UniProtKB - Q9NYF0 (DACT1_HUMAN)
Dapper homolog 1
DACT1
Functioni
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity).
The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.
By similarity5 PublicationsGO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- delta-catenin binding Source: UniProtKB
- histone deacetylase binding Source: ParkinsonsUK-UCL
- protein kinase A binding Source: UniProtKB
- protein kinase C binding Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- embryonic hindgut morphogenesis Source: UniProtKB
- negative regulation of beta-catenin-TCF complex assembly Source: ParkinsonsUK-UCL
- negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of protein binding Source: ParkinsonsUK-UCL
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: UniProtKB
- neural tube development Source: ParkinsonsUK-UCL
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of cellular protein catabolic process Source: ParkinsonsUK-UCL
- positive regulation of protein binding Source: ParkinsonsUK-UCL
- positive regulation of protein catabolic process Source: MGI
- positive regulation of Wnt signaling pathway Source: UniProtKB
- regulation of canonical Wnt signaling pathway Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- regulation of Wnt signaling pathway, planar cell polarity pathway Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NYF0 |
Reactomei | R-HSA-4641258, Degradation of DVL |
SignaLinki | Q9NYF0 |
SIGNORi | Q9NYF0 |
Names & Taxonomyi
Protein namesi | Recommended name: Dapper homolog 1Short name: hDPR1 Alternative name(s): Dapper antagonist of catenin 1 Hepatocellular carcinoma novel gene 3 protein |
Gene namesi | Name:DACT1 Synonyms:DPR1, HNG3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17748, DACT1 |
MIMi | 607861, gene |
neXtProti | NX_Q9NYF0 |
VEuPathDBi | HostDB:ENSG00000165617 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: ParkinsonsUK-UCL
Other locations
Keywords - Cellular componenti
Cell junction, Cytoplasm, Nucleus, SynapsePathology & Biotechi
Involvement in diseasei
Neural tube defects (NTD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068427 | 45 | R → W in NTD; uncertain pathological significance; does not affect interaction with DVL2; does not affect subcellular location; increases RHOA activation but decreases the ability to activate JNK. 1 PublicationCorresponds to variant dbSNP:rs778976254Ensembl. | 1 | |
Natural variantiVAR_068429 | 356 | N → K in NTD; does not affect interaction with DVL2; does not affect subcellular location; results in reduced RHOA and JNK activation. 1 Publication | 1 |
Townes-Brocks syndrome 2 (TBS2)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080125 | 419 – 836 | Missing in TBS2; the mutant protein is stable and expressed. 1 PublicationAdd BLAST | 418 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 132 | L → A: Abolishes nuclear export; when associated with A-136. 1 Publication | 1 | |
Mutagenesisi | 136 | I → A: Abolishes nuclear export; when associated with A-132. 1 Publication | 1 | |
Mutagenesisi | 237 | S → A: Impairs interaction with YWHAB. Abolishes interaction with YWHAB; when associated with A-827. | 1 | |
Mutagenesisi | 622 – 623 | KK → AA: Partial nuclear accumulation upon LMB treatment. 1 Publication | 2 | |
Mutagenesisi | 827 | S → A: Abolishes interaction with YWHAB; when associated with A-237. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 51339 |
MalaCardsi | DACT1 |
MIMi | 182940, phenotype 617466, phenotype |
OpenTargetsi | ENSG00000165617 |
Orphaneti | 63260, Craniorachischisis 268823, Occipital encephalocele 857, Townes-Brocks syndrome |
PharmGKBi | PA134957283 |
Miscellaneous databases
Pharosi | Q9NYF0, Tbio |
Genetic variation databases
BioMutai | DACT1 |
DMDMi | 34098740 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191353 | 1 – 836 | Dapper homolog 1Add BLAST | 836 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 237 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 827 | Phosphoserine; by PKA1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9NYF0 |
MassIVEi | Q9NYF0 |
PaxDbi | Q9NYF0 |
PeptideAtlasi | Q9NYF0 |
PRIDEi | Q9NYF0 |
ProteomicsDBi | 2406 83217 [Q9NYF0-1] |
PTM databases
iPTMneti | Q9NYF0 |
PhosphoSitePlusi | Q9NYF0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165617, Expressed in cortical plate and 168 other tissues |
ExpressionAtlasi | Q9NYF0, baseline and differential |
Genevisiblei | Q9NYF0, HS |
Organism-specific databases
HPAi | ENSG00000165617, Low tissue specificity |
Interactioni
Subunit structurei
Can form homodimers and heterodimers with DACT2 or DACT3.
Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity).
Interacts with DVL2.
Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827.
Interacts with CTNNB1 and HDAC1.
Interacts with GSK3B; the interaction is indicative for an association of DACT1 with the beta-catenin destruction complex.
Interacts with GSK3A.
By similarity6 PublicationsBinary interactionsi
Q9NYF0
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] | 3 | EBI-3951744,EBI-491549 |
DVL2 [O14641] | 6 | EBI-3951744,EBI-740850 |
GSK3B [P49841] | 3 | EBI-3951744,EBI-373586 |
YWHAB [P31946] | 4 | EBI-3951744,EBI-359815 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- delta-catenin binding Source: UniProtKB
- histone deacetylase binding Source: ParkinsonsUK-UCL
- protein kinase A binding Source: UniProtKB
- protein kinase C binding Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 119486, 35 interactors |
IntActi | Q9NYF0, 23 interactors |
MINTi | Q9NYF0 |
STRINGi | 9606.ENSP00000337439 |
Miscellaneous databases
RNActi | Q9NYF0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9NYF0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 47 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 92 – 156 | Required for self-associationBy similarityAdd BLAST | 65 | |
Regioni | 316 – 335 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 350 – 374 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 401 – 521 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 588 – 679 | DisorderedSequence analysisAdd BLAST | 92 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 92 – 156 | Sequence analysisAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 132 – 141 | Nuclear export signal | 10 | |
Motifi | 610 – 623 | Bipartite nuclear localization signalCuratedAdd BLAST | 14 | |
Motifi | 826 – 836 | PDZ-bindingBy similarityAdd BLAST | 11 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 23 – 47 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 401 – 421 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 473 – 487 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 504 – 521 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 604 – 625 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 656 – 670 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QVXB, Eukaryota |
GeneTreei | ENSGT00950000183181 |
HOGENOMi | CLU_021211_1_0_1 |
InParanoidi | Q9NYF0 |
OMAi | VADVHPK |
OrthoDBi | 674318at2759 |
PhylomeDBi | Q9NYF0 |
TreeFami | TF331300 |
Family and domain databases
InterProi | View protein in InterPro IPR024848, Dact1 IPR024843, Dapper |
PANTHERi | PTHR15919, PTHR15919, 1 hit PTHR15919:SF12, PTHR15919:SF12, 1 hit |
Pfami | View protein in Pfam PF15268, Dapper, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKPSPAGTAK ELEPPAPARG EQRTAEPEGR WREKGEADTE RQRTRERQEA
60 70 80 90 100
TLAGLAELEY LRQRQELLVR GALRGAGGAG AAAPRAGELL GEAAQRSRLE
110 120 130 140 150
EKFLEENILL LRKQLNCLRR RDAGLLNQLQ ELDKQISDLR LDVEKTSEEH
160 170 180 190 200
LETDSRPSSG FYELSDGASG SLSNSSNSVF SECLSSCHSS TCFCSPLEAT
210 220 230 240 250
LSLSDGCPKS ADLIGLLEYK EGHCEDQASG AVCRSLSTPQ FNSLDVIADV
260 270 280 290 300
NPKYQCDLVS KNGNDVYRYP SPLHAVAVQS PMFLLCLTGN PLREEDRLGN
310 320 330 340 350
HASDICGGSE LDAVKTDSSL PSPSSLWSAS HPSSSKKMDG YILSLVQKKT
360 370 380 390 400
HPVRTNKPRT SVNADPTKGL LRNGSVCVRA PGGVSQGNSV NLKNSKQACL
410 420 430 440 450
PSGGIPSLNN GTFSPPKQWS KESKAEQAES KRVPLPEGCP SGAASDLQSK
460 470 480 490 500
HLPKTAKPAS QEHARCSAIG TGESPKESAQ LSGASPKESP SRGPAPPQEN
510 520 530 540 550
KVVQPLKKMS QKNSLQGVPP ATPPLLSTAF PVEERPALDF KSEGSSQSLE
560 570 580 590 600
EAHLVKAQFI PGQQPSVRLH RGHRNMGVVK NSSLKHRGPA LQGLENGLPT
610 620 630 640 650
VREKTRAGSK KCRFPDDLDT NKKLKKASSK GRKSGGGPEA GVPGRPAGGG
660 670 680 690 700
HRAGSRAHGH GREAVVAKPK HKRTDYRRWK SSAEISYEEA LRRARRGRRE
710 720 730 740 750
NVGLYPAPVP LPYASPYAYV ASDSEYSAEC ESLFHSTVVD TSEDEQSNYT
760 770 780 790 800
TNCFGDSESS VSEGEFVGES TTTSDSEESG GLIWSQFVQT LPIQTVTAPD
810 820 830
LHNHPAKTFV KIKASHNLKK KILRFRSGSL KLMTTV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z673 | B7Z673_HUMAN | Dapper homolog 1 | DACT1 | 555 | Annotation score: | ||
C9JGV7 | C9JGV7_HUMAN | Dapper homolog 1 | DACT1 | 130 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068427 | 45 | R → W in NTD; uncertain pathological significance; does not affect interaction with DVL2; does not affect subcellular location; increases RHOA activation but decreases the ability to activate JNK. 1 PublicationCorresponds to variant dbSNP:rs778976254Ensembl. | 1 | |
Natural variantiVAR_036461 | 124 | G → C in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_068428 | 142 | D → G Found in a patient with craniorachischisis; sporadic case; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_068429 | 356 | N → K in NTD; does not affect interaction with DVL2; does not affect subcellular location; results in reduced RHOA and JNK activation. 1 Publication | 1 | |
Natural variantiVAR_080125 | 419 – 836 | Missing in TBS2; the mutant protein is stable and expressed. 1 PublicationAdd BLAST | 418 | |
Natural variantiVAR_053057 | 446 | D → N. Corresponds to variant dbSNP:rs34015825Ensembl. | 1 | |
Natural variantiVAR_053058 | 464 | A → V1 PublicationCorresponds to variant dbSNP:rs17832998Ensembl. | 1 | |
Natural variantiVAR_053059 | 628 | S → A. Corresponds to variant dbSNP:rs17094821Ensembl. | 1 | |
Natural variantiVAR_036462 | 682 | S → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1198900887Ensembl. | 1 | |
Natural variantiVAR_053060 | 697 | G → S. Corresponds to variant dbSNP:rs698025Ensembl. | 1 | |
Natural variantiVAR_068430 | 702 | V → G Found in a patient with closed spina bifida; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1028180302Ensembl. | 1 | |
Natural variantiVAR_068431 | 800 | D → G1 PublicationCorresponds to variant dbSNP:rs773720154Ensembl. | 1 | |
Natural variantiVAR_068432 | 808 | T → K Found in a patient with encephalocele; sporadic case; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044198 | 213 – 249 | Missing in isoform 2. CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133312 Genomic DNA No translation available. BX161433 mRNA Translation: CAD61905.1 Different initiation. AF251079 mRNA Translation: AAF65569.1 Different initiation. BK000256 mRNA Translation: DAA00310.1 |
CCDSi | CCDS41961.1 [Q9NYF0-2] CCDS9736.1 [Q9NYF0-1] |
RefSeqi | NP_001072988.1, NM_001079520.1 [Q9NYF0-2] NP_057735.2, NM_016651.5 [Q9NYF0-1] XP_006720230.1, XM_006720167.3 |
Genome annotation databases
Ensembli | ENST00000335867.4; ENSP00000337439.4; ENSG00000165617.15 ENST00000395153.8; ENSP00000378582.3; ENSG00000165617.15 [Q9NYF0-2] |
GeneIDi | 51339 |
KEGGi | hsa:51339 |
MANE-Selecti | ENST00000395153.8; ENSP00000378582.3; NM_001079520.2; NP_001072988.1 [Q9NYF0-2] |
UCSCi | uc001xdw.4, human [Q9NYF0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) (DACT1) Leiden Open Variation Database (LOVD) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133312 Genomic DNA No translation available. BX161433 mRNA Translation: CAD61905.1 Different initiation. AF251079 mRNA Translation: AAF65569.1 Different initiation. BK000256 mRNA Translation: DAA00310.1 |
CCDSi | CCDS41961.1 [Q9NYF0-2] CCDS9736.1 [Q9NYF0-1] |
RefSeqi | NP_001072988.1, NM_001079520.1 [Q9NYF0-2] NP_057735.2, NM_016651.5 [Q9NYF0-1] XP_006720230.1, XM_006720167.3 |
3D structure databases
AlphaFoldDBi | Q9NYF0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119486, 35 interactors |
IntActi | Q9NYF0, 23 interactors |
MINTi | Q9NYF0 |
STRINGi | 9606.ENSP00000337439 |
PTM databases
iPTMneti | Q9NYF0 |
PhosphoSitePlusi | Q9NYF0 |
Genetic variation databases
BioMutai | DACT1 |
DMDMi | 34098740 |
Proteomic databases
jPOSTi | Q9NYF0 |
MassIVEi | Q9NYF0 |
PaxDbi | Q9NYF0 |
PeptideAtlasi | Q9NYF0 |
PRIDEi | Q9NYF0 |
ProteomicsDBi | 2406 83217 [Q9NYF0-1] |
Protocols and materials databases
Antibodypediai | 66, 155 antibodies from 24 providers |
DNASUi | 51339 |
Genome annotation databases
Ensembli | ENST00000335867.4; ENSP00000337439.4; ENSG00000165617.15 ENST00000395153.8; ENSP00000378582.3; ENSG00000165617.15 [Q9NYF0-2] |
GeneIDi | 51339 |
KEGGi | hsa:51339 |
MANE-Selecti | ENST00000395153.8; ENSP00000378582.3; NM_001079520.2; NP_001072988.1 [Q9NYF0-2] |
UCSCi | uc001xdw.4, human [Q9NYF0-1] |
Organism-specific databases
CTDi | 51339 |
DisGeNETi | 51339 |
GeneCardsi | DACT1 |
HGNCi | HGNC:17748, DACT1 |
HPAi | ENSG00000165617, Low tissue specificity |
MalaCardsi | DACT1 |
MIMi | 182940, phenotype 607861, gene 617466, phenotype |
neXtProti | NX_Q9NYF0 |
OpenTargetsi | ENSG00000165617 |
Orphaneti | 63260, Craniorachischisis 268823, Occipital encephalocele 857, Townes-Brocks syndrome |
PharmGKBi | PA134957283 |
VEuPathDBi | HostDB:ENSG00000165617 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVXB, Eukaryota |
GeneTreei | ENSGT00950000183181 |
HOGENOMi | CLU_021211_1_0_1 |
InParanoidi | Q9NYF0 |
OMAi | VADVHPK |
OrthoDBi | 674318at2759 |
PhylomeDBi | Q9NYF0 |
TreeFami | TF331300 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYF0 |
Reactomei | R-HSA-4641258, Degradation of DVL |
SignaLinki | Q9NYF0 |
SIGNORi | Q9NYF0 |
Miscellaneous databases
BioGRID-ORCSi | 51339, 10 hits in 1075 CRISPR screens |
ChiTaRSi | DACT1, human |
GenomeRNAii | 51339 |
Pharosi | Q9NYF0, Tbio |
PROi | PR:Q9NYF0 |
RNActi | Q9NYF0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165617, Expressed in cortical plate and 168 other tissues |
ExpressionAtlasi | Q9NYF0, baseline and differential |
Genevisiblei | Q9NYF0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024848, Dact1 IPR024843, Dapper |
PANTHERi | PTHR15919, PTHR15919, 1 hit PTHR15919:SF12, PTHR15919:SF12, 1 hit |
Pfami | View protein in Pfam PF15268, Dapper, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DACT1_HUMAN | |
Accessioni | Q9NYF0Primary (citable) accession number: Q9NYF0 Secondary accession number(s): A8MYJ2, Q86TY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 15, 2003 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families