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Protein

Homeobox protein Hox-C10

Gene

HOXC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi268 – 327HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3I
Gene namesi
Name:HOXC10
Synonyms:HOX3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000180818.4
HGNCiHGNC:5122 HOXC10
MIMi605560 gene
neXtProtiNX_Q9NYD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3226
OpenTargetsiENSG00000180818
PharmGKBiPA29397

Polymorphism and mutation databases

BioMutaiHOXC10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001901 – 342Homeobox protein Hox-C10Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineCombined sources1
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei189PhosphoserineCombined sources1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NYD6
PaxDbiQ9NYD6
PeptideAtlasiQ9NYD6
PRIDEiQ9NYD6
ProteomicsDBi83216

PTM databases

iPTMnetiQ9NYD6
PhosphoSitePlusiQ9NYD6

Expressioni

Gene expression databases

BgeeiENSG00000180818 Expressed in 110 organ(s), highest expression level in quadriceps femoris
CleanExiHS_HOXC10
ExpressionAtlasiQ9NYD6 baseline and differential
GenevisibleiQ9NYD6 HS

Organism-specific databases

HPAiHPA053919

Interactioni

Protein-protein interaction databases

BioGridi109466, 11 interactors
IntActiQ9NYD6, 4 interactors
STRINGi9606.ENSP00000307321

Structurei

3D structure databases

ProteinModelPortaliQ9NYD6
SMRiQ9NYD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiQ9NYD6
KOiK17444
OMAiCPRNVTP
OrthoDBiEOG091G0LON
PhylomeDBiQ9NYD6
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NYD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA
60 70 80 90 100
PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS
110 120 130 140 150
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR
160 170 180 190 200
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE
210 220 230 240 250
TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK
260 270 280 290 300
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
310 320 330 340
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
Length:342
Mass (Da):38,073
Last modified:January 23, 2002 - v2
Checksum:iBD8127FD43C2A37B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAG4D6RAG4_HUMAN
Homeobox protein Hox-C10
HOXC10
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118K → N in AAF67759 (PubMed:10835276).Curated1
Sequence conflicti265A → G in CAA68000 (PubMed:9357979).Curated1
Sequence conflicti271Missing in CAA68000 (PubMed:9357979).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255675 mRNA Translation: AAF67759.1
BC001293 mRNA Translation: AAH01293.1
X99684 mRNA Translation: CAA67999.1
X99685 mRNA Translation: CAA68000.1
CCDSiCCDS8868.1
PIRiB60941
RefSeqiNP_059105.2, NM_017409.3
UniGeneiHs.44276

Genome annotation databases

EnsembliENST00000303460; ENSP00000307321; ENSG00000180818
GeneIDi3226
KEGGihsa:3226
UCSCiuc001sen.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255675 mRNA Translation: AAF67759.1
BC001293 mRNA Translation: AAH01293.1
X99684 mRNA Translation: CAA67999.1
X99685 mRNA Translation: CAA68000.1
CCDSiCCDS8868.1
PIRiB60941
RefSeqiNP_059105.2, NM_017409.3
UniGeneiHs.44276

3D structure databases

ProteinModelPortaliQ9NYD6
SMRiQ9NYD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109466, 11 interactors
IntActiQ9NYD6, 4 interactors
STRINGi9606.ENSP00000307321

PTM databases

iPTMnetiQ9NYD6
PhosphoSitePlusiQ9NYD6

Polymorphism and mutation databases

BioMutaiHOXC10

Proteomic databases

MaxQBiQ9NYD6
PaxDbiQ9NYD6
PeptideAtlasiQ9NYD6
PRIDEiQ9NYD6
ProteomicsDBi83216

Protocols and materials databases

DNASUi3226
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303460; ENSP00000307321; ENSG00000180818
GeneIDi3226
KEGGihsa:3226
UCSCiuc001sen.4 human

Organism-specific databases

CTDi3226
DisGeNETi3226
EuPathDBiHostDB:ENSG00000180818.4
GeneCardsiHOXC10
HGNCiHGNC:5122 HOXC10
HPAiHPA053919
MIMi605560 gene
neXtProtiNX_Q9NYD6
OpenTargetsiENSG00000180818
PharmGKBiPA29397
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiQ9NYD6
KOiK17444
OMAiCPRNVTP
OrthoDBiEOG091G0LON
PhylomeDBiQ9NYD6
TreeFamiTF317819

Miscellaneous databases

GeneWikiiHOXC10
GenomeRNAii3226
PROiPR:Q9NYD6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180818 Expressed in 110 organ(s), highest expression level in quadriceps femoris
CleanExiHS_HOXC10
ExpressionAtlasiQ9NYD6 baseline and differential
GenevisibleiQ9NYD6 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC10_HUMAN
AccessioniPrimary (citable) accession number: Q9NYD6
Secondary accession number(s): O15219, O15220, Q9BVD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2002
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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