HOXC10

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	268 – 327	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10835276
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10835276

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
embryonic limb morphogenesis Source: Ensembl
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 28186086
neuromuscular process Source: Ensembl
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10835276
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10835276
proximal/distal pattern formation Source: Ensembl
skeletal system development Source: Ensembl
spinal cord motor neuron cell fate specification Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-C10 Alternative name(s): Homeobox protein Hox-3I
Gene namesⁱ	Name:HOXC10 Synonyms:HOX3I
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180818.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5122 HOXC10
MIMⁱ	605560 gene
neXtProtⁱ	NX_Q9NYD6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3226
Open Targets More...OpenTargetsⁱ	ENSG00000180818
PharmGKBⁱ	PA29397

Polymorphism and mutation databases

BioMutaⁱ	HOXC10

BioMutaⁱ

HOXC10

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200190	1 – 342	Homeobox protein Hox-C10Add BLAST		342

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	PhosphothreonineCombined sources	1
Cross-linkⁱ	106	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	189	PhosphoserineCombined sources	1
Cross-linkⁱ	195	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	254	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NYD6
PaxDbⁱ	Q9NYD6
PeptideAtlas More...PeptideAtlasⁱ	Q9NYD6
PRIDEⁱ	Q9NYD6
ProteomicsDBⁱ	83216

PTM databases

iPTMnetⁱ	Q9NYD6
PhosphoSitePlusⁱ	Q9NYD6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180818 Expressed in 110 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_HOXC10
ExpressionAtlasⁱ	Q9NYD6 baseline and differential
Genevisibleⁱ	Q9NYD6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053919

HPAⁱ

HPA053919

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109466, 11 interactors
IntActⁱ	Q9NYD6, 4 interactors
STRINGⁱ	9606.ENSP00000307321

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYD6
SMRⁱ	Q9NYD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Abd-B homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231182
HOVERGENⁱ	HBG052934
InParanoidⁱ	Q9NYD6
KEGG Orthology (KO) More...KOⁱ	K17444
OMAⁱ	CPRNVTP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	Q9NYD6
TreeFamⁱ	TF317819

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NYD6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA 
        60         70         80         90        100
PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS 
       110        120        130        140        150
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR 
       160        170        180        190        200
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE 
       210        220        230        240        250
TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK 
       260        270        280        290        300
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 
       310        320        330        340 
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT

Length:342

Mass (Da):38,073

Last modified:January 23, 2002 - v2

Checksum:ⁱBD8127FD43C2A37B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RAG4	D6RAG4_HUMAN		Homeobox protein Hox-C10 Homeobox protein Hox-C10	HOXC10	127	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	118	K → N in AAF67759 (PubMed:10835276).Curated	1
Sequence conflictⁱ	265	A → G in CAA68000 (PubMed:9357979).Curated	1
Sequence conflictⁱ	271	Missing in CAA68000 (PubMed:9357979).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF255675 mRNA Translation: AAF67759.1 BC001293 mRNA Translation: AAH01293.1 X99684 mRNA Translation: CAA67999.1 X99685 mRNA Translation: CAA68000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8868.1
PIRⁱ	B60941
NCBI Reference Sequences More...RefSeqⁱ	NP_059105.2, NM_017409.3
UniGeneⁱ	Hs.44276

Genome annotation databases

Ensemblⁱ	ENST00000303460; ENSP00000307321; ENSG00000180818
GeneIDⁱ	3226
KEGGⁱ	hsa:3226
UCSC genome browser More...UCSCⁱ	uc001sen.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NYD6	Homeo box C10		HUMAN		342	UniRef100_Q9NYD6
Homeobox protein Hox-C10 (Fragment)		HUMAN		127

Protein	Similar proteins		Species	Score	Length	Source
Q9NYD6	Homeobox protein Hox-C10		MACMU		342	UniRef90_Q9NYD6
Homeobox protein Hox-C10		MACNE		342
Homeobox protein Hox-C10		MOUSE		342
Homeobox protein Hox-C10		PONPY		342
Homeo box C10		HUMAN		342
+112

Protein	Similar proteins		Species	Score	Length	Source
Q9NYD6	Homeobox protein Hox-C10		PONPY		342	UniRef50_Q9NYD6
Homeobox protein Hox-C10		MACMU		342
Homeobox protein Hox-C10		MACNE		342
Homeobox protein Hox-C10		MOUSE		342
Homeo box C10		HUMAN		342
+231

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF255675 mRNA Translation: AAF67759.1 BC001293 mRNA Translation: AAH01293.1 X99684 mRNA Translation: CAA67999.1 X99685 mRNA Translation: CAA68000.1
CCDSⁱ	CCDS8868.1
PIRⁱ	B60941
RefSeqⁱ	NP_059105.2, NM_017409.3
UniGeneⁱ	Hs.44276

3D structure databases

ProteinModelPortalⁱ	Q9NYD6
SMRⁱ	Q9NYD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109466, 11 interactors
IntActⁱ	Q9NYD6, 4 interactors
STRINGⁱ	9606.ENSP00000307321

PTM databases

iPTMnetⁱ	Q9NYD6
PhosphoSitePlusⁱ	Q9NYD6

Polymorphism and mutation databases

BioMutaⁱ	HOXC10

BioMutaⁱ

HOXC10

Proteomic databases

MaxQBⁱ	Q9NYD6
PaxDbⁱ	Q9NYD6
PeptideAtlasⁱ	Q9NYD6
PRIDEⁱ	Q9NYD6
ProteomicsDBⁱ	83216

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3226
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303460; ENSP00000307321; ENSG00000180818
GeneIDⁱ	3226
KEGGⁱ	hsa:3226
UCSCⁱ	uc001sen.4 human

Organism-specific databases

CTDⁱ	3226
DisGeNETⁱ	3226
EuPathDBⁱ	HostDB:ENSG00000180818.4
GeneCardsⁱ	HOXC10
HGNCⁱ	HGNC:5122 HOXC10
HPAⁱ	HPA053919
MIMⁱ	605560 gene
neXtProtⁱ	NX_Q9NYD6
OpenTargetsⁱ	ENSG00000180818
PharmGKBⁱ	PA29397
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231182
HOVERGENⁱ	HBG052934
InParanoidⁱ	Q9NYD6
KOⁱ	K17444
OMAⁱ	CPRNVTP
OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	Q9NYD6
TreeFamⁱ	TF317819

Miscellaneous databases

GeneWikiⁱ	HOXC10
GenomeRNAiⁱ	3226
Protein Ontology More...PROⁱ	PR:Q9NYD6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180818 Expressed in 110 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_HOXC10
ExpressionAtlasⁱ	Q9NYD6 baseline and differential
Genevisibleⁱ	Q9NYD6 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXC10_HUMAN
Accessionⁱ	Q9NYD6Primary (citable) accession number: Q9NYD6 Secondary accession number(s): O15219, O15220, Q9BVD5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	January 23, 2002
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYD6 (HXC10_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Homeobox protein Hox-C10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ