UniProtKB - Q9NYD6 (HXC10_HUMAN)
Protein
Homeobox protein Hox-C10
Gene
HOXC10
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 268 – 327 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- neuromuscular process Source: Ensembl
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- proximal/distal pattern formation Source: Ensembl
- skeletal system development Source: Ensembl
- spinal cord motor neuron cell fate specification Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NYD6 |
SIGNORi | Q9NYD6 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-C10Alternative name(s): Homeobox protein Hox-3I |
Gene namesi | Name:HOXC10 Synonyms:HOX3I |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180818.4 |
HGNCi | HGNC:5122, HOXC10 |
MIMi | 605560, gene |
neXtProti | NX_Q9NYD6 |
Subcellular locationi
Nucleus
Nucleus
- nuclear body Source: HPA
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3226 |
OpenTargetsi | ENSG00000180818 |
PharmGKBi | PA29397 |
Miscellaneous databases
Pharosi | Q9NYD6, Tbio |
Polymorphism and mutation databases
BioMutai | HOXC10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200190 | 1 – 342 | Homeobox protein Hox-C10Add BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 106 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 189 | PhosphoserineCombined sources | 1 | |
Cross-linki | 195 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 254 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9NYD6 |
MassIVEi | Q9NYD6 |
MaxQBi | Q9NYD6 |
PaxDbi | Q9NYD6 |
PeptideAtlasi | Q9NYD6 |
PRIDEi | Q9NYD6 |
ProteomicsDBi | 83216 |
PTM databases
iPTMneti | Q9NYD6 |
PhosphoSitePlusi | Q9NYD6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180818, Expressed in quadriceps femoris and 130 other tissues |
ExpressionAtlasi | Q9NYD6, baseline and differential |
Genevisiblei | Q9NYD6, HS |
Organism-specific databases
HPAi | ENSG00000180818, Group enriched (kidney, skeletal muscle) |
Interactioni
Binary interactionsi
Q9NYD6
With | #Exp. | IntAct |
---|---|---|
USP21 [Q9UK80] | 3 | EBI-1188075,EBI-373242 |
Protein-protein interaction databases
BioGRIDi | 109466, 13 interactors |
IntActi | Q9NYD6, 8 interactors |
STRINGi | 9606.ENSP00000307321 |
Miscellaneous databases
RNActi | Q9NYD6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000160855 |
HOGENOMi | CLU_057871_0_0_1 |
InParanoidi | Q9NYD6 |
OMAi | TPHCAGA |
OrthoDBi | 976319at2759 |
PhylomeDBi | Q9NYD6 |
TreeFami | TF317819 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NYD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA
60 70 80 90 100
PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS
110 120 130 140 150
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR
160 170 180 190 200
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE
210 220 230 240 250
TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK
260 270 280 290 300
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
310 320 330 340
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RAG4 | D6RAG4_HUMAN | Homeobox protein Hox-C10 | HOXC10 | 127 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | K → N in AAF67759 (PubMed:10835276).Curated | 1 | |
Sequence conflicti | 265 | A → G in CAA68000 (PubMed:9357979).Curated | 1 | |
Sequence conflicti | 271 | Missing in CAA68000 (PubMed:9357979).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF255675 mRNA Translation: AAF67759.1 BC001293 mRNA Translation: AAH01293.1 X99684 mRNA Translation: CAA67999.1 X99685 mRNA Translation: CAA68000.1 |
CCDSi | CCDS8868.1 |
PIRi | B60941 |
RefSeqi | NP_059105.2, NM_017409.3 |
Genome annotation databases
Ensembli | ENST00000303460; ENSP00000307321; ENSG00000180818 |
GeneIDi | 3226 |
KEGGi | hsa:3226 |
UCSCi | uc001sen.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF255675 mRNA Translation: AAF67759.1 BC001293 mRNA Translation: AAH01293.1 X99684 mRNA Translation: CAA67999.1 X99685 mRNA Translation: CAA68000.1 |
CCDSi | CCDS8868.1 |
PIRi | B60941 |
RefSeqi | NP_059105.2, NM_017409.3 |
3D structure databases
SMRi | Q9NYD6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109466, 13 interactors |
IntActi | Q9NYD6, 8 interactors |
STRINGi | 9606.ENSP00000307321 |
PTM databases
iPTMneti | Q9NYD6 |
PhosphoSitePlusi | Q9NYD6 |
Polymorphism and mutation databases
BioMutai | HOXC10 |
Proteomic databases
jPOSTi | Q9NYD6 |
MassIVEi | Q9NYD6 |
MaxQBi | Q9NYD6 |
PaxDbi | Q9NYD6 |
PeptideAtlasi | Q9NYD6 |
PRIDEi | Q9NYD6 |
ProteomicsDBi | 83216 |
Protocols and materials databases
Antibodypediai | 15311, 406 antibodies |
DNASUi | 3226 |
Genome annotation databases
Ensembli | ENST00000303460; ENSP00000307321; ENSG00000180818 |
GeneIDi | 3226 |
KEGGi | hsa:3226 |
UCSCi | uc001sen.4, human |
Organism-specific databases
CTDi | 3226 |
DisGeNETi | 3226 |
EuPathDBi | HostDB:ENSG00000180818.4 |
GeneCardsi | HOXC10 |
HGNCi | HGNC:5122, HOXC10 |
HPAi | ENSG00000180818, Group enriched (kidney, skeletal muscle) |
MIMi | 605560, gene |
neXtProti | NX_Q9NYD6 |
OpenTargetsi | ENSG00000180818 |
PharmGKBi | PA29397 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000160855 |
HOGENOMi | CLU_057871_0_0_1 |
InParanoidi | Q9NYD6 |
OMAi | TPHCAGA |
OrthoDBi | 976319at2759 |
PhylomeDBi | Q9NYD6 |
TreeFami | TF317819 |
Enzyme and pathway databases
PathwayCommonsi | Q9NYD6 |
SIGNORi | Q9NYD6 |
Miscellaneous databases
BioGRID-ORCSi | 3226, 119 hits in 866 CRISPR screens |
GeneWikii | HOXC10 |
GenomeRNAii | 3226 |
Pharosi | Q9NYD6, Tbio |
PROi | PR:Q9NYD6 |
RNActi | Q9NYD6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180818, Expressed in quadriceps femoris and 130 other tissues |
ExpressionAtlasi | Q9NYD6, baseline and differential |
Genevisiblei | Q9NYD6, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXC10_HUMAN | |
Accessioni | Q9NYD6Primary (citable) accession number: Q9NYD6 Secondary accession number(s): O15219, O15220, Q9BVD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | January 23, 2002 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries