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Protein

Protein FAM53C

Gene

FAM53C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM53CCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM53CImported
Synonyms:C5orf6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000120709.10

Human Gene Nomenclature Database

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HGNCi
HGNC:1336 FAM53C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609372 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYF3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000120709

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25917

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM53C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
66774134

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895461 – 392Protein FAM53CAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NYF3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NYF3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYF3

PeptideAtlas

More...
PeptideAtlasi
Q9NYF3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYF3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83218

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120709 Expressed in 230 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_FAM53C

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYF3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYF3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042796

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119458, 60 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NYF3, 17 interactors

Molecular INTeraction database

More...
MINTi
Q9NYF3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239906

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NYF3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIF0 Eukaryota
ENOG410YEWD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063371

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059662

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051537

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYF3

Identification of Orthologs from Complete Genome Data

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OMAi
DFSKMTQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G091O

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYF3

TreeFam database of animal gene trees

More...
TreeFami
TF332095

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029356 FAM53

The PANTHER Classification System

More...
PANTHERi
PTHR28567 PTHR28567, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15242 FAM53, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NYF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW
60 70 80 90 100
RGLPHCSCAE FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP
110 120 130 140 150
PDPEKLPVPP APPSKRHCRS LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS
160 170 180 190 200
GGGGGPQVPH QSPPKRVSSL RFLQAPSASS QCAPAHRPYS PPFFSLALAQ
210 220 230 240 250
DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ ASRFLPSARS
260 270 280 290 300
SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL
310 320 330 340 350
DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS
360 370 380 390
QVLSESEEEE EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN
Length:392
Mass (Da):43,091
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28ED288D94D81073
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE00D6RE00_HUMAN
Protein FAM53C
FAM53C
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHW3D6RHW3_HUMAN
Protein FAM53C
FAM53C
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05308921R → C. Corresponds to variant dbSNP:rs35360938Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF251040 mRNA Translation: AAF63766.1
AK315567 mRNA Translation: BAG37942.1
CH471062 Genomic DNA Translation: EAW62143.1
CH471062 Genomic DNA Translation: EAW62144.1
BC000259 mRNA Translation: AAH00259.1
BC052993 mRNA Translation: AAH52993.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4204.1

NCBI Reference Sequences

More...
RefSeqi
NP_001129119.1, NM_001135647.1
NP_057689.1, NM_016605.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.54056

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000239906; ENSP00000239906; ENSG00000120709
ENST00000434981; ENSP00000403705; ENSG00000120709

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51307

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51307

UCSC genome browser

More...
UCSCi
uc003lcv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251040 mRNA Translation: AAF63766.1
AK315567 mRNA Translation: BAG37942.1
CH471062 Genomic DNA Translation: EAW62143.1
CH471062 Genomic DNA Translation: EAW62144.1
BC000259 mRNA Translation: AAH00259.1
BC052993 mRNA Translation: AAH52993.1
CCDSiCCDS4204.1
RefSeqiNP_001129119.1, NM_001135647.1
NP_057689.1, NM_016605.2
UniGeneiHs.54056

3D structure databases

ProteinModelPortaliQ9NYF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119458, 60 interactors
IntActiQ9NYF3, 17 interactors
MINTiQ9NYF3
STRINGi9606.ENSP00000239906

PTM databases

iPTMnetiQ9NYF3
PhosphoSitePlusiQ9NYF3

Polymorphism and mutation databases

BioMutaiFAM53C
DMDMi66774134

Proteomic databases

EPDiQ9NYF3
MaxQBiQ9NYF3
PaxDbiQ9NYF3
PeptideAtlasiQ9NYF3
PRIDEiQ9NYF3
ProteomicsDBi83218

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51307
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239906; ENSP00000239906; ENSG00000120709
ENST00000434981; ENSP00000403705; ENSG00000120709
GeneIDi51307
KEGGihsa:51307
UCSCiuc003lcv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51307
EuPathDBiHostDB:ENSG00000120709.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM53C

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0200731
HGNCiHGNC:1336 FAM53C
HPAiHPA042796
MIMi609372 gene
neXtProtiNX_Q9NYF3
OpenTargetsiENSG00000120709
PharmGKBiPA25917

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIF0 Eukaryota
ENOG410YEWD LUCA
GeneTreeiENSGT00530000063371
HOGENOMiHOG000059662
HOVERGENiHBG051537
InParanoidiQ9NYF3
OMAiDFSKMTQ
OrthoDBiEOG091G091O
PhylomeDBiQ9NYF3
TreeFamiTF332095

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM53C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51307

Protein Ontology

More...
PROi
PR:Q9NYF3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120709 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_FAM53C
ExpressionAtlasiQ9NYF3 baseline and differential
GenevisibleiQ9NYF3 HS

Family and domain databases

InterProiView protein in InterPro
IPR029356 FAM53
PANTHERiPTHR28567 PTHR28567, 1 hit
PfamiView protein in Pfam
PF15242 FAM53, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA53C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYF3
Secondary accession number(s): B2RDJ5, D3DQB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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