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Protein

Solute carrier organic anion transporter family member 1C1

Gene

SLCO1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.15 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
Organic anion transporter F
Short name:
OATP-F
Organic anion transporter polypeptide-related protein 5
Short name:
OAT-RP-5
Short name:
OATPRP5
Organic anion-transporting polypeptide 14
Short name:
OATP-14
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:SLCO1C1
Synonyms:OATP14, OATP1C1, OATPF, SLC21A14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139155.8
HGNCiHGNC:13819 SLCO1C1
MIMi613389 gene
neXtProtiNX_Q9NYB5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 63Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini64 – 82ExtracellularSequence analysisAdd BLAST19
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 109CytoplasmicSequence analysis6
Transmembranei110 – 134Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini135 – 184ExtracellularSequence analysisAdd BLAST50
Transmembranei185 – 213Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini214 – 232CytoplasmicSequence analysisAdd BLAST19
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 271ExtracellularSequence analysisAdd BLAST18
Transmembranei272 – 296Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini297 – 348CytoplasmicSequence analysisAdd BLAST52
Transmembranei349 – 370Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini371 – 390ExtracellularSequence analysisAdd BLAST20
Transmembranei391 – 414Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini415 – 418CytoplasmicSequence analysis4
Transmembranei419 – 442Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini443 – 554ExtracellularSequence analysisAdd BLAST112
Transmembranei555 – 577Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini578 – 586CytoplasmicSequence analysis9
Transmembranei587 – 612Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini613 – 646ExtracellularSequence analysisAdd BLAST34
Transmembranei647 – 664Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini665 – 712CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53919
OpenTargetsiENSG00000139155
PharmGKBiPA37815

Chemistry databases

ChEMBLiCHEMBL2073697
DrugBankiDB00286 Conjugated Equine Estrogens
DB00509 Dextrothyroxine
DB00586 Diclofenac
DB00390 Digoxin
DB00917 Dinoprostone
DB00783 Estradiol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00939 Meclofenamic acid
DB00563 Methotrexate
DB01092 Ouabain
DB00252 Phenytoin
DB01032 Probenecid
DB04348 Taurocholic Acid

Polymorphism and mutation databases

BioMutaiSLCO1C1
DMDMi27734564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910541 – 712Solute carrier organic anion transporter family member 1C1Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi476 ↔ 502PROSITE-ProRule annotation
Disulfide bondi480 ↔ 491PROSITE-ProRule annotation
Disulfide bondi482 ↔ 506PROSITE-ProRule annotation
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi533N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NYB5
PeptideAtlasiQ9NYB5
PRIDEiQ9NYB5
ProteomicsDBi83207
83208 [Q9NYB5-2]

PTM databases

iPTMnetiQ9NYB5
PhosphoSitePlusiQ9NYB5

Expressioni

Tissue specificityi

Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.1 Publication

Gene expression databases

BgeeiENSG00000139155 Expressed in 124 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLCO1C1
ExpressionAtlasiQ9NYB5 baseline and differential
GenevisibleiQ9NYB5 HS

Interactioni

Protein-protein interaction databases

IntActiQ9NYB5, 2 interactors
MINTiQ9NYB5
STRINGi9606.ENSP00000370964

Structurei

3D structure databases

ProteinModelPortaliQ9NYB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini470 – 525Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9NYB5
KOiK08747
OMAiDASSSMW
OrthoDBiEOG091G08QD
PhylomeDBiQ9NYB5

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
IPR030764 OATP1C1
PANTHERiPTHR11388 PTHR11388, 1 hit
PTHR11388:SF99 PTHR11388:SF99, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NYB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS
60 70 80 90 100
FVYFAKALAE GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCVIMG VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS
160 170 180 190 200
ISPCLLESSS QLPVSVMEKS KSKISNECEV DTSSSMWIYV FLGNLLRGIG
210 220 230 240 250
ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF LLGSLCAKLY
260 270 280 290 300
VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP
310 320 330 340 350
RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF
360 370 380 390 400
GNPVYFLYLC TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI
410 420 430 440 450
PAVALGIFSG GIVMKKFRIS VCGAAKLYLG SSVFGYLLFL SLFALGCENS
460 470 480 490 500
DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC KCSETKWEPM CGENGITYVS
510 520 530 540 550
ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR CQKDNGCPQM
560 570 580 590 600
FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA
610 620 630 640 650
GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRH IYLGLTVILG
660 670 680 690 700
TVSILLSIAV LFILKKNYVS KHRSFITKRE RTMVSTRFQK ENYTTSDHLL
710
QPNYWPGKET QL
Length:712
Mass (Da):78,696
Last modified:October 1, 2000 - v1
Checksum:iCB6D37AAAA8FA7CD
GO
Isoform 2 (identifier: Q9NYB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-225: Missing.

Note: No experimental confirmation available.
Show »
Length:663
Mass (Da):73,268
Checksum:i2F53E8BAB882A069
GO
Isoform 3 (identifier: Q9NYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Show »
Length:730
Mass (Da):80,665
Checksum:iC847E62D6D03E2E8
GO
Isoform 4 (identifier: Q9NYB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     640-712: HIYLGLTVIL...NYWPGKETQL → YQIKSIPASH...KIPKGKLHYK

Note: No experimental confirmation available.Curated
Show »
Length:612
Mass (Da):67,677
Checksum:iE8A59A7530E0B475
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6S4F5H6S4_HUMAN
Solute carrier organic anion transp...
SLCO1C1
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444A → T in BAH14027 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q9NYB5-4)
Sequence conflicti559S → F in BAH11737 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9NYB5-3)
Sequence conflicti660T → S in BAH14027 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452781 – 118Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_042882177 – 225Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_045279640 – 712HIYLG…KETQL → YQIKSIPASHCYSIPDLHNA TDTNKFSCHFTACKTYISGT NCDTGHSVNSPKHCSTFHFK EKLCFKTQKFYNQERKNNGV YKIPKGKLHYK in isoform 3 and isoform 4. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260704 mRNA Translation: AAF70338.1
AF205076 mRNA Translation: AAG42208.1
AK294333 mRNA Translation: BAH11737.1
AK296236 mRNA Translation: BAH12289.1
AK303713 mRNA Translation: BAH14027.1
AL834209 mRNA Translation: CAI46209.1
AC092491 Genomic DNA No translation available.
BC022461 mRNA Translation: AAH22461.1
CCDSiCCDS53757.1 [Q9NYB5-3]
CCDS53758.1 [Q9NYB5-2]
CCDS53759.1 [Q9NYB5-4]
CCDS8683.1 [Q9NYB5-1]
RefSeqiNP_001139416.1, NM_001145944.1 [Q9NYB5-4]
NP_001139417.1, NM_001145945.1 [Q9NYB5-2]
NP_001139418.1, NM_001145946.1 [Q9NYB5-3]
NP_059131.1, NM_017435.4 [Q9NYB5-1]
XP_005253451.1, XM_005253394.2 [Q9NYB5-1]
XP_005253453.1, XM_005253396.2 [Q9NYB5-4]
XP_011519011.1, XM_011520709.2
XP_016874973.1, XM_017019484.1
XP_016874974.1, XM_017019485.1
UniGeneiHs.47261

Genome annotation databases

EnsembliENST00000266509; ENSP00000266509; ENSG00000139155 [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155 [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155 [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155 [Q9NYB5-3]
GeneIDi53919
KEGGihsa:53919
UCSCiuc001rei.3 human [Q9NYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260704 mRNA Translation: AAF70338.1
AF205076 mRNA Translation: AAG42208.1
AK294333 mRNA Translation: BAH11737.1
AK296236 mRNA Translation: BAH12289.1
AK303713 mRNA Translation: BAH14027.1
AL834209 mRNA Translation: CAI46209.1
AC092491 Genomic DNA No translation available.
BC022461 mRNA Translation: AAH22461.1
CCDSiCCDS53757.1 [Q9NYB5-3]
CCDS53758.1 [Q9NYB5-2]
CCDS53759.1 [Q9NYB5-4]
CCDS8683.1 [Q9NYB5-1]
RefSeqiNP_001139416.1, NM_001145944.1 [Q9NYB5-4]
NP_001139417.1, NM_001145945.1 [Q9NYB5-2]
NP_001139418.1, NM_001145946.1 [Q9NYB5-3]
NP_059131.1, NM_017435.4 [Q9NYB5-1]
XP_005253451.1, XM_005253394.2 [Q9NYB5-1]
XP_005253453.1, XM_005253396.2 [Q9NYB5-4]
XP_011519011.1, XM_011520709.2
XP_016874973.1, XM_017019484.1
XP_016874974.1, XM_017019485.1
UniGeneiHs.47261

3D structure databases

ProteinModelPortaliQ9NYB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NYB5, 2 interactors
MINTiQ9NYB5
STRINGi9606.ENSP00000370964

Chemistry databases

ChEMBLiCHEMBL2073697
DrugBankiDB00286 Conjugated Equine Estrogens
DB00509 Dextrothyroxine
DB00586 Diclofenac
DB00390 Digoxin
DB00917 Dinoprostone
DB00783 Estradiol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00939 Meclofenamic acid
DB00563 Methotrexate
DB01092 Ouabain
DB00252 Phenytoin
DB01032 Probenecid
DB04348 Taurocholic Acid

Protein family/group databases

TCDBi2.A.60.1.15 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ9NYB5
PhosphoSitePlusiQ9NYB5

Polymorphism and mutation databases

BioMutaiSLCO1C1
DMDMi27734564

Proteomic databases

PaxDbiQ9NYB5
PeptideAtlasiQ9NYB5
PRIDEiQ9NYB5
ProteomicsDBi83207
83208 [Q9NYB5-2]

Protocols and materials databases

DNASUi53919
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266509; ENSP00000266509; ENSG00000139155 [Q9NYB5-1]
ENST00000540354; ENSP00000438665; ENSG00000139155 [Q9NYB5-2]
ENST00000545102; ENSP00000444527; ENSG00000139155 [Q9NYB5-4]
ENST00000545604; ENSP00000444149; ENSG00000139155 [Q9NYB5-3]
GeneIDi53919
KEGGihsa:53919
UCSCiuc001rei.3 human [Q9NYB5-1]

Organism-specific databases

CTDi53919
DisGeNETi53919
EuPathDBiHostDB:ENSG00000139155.8
GeneCardsiSLCO1C1
HGNCiHGNC:13819 SLCO1C1
MIMi613389 gene
neXtProtiNX_Q9NYB5
OpenTargetsiENSG00000139155
PharmGKBiPA37815
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9NYB5
KOiK08747
OMAiDASSSMW
OrthoDBiEOG091G08QD
PhylomeDBiQ9NYB5

Enzyme and pathway databases

ReactomeiR-HSA-879518 Transport of organic anions

Miscellaneous databases

GenomeRNAii53919
PROiPR:Q9NYB5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139155 Expressed in 124 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLCO1C1
ExpressionAtlasiQ9NYB5 baseline and differential
GenevisibleiQ9NYB5 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
IPR030764 OATP1C1
PANTHERiPTHR11388 PTHR11388, 1 hit
PTHR11388:SF99 PTHR11388:SF99, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO1C1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYB5
Secondary accession number(s): B7Z251
, B7Z3Q3, B7Z8P1, F5GZD6, Q5JPA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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