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Entry version 154 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Solute carrier organic anion transporter family member 1C1

Gene

SLCO1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-879518 Transport of organic anions

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.15 the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
Organic anion transporter F
Short name:
OATP-F
Organic anion transporter polypeptide-related protein 5
Short name:
OAT-RP-5
Short name:
OATPRP5
Organic anion-transporting polypeptide 14
Short name:
OATP-14
Solute carrier family 21 member 14
Thyroxine transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO1C1
Synonyms:OATP14, OATP1C1, OATPF, SLC21A14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13819 SLCO1C1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613389 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYB5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 63Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini64 – 82ExtracellularSequence analysisAdd BLAST19
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 109CytoplasmicSequence analysis6
Transmembranei110 – 134Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini135 – 184ExtracellularSequence analysisAdd BLAST50
Transmembranei185 – 213Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini214 – 232CytoplasmicSequence analysisAdd BLAST19
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 271ExtracellularSequence analysisAdd BLAST18
Transmembranei272 – 296Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini297 – 348CytoplasmicSequence analysisAdd BLAST52
Transmembranei349 – 370Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini371 – 390ExtracellularSequence analysisAdd BLAST20
Transmembranei391 – 414Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini415 – 418CytoplasmicSequence analysis4
Transmembranei419 – 442Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini443 – 554ExtracellularSequence analysisAdd BLAST112
Transmembranei555 – 577Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini578 – 586CytoplasmicSequence analysis9
Transmembranei587 – 612Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini613 – 646ExtracellularSequence analysisAdd BLAST34
Transmembranei647 – 664Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini665 – 712CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53919

Open Targets

More...
OpenTargetsi
ENSG00000139155

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37815

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073697

Drug and drug target database

More...
DrugBanki
DB00286 Conjugated Equine Estrogens
DB00509 Dextrothyroxine
DB00586 Diclofenac
DB00390 Digoxin
DB00917 Dinoprostone
DB00783 Estradiol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00939 Meclofenamic acid
DB00563 Methotrexate
DB01092 Ouabain
DB00252 Phenytoin
DB01032 Probenecid
DB04348 Taurocholic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO1C1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27734564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910541 – 712Solute carrier organic anion transporter family member 1C1Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi476 ↔ 502PROSITE-ProRule annotation
Disulfide bondi480 ↔ 491PROSITE-ProRule annotation
Disulfide bondi482 ↔ 506PROSITE-ProRule annotation
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi533N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYB5

PeptideAtlas

More...
PeptideAtlasi
Q9NYB5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYB5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83207
83208 [Q9NYB5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139155 Expressed in 124 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NYB5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYB5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9NYB5, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9NYB5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000444149

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini470 – 525Kazal-likePROSITE-ProRule annotationAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626 Eukaryota
ENOG410XRSF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182876

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231269

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYB5

KEGG Orthology (KO)

More...
KOi
K08747

Identification of Orthologs from Complete Genome Data

More...
OMAi
DASSSMW

Database of Orthologous Groups

More...
OrthoDBi
1029129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYB5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
IPR030764 OATP1C1

The PANTHER Classification System

More...
PANTHERi
PTHR11388 PTHR11388, 1 hit
PTHR11388:SF99 PTHR11388:SF99, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805 oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS
60 70 80 90 100
FVYFAKALAE GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCVIMG VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS
160 170 180 190 200
ISPCLLESSS QLPVSVMEKS KSKISNECEV DTSSSMWIYV FLGNLLRGIG
210 220 230 240 250
ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF LLGSLCAKLY
260 270 280 290 300
VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP
310 320 330 340 350
RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF
360 370 380 390 400
GNPVYFLYLC TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI
410 420 430 440 450
PAVALGIFSG GIVMKKFRIS VCGAAKLYLG SSVFGYLLFL SLFALGCENS
460 470 480 490 500
DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC KCSETKWEPM CGENGITYVS
510 520 530 540 550
ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR CQKDNGCPQM
560 570 580 590 600
FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA
610 620 630 640 650
GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRH IYLGLTVILG
660 670 680 690 700
TVSILLSIAV LFILKKNYVS KHRSFITKRE RTMVSTRFQK ENYTTSDHLL
710
QPNYWPGKET QL
Length:712
Mass (Da):78,696
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB6D37AAAA8FA7CD
GO
Isoform 2 (identifier: Q9NYB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-225: Missing.

Note: No experimental confirmation available.
Show »
Length:663
Mass (Da):73,268
Checksum:i2F53E8BAB882A069
GO
Isoform 3 (identifier: Q9NYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Show »
Length:730
Mass (Da):80,665
Checksum:iC847E62D6D03E2E8
GO
Isoform 4 (identifier: Q9NYB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Note: No experimental confirmation available.Curated
Show »
Length:612
Mass (Da):67,677
Checksum:iE8A59A7530E0B475
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6S4F5H6S4_HUMAN
Solute carrier organic anion transp...
SLCO1C1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444A → T in BAH14027 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q9NYB5-4)
Sequence conflicti559S → F in BAH11737 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9NYB5-3)
Sequence conflicti660T → S in BAH14027 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452781 – 118Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_042882177 – 225Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_045279640 – 712HIYLG…KETQL → YQIKSIPASHCYSIPDLHNA TDTNKFSCHFTACKTYISGT NCDTGHSVNSPKHCSTFHFK EKLCFKTQKFYNQERKNNGV YKIPKGKLHYK in isoform 3 and isoform 4. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF260704 mRNA Translation: AAF70338.1
AF205076 mRNA Translation: AAG42208.1
AK294333 mRNA Translation: BAH11737.1
AK296236 mRNA Translation: BAH12289.1
AK303713 mRNA Translation: BAH14027.1
AL834209 mRNA Translation: CAI46209.1
AC092491 Genomic DNA No translation available.
BC022461 mRNA Translation: AAH22461.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53757.1 [Q9NYB5-3]
CCDS53758.1 [Q9NYB5-2]
CCDS53759.1 [Q9NYB5-4]
CCDS8683.1 [Q9NYB5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001139416.1, NM_001145944.1 [Q9NYB5-4]
NP_001139417.1, NM_001145945.1 [Q9NYB5-2]
NP_001139418.1, NM_001145946.1 [Q9NYB5-3]
NP_059131.1, NM_017435.4 [Q9NYB5-1]
XP_005253451.1, XM_005253394.2 [Q9NYB5-1]
XP_005253453.1, XM_005253396.2 [Q9NYB5-4]
XP_011519011.1, XM_011520709.2
XP_016874973.1, XM_017019484.1
XP_016874974.1, XM_017019485.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266509; ENSP00000266509; ENSG00000139155 [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155 [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155 [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155 [Q9NYB5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53919

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:53919

UCSC genome browser

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UCSCi
uc001rei.3 human [Q9NYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260704 mRNA Translation: AAF70338.1
AF205076 mRNA Translation: AAG42208.1
AK294333 mRNA Translation: BAH11737.1
AK296236 mRNA Translation: BAH12289.1
AK303713 mRNA Translation: BAH14027.1
AL834209 mRNA Translation: CAI46209.1
AC092491 Genomic DNA No translation available.
BC022461 mRNA Translation: AAH22461.1
CCDSiCCDS53757.1 [Q9NYB5-3]
CCDS53758.1 [Q9NYB5-2]
CCDS53759.1 [Q9NYB5-4]
CCDS8683.1 [Q9NYB5-1]
RefSeqiNP_001139416.1, NM_001145944.1 [Q9NYB5-4]
NP_001139417.1, NM_001145945.1 [Q9NYB5-2]
NP_001139418.1, NM_001145946.1 [Q9NYB5-3]
NP_059131.1, NM_017435.4 [Q9NYB5-1]
XP_005253451.1, XM_005253394.2 [Q9NYB5-1]
XP_005253453.1, XM_005253396.2 [Q9NYB5-4]
XP_011519011.1, XM_011520709.2
XP_016874973.1, XM_017019484.1
XP_016874974.1, XM_017019485.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9NYB5, 2 interactors
MINTiQ9NYB5
STRINGi9606.ENSP00000444149

Chemistry databases

ChEMBLiCHEMBL2073697
DrugBankiDB00286 Conjugated Equine Estrogens
DB00509 Dextrothyroxine
DB00586 Diclofenac
DB00390 Digoxin
DB00917 Dinoprostone
DB00783 Estradiol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00939 Meclofenamic acid
DB00563 Methotrexate
DB01092 Ouabain
DB00252 Phenytoin
DB01032 Probenecid
DB04348 Taurocholic Acid

Protein family/group databases

TCDBi2.A.60.1.15 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ9NYB5
PhosphoSitePlusiQ9NYB5

Polymorphism and mutation databases

BioMutaiSLCO1C1
DMDMi27734564

Proteomic databases

PaxDbiQ9NYB5
PeptideAtlasiQ9NYB5
PRIDEiQ9NYB5
ProteomicsDBi83207
83208 [Q9NYB5-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
53919
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266509; ENSP00000266509; ENSG00000139155 [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155 [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155 [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155 [Q9NYB5-3]
GeneIDi53919
KEGGihsa:53919
UCSCiuc001rei.3 human [Q9NYB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
53919
DisGeNETi53919

GeneCards: human genes, protein and diseases

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GeneCardsi
SLCO1C1
HGNCiHGNC:13819 SLCO1C1
MIMi613389 gene
neXtProtiNX_Q9NYB5
OpenTargetsiENSG00000139155
PharmGKBiPA37815

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00950000182876
HOGENOMiHOG000231269
InParanoidiQ9NYB5
KOiK08747
OMAiDASSSMW
OrthoDBi1029129at2759
PhylomeDBiQ9NYB5

Enzyme and pathway databases

ReactomeiR-HSA-879518 Transport of organic anions

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53919

Protein Ontology

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PROi
PR:Q9NYB5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139155 Expressed in 124 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ9NYB5 baseline and differential
GenevisibleiQ9NYB5 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
IPR030764 OATP1C1
PANTHERiPTHR11388 PTHR11388, 1 hit
PTHR11388:SF99 PTHR11388:SF99, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO1C1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYB5
Secondary accession number(s): B7Z251
, B7Z3Q3, B7Z8P1, F5GZD6, Q5JPA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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