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Protein

Protein FAM53C

Gene

FAM53C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM53CCurated
Gene namesi
Name:FAM53CImported
Synonyms:C5orf6Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120709.10
HGNCiHGNC:1336 FAM53C
MIMi609372 gene
neXtProtiNX_Q9NYF3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120709
PharmGKBiPA25917

Polymorphism and mutation databases

BioMutaiFAM53C
DMDMi66774134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895461 – 392Protein FAM53CAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NYF3
MaxQBiQ9NYF3
PaxDbiQ9NYF3
PeptideAtlasiQ9NYF3
PRIDEiQ9NYF3
ProteomicsDBi83218

PTM databases

iPTMnetiQ9NYF3
PhosphoSitePlusiQ9NYF3

Expressioni

Gene expression databases

BgeeiENSG00000120709 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_FAM53C
ExpressionAtlasiQ9NYF3 baseline and differential
GenevisibleiQ9NYF3 HS

Organism-specific databases

HPAiHPA042796

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119458, 59 interactors
IntActiQ9NYF3, 17 interactors
MINTiQ9NYF3
STRINGi9606.ENSP00000239906

Structurei

3D structure databases

ProteinModelPortaliQ9NYF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

eggNOGiENOG410IIF0 Eukaryota
ENOG410YEWD LUCA
GeneTreeiENSGT00530000063371
HOGENOMiHOG000059662
HOVERGENiHBG051537
InParanoidiQ9NYF3
OMAiDFSKMTQ
OrthoDBiEOG091G091O
PhylomeDBiQ9NYF3
TreeFamiTF332095

Family and domain databases

InterProiView protein in InterPro
IPR029356 FAM53
PANTHERiPTHR28567 PTHR28567, 1 hit
PfamiView protein in Pfam
PF15242 FAM53, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9NYF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW
60 70 80 90 100
RGLPHCSCAE FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP
110 120 130 140 150
PDPEKLPVPP APPSKRHCRS LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS
160 170 180 190 200
GGGGGPQVPH QSPPKRVSSL RFLQAPSASS QCAPAHRPYS PPFFSLALAQ
210 220 230 240 250
DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ ASRFLPSARS
260 270 280 290 300
SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL
310 320 330 340 350
DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS
360 370 380 390
QVLSESEEEE EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN
Length:392
Mass (Da):43,091
Last modified:October 1, 2000 - v1
Checksum:i28ED288D94D81073
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE00D6RE00_HUMAN
Protein FAM53C
FAM53C
114Annotation score:
D6RHW3D6RHW3_HUMAN
Protein FAM53C
FAM53C
165Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05308921R → C. Corresponds to variant dbSNP:rs35360938Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251040 mRNA Translation: AAF63766.1
AK315567 mRNA Translation: BAG37942.1
CH471062 Genomic DNA Translation: EAW62143.1
CH471062 Genomic DNA Translation: EAW62144.1
BC000259 mRNA Translation: AAH00259.1
BC052993 mRNA Translation: AAH52993.1
CCDSiCCDS4204.1
RefSeqiNP_001129119.1, NM_001135647.1
NP_057689.1, NM_016605.2
UniGeneiHs.54056

Genome annotation databases

EnsembliENST00000239906; ENSP00000239906; ENSG00000120709
ENST00000434981; ENSP00000403705; ENSG00000120709
GeneIDi51307
KEGGihsa:51307
UCSCiuc003lcv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA53C_HUMAN
AccessioniPrimary (citable) accession number: Q9NYF3
Secondary accession number(s): B2RDJ5, D3DQB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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