST00000392348; ENSP00000376159; ENSG00000029363 [Q9NYF8-3] ENST00000527759; ENSP00000434826; ENSG00000029363 [Q9NYF8-2] ENST00000530767; ENSP00000436501; ENSG00000029363 [Q9NYF8-4] ENST00000531224; ENSP00000435210; ENSG00000029363 [Q9NYF8-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 9774 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:9774 |
UCSC genome browser More...UCSCi | uc003qgw.2 human [Q9NYF8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Polymorphism<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
| Protein | Similar proteins | Species | Score | Length | Source | |
|---|---|---|---|---|---|---|
| Q9NYF8 | BCL2-associated transcription factor 1 | 920 | UniRef100_Q9NYF8 | |||
| BCL2 associated transcription factor 1 | 920 | |||||
| Q9NYF8-2 | BCL2-associated transcription factor 1 | 918 | UniRef100_K7DBX3 | |||
| Q9NYF8-4 | BCL2-associated transcription factor 1 | 747 | UniRef100_K7D7C7 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi
| Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF249273 mRNA Translation: AAF64304.1 D79986 mRNA Translation: BAA11481.2 Different initiation. AL121713 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47950.1 CH471051 Genomic DNA Translation: EAW47951.1 BC047687 mRNA Translation: AAH47687.1 Sequence problems. BC047887 mRNA Translation: AAH47887.1 Sequence problems. BC056894 mRNA Translation: AAH56894.1 Sequence problems. BC063846 mRNA Translation: AAH63846.1 Sequence problems. BC132780 mRNA Translation: AAI32781.1 BC144281 mRNA Translation: AAI44282.1 |
| CCDSi | CCDS47485.1 [Q9NYF8-4] CCDS47486.1 [Q9NYF8-3] CCDS5177.1 [Q9NYF8-1] CCDS75525.1 [Q9NYF8-2] |
| RefSeqi | NP_001070908.1, NM_001077440.1 [Q9NYF8-3] NP_001070909.1, NM_001077441.1 [Q9NYF8-4] NP_001287967.1, NM_001301038.1 [Q9NYF8-2] NP_055554.1, NM_014739.2 [Q9NYF8-1] |
| UniGenei | Hs.486542 |
3D structure databases
| ProteinModelPortali | Q9NYF8 |
| ModBasei | Search... |
| MobiDBi | Search... |
Protein-protein interaction databases
| BioGridi | 115118, 120 interactors |
| IntActi | Q9NYF8, 75 interactors |
| MINTi | Q9NYF8 |
| STRINGi | 9606.ENSP00000435210 |
PTM databases
| iPTMneti | Q9NYF8 |
| PhosphoSitePlusi | Q9NYF8 |
| SwissPalmi | Q9NYF8 |
Polymorphism and mutation databases
| BioMutai | BCLAF1 |
| DMDMi | 47605556 |
Proteomic databases
| EPDi | Q9NYF8 |
| MaxQBi | Q9NYF8 |
| PaxDbi | Q9NYF8 |
| PeptideAtlasi | Q9NYF8 |
| PRIDEi | Q9NYF8 |
| ProteomicsDBi | 83221 83222 [Q9NYF8-2] 83223 [Q9NYF8-3] 83224 [Q9NYF8-4] |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000353331; ENSP00000229446; ENSG00000029363 [Q9NYF8-3] ENST00000392348; ENSP00000376159; ENSG00000029363 [Q9NYF8-3] ENST00000527759; ENSP00000434826; ENSG00000029363 [Q9NYF8-2] ENST00000530767; ENSP00000436501; ENSG00000029363 [Q9NYF8-4] ENST00000531224; ENSP00000435210; ENSG00000029363 [Q9NYF8-1] |
| GeneIDi | 9774 |
| KEGGi | hsa:9774 |
| UCSCi | uc003qgw.2 human [Q9NYF8-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 9774 |
| DisGeNETi | 9774 |
| EuPathDBi | HostDB:ENSG00000029363.15 |
GeneCards: human genes, protein and diseases More...GeneCardsi | BCLAF1 |
| HGNCi | HGNC:16863 BCLAF1 |
| HPAi | HPA006484 HPA006669 HPA027770 |
| MIMi | 612588 gene |
| neXtProti | NX_Q9NYF8 |
| OpenTargetsi | ENSG00000029363 |
| PharmGKBi | PA134868035 |
Human Unidentified Gene-Encoded large proteins database More...HUGEi | Search... |
GenAtlas: human gene database More...GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG410IJCD Eukaryota ENOG4110X68 LUCA |
| GeneTreei | ENSGT00530000063211 |
| HOVERGENi | HBG050681 |
| InParanoidi | Q9NYF8 |
| KOi | K13087 |
| OMAi | TSHRNTE |
| OrthoDBi | EOG091G03HU |
| PhylomeDBi | Q9NYF8 |
| TreeFami | TF335939 |
Miscellaneous databases
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data More...ChiTaRSi | BCLAF1 human |
The Gene Wiki collection of pages on human genes and proteins More...GeneWikii | BCLAF1 |
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens More...GenomeRNAii | 9774 |
Protein Ontology More...PROi | PR:Q9NYF8 |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000029363 Expressed in 242 organ(s), highest expression level in substantia nigra |
| CleanExi | HS_BCLAF1 |
| ExpressionAtlasi | Q9NYF8 baseline and differential |
| Genevisiblei | Q9NYF8 HS |
Family and domain databases
| InterProi | View protein in InterPro IPR026668 Bcl-2_assoc_TF1 IPR029199 THRAP3_BCLAF1 |
| PANTHERi | PTHR15268 PTHR15268, 1 hit PTHR15268:SF4 PTHR15268:SF4, 1 hit |
| Pfami | View protein in Pfam PF15440 THRAP3_BCLAF1, 1 hit |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | BCLF1_HUMAN | |
| <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q9NYF8Primary (citable) accession number: Q9NYF8 Secondary accession number(s): A2RU75 , B7ZM58, E1P586, Q14673, Q86WU6, Q86WY0 | |
| <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
| Last sequence update: | May 24, 2004 | |
| Last modified: | September 12, 2018 | |
| This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
| <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
