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Protein

Sphingosine kinase 1

Gene

SPHK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.2 Publications

Miscellaneous

Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=14 µM for sphingosine1 Publication
  2. KM=20 µM for dihydrosphingosine1 Publication
  3. KM=77 µM for ATP1 Publication

    pH dependencei

    Optimum pH is 7.4.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei81Proton donor/acceptor1 Publication1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei86ATP1
    Binding sitei178Substrate1
    Binding sitei185ATP1
    Binding sitei191ATP1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi22 – 24ATP3
    Nucleotide bindingi54 – 58ATP5
    Nucleotide bindingi111 – 113ATP3
    Nucleotide bindingi341 – 343ATP3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB
    • calmodulin binding Source: UniProtKB
    • D-erythro-sphingosine kinase activity Source: UniProtKB
    • DNA binding Source: MGI
    • magnesium ion binding Source: UniProtKB
    • NAD+ kinase activity Source: InterPro
    • protein phosphatase 2A binding Source: BHF-UCL
    • sphinganine kinase activity Source: MGI
    • sphingosine-1-phosphate receptor activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionCalmodulin-binding, Kinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.91 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1660661 Sphingolipid de novo biosynthesis
    R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
    R-HSA-5218921 VEGFR2 mediated cell proliferation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9NYA1

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    Q9NYA1

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9NYA1

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000111

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sphingosine kinase 1 (EC:2.7.1.913 Publications)
    Short name:
    SK 1
    Short name:
    SPK 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SPHK1
    Synonyms:SPHK, SPK
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000176170.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11240 SPHK1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603730 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NYA1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi81D → A: Loss of enzyme activity. 1 Publication1
    Mutagenesisi81D → N: Strongly reduced enzyme activity. 1 Publication1
    Mutagenesisi82G → D: Loss of enzyme activity. 1 Publication1
    Mutagenesisi197F → A: Abolishes interaction with CIB1; when associated with A-198. 1
    Mutagenesisi198L → A: Abolishes interaction with CIB1; when associated with A-197. 1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8877

    Open Targets

    More...
    OpenTargetsi
    ENSG00000176170

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA36070

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4394

    Drug and drug target database

    More...
    DrugBanki
    DB08868 Fingolimod

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2204

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SPHK1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    17369329

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813571 – 384Sphingosine kinase 1Add BLAST384

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei193PhosphothreonineCombined sources1
    Modified residuei225Phosphoserine1 Publication1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NYA1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NYA1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NYA1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NYA1

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    83202
    83203 [Q9NYA1-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NYA1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NYA1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000176170 Expressed in 153 organ(s), highest expression level in tibial nerve

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_SPHK1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NYA1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NYA1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA022829
    HPA028761

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP (PubMed:12080051). Interacts with CIB1, the interaction occurs in a calcium-dependent manner (PubMed:19854831). Interacts with TRAF2 (PubMed:20577214).By similarity3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114396, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NYA1, 56 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9NYA1

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000313681

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9NYA1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1384
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9NYA1

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NYA1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 159DAGKcPROSITE-ProRule annotationAdd BLAST148

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 82Substrate binding4

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi147 – 155Nuclear export signal 19
    Motifi161 – 169Nuclear export signal 29

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1116 Eukaryota
    COG1597 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157864

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000111460

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG054796

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NYA1

    KEGG Orthology (KO)

    More...
    KOi
    K04718

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NCTRLLC

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G06SM

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NYA1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF354296

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.10330, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017438 ATP-NAD_kinase_N
    IPR001206 Diacylglycerol_kinase_cat_dom
    IPR016064 NAD/diacylglycerol_kinase_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00781 DAGK_cat, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00046 DAGKc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF111331 SSF111331, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50146 DAGK, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NYA1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT
    60 70 80 90 100
    LMLTERRNHA RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA
    110 120 130 140 150
    IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM
    160 170 180 190 200
    NLLSLHTASG LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLRL
    210 220 230 240 250
    AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP LEEPVPSHWT
    260 270 280 290 300
    VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL
    310 320 330 340 350
    RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV
    360 370 380
    QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL
    Length:384
    Mass (Da):42,518
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB04A7F2034C2DB0
    GO
    Isoform 2 (identifier: Q9NYA1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSAQVLGFLR...WQREPRVEVM

    Show »
    Length:470
    Mass (Da):51,054
    Checksum:iF6BF2D324E12CFC0
    GO
    Isoform 3 (identifier: Q9NYA1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-3: P → PVVGCGRGLFGFVFS

    Show »
    Length:398
    Mass (Da):43,944
    Checksum:i7F2C9B26C030E560
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7EMA4K7EMA4_HUMAN
    Sphingosine kinase 1
    SPHK1
    152Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EJ32K7EJ32_HUMAN
    Sphingosine kinase 1
    SPHK1
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Missing in CAB92131 (Ref. 4) Curated1
    Sequence conflicti11 – 15LPRPC → ARL in CAB92131 (Ref. 4) Curated5
    Sequence conflicti114 – 115NA → KP in CAB92131 (Ref. 4) Curated2
    Sequence conflicti251V → M in AAF73423 (PubMed:10802064).Curated1
    Sequence conflicti260V → I in AAF73423 (PubMed:10802064).Curated1
    Sequence conflicti302L → F in AAF73423 (PubMed:10802064).Curated1
    Sequence conflicti325V → G in CAB92131 (Ref. 4) Curated1
    Sequence conflicti337V → M in AAG01980 (PubMed:10947957).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Isoform 2 (identifier: Q9NYA1-2)
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti34A → T. Corresponds to variant dbSNP:rs346803Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0354531M → MSAQVLGFLRSWTPLPLAAP RGPAAAGNDAGAPAATAPGG EGEPHSRPCDARLGSTDKEL KAGAAATGSAPTAPGTPWQR EPRVEVM in isoform 2. 2 Publications1
    Alternative sequenceiVSP_0470783P → PVVGCGRGLFGFVFS in isoform 3. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF266756 mRNA Translation: AAF73470.1
    AF238083 mRNA Translation: AAF73423.1
    AF200328 mRNA Translation: AAG01980.1
    AK023393 mRNA Translation: BAB14558.1
    AK292294 mRNA Translation: BAF84983.1
    AK022402 mRNA Translation: BAB14028.1
    AJ245504 mRNA Translation: CAB92131.1
    AC090699 Genomic DNA No translation available.
    CH471099 Genomic DNA Translation: EAW89392.1
    CH471099 Genomic DNA Translation: EAW89393.1
    BC009419 mRNA Translation: AAH09419.1
    BC014439 mRNA Translation: AAH14439.1
    BC030553 mRNA Translation: AAH30553.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11744.1 [Q9NYA1-2]
    CCDS45785.1 [Q9NYA1-1]
    CCDS59297.1 [Q9NYA1-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001136073.1, NM_001142601.1 [Q9NYA1-1]
    NP_001136074.1, NM_001142602.1 [Q9NYA1-1]
    NP_068807.2, NM_021972.3 [Q9NYA1-3]
    NP_892010.2, NM_182965.2 [Q9NYA1-2]
    XP_005257823.1, XM_005257766.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.68061

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000323374; ENSP00000313681; ENSG00000176170 [Q9NYA1-2]
    ENST00000392496; ENSP00000376285; ENSG00000176170 [Q9NYA1-1]
    ENST00000545180; ENSP00000440970; ENSG00000176170 [Q9NYA1-1]
    ENST00000590959; ENSP00000468547; ENSG00000176170 [Q9NYA1-3]
    ENST00000592299; ENSP00000465726; ENSG00000176170 [Q9NYA1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8877

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8877

    UCSC genome browser

    More...
    UCSCi
    uc002jrf.1 human [Q9NYA1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF266756 mRNA Translation: AAF73470.1
    AF238083 mRNA Translation: AAF73423.1
    AF200328 mRNA Translation: AAG01980.1
    AK023393 mRNA Translation: BAB14558.1
    AK292294 mRNA Translation: BAF84983.1
    AK022402 mRNA Translation: BAB14028.1
    AJ245504 mRNA Translation: CAB92131.1
    AC090699 Genomic DNA No translation available.
    CH471099 Genomic DNA Translation: EAW89392.1
    CH471099 Genomic DNA Translation: EAW89393.1
    BC009419 mRNA Translation: AAH09419.1
    BC014439 mRNA Translation: AAH14439.1
    BC030553 mRNA Translation: AAH30553.1
    CCDSiCCDS11744.1 [Q9NYA1-2]
    CCDS45785.1 [Q9NYA1-1]
    CCDS59297.1 [Q9NYA1-3]
    RefSeqiNP_001136073.1, NM_001142601.1 [Q9NYA1-1]
    NP_001136074.1, NM_001142602.1 [Q9NYA1-1]
    NP_068807.2, NM_021972.3 [Q9NYA1-3]
    NP_892010.2, NM_182965.2 [Q9NYA1-2]
    XP_005257823.1, XM_005257766.2
    UniGeneiHs.68061

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3VZBX-ray2.00A/B/C9-364[»]
    3VZCX-ray2.30A/B/C/D/E/F9-364[»]
    3VZDX-ray2.30A/B/C/D/E/F9-364[»]
    4L02X-ray2.75A/B/C9-364[»]
    4V24X-ray1.80A/B1-363[»]
    ProteinModelPortaliQ9NYA1
    SMRiQ9NYA1
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114396, 12 interactors
    IntActiQ9NYA1, 56 interactors
    MINTiQ9NYA1
    STRINGi9606.ENSP00000313681

    Chemistry databases

    BindingDBiQ9NYA1
    ChEMBLiCHEMBL4394
    DrugBankiDB08868 Fingolimod
    GuidetoPHARMACOLOGYi2204
    SwissLipidsiSLP:000000111

    PTM databases

    iPTMnetiQ9NYA1
    PhosphoSitePlusiQ9NYA1

    Polymorphism and mutation databases

    BioMutaiSPHK1
    DMDMi17369329

    Proteomic databases

    MaxQBiQ9NYA1
    PaxDbiQ9NYA1
    PeptideAtlasiQ9NYA1
    PRIDEiQ9NYA1
    ProteomicsDBi83202
    83203 [Q9NYA1-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    8877
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000323374; ENSP00000313681; ENSG00000176170 [Q9NYA1-2]
    ENST00000392496; ENSP00000376285; ENSG00000176170 [Q9NYA1-1]
    ENST00000545180; ENSP00000440970; ENSG00000176170 [Q9NYA1-1]
    ENST00000590959; ENSP00000468547; ENSG00000176170 [Q9NYA1-3]
    ENST00000592299; ENSP00000465726; ENSG00000176170 [Q9NYA1-1]
    GeneIDi8877
    KEGGihsa:8877
    UCSCiuc002jrf.1 human [Q9NYA1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8877
    DisGeNETi8877
    EuPathDBiHostDB:ENSG00000176170.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SPHK1
    HGNCiHGNC:11240 SPHK1
    HPAiHPA022829
    HPA028761
    MIMi603730 gene
    neXtProtiNX_Q9NYA1
    OpenTargetsiENSG00000176170
    PharmGKBiPA36070

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1116 Eukaryota
    COG1597 LUCA
    GeneTreeiENSGT00940000157864
    HOGENOMiHOG000111460
    HOVERGENiHBG054796
    InParanoidiQ9NYA1
    KOiK04718
    OMAiNCTRLLC
    OrthoDBiEOG091G06SM
    PhylomeDBiQ9NYA1
    TreeFamiTF354296

    Enzyme and pathway databases

    BRENDAi2.7.1.91 2681
    ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
    R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
    R-HSA-5218921 VEGFR2 mediated cell proliferation
    SABIO-RKiQ9NYA1
    SignaLinkiQ9NYA1
    SIGNORiQ9NYA1

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SPHK1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Sphingosine_kinase_1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8877

    Protein Ontology

    More...
    PROi
    PR:Q9NYA1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000176170 Expressed in 153 organ(s), highest expression level in tibial nerve
    CleanExiHS_SPHK1
    ExpressionAtlasiQ9NYA1 baseline and differential
    GenevisibleiQ9NYA1 HS

    Family and domain databases

    Gene3Di3.40.50.10330, 1 hit
    InterProiView protein in InterPro
    IPR017438 ATP-NAD_kinase_N
    IPR001206 Diacylglycerol_kinase_cat_dom
    IPR016064 NAD/diacylglycerol_kinase_sf
    PfamiView protein in Pfam
    PF00781 DAGK_cat, 1 hit
    SMARTiView protein in SMART
    SM00046 DAGKc, 1 hit
    SUPFAMiSSF111331 SSF111331, 1 hit
    PROSITEiView protein in PROSITE
    PS50146 DAGK, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPHK1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NYA1
    Secondary accession number(s): Q8N632
    , Q96GK1, Q9HD92, Q9NY70, Q9NYL3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
    Last sequence update: October 1, 2000
    Last modified: December 5, 2018
    This is version 164 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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