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Entry version 130 (11 Dec 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Golgin subfamily A member 6A

Gene

GOLGA6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • Golgi organization Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6A
Alternative name(s):
Golgin linked to PML
Golgin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA6A
Synonyms:GLP, GOLGA6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159289.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13567 GOLGA6A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610288 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NYA3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
342096

Open Targets

More...
OpenTargetsi
ENSG00000159289

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38364

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NYA3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA6A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900691 – 693Golgin subfamily A member 6AAdd BLAST693

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NYA3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NYA3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NYA3

PeptideAtlas

More...
PeptideAtlasi
Q9NYA3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NYA3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83204

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NYA3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NYA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in seminiferous tubes in testis. Highly expressed in spermatids, barely detectable in late pachytene spermatocytes, and not detectable in spermatogonia. Detected at intermediate levels in pancreas and lymph nodes, and at much lower levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, lung, placenta, brain and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159289 Expressed in 69 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NYA3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044978
HPA050087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131163, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9NYA3, 46 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290438

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NYA3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NYA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili14 – 611Sequence analysisAdd BLAST598

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4725 Eukaryota
ENOG410ZIE4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000062932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NYA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQEAMSG

Database of Orthologous Groups

More...
OrthoDBi
358120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NYA3

TreeFam database of animal gene trees

More...
TreeFami
TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024858 Golgin_A

The PANTHER Classification System

More...
PANTHERi
PTHR10881 PTHR10881, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15070 GOLGA2L5, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NYA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK
60 70 80 90 100
TDSSPETTTS GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK
110 120 130 140 150
QVEHQLEEAK KTNNEIHKAQ MERLETINIL TLEKADLKTT LYHTKRAARH
160 170 180 190 200
FEEESKDLAG RLQYSLQRIQ ELERALCAVS TQQQEEDRSS SCREAVLQRW
210 220 230 240 250
LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER ARWQERMWKM
260 270 280 290 300
SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
310 320 330 340 350
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE
360 370 380 390 400
AQRVREQERL CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE
410 420 430 440 450
RLQKQEKRLW DQEERLWKKE ERLQKQEERL ALSQNHKLDK QLAEPQCSFE
460 470 480 490 500
DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA ASHQNQQLET QLSLVALPGE
510 520 530 540 550
GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE KADGTEQVER
560 570 580 590 600
RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
610 620 630 640 650
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ
660 670 680 690
DVFYEVSLDN NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT
Length:693
Mass (Da):79,946
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD54FA366168C27B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86S → N in AAF72196 (PubMed:11161787).Curated1
Sequence conflicti123R → Q in AAF72196 (PubMed:11161787).Curated1
Sequence conflicti134K → E in BAF85263 (PubMed:14702039).Curated1
Sequence conflicti198Q → H in AAF72535 (PubMed:11161787).Curated1
Sequence conflicti561 – 566VTDGMR → LCPLTG in AAF72535 (PubMed:11161787).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047540200W → R1 PublicationCorresponds to variant dbSNP:rs2018461Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF263742 mRNA Translation: AAF72196.1
AF266285 Genomic DNA Translation: AAF72535.1
AK292574 mRNA Translation: BAF85263.1
AC013486 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32290.1

NCBI Reference Sequences

More...
RefSeqi
NP_001033729.2, NM_001038640.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290438; ENSP00000290438; ENSG00000159289

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
342096

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:342096

UCSC genome browser

More...
UCSCi
uc002axa.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263742 mRNA Translation: AAF72196.1
AF266285 Genomic DNA Translation: AAF72535.1
AK292574 mRNA Translation: BAF85263.1
AC013486 Genomic DNA No translation available.
CCDSiCCDS32290.1
RefSeqiNP_001033729.2, NM_001038640.2

3D structure databases

SMRiQ9NYA3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131163, 1 interactor
IntActiQ9NYA3, 46 interactors
STRINGi9606.ENSP00000290438

PTM databases

iPTMnetiQ9NYA3
PhosphoSitePlusiQ9NYA3

Polymorphism and mutation databases

BioMutaiGOLGA6A
DMDMi215274151

Proteomic databases

jPOSTiQ9NYA3
MassIVEiQ9NYA3
PaxDbiQ9NYA3
PeptideAtlasiQ9NYA3
PRIDEiQ9NYA3
ProteomicsDBi83204

Genome annotation databases

EnsembliENST00000290438; ENSP00000290438; ENSG00000159289
GeneIDi342096
KEGGihsa:342096
UCSCiuc002axa.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
342096
DisGeNETi342096
EuPathDBiHostDB:ENSG00000159289.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGA6A
HGNCiHGNC:13567 GOLGA6A
HPAiHPA044978
HPA050087
MIMi610288 gene
neXtProtiNX_Q9NYA3
OpenTargetsiENSG00000159289
PharmGKBiPA38364

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
InParanoidiQ9NYA3
OMAiSQEAMSG
OrthoDBi358120at2759
PhylomeDBiQ9NYA3
TreeFamiTF316990

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
342096
PharosiQ9NYA3 Tdark

Protein Ontology

More...
PROi
PR:Q9NYA3
RNActiQ9NYA3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159289 Expressed in 69 organ(s), highest expression level in right testis
GenevisibleiQ9NYA3 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOG6A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYA3
Secondary accession number(s): A8K959, Q9NYA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 25, 2008
Last modified: December 11, 2019
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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