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Entry version 161 (16 Oct 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Dynein heavy chain 9, axonemal

Gene

DNAH9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1870 – 1877ATPSequence analysis8
Nucleotide bindingi2151 – 2158ATPSequence analysis8
Nucleotide bindingi2478 – 2485ATPSequence analysis8
Nucleotide bindingi2825 – 2832ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 9, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 9
Ciliary dynein heavy chain 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH9
Synonyms:DNAH17L, DNAL1, KIAA0357
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2953 DNAH9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603330 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYC9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 40 (CILD40)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Some patients exhibit randomization of left-right body asymmetry and situs inversus. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD40 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081802666 – 4486Missing in CILD40. 1 PublicationAdd BLAST3821
Natural variantiVAR_0818031674G → R in CILD40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140721719Ensembl.1
Natural variantiVAR_0818041881K → E in CILD40; associated in cis with H-2965; no protein detected by Western blot when associated with H-2965; loss of localization to cilium axonema associated with H-2965. 1 Publication1
Natural variantiVAR_0818052751 – 4486Missing in CILD40; loss of localization to cilium axonema. 1 PublicationAdd BLAST1736
Natural variantiVAR_0818062965R → H in CILD40; associated in cis with E-1881; no protein detected by Western blot when associated with E-1881; loss of localization to cilium axonema when associated with E-1881. 1 PublicationCorresponds to variant dbSNP:rs375908701EnsemblClinVar.1
Natural variantiVAR_0818073398R → L in CILD40. 1 Publication1
Natural variantiVAR_0818083889 – 4486Missing in CILD40. 1 PublicationAdd BLAST598
Natural variantiVAR_0818094123D → N in CILD40; loss of localization to cilium axonema. 1 PublicationCorresponds to variant dbSNP:rs1267599270EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
1770

MalaCards human disease database

More...
MalaCardsi
DNAH9
MIMi618300 phenotype

Open Targets

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OpenTargetsi
ENSG00000007174

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
157769 Situs ambiguus
101063 Situs inversus totalis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27406

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYC9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DNAH9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146321 – 4486Dynein heavy chain 9, axonemalAdd BLAST4486

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NYC9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NYC9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NYC9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NYC9

PeptideAtlas

More...
PeptideAtlasi
Q9NYC9

PRoteomics IDEntifications database

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PRIDEi
Q9NYC9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
83213 [Q9NYC9-1]
83214 [Q9NYC9-2]
83215 [Q9NYC9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NYC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in upper and lower respiratory airway epithelia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000007174 Expressed in 118 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NYC9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NYC9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052641

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Interacts with CCDC114 (PubMed:30471718).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108109, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9NYC9, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262442

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NYC9

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1831StemBy similarityAdd BLAST1831
Regioni1832 – 2053AAA 1By similarityAdd BLAST222
Regioni2113 – 2334AAA 2By similarityAdd BLAST222
Regioni2440 – 2688AAA 3By similarityAdd BLAST249
Regioni2787 – 3036AAA 4By similarityAdd BLAST250
Regioni3051 – 3341StalkBy similarityAdd BLAST291
Regioni3429 – 3656AAA 5By similarityAdd BLAST228
Regioni3866 – 4092AAA 6By similarityAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili381 – 410Sequence analysisAdd BLAST30
Coiled coili504 – 529Sequence analysisAdd BLAST26
Coiled coili639 – 662Sequence analysisAdd BLAST24
Coiled coili752 – 823Sequence analysisAdd BLAST72
Coiled coili1326 – 1355Sequence analysisAdd BLAST30
Coiled coili3051 – 3154Sequence analysisAdd BLAST104
Coiled coili3285 – 3341Sequence analysisAdd BLAST57
Coiled coili3640 – 3675Sequence analysisAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237309

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NYC9

KEGG Orthology (KO)

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KOi
K10408

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEDMADL

Database of Orthologous Groups

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OrthoDBi
1492at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYC9

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR030443 DNAH9
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR10676 PTHR10676, 1 hit
PTHR10676:SF257 PTHR10676:SF257, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLAEERAAL AAENADGEPG ADRRLRLLGT YVAMSLRPAA GAWERCAGSA
60 70 80 90 100
EAEQLLQAFL GRDAAEGPRP LLVVRPGPRG LAIRPGLEVG PESGLAGAKA
110 120 130 140 150
LFFLRTGPEP PGPDSFRGAV VCGDLPAAPL EHLAALFSEV VLPVLANEKN
160 170 180 190 200
RLNWPHMICE DVRRHAHSLQ CDLSVILEQV KGKTLLPLPA GSEKMEFADS
210 220 230 240 250
KSETVLDSID KSVIYAIESA VIKWSYQVQV VLKRESSQPL LQGENPTPKV
260 270 280 290 300
ELEFWKSRYE DLKYIYNQLR TITVRGMAKL LDKLQSSYFP AFKAMYRDVV
310 320 330 340 350
AALAEAQDIH VHLIPLQRHL EALENAEFPE VKPQLRPLLH VVCLIWATCK
360 370 380 390 400
SYRSPGRLTV LLQEICNLLI QQASNYLSPE DLLRSEVEES QRKLQVVSDT
410 420 430 440 450
LSFFKQEFQD RRENLHTYFK ENQEVKEWDF QSSLVFVRLD GFLGQLHVVE
460 470 480 490 500
GLLKTALDFH KLGKVEFSGV RGNALSQQVQ QMHEEFQEMY RLLSGSSSDC
510 520 530 540 550
LYLQSTDFEN DVSEFNQKVE DLDRRLGTIF IQAFDDAPGL EHAFKLLDIA
560 570 580 590 600
GNLLERPLVA RDTSDKYLVL IQMFNKDLDA VRMIYSQHVQ EEAELGFSPV
610 620 630 640 650
HKNMPTVAGG LRWAQELRQR IQGPFSNFGR ITHPCMESAE GKRMQQKYED
660 670 680 690 700
MLSLLEKYET RLYEDWCRTV SEKSQYNLSQ PLLKRDPETK EITINFNPQL
710 720 730 740 750
ISVLKEMSYL EPREMKHMPE TAAAMFSSRD FYRQLVANLE LMANWYNKVM
760 770 780 790 800
KTLLEVEFPL VEEELQNIDL RLRAAEETLN WKTEGICDYV TEITSSIHDL
810 820 830 840 850
EQRIQKTKDN VEEIQNIMKT WVTPIFKTKD GKRESLLSLD DRHDRMEKYY
860 870 880 890 900
NLIKESGLKI HALVQENLGL FSADPTSNIW KTYVNSIDNL LLNGFFLAIE
910 920 930 940 950
CSLKYLLENT ECKAGLTPIF EAQLSLAIPE LVFYPSLESG VKGGFCDIVE
960 970 980 990 1000
GLITSIFRIP SLVPRLSPQN GSPHYQVDLD GIPDLANMRR TLMERVQRMM
1010 1020 1030 1040 1050
GLCCGYQSTF SQYSYLYVED RKEVLGQFLL YGHILTPEEI EDHVEDGIPE
1060 1070 1080 1090 1100
NPPLLSQFKV QIDSYETLYE EVCRLEPIKV FDGWMKIDIR PFKASLLNII
1110 1120 1130 1140 1150
KRWSLLFKQH LVDHVTHSLA NLDAFIKKSE SGLLKKVEKG DFQGLVEIMG
1160 1170 1180 1190 1200
HLMAVKERQS NTDEMFEPLK QTIELLKTYE QELPETVFKQ LEELPEKWNN
1210 1220 1230 1240 1250
IKKVAITVKQ QVAPLQANEV TLLRQRCTAF DAEQQQFWEQ FHKEAPFRFD
1260 1270 1280 1290 1300
SIHPHQMLDA RHIEIQQMES TMASISESAS LFEVNVPDYK QLRQCRKEVC
1310 1320 1330 1340 1350
QLKELWDTIG MVTSSIHAWE TTPWRNINVE AMELECKQFA RHIRNLDKEV
1360 1370 1380 1390 1400
RAWDAFTGLE STVWNTLSSL RAVAELQNPA IRERHWRQLM QATGVSFTMD
1410 1420 1430 1440 1450
QDTTLAHLLQ LQLHHYEDEV RGIVDKAAKE MGMEKTLKEL QTTWAGMEFQ
1460 1470 1480 1490 1500
YEPHPRTNVP LLCSDEDLIE VLEDNQVQLQ NLVMSKYVAF FLEEVSGWQK
1510 1520 1530 1540 1550
KLSTVDAVIS IWFEVQRTWT HLESIFTGSE DIRAQLPQDS KRFEGIDIDF
1560 1570 1580 1590 1600
KELAYDAQKI PNVVQTTNKP GLYEKLEDIQ GRLCLCEKAL AEYLDTKRLA
1610 1620 1630 1640 1650
FPRFYFLSSS DLLDILSNGT APQQVQRHLS KLFDNMAKMR FQLDASGEPT
1660 1670 1680 1690 1700
KTSLGMYSKE EEYVAFSEPC DCSGQVEIWL NHVLGHMKAT VRHEMTEGVT
1710 1720 1730 1740 1750
AYEEKPREQW LFDHPAQVAL TCTQIWWTTE VGMAFARLEE GYESAMKDYY
1760 1770 1780 1790 1800
KKQVAQLKTL ITMLIGQLSK GDRQKIMTIC TIDVHARDVV AKMIAQKVDN
1810 1820 1830 1840 1850
AQAFLWLSQL RHRWDDEVKH CFANICDAQF LYSYEYLGNT PRLVITPLTD
1860 1870 1880 1890 1900
RCYITLTQSL HLTMSGAPAG PAGTGKTETT KDLGRALGIL VYVFNCSEQM
1910 1920 1930 1940 1950
DYKSCGNIYK GLAQTGAWGC FDEFNRISVE VLSVVAVQVK SIQDAIRDKK
1960 1970 1980 1990 2000
QWFSFLGEEI SLNPSVGIFI TMNPGYAGRT ELPENLKSLF RPCAMVVPDF
2010 2020 2030 2040 2050
ELICEIMLVA EGFIEAQSLA RKFITLYQLC KELLSKQDHY DWGLRAIKSV
2060 2070 2080 2090 2100
LVVAGSLKRG DPDRPEDQVL MRSLRDFNIP KIVTDDMPIF MGLIGDLFPA
2110 2120 2130 2140 2150
LDVPRRRDPN FEALVRKAIV DLKLQAEDNF VLKVVQLEEL LAVRHSVFVV
2160 2170 2180 2190 2200
GGAGTGKSQV LRSLHKTYQI MKRRPVWTDL NPKAVTNDEL FGIINPATGE
2210 2220 2230 2240 2250
WKDGLFSSIM RELANITHDG PKWILLDGDI DPMWIESLNT VMDDNKVLTL
2260 2270 2280 2290 2300
ASNERIPLNP TMKLLFEISH LRTATPATVS RAGILYINPA DLGWNPPVSS
2310 2320 2330 2340 2350
WIEKREIQTE RANLTILFDK YLPTCLDTLR TRFKKIIPIP EQSMVQMVCH
2360 2370 2380 2390 2400
LLECLLTTED IPADCPKEIY EHYFVFAAIW AFGGAMVQDQ LVDYRAEFSK
2410 2420 2430 2440 2450
WWLTEFKTVK FPSQGTIFDY YIDPETKKFE PWSKLVPQFE FDPEMPLQAC
2460 2470 2480 2490 2500
LVHTSETIRV CYFMERLMAR QRPVMLVGTA GTGKSVLVGA KLASLDPEAY
2510 2520 2530 2540 2550
LVKNVPFNYY TTSAMLQAVL EKPLEKKAGR NYGPPGNKKL IYFIDDMNMP
2560 2570 2580 2590 2600
EVDAYGTVQP HTIIRQHLDY GHWYDRSKLS LKEITNVQYV SCMNPTAGSF
2610 2620 2630 2640 2650
TINPRLQRHF SVFVLSFPGA DALSSIYSII LTQHLKLGNF PASLQKSIPP
2660 2670 2680 2690 2700
LIDLALAFHQ KIATTFLPTG IKFHYIFNLR DFANIFQGIL FSSVECVKST
2710 2720 2730 2740 2750
WDLIRLYLHE SNRVYRDKMV EEKDFDLFDK IQTEVLKKTF DDIEDPVEQT
2760 2770 2780 2790 2800
QSPNLYCHFA NGIGEPKYMP VQSWELLTQT LVEALENHNE VNTVMDLVLF
2810 2820 2830 2840 2850
EDAMRHVCHI NRILESPRGN ALLVGVGGSG KQSLTRLAAF ISSMDVFQIT
2860 2870 2880 2890 2900
LRKGYQIQDF KMDLASLCLK AGVKNLNTVF LMTDAQVADE RFLVLINDLL
2910 2920 2930 2940 2950
ASGEIPDLYS DDEVENIISN VRNEVKSQGL VDNRENCWKF FIDRIRRQLK
2960 2970 2980 2990 3000
VTLCFSPVGN KLRVRSRKFP AIVNCTAIHW FHEWPQQALE SVSLRFLQNT
3010 3020 3030 3040 3050
EGIEPTVKQS ISKFMAFVHT SVNQTSQSYL SNEQRYNYTT PKSFLEFIRL
3060 3070 3080 3090 3100
YQSLLHRHRK ELKCKTERLE NGLLKLHSTS AQVDDLKAKL AAQEVELKQK
3110 3120 3130 3140 3150
NEDADKLIQV VGVETDKVSR EKAMADEEEQ KVAVIMLEVK QKQKDCEEDL
3160 3170 3180 3190 3200
AKAEPALTAA QAALNTLNKT NLTELKSFGS PPLAVSNVSA AVMVLMAPRG
3210 3220 3230 3240 3250
RVPKDRSWKA AKVTMAKVDG FLDSLINFNK ENIHENCLKA IRPYLQDPEF
3260 3270 3280 3290 3300
NPEFVATKSY AAAGLCSWVI NIVRFYEVFC DVEPKRQALN KATADLTAAQ
3310 3320 3330 3340 3350
EKLAAIKAKI AHLNENLAKL TARFEKATAD KLKCQQEAEV TAVTISLANR
3360 3370 3380 3390 3400
LVGGLASENV RWADAVQNFK QQERTLCGDI LLITAFISYL GFFTKKYRQS
3410 3420 3430 3440 3450
LLDRTWRPYL SQLKTPIPVT PALDPLRMLM DDADVAAWQN EGLPADRMSV
3460 3470 3480 3490 3500
ENATILINCE RWPLMVDPQL QGIKWIKNKY GEDLRVTQIG QKGYLQIIEQ
3510 3520 3530 3540 3550
ALEAGAVVLI ENLEESIDPV LGPLLGREVI KKGRFIKIGD KECEYNPKFR
3560 3570 3580 3590 3600
LILHTKLANP HYQPELQAQA TLINFTVTRD GLEDQLLAAV VSMERPDLEQ
3610 3620 3630 3640 3650
LKSDLTKQQN GFKITLKTLE DSLLSRLSSA SGNFLGETVL VENLEITKQT
3660 3670 3680 3690 3700
AAEVEKKVQE AKVTEVKINE AREHYRPAAA RASLLYFIMN DLSKIHPMYQ
3710 3720 3730 3740 3750
FSLKAFSIVF QKAVERAAPD ESLRERVANL IDSITFSVYQ YTIRGLFECD
3760 3770 3780 3790 3800
KLTYLAQLTF QILLMNREVN AVELDFLLRS PVQTGTASPV EFLSHQAWGA
3810 3820 3830 3840 3850
VKVLSSMEEF SNLDRDIEGS AKSWKKFVES ECPEKEKLPQ EWKNKTALQR
3860 3870 3880 3890 3900
LCMLRAMRPD RMTYALRDFV EEKLGSKYVV GRALDFATSF EESGPATPMF
3910 3920 3930 3940 3950
FILSPGVDPL KDVESQGRKL GYTFNNQNFH NVSLGQGQEV VAEAALDLAA
3960 3970 3980 3990 4000
KKGHWVILQN IHLVAKWLST LEKKLEEHSE NSHPEFRVFM SAEPAPSPEG
4010 4020 4030 4040 4050
HIIPQGILEN SIKITNEPPT GMHANLHKAL DNFTQDTLEM CSRETEFKSI
4060 4070 4080 4090 4100
LFALCYFHAV VAERRKFGPQ GWNRSYPFNT GDLTISVNVL YNFLEANAKV
4110 4120 4130 4140 4150
PYDDLRYLFG EIMYGGHITD DWDRRLCRTY LGEFIRPEML EGELSLAPGF
4160 4170 4180 4190 4200
PLPGNMDYNG YHQYIDAELP PESPYLYGLH PNAEIGFLTQ TSEKLFRTVL
4210 4220 4230 4240 4250
ELQPRDSQAR DGAGATREEK VKALLEEILE RVTDEFNIPE LMAKVEERTP
4260 4270 4280 4290 4300
YIVVAFQECG RMNILTREIQ RSLRELELGL KGELTMTSHM ENLQNALYFD
4310 4320 4330 4340 4350
MVPESWARRA YPSTAGLAAW FPDLLNRIKE LEAWTGDFTM PSTVWLTGFF
4360 4370 4380 4390 4400
NPQSFLTAIM QSTARKNEWP LDQMALQCDM TKKNREEFRS PPREGAYIHG
4410 4420 4430 4440 4450
LFMEGACWDT QAGIITEAKL KDLTPPMPVM FIKAIPADKQ DCRSVYSCPV
4460 4470 4480
YKTSQRGPTY VWTFNLKTKE NPSKWVLAGV ALLLQI
Length:4,486
Mass (Da):511,877
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27EB53C39FA3A293
GO
Isoform 2 (identifier: Q9NYC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3961-4036: Missing.

Note: No experimental confirmation available.
Show »
Length:4,410
Mass (Da):503,345
Checksum:i62B16681AF5C0C04
GO
Isoform 3 (identifier: Q9NYC9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3688: Missing.

Note: No experimental confirmation available.
Show »
Length:798
Mass (Da):91,135
Checksum:iCAC7718F47D65599
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EP17E7EP17_HUMAN
Dynein heavy chain 9, axonemal
DNAH9
4,410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLM9J3QLM9_HUMAN
Dynein heavy chain 9, axonemal
DNAH9
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQK8J3QQK8_HUMAN
Dynein heavy chain 9, axonemal
DNAH9
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMX3K7EMX3_HUMAN
Dynein heavy chain 9, axonemal
DNAH9
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP21K7EP21_HUMAN
Dynein heavy chain 9, axonemal
DNAH9
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2216I → T in BAA21573 (PubMed:9205841).Curated1
Sequence conflicti2505V → L in AAF69004 (Ref. 1) Curated1
Sequence conflicti3678A → T in AAF69004 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046312151R → H. Corresponds to variant dbSNP:rs17599639Ensembl.1
Natural variantiVAR_046313445Q → R2 PublicationsCorresponds to variant dbSNP:rs9892256Ensembl.1
Natural variantiVAR_081802666 – 4486Missing in CILD40. 1 PublicationAdd BLAST3821
Natural variantiVAR_036214771R → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_046314842R → W. Corresponds to variant dbSNP:rs16945138Ensembl.1
Natural variantiVAR_0463151158R → W. Corresponds to variant dbSNP:rs8070501Ensembl.1
Natural variantiVAR_0463161221T → A. Corresponds to variant dbSNP:rs9916482Ensembl.1
Natural variantiVAR_0818031674G → R in CILD40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140721719Ensembl.1
Natural variantiVAR_0818041881K → E in CILD40; associated in cis with H-2965; no protein detected by Western blot when associated with H-2965; loss of localization to cilium axonema associated with H-2965. 1 Publication1
Natural variantiVAR_0463172087M → V. Corresponds to variant dbSNP:rs9892290Ensembl.1
Natural variantiVAR_0463182195N → S. Corresponds to variant dbSNP:rs3744581EnsemblClinVar.1
Natural variantiVAR_0463192438Q → H. Corresponds to variant dbSNP:rs2277658Ensembl.1
Natural variantiVAR_0362152653D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0818052751 – 4486Missing in CILD40; loss of localization to cilium axonema. 1 PublicationAdd BLAST1736
Natural variantiVAR_0463202961K → R. Corresponds to variant dbSNP:rs11870983Ensembl.1
Natural variantiVAR_0818062965R → H in CILD40; associated in cis with E-1881; no protein detected by Western blot when associated with E-1881; loss of localization to cilium axonema when associated with E-1881. 1 PublicationCorresponds to variant dbSNP:rs375908701EnsemblClinVar.1
Natural variantiVAR_0463212968K → N. Corresponds to variant dbSNP:rs11871037Ensembl.1
Natural variantiVAR_0818073398R → L in CILD40. 1 Publication1
Natural variantiVAR_0362163664T → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138874996Ensembl.1
Natural variantiVAR_0463223726R → Q. Corresponds to variant dbSNP:rs16945431Ensembl.1
Natural variantiVAR_0463233726R → W. Corresponds to variant dbSNP:rs3760436Ensembl.1
Natural variantiVAR_0818083889 – 4486Missing in CILD40. 1 PublicationAdd BLAST598
Natural variantiVAR_0463244036D → N. Corresponds to variant dbSNP:rs17612861EnsemblClinVar.1
Natural variantiVAR_0818094123D → N in CILD40; loss of localization to cilium axonema. 1 PublicationCorresponds to variant dbSNP:rs1267599270EnsemblClinVar.1
Natural variantiVAR_0463254374M → I1 PublicationCorresponds to variant dbSNP:rs1990236EnsemblClinVar.1
Natural variantiVAR_0463264443R → C. Corresponds to variant dbSNP:rs9913494Ensembl.1
Natural variantiVAR_0463274462W → R. Corresponds to variant dbSNP:rs8074656Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0434431 – 3688Missing in isoform 3. 1 PublicationAdd BLAST3688
Alternative sequenceiVSP_0352853961 – 4036Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257737 mRNA Translation: AAF69004.1
AJ404468 mRNA Translation: CAB94756.1
AC005209 Genomic DNA No translation available.
AC005410 Genomic DNA No translation available.
AC005701 Genomic DNA No translation available.
BC128421 mRNA Translation: AAI28422.1
AB002355 mRNA Translation: BAA21573.2
AJ132088 mRNA Translation: CAA10561.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11160.1 [Q9NYC9-1]
CCDS11161.1 [Q9NYC9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001363.2, NM_001372.3 [Q9NYC9-1]
NP_004653.2, NM_004662.2 [Q9NYC9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262442; ENSP00000262442; ENSG00000007174 [Q9NYC9-1]
ENST00000608377; ENSP00000476951; ENSG00000007174 [Q9NYC9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1770

UCSC genome browser

More...
UCSCi
uc002gne.3 human [Q9NYC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257737 mRNA Translation: AAF69004.1
AJ404468 mRNA Translation: CAB94756.1
AC005209 Genomic DNA No translation available.
AC005410 Genomic DNA No translation available.
AC005701 Genomic DNA No translation available.
BC128421 mRNA Translation: AAI28422.1
AB002355 mRNA Translation: BAA21573.2
AJ132088 mRNA Translation: CAA10561.1
CCDSiCCDS11160.1 [Q9NYC9-1]
CCDS11161.1 [Q9NYC9-3]
RefSeqiNP_001363.2, NM_001372.3 [Q9NYC9-1]
NP_004653.2, NM_004662.2 [Q9NYC9-3]

3D structure databases

SMRiQ9NYC9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108109, 4 interactors
IntActiQ9NYC9, 1 interactor
STRINGi9606.ENSP00000262442

PTM databases

iPTMnetiQ9NYC9
PhosphoSitePlusiQ9NYC9

Polymorphism and mutation databases

BioMutaiDNAH9
DMDMi311033454

Proteomic databases

EPDiQ9NYC9
jPOSTiQ9NYC9
MassIVEiQ9NYC9
PaxDbiQ9NYC9
PeptideAtlasiQ9NYC9
PRIDEiQ9NYC9
ProteomicsDBi83213 [Q9NYC9-1]
83214 [Q9NYC9-2]
83215 [Q9NYC9-3]

Genome annotation databases

EnsembliENST00000262442; ENSP00000262442; ENSG00000007174 [Q9NYC9-1]
ENST00000608377; ENSP00000476951; ENSG00000007174 [Q9NYC9-3]
GeneIDi1770
KEGGihsa:1770
UCSCiuc002gne.3 human [Q9NYC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1770
DisGeNETi1770

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNAH9
HGNCiHGNC:2953 DNAH9
HPAiHPA052641
MalaCardsiDNAH9
MIMi603330 gene
618300 phenotype
neXtProtiNX_Q9NYC9
OpenTargetsiENSG00000007174
Orphaneti157769 Situs ambiguus
101063 Situs inversus totalis
PharmGKBiPA27406

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000159717
HOGENOMiHOG000237309
InParanoidiQ9NYC9
KOiK10408
OMAiMEDMADL
OrthoDBi1492at2759
PhylomeDBiQ9NYC9
TreeFamiTF316836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH9 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DNAH9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1770
PharosiQ9NYC9

Protein Ontology

More...
PROi
PR:Q9NYC9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007174 Expressed in 118 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ9NYC9 baseline and differential
GenevisibleiQ9NYC9 HS

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR030443 DNAH9
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF257 PTHR10676:SF257, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 4 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYC9
Secondary accession number(s): A2VCQ8
, O15064, O95494, Q9NQ28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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